Effect of topiramate on cognitive function and activity level following neonatal seizures

2005 ◽  
Vol 6 (4) ◽  
pp. 529-536 ◽  
Author(s):  
Qian Zhao ◽  
Yingchun Hu ◽  
Gregory L. Holmes
Keyword(s):  
Cognitive Function ◽  
Activity Level ◽  
Neonatal Seizures

scholarly journals Relations of Food Pattern and Physical Activity with Academic Achievement and Cognitive Function

2020 ◽  
Vol 2 (2) ◽  
pp. 56-65
Author(s):  
Ayu Wulandari ◽  
Zulhaida Lubis ◽  
Evawani Aritonang
Keyword(s):  
Physical Activity ◽  
Academic Achievement ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Activity Level ◽  
P Value ◽  
Moderate Physical Activity ◽  
Cross Sectional ◽  
Food Pattern ◽  
Food Patterns

Introduction: The results of the initial survey showed that there were seven children with low food pattern and moderate physical activity was having a cognitive function and low academic achievement at school, and three children with good food pattern and moderate physical activity were having good cognitive and high academic achievement in school. This study was to determine the relations of food patterns and physical activity with academic achievement and cognitive function. Methods: This study was a cross-sectional study that was conducted at Elementary School 2 Blangkeujeren, West Labuhanhaji Sub-district, South Aceh District from March 2017 to June 2017. This study used a total sampling design is 81 students. Subjects are all students in grade five (42 students) and six (39 students). Data were collected by using questionnaires include Food Frequency Questionary (FFQ), Food Recall 24 hours, Physical Activity Level (PAL). Last year's report card value and the Mini-Mental State Examination (MMSE) were used to assess cognitive children. Results: The relationship between the type and the amount of macro and micronutrient intake obtained p-value<0.05. This study also showed a relationship between food patterns and cognitive function in children. Based on the research results, there is a relationship between physical activity and academic achievement (p<0.05). There is a relationship between physical activity and cognitive function in children. Conclusion: There is a relationship between food patterns, physical activity, academic achievement, and cognitive function.

scholarly journals The Relationship of Physical Activity Level With Arterial Stiffness, Cerebral Blood Flow, and Cognitive Function in Young Adults

2021 ◽  
Vol 30 (4) ◽  
pp. 527-536
Author(s):  
Ruda Lee ◽  
Jin-Su Kim ◽  
Eui-Young Lee ◽  
Shin-Young Park ◽  
Moon-Hyon Hwang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Arterial Stiffness ◽  
Physical Activity Level ◽  
Activity Level ◽  
Step Counts ◽  
Intensity Physical Activity ◽  
Relationship Of

PURPOSE: This study aimed to investigate the relationship of physical activity level with arterial stiffness, cerebral blood flow, and cognitive function in young adults.METHODS: Forty-six young adults participated in this cross-sectional study. Physical activity levels were assessed for seven consecutive days using accelerometers. To assess arterial stiffness, the carotid–femoral artery pulse wave velocity (cfPWV) and augmentation index (AIx) were measured. Cognitive function was assessed using the Stroop Color-Word test, and cerebral blood flow was evaluated using near-infrared spectroscopy devices during the cognitive function test.RESULTS: AIx was inversely associated with axis-1 counts, vector magnitude counts, moderate-intensity physical activity (MPA) time, and moderate-to-vigorous intensity physical activity (MVPA) time (r≤-0.31, p≤.04). The AIx adjusted to the heart rate of 75 beats per minute was inversely correlated with axis-1 counts, vector magnitude counts, step counts, MPA time, and MVPA time (r≤-0.33, p≤.03). There was no relationship between cfPWV and physical activity level parameters (r≤0.10, p≥.51). The difference between oxygenated and deoxygenated hemoglobin levels was positively related to axis-1 counts, step counts, MPA time, and MVPA time (r≥0.31, p≤.04). Regarding cognitive function, the response time for the presented words was negatively associated with step counts (r=-0.42, p<.01) and MPA time (r=-0.29, p=.048), and response time on the presented words with matched color was negatively related to step counts (r=-0.31, p=.04).CONCLUSIONS: More physically active adults are more likely to have lower arterial stiffness, increased brain oxygenation, and better cognitive function, even if they are young and healthy.

scholarly journals Contrasting prenatal nutrition and environmental exposures in association with birth weight and cognitive function in children at 7 years

2020 ◽  
pp. bmjnph-2020-000099
Author(s):  
Chris Gennings ◽  
Alicja Wolk ◽  
Niclas Hakansson ◽  
Christian Lindh ◽  
Carl-Gustaf Bornehag
Keyword(s):  
Birth Weight ◽  
Cognitive Function ◽  
Environmental Exposures ◽  
Activity Level ◽  
Food Sources ◽  
Environmental Toxicants ◽  
Dietary Restrictions ◽  
Good Nutrition ◽  
Nutritional Needs ◽  
The Impact

