Examining Racial Differences in Community Integration between Black and White Homeless Veterans

1. We measured urinary kallikrein (kininogenin) excretion in black and white normotensive subjects during a variety of manipulations of salt and water balance. 2. A large intravenous saline load administered while the subjects were on an unrestricted sodium diet did not significantly change urinary kallikrein activity in either racial group. 3. After several days of dietary sodium restriction both racial groups increased their urinary kallikrein activity. An intravenous water load given then further increased urinary kallikrein activity. White subjects were studied for an additional 24 h period, and urinary kallikrein activity returned to pre-water load values, indicating that the excretion of a water load in sodium-depleted subjects is associated with an increase in kallikrein excretion. 4. Black subjects excreted less kallikrein in the urine than white subjects during the initial 24 h periods of unrestricted dietary sodium intake, but there were no other significant racial differences during the other experimental conditions.

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Racial Differences in the Sums of Skinfolds and Percentage of Body Fat Estimated from Impedance in Black and White Girls, 9 to 19 Years of Age: The National Heart, Lung, and Blood Institute Growth and Health Study

Obesity ◽

10.1038/oby.2001.37 ◽

2001 ◽

Vol 9 (5) ◽

pp. 297-305 ◽

Cited By ~ 27

Author(s):

John A. Morrison ◽

Bruce A. Barton ◽

Eva Obarzanek ◽

Patricia B. Crawford ◽

Shumei S. Guo ◽

...

Keyword(s):

Racial Differences ◽

Body Fat ◽

Health Study ◽

Black And White ◽

Blood Institute ◽

White Girls ◽

Percentage Of Body Fat ◽

National Heart ◽

National Heart Lung

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Race Differences in Antisocial Behaviors and Attitudes and Early Initiation of Substance Use

Journal of Drug Education ◽

10.2190/3bhh-3nat-bynk-d3vc ◽

1992 ◽

Vol 22 (2) ◽

pp. 115-130 ◽

Cited By ~ 32

Author(s):

Elizabeth A. Wells ◽

Diane M. Morrison ◽

Mary R. Gillmore ◽

Richard F. Catalano ◽

Bonita Iritani ◽

...

Keyword(s):

Antisocial Behavior ◽

Racial Differences ◽

Asian American ◽

Economic Status ◽

Fifth Grade ◽

Racial Groups ◽

White Children ◽

Black And White ◽

Antisocial Attitudes ◽

American Children

This article examines racial differences in self-reported delinquency, school trouble, antisocial attitudes, and toughness and in teacher-rated aggressive and inattentive behaviors among fifth grade black, white, and Asian American subjects. Also examined are the relationships of these variables to substance initiation within each racial group. Controlling for socio-economic status, racial groups differed from one another in self-reported delinquency, school trouble and toughness, and in teacher-rated aggressiveness and inattention. Antisocial behavior and attitudes were stronger predictors of substance initiation for Asian American than for black and white children. For white children both self-reported and teacher-rated behavior were significantly related to substance initiation. For black children, only self-reported antisocial behavior, and for Asian American children only self-reported delinquent behavior and attitudes predicted substance initiation. Implications for prevention and research are discussed.

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Looking Like a Winner: Candidate Appearance and Electoral Success in New Democracies

World Politics ◽

10.1017/s0043887110000195 ◽

2010 ◽

Vol 62 (4) ◽

pp. 561-593 ◽

Cited By ~ 95

Author(s):

Chappell Lawson ◽

Gabriel S. Lenz ◽

Andy Baker ◽

Michael Myers

Keyword(s):

Racial Differences ◽

New Democracies ◽

Elected Officials ◽

Electoral Success ◽

Black And White ◽

Profound Influence ◽

Snap Judgments

A flurry of recent studies indicates that candidates who simply look more capable or attractive are more likely to win elections. In this article, the authors investigate whether voters' snap judgments of appearance travel across cultures and whether they influence elections in new democracies. They show unlabeled, black-and-white pictures of Mexican and Brazilian candidates' faces to subjects living in America and India, asking them which candidates would be better elected officials. Despite cultural, ethnic, and racial differences, Americans and Indians agree about which candidates are superficially appealing (correlations ranging from .70 to .87). Moreover, these superficial judgments appear to have a profound influence on Mexican and Brazilian voters, as the American and Indian judgments predict actual election returns with surprising accuracy. These effects, the results also suggest, may depend on the rules of the electoral game, with institutions exacerbating or mitigating the effects of appearance.

