scholarly journals HPLC/DAD Comparison of Sixteen Bioactive Components between Da-Cheng-Qi Decoction and its Parent Herbal Medicines

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500
Author(s):  
Fengguo Xu ◽  
Ying Liu ◽  
Rui Song ◽  
Haijuan Dong ◽  
Zunjian Zhang
Keyword(s):  
Herbal Medicines ◽  
Preparation Procedure ◽  
Bioactive Components ◽  
Natural Medicines ◽  
Radix Et Rhizoma Rhei

Differences in the contents of sixteen bioactive components (three tannins, five anthraquinones, six flavonoids and two neolignans) between Da-Cheng-Qi decoction (DCQD) and its three constitutional herbal medicines (Radix et Rhizoma Rhei, Cortex Magnoliae officinalis, and Fructus Aurantii Immaturus) were compared using validated HPLC/DAD methods. The results indicated that there existed some kinds of interactions between these constitutional natural medicines during the DCQD preparation procedure, which could either enhance or depress the extractive rates of bioactive components.

Natural Phytochemicals and Their Therapeutic Role in Management of Several Diseases: A Review

2020 ◽  
Vol 6 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Nitin R. Shirsath ◽  
Ajaygiri K. Goswami
Keyword(s):  
Side Effects ◽  
Low Cost ◽  
Herbal Medicines ◽  
Biological Source ◽  
Natural Medicine ◽  
Synthetic Chemicals ◽  
Alternative Approach ◽  
Health Related ◽  
Activity Mechanism ◽  
Natural Medicines

Introduction: These days, a lot of people face some health-related problems in day to day life. The conventional synthetic medicine is not effective enough to cure them alone. The conventional therapy for the management of these health-related issues involves the use of hazardous synthetic chemicals and surgical diagnosis, which have lots of serious side effects. It is necessary to conduct research on herbal medicines, this is an alternative approach to avoid the side effects of synthetic medicines to achieve high effectiveness, low cost and improve patient compliance. Methods: The present survey is an analysis of some of the available data on the use of plants with their biological source, active phytochemicals constituents and a probable activity/ mechanism of action of several classes of drugs. This work also focused on highlighting the advantages of natural medicines for maximum utilization. Results: This article aims to increase awareness about natural medicine and help people find a suitable herbal medicine for the treatment of specific diseases. Conclusion: This article also exhibits the scope for further process in the development of new natural substance for the management of several diseases.

scholarly journals Regeneration and Reuse of Immunoaffinity Column for Highly Efficient Clean-Up and Economic Detection of Ochratoxin A in Malt and Ginger

Toxins ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 462 ◽  
Author(s):  
Xi Liu ◽  
Xiaofei Liu ◽  
Pinxuan Huang ◽  
Fang Wei ◽  
Guangyao Ying ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
High Performance ◽  
Ph Value ◽  
Low Cost ◽  
Herbal Medicines ◽  
Preparation Procedure ◽  
Preservation Solution ◽  
Traditional Procedure ◽  
Sample Extraction ◽  
Sample Preparation Procedure

Immunoaffinity columns (IACs) are most popularly used for mycotoxin clean-up in complex matrices prior to chromatographic analysis. But, their high cost has limited their wide application and the regeneration of IACs for multiple instances of reuse is important. This study aimed to investigate the feasibility of regeneration and reuse of IACs for purification of ochratoxin A (OTA) in spiked raw malt and dried ginger samples followed by high performance liquid chromatography-fluorescence detection. After each use, the IACs were filled with phosphate buffer saline (PBS) as the preservation solution and stored at 8 °C overnight for regeneration and reuse until the recovery rate was <70%. The results showed that matrix type, preparation procedure, and pH value of sample extraction exhibited major effects on the reuse of IACs for OTA clean-up. While, after modifying the sample preparation procedure using water as the diluent and the solution at a pH of 7 to 8, the IACs could be used eight and three times for the spiked raw malt and dried ginger samples with OTA after regeneration. Regarding the traditional procedure recommended in Chinese Pharmacopoeia (2015 edition), the IACs could be used for three and two times for the spiked raw malt and dried ginger samples with OTA, respectively. Therefore, the corresponding experimental cost could be reduced to one-eighth and one-third of the original cost. This is the first study on the regeneration and reuse of IACs for OTA clean-up in complex Chinese herbal medicines, providing a green and economical tool for a large number of samples analysis with low cost.

