Challenging the current paradigm of the chemiosmotic theory for cyanide toxicity

Toxicology ◽  
2020 ◽  
Vol 432 ◽  
pp. 152377
Author(s):  
Kendall Wallace
2020 ◽  
Vol 28 (3) ◽  
pp. 360-370
Author(s):  
Stanislav N. Kotlyarov ◽  
Anna A. Kotlyarova

Despite all achievements of the modern medicine, the problem of chronic obstructive pulmonary disease (COPD) does not lose its relevance. The current paradigm suggests a key role of macrophages in inflammation in COPD. Macrophages are known to be heterogeneous in their functions. This heterogeneity is determined by their immunometabolic profile and also by peculiarities of lipid homeostasis of cells. Aim. To analyze the role of the ABCA1 transporter, a member of the ABC A subfamily, in the pathogenesis of COPD. The expression of ABCA1 in lung tissues is on the second place after the liver, which shows the important role of the carrier and of lipid homeostasis in the function of lungs. Analysis of the literature shows that participation of the transporter in inflammation consists in regulation of the content of cholesterol in the lipid rafts of the membranes, in phagocytosis and apoptosis. Conclusion. Through regulation of the process of reverse transport of cholesterol in macrophages of lungs, ABCA1 can change their inflammatory response, which makes a significant contribution to the pathogenesis of COPD.


Author(s):  
Francisco J. Ayala ◽  
Camilo J. Cela-Conde

This chapter starts with the general principles of the theory of evolution by natural selection advanced by Darwin and the Mendelian theory of heredity. Next comes consideration of the “new-Darwinian synthesis” or “synthetic theory,” which integrates both precedents into what has become the current paradigm of the life sciences. Molecular evolution and population genetics follow, including epigenetic processes. Next, special models of selection are considered, such as sexual selection and the models that account for altruistic behavior. After the mechanisms of speciation, the main concepts of systematics are explored, which facilitate understanding of different traits. The chapter finally explores the fundamental concepts of taxonomy and the methods from phenetics to cladistics, that makes it possible to evaluate the diversity of organisms and the methods for dating the fossil record.


2021 ◽  
Vol 13 (4) ◽  
pp. 1608
Author(s):  
Rubén Cordera ◽  
Soledad Nogués ◽  
Esther González-González ◽  
José Luis Moura

Autonomous vehicles (AVs) can generate major changes in urban systems due to their ability to use road infrastructures more efficiently and shorten trip times. However, there is great uncertainty about these effects and about whether the use of these vehicles will continue to be private, in continuity with the current paradigm, or whether they will become shared (carsharing/ridesharing). In order to try to shed light on these matters, the use of a scenario-based methodology and the evaluation of the scenarios using a land use–transport interaction model (LUTI model TRANSPACE) is proposed. This model allows simulating the impacts that changes in the transport system can generate on the location of households and companies oriented to local demand and accessibility conditions. The obtained results allow us to state that, if AVs would generate a significant increase in the capacity of urban and interurban road infrastructures, the impacts on mobility and on the location of activities could be positive, with a decrease in the distances traveled, trip times, and no evidence of significant urban sprawl processes. However, if these increases in capacity are accompanied by a large augment in the demand for shared journeys by new users (young, elderly) or empty journeys, the positive effects could disappear. Thus, this scenario would imply an increase in trip times, reduced accessibilities, and longer average distances traveled, all of which could cause the unwanted effect of expelling activities from the consolidated urban center.


Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 7
Author(s):  
Tomislav Meštrović ◽  
Mario Matijašić ◽  
Mihaela Perić ◽  
Hana Čipčić Paljetak ◽  
Anja Barešić ◽  
...  

The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the contamination of the periurethral space by specific uropathogens residing in the gut, which is followed by urethral colonization and pathogen ascension to the urinary bladder. Consequently, studying the relationship between gut microbiota and the subsequent development of bacteriuria and UTI represents an important field of research. However, the well-established diagnostic and therapeutic paradigm for urinary tract infections (UTIs) has come into question with the discovery of a multifaceted, symbiotic microbiome in the healthy urogenital tract. More specifically, emerging data suggest that vaginal dysbiosis may result in Escherichia coli colonization and prompt recurrent UTIs, while urinary microbiome perturbations may precede the development of UTIs and other pathologic conditions of the urinary system. The question is whether these findings can be exploited for risk reduction and treatment purposes. This review aimed to appraise the three aforementioned specific microbiomes regarding their potential influence on UTI development by focusing on the recent studies in the field and assessing the potential linkages between these different niches, as well as evaluating the state of translational research for novel therapeutic and preventative approaches.