BackgroundGood nutrition is essential for individual health, a notion that is particularly true during pregnancy. We have used a nutrition index that measures the adequacy of one’s diet relative to the unique nutritional needs of individuals due to, for example, their activity level, dietary restrictions, lifestyle and body size. The use of this personalised metric of dietary nutritiousness in the analysis of prenatal environmental exposures and developmental outcomes permits testing for potential mitigating effects of good nutrition. We also provide an analysis strategy for investigating the balance in beneficial food sources which are also the source of environmental toxicants.MethodsA holistic measure of nutrition, My Nutrition Index (MNI), measures the nutrient quality (ie, ‘nutritiousness’) of a specified daily diet. MNI is calculated based on quantification of dozens of macronutrients and micronutrients that are specific to an individual’s nutritional needs by incorporating dietary restrictions, subject characteristics, activity level and health behaviours. The Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy Study is a Swedish pregnancy cohort, with prenatal endocrine disrupting chemicals (EDCs) exposure and dietary data available. This makes it possible to test for the potential mitigating effects of good nutrition on health and development effects in offspring from EDCs.ResultsUsing prenatal Food Frequency Questionnaire data to construct an individual’s MNI, the index was significantly and positively associated with important metabolic outcome (as measured by birth weight) and cognitive function at age 7 years (as measured by WISC IQ) in children when adjusted for covariates and prenatal concentrations of an EDC. In a stratified analysis of ‘low’ and ‘high’ fish consumption, a potential source of perfluoro-octanesulfonic acid (PFOS), the association between PFOS and birth weight was diminished in the high consumption group compared with the low consumption group.ConclusionsThus, MNI is evidently a metric of the general nutritiousness of daily diets and is useful in environmental health studies in representing the impact of good nutrition, even during pregnancy.

Long-Term Effects of Individually Tailored Physical Training and Activity on Physical Function, Well-Being and Cognition in Scandinavian Nursing Home Residents: A Randomized Controlled Trial

Gerontology ◽  
2016 ◽  
Vol 62 (6) ◽  
pp. 571-580 ◽  
Author(s):  
Kerstin Frändin ◽  
Helena Grönstedt ◽  
Jorunn L. Helbostad ◽  
Astrid Bergland ◽  
Mette Andresen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Nursing Home ◽  
Cognitive Function ◽  
Physical Activity Level ◽  
Nursing Home Residents ◽  
Well Being ◽  
Activity Level ◽  
Long Term Effects ◽  
Physical Functions

Background: The preservation of physical functions such as muscle strength, balance and mobility is fundamental to maintaining independence in activities of daily living (ADL). The physical activity level of most nursing home residents is very low, which implies that they are often subject to a decline in health, mobility, autonomy and social contacts and are also at risk of suffering a decline in mental well-being. In a previous study, we demonstrated that transfers, balance and physical activity level improved after 3 months of individually tailored intervention in nursing home residents. Objective: To evaluate the long-term effects on ADL, balance function, physical activity level, physical performance, falls-related self-efficacy, well-being and cognitive function 3 months after the completion of our intervention in nursing home residents. Methods: The study was a multicenter randomized, controlled clinical trial with a parallel-group design. It was conducted in nursing homes in Sweden, Norway and Denmark, with an intervention period lasting 3 months and a follow-up at 6 months. Initially, 322 nursing home residents with a mean age of 85 years were included; 85 from Sweden, 171 from Norway and 66 from Denmark. Of these, 241 [129 intervention group (IG), 112 control group (CG)] were eligible for the 6-month follow-up tests. The level of dependence in ADL, physical activity level, several dimensions of physical function, well-being, falls-related self-efficacy and cognitive function were assessed with reliable and valid instruments at baseline, immediately after 3 months of intervention and 3 months later at the 6-month follow-up. Results: After 3 months of intervention and an additional period of 3 months without intervention, only the following 2 variables demonstrated significant group differences: social and cognitive function, measured by the Functional Independence Measure n-r, where the IG deteriorated while the CG was almost stable. However, regarding transfers, the IG deteriorated significantly less than the CG. Conclusion: Without supervised physical exercise that challenged the individuals' capability, gains in ADL function, balance and transfer ability deteriorated during the 3 months following the intervention period. Thus, continuous, individually adjusted and supported physical activity seems crucial for the maintenance of physical functions in these vulnerable elderly persons.

scholarly journals The Effect of Diabetes Medication on Cognitive Function: Evidence from the PATH Through Life Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Pushpani M. Herath ◽  
Nicolas Cherbuin ◽  
Ranmalee Eramudugolla ◽  
Kaarin J. Anstey
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Cognitive Function ◽  
Pharmacological Treatment ◽  
Verbal Learning ◽  
Activity Level ◽  
Hypoglycemic Agents ◽  
Diabetes Treatment ◽  
Cognitive Domains ◽  
Life Study