scholarly journals Pharmacokinetic Comparison in Rats of Six Bioactive Compounds between Da-Cheng-Qi Decoction and its Parent Herbal Medicines

2010 ◽  
Vol 5 (5) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Fengguo Xu ◽  
Ying Liu ◽  
Haijuan Dong ◽  
Rui Song ◽  
Zunjian Zhang
Keyword(s):  
Raw Materials ◽  
Herbal Medicines ◽  
Pharmacokinetic Parameters ◽  
Plasma Samples ◽  
Active Components ◽  
Statistical Comparison ◽  
Aloe Emodin ◽  
Student’S T ◽  
Radix Et Rhizoma Rhei ◽  
Student’S T Test

Da-Cheng-Qi decoction (DCQD) is a purgative compound prescription used in China and East Asia. In this paper, pharmacokinetic differences of six major active components (rhein, emodin, aloe-emodin, magnolol, naringenin and hesperetin) between DCQD and its three constitutional herbal medicines i.e. Radix et Rhizoma Rhei, Cortex Magnoliae officinalis and Fructus Aurantii Immaturus were investigated in rats after oral administration. Plasma samples were analyzed for the quantification of the six active components using validated LC-MS/MS methods. Unpaired Student's t-test was used for statistical comparison. Significant differences ( p<0.05) in the main pharmacokinetic parameters for rhein, emodin, aloe-emodin, magnolol, naringenin and hesperetin were found between DCQD and the decoction of its constitutional single herbal medicines, which demonstrated the presence of drug-drug interactions between these constitutional raw materials of DCQD occurring either in the procedure of decoction or during ADME process.

scholarly journals Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaolei Zhao ◽  
Jingxiang Pang ◽  
Jialei Fu ◽  
Meina Yang ◽  
Eduard Van Wijk ◽  
...  
Keyword(s):  
Photon Emission ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Bioactive Constituents ◽  
Curative Effect ◽  
Active Compounds ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Living Organisms ◽  
Natural Medicines

Ultraweak photon emission emitted by all living organisms has been confirmed to be a noninvasive indicator for their physiological and pathological characteristics. In this study, we investigated the characteristics of spontaneous photon emission (SPE) and the contents of specific active compounds of roots and flowers buds of several fresh Chinese herbal medicines (natural medicines) with different growth ages and varieties. The results revealed that the contents of specific active compounds from same species herbs with different growth ages and varieties were significantly different, and this difference could be reflected by their SPE. Because the contents of specific bioactive constituents in Chinese herbs are closely related to their quality and curative effect, the SPE measurement technique may contribute to the quality control of Chinese herbal medicine in the future.

scholarly journals A review of available herbal medicine options for the treatment of chronic insomnia

2021 ◽  
Vol 15 (5) ◽  
pp. 1589-1598
Author(s):  
Z. Poursaleh ◽  
M. Khodadoost ◽  
E. Vahedi ◽  
M. M. A. Attari ◽  
M. Jafari ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Herbal Medicine ◽  
Adverse Effects ◽  
Randomized Clinical Trials ◽  
Herbal Medicines ◽  
Chronic Insomnia ◽  
Bioactive Metabolites ◽  
Additional Information ◽  
Sedative Activity ◽  
Natural Medicines

Background: Insomnia is a universal health problem that affects the health and quality of life of people worldwide. During the last decade treatment of insomnia with herbal has been introduced to be effective but unfortunately, the safety and efficacy of these medicines are currently uncertain. However, the administration of various herbal medicines for insomnia is increasing mainly due to the diversity of various adverse effects of western medication. Objective: The present study is aimed to investigate available herbal medicine options for the treatment of chronic insomnia. Method: All demanded data were retrieved from electronic databases, Natural Medicines, TCMID, Natural Medicines Comprehensive Database, MedlinePlus, PubMed, EMBASE, and Google Scholar. Among them, randomized clinical trials were chosen precisely to be investigated more for seeking any additional information related to the treatment of chronic insomnia. All related papers in English and Persian languages included in the study criteria. At first, 162 articles were chosen to be investigated, then after screening all articles based on the PRISMA method, 83 qualified articles remained to be investigated carefully. Results: Herbal plants with medical properties as sedative agents are obtaining more and more attention because they contain various types of natural bioactive metabolites with the lowest rate of adverse effects. Moreover, these novel medicines are highly economic, with high efficacy while could be available easily. Conclusion: The data from this study demonstrated that medical plants could yield sedative activity and some of them are effective for insomnia, but we must not forget that further clinical trials are demanded to approve this. Keywords: Sleep disorders, Chronic insomnia, Herbal medicine, Alternative medication, Treatment.