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Abstract T P146: Vitamin D Deficiency is Associated With Stroke in Black and White Participants of the REGARDS Study

Stroke ◽

10.1161/str.45.suppl_1.tp146 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

Suzanne E Judd ◽

Virginia J Howard ◽

Paul Muntner ◽

Brett M Kissela ◽

Bhupesh Panwar ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Racial Differences ◽

Sex Education ◽

The United States ◽

Dietary Vitamin ◽

Equal Distribution ◽

Black And White ◽

Increased Risk ◽

Regards Study

Objective: Black Americans are at greater risk of both stroke and vitamin D deficiency than white Americans. We have previously shown that both higher dietary vitamin D and sunlight exposure are associated with decreased risk of stroke; however, serum 25(OH) is thought to be a better marker of vitamin D status. Methods: Using a case cohort design, we examined the association of plasma 25(OH)D with incident stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a cohort of black and white participants from across the United States enrolled between 2003 and 2007. Medical records were reviewed by physicians and strokes were classified on the basis of symptoms and neuroimaging. Strokes through July 1, 2011 were included. A stratified cohort sample was selected to ensure approximately equal numbers of black and white participants and an equal distribution across ages. We used Cox proportional hazards models weighted back to the original 30,239 participants, excluding those with history of stroke. Serum 25(OH)D was measured by Immunodetection Systems ELISA. Results: Over mean follow-up of 4.4 years, there were 539 ischemic and 71 hemorrhagic strokes. The stroke-free sub-cohort included 939 participants. After adjustment for age, race, sex, education, diabetes, hypertension, smoking, atrial fibrillation, heart disease, physical activity, kidney function, calcium and phosphorous, 25(OH)D level 30 ng/mL. The direction of association was similar for hemorrhagic stroke though not statistically significant (HR=1.59; 95%CI=0.78, 3.24). Vitamin D deficiency was associated with an increased risk of all stroke (HR=1.54; 95%CI=1.05, 2.23). This effect was greater in blacks (HR=2.09; 95%CI=1.09, 3.99) than whites (HR=1.38; 95%CI=0.78, 2.42). Results were not as strong when we modeled 25(OH)D as a continuous variable (HR=0.99 per 1 ng/ml change in 25(OH)D; 95%CI=0.98, 1.01). Discussion: Similar to low vitamin D intake, vitamin D deficiency is a risk factor for incident stroke. These findings support evidence from cardiovascular and cancer epidemiology that treating low 25(OH)D may prevent strokes.

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Abstract P181: Contribution of C-Reactive Protein to Racial Disparities in Incident Hypertension: The REasons for Geographic And Racial Differences in Stroke Study (REGARDS)

Circulation ◽

10.1161/circ.137.suppl_1.p181 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Timothy B Plante ◽

D L Long ◽

George Howard ◽

April P Carson ◽

Virginia J Howard ◽

...

Keyword(s):