2021 ◽  
Vol 141 (5) ◽  
pp. S65
Author(s):  
M. Laughter ◽  
M. Yemc ◽  
C.L. Presley ◽  
K.J. Pulsipher ◽  
M.D. Szeto ◽  
...  

2019 ◽  
Vol 6 (2) ◽  
pp. 190-209
Author(s):  
Jeong Eun Annabel We

This article argues that the spirit of Bandung’s relevance in a time of resurgent fascist mobilization is in the new logic of movement that the 1955 Afro-Asian conference in Bandung, Indonesia espoused. The critiques of liberal humanism and its relation to fascism by Ernst Bloch, Takeuchi Yoshimi, and Aimé Césaire reveal that an underlying problem of coloniality and movement remain in current paradigm of liberalism. The article situates conceptual reworkings of colonial-fascist movement by the thinkers Takeuchi Yoshimi, Frantz Fanon, and Ch’oe In-Hun within the trajectory of the spirit of Bandung. Through this engagement, the article argues that the spirit of Bandung has called for revolutionary movement beyond the grids of colonial mobility in the transpacific.


2019 ◽  
Vol 25 (2) ◽  
pp. 257-284
Author(s):  
Armen E. Petrosyan

Purpose The paper aims to present a systematic conceptual analysis of the problem of organizational goal and to reduce the insights into it provided by the main conceptions taken in their development from one to another, to break out of the ruling paradigm and outline a new solution. Design/methodology/approach The study has been carried out from the historical and critical perspective. Findings The paper discovers the logic of the evolution the approaches to organizational goals have undergone and portrays it in a matrix form in the heart of which is the “zigzag effect”: each posterior stage returns to the essential elements rejected by those preceding it, and the last stage, being diametrically opposite to the first, is, at that, as well as the latter, akin to the intermediate stages. The opportunities afforded by the current paradigm have been exhausted and it seems to run to an impasse. Instead, the author suggests a new frame of orientation: organizational goals are closely interknit with personal, but not reducible to them and bear fundamentally transpersonal character, while the mechanism of involving the preferences of individuals and groups in goal-setting is based on the self-contained interests of the organization they pertain to. Research limitations/implications The findings, conclusions and generalizations obtained can serve for a necessary ground to researchers getting deeper into the essence of what bonds organizational life and activity. Practical implications The material empowers practitioners to comprehend the difficulties of framing cohesive goal and find efficient ways to overcome them. It is of value also to the teachers seeking to present a more exact and elaborate view of teleological foundations of management and organization theory. Originality/value Both the conceptual analysis of the evolution of the approaches to organizational goals and the author’s exposition of its logic and vision of their nature are provided for the first time.


2014 ◽  
Vol 21 (3) ◽  
pp. 191-198 ◽  
Author(s):  
Olalekan Michael Ogundele ◽  
Philip Adeyemi Adeniyi ◽  
Duyilemi Chris Ajonijebu ◽  
Amin Abdulbasit ◽  
Ansa Emmanuel Cobham ◽  
...  

Author(s):  
Francis J. M. Farley

The redshifts and luminosities of type 1A supernovae are conventionally fitted with the current paradigm, which holds that the galaxies are locally stationary in an expanding metric. The fit fails unless the expansion is accelerating; driven perhaps by ‘dark energy’. Is the recession of the galaxies slowed down by gravity or speeded up by some repulsive force? To shed light on this question the redshifts and apparent magnitudes of type 1A supernovae are re-analysed in a cartesian frame of reference omitting gravitational effects. The redshift is ascribed to the relativistic Doppler effect which gives the recession velocity when the light was emitted; if this has not changed, the distance reached and the luminosity follow immediately. This simple concept fits the observations surprisingly well with the Hubble constant H 0 =62.9±0.3 km s −1  Mpc −1 . It appears that the galaxies recede at unchanging velocities, so on the largest scale there is no significant intergalactic force. Reasons for the apparent absence of an intergalactic force are discussed.


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