scholarly journals Concise review: Medicinal plants are effective against leishmaniasis

2017 ◽  
Vol 4 (11) ◽  
pp. 1775
Author(s):  
Mahmoud Bahmani ◽  
Naser Abbasi ◽  
Masih Hosseini ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Medicinal Plants ◽  
Adverse Effects ◽  
Herbal Medicines ◽  
Pubmed Central ◽  
Pentavalent Antimony ◽  
Artemisia Aucheri ◽  
Tropical Areas ◽  
Review Study ◽  
Great Health ◽  
Natural Medicines

Leishmaniasis is an important zoonotic parasitic disease in tropical areas. It is a neglected disease and is a great health catastrophe in Iran. Pentavalent antimony compounds are used for its treatment, but they have adverse effects. Therefore, the use of natural herbs with low adverse effects seems necessary for treatment of Leishmaniasis. In this study, we tried to introduce the natural medicines effective against Leishmaniasis. In this review study, keywords searched included natural medicines, herbal medicines, medicinal plants, Leishmaniasis, and treatment in relevant publications published between 1990 and 2017. Searching was on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The relevant articles were reviewed for the review study. The results showed that medicinal plants: Ferula assafoatida (with IC50 of 0.38 mg/ml), Glycyrrhiza glabra (with IC50 of 25mg/ml), Allium sativum (with IC50 of 0.57 mg/ml), Cephalis ipecacuana (with IC50 of 0.01 mg/ml), Artemisia aucheri (with IC50 of 0.46 mg/ml) and Eucalyptus globulus (with IC50 of 0.17 mg/ml) were the natural medicines effective against the disease. Compositions with di-, tri-, tetra-Sulfide, Coumarin derivatives, Camuou-nephrole, Episamarcandine, Amblipernine, Carnephrole, Azafoetidine, Froxolicin, Azafoetidinole, Saradaferine, 1, 8 Cineole, Scopodreniole, Semen, Sabinine, Cineole, Inaleole, Eojenole, Farenzole, Borneol, Allicin, acid Glycerisic, Emetine and Cephalin can have the potential to produce potent drugs against Leishmaniasis. In sum, there are some specific medicinal plants and compounds effective against Leishmaniasis which can be used per se or following changes in their formula to prepare and introduce new drags against this disease.

scholarly journals Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Ying He ◽  
Mei-Bian Hu ◽  
Ruo-Lan Li ◽  
Rong Zhao ◽  
Lin-Hong Fan ◽  
...  
Keyword(s):  
Epileptic Seizures ◽  
Brain Dysfunction ◽  
Bioactive Components ◽  
Cure Rate ◽  
Sugar Degradation ◽  
Genetic Level ◽  
Low Toxicity ◽  
Natural Drugs ◽  
Glial Cell Proliferation ◽  
Natural Medicines

Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation. Although the mechanism of epilepsy research has reached up to the genetic level, the presently available treatment and recovery records of epilepsy does not seem promising. Recently, natural medicines have attracted more researches owing to their low toxicity and side-effects as well as the excellent efficacy, especially in chronic diseases. In this study, the antiepileptic mechanism of the bioactive components of natural drugs was reviewed so as to provide a reference for the development of potential antiepileptic drugs. Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically. Improving the accuracy of medication and the cure rate is expected to compensate for the shortage of the conventional epilepsy treatment drugs.

Herbal medicines - safe and effective?

1986 ◽  
Vol 24 (25) ◽  
pp. 97-100
Keyword(s):  
Complementary Medicine ◽  
General Practitioners ◽  
Herbal Medicines ◽  
Recent Survey ◽  
Natural Medicines

Many people use herbal medicines for minor, self-limiting conditions. The failure of orthodox medicines to cure and anxiety about their potentially serious unwanted effects, have led some to turn to herbal medicines for treatment of more chronic and disabling conditions as well, often in the belief, that time-honoured natural medicines must be safe. A recent survey found that general practitioners understood less about herbal medicines than about other disciplines in complementary medicine.1

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