Racial Differences ◽

Medication Use ◽

Dietary Factors ◽

C Reactive Protein ◽

Incident Hypertension ◽

Black And White ◽

Reactive Protein ◽

Stroke Study ◽

Diet Pattern ◽

The Impact

Introduction: In the US, blacks are at higher risk of hypertension than whites. The single largest contributor to this disparity is the Southern Diet pattern. Inflammation biomarkers are associated with risk of hypertension, and C-reactive protein (CRP) is higher in blacks than whites. We studied whether elevated CRP in blacks relative to whites contributes to the racial disparity in hypertension in blacks. Methods: We included 6,548 black and white men and women age ≥45 years from the REGARDS cohort without hypertension at baseline ('03-'07) and who completed visit 2 in '13-'16. Incident hypertension was defined as BP ≥140/90 mm Hg or hypertension medication use at visit 2. Using logistic regression, the black:white odds ratio (OR) for incident hypertension was calculated adjusting for age, sex, race, and baseline SBP. We assessed the percent change in the black:white OR for incident hypertension after adding CRP. The 95% CI was calculated using 1,000 bootstrapped samples. We determined the impact of known hypertension risk factors and anti-inflammatory medications on the percent mediation by CRP. Results: Hypertension developed in 46% of blacks and 33% of whites. Adjusting for demographics, the black:white OR (95% CI) was 1.51, which was reduced to 1.46, a 9.3% reduction (95% CI 5.4%, 13.2%) by CRP (Table). In models including exercise, waist circumference, BMI, and depressive symptoms, the percent mediation by CRP was 3.7% (1.0%, 6.4%). Similar patterns were seen for models incorporating socioeconomic factors and medication use. After adding Southern diet pattern and dietary Na/K ratio, CRP no longer attenuated the association (1.3% mediation; -1.5, 4.1). Conclusions: CRP significantly attenuated the black-white difference in incident hypertension; however, once dietary factors were accounted for, CRP had no impact on the black:white difference in incident hypertension. Thus, inflammation as measured by CRP, may be part of the reason that dietary factors influence the black:white disparity in incident hypertension.

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Abstract MP008: Racial Differences in Total, Free, and Bioavailable 25(OH)D and PTH Levels and CVD Risk Among Postmenopausal Women

Circulation ◽

10.1161/circ.135.suppl_1.mp008 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Xi Zhang ◽

Wanzhu Tu ◽

Lesley Tinker ◽

JoAnn E Manson ◽

Simin Liu ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Black Women ◽

Postmenopausal Women ◽

Racial Differences ◽

White Women ◽

Sitting Time ◽

Cvd Risk ◽

Black And White ◽

Circulating Levels

Background: Recent evidence suggests that racial differences in circulating levels of free or bioavailable 25(OH)D rather than total 25(OH)D may explain the apparent racial disparities in cardiovascular disease(CVD).However, few prospective studies have directly tested this hypothesis. Objective: Our study prospectively examined black white differences in the associations of total, free, and bioavailable 25(OH)D, vitamin D binding protein (VDBP), and parathyroid hormone (PTH) levels at baseline with incident CVD in a large, multi-ethnic, geographically diverse cohort of postmenopausal women. Method: We conducted a case-cohort study among 79,705 black and non-Hispanic white postmenopausal women aged 50 to 79 years and free of CVD at baseline in the Women’s Health Initiative Observational Study (WHI-OS). We included a randomly chosen subcohort of 1,300 black and 1,500 white noncases at baseline and a total of 550 black and 1,500 white women who developed incident CVD during the follow up. We directly measured circulating levels of total 25(OH)D, VDBP (monoclonal antibody assay), albumin, and PTH and calculated free and bioavailable vitamin D levels. Weighted Cox proportional hazards models were used while adjusting for known CVD risk factors. Results: At baseline, white women had higher mean levels of total 25(OH)D and VDBP and lower mean levels of free and bioavailable 25(OH)D and PTH than black women (all P values < 0.0001). White cases had lower levels of total 25(OH)D and VDBP and higher levels of PTH than white noncases, while black cases had higher levels of PTH than black noncases (all P values < 0.05). There was a trend toward an increased CVD risk associated with low total 25(OH)D and VDBP levels or elevated PTH levels in both US black and white women. In the multivariable analyses, the total, free, and bioavailable 25(OH)D, and VDBP were not significantly associated with CVD risk in black or white women. A statistically significant association between higher PTH levels and increased CVD risk persisted in white women, however. The multivariate-adjusted hazard ratios [HRs] comparing the extreme quartiles of PTH were 1.37 (95% CI: 1.06-1.77; P-trend=0.02) for white women and 1.12 (95% CI: 0.79-1.58; P-trend=0.37) for black women. This positive association among white women was also independent of total, free, and bioavailable 25(OH)D or VDBP. There were no significant interactions with other pre-specified factors, including BMI, season of blood draw, sunlight exposure, recreational physical activity, sitting time, or renal function. Interpretation: Findings from a large multiethnic case-cohort study of US black and white postmenopausal women do not support the notion that circulating levels of vitamin D biomarkers may explain black-white disparities in CVD but indicate that PTH excess may be an independent risk factor for CVD in white women.

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