Objective. To examine the effect of diabetes treatment on change of measures of specific cognitive domains over 4 years.Research Design and Methods. The sample was drawn from a population-based cohort study in Australia (the PATH Through Life Study) and comprised 1814 individuals aged 65–69 years at first measurement, of whom 211 were diagnosed with diabetes. Cognitive function was measured using 10 neuropsychological tests. The effect of type of diabetes treatment (diet, oral hypoglycemic agents, and insulin) on measures of specific cognitive domains was assessed using Generalized Linear Models adjusted for age, sex, education, smoking, physical activity level, BMI, and hypertension.Results. Comparison of cognitive function between diabetes treatment groups showed no significant effect of type of pharmacological treatment on cognitive function compared to diet only group or no diabetes group. Of those on oral hypoglycaemic treatment only, participants who used metformin alone had better cognitive function at baseline for the domains of verbal learning, working memory, and executive function compared to participants on other forms of diabetic treatment.Conclusion. This study did not observe significant effect from type of pharmacological treatment for diabetes on cognitive function except that participants who only used metformin showed significant protective effect from metformin on domain of verbal learning, working memory, and executive function.

The relationship between activity level and cognitive function in Chinese community-dwelling elderly

2021 ◽  
pp. 1-9
Author(s):  
Man-Li Liu ◽  
Li-Jun Jiang ◽  
Wen-Xiao Wang ◽  
Xiao Zhang ◽  
Xiao-Hua Xing ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Community Dwelling ◽  
Activity Level ◽  
Chinese Community ◽  
The Relationship

scholarly journals What Could Aid in Slowing Down Cognitive Function?

2021 ◽  
Vol 28 (2) ◽  
pp. E202124
Author(s):  
Azad Ilhan ◽  
Murat Varli ◽  
Pelin Bilgic
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Physical Activity Level ◽  
Short Form ◽  
Daily Intake ◽  
Depression Scale ◽  
Activity Level ◽  
Vitamin B3 ◽  
Slowing Down ◽  
Depression Status

The objective of this research was to assess the relationship between cognitive function, physical activity level, nutritional and depression status in the elderly. Materials and Methods. A total of 200 individuals (≥ 65 years) were included in the study. General characteristics of the individuals, biochemical findings, nutritional habits, 24-hour physical activity level and food consumption records were assessed. Cognitive function and depression status were screened by the Standardized Mini-Mental State Examination (S-MMSE) and Geriatric Depression Scale-Short Form (GDS-SF), respectively. Results. Thirty-eight (19%) of the 200 individuals were diagnosed with dementia. On the evaluation of all the individuals, moderate and statistically significant negative correlation (r=-0.558, p < 0.01) was found between the S-MMSE and GDS-SF values. In addition, a moderate and statistically significant positive correlation was found between the S-MMSE and physical activity level values (r=0.553, p < 0.01). Vitamin B1, vitamin B2, vitamin B3, vitamin B6, and zinc intakes were lower in women than in men (p < 0.05). Moreover, it was observed that the vitamin B3 and calcium intakes were below the recommended daily intake in both the genders. Conclusions. Proper nutritional treatment and increasing the levels of physical activity may aid in slowing down the progression of dementia.

scholarly journals Physical Function, Cognitive Function and Daily Activities in Patients Hospitalized Due to COVID-19: A Descriptive Cross-Sectional Study in Sweden

2021 ◽  
Vol 18 (21) ◽  
pp. 11600
Author(s):  
Alexandra Larsson ◽  
Annie Palstam ◽  
Hanna Persson
Keyword(s):  
Cognitive Function ◽  
Physical Function ◽  
Average Length ◽  
Length Of Hospital Stay ◽  
Cross Sectional Study ◽  
Activity Level ◽  
Daily Activities ◽  
Sectional Study ◽  
Cross Sectional ◽  
Body Strength

An estimated 14–20% of people infected with COVID-19 require medical care. The aim of the present study was to evaluate physical function, cognitive function, and daily activities in patients hospitalized due to COVID-19, and to investigate differences depending on age and admission to the intensive care unit (ICU). This prospective descriptive cross-sectional study included a consecutive sample of 211 patients (mean age 65.1 years, 67.3% men) hospitalized due to COVID-19 in Sweden. Data regarding physical function and daily activities were collected in hospital from July 2020 to February 2021. The average length of hospital stay was 33.8 days, and 48.8% of the patients were admitted to the ICU. Physical function (grip- and lower body strength) was reduced in both groups, and significantly more in the older group, ≥65 years old, compared to the younger. Furthermore, the older group also had significantly less ability to perform activities in daily life, and had significantly reduced cognitive function as compared to the younger age group. In patients treated in the ICU, physical impairments as well as the activity level were significantly more pronounced compared to patients not treated in the ICU. Patients hospitalized due to COVID-19 are physically impaired, have mild cognitive impairments, and have difficulties performing daily activities. The findings in this study indicate the need for out-patient follow-up and rehabilitation for patients hospitalized due to COVID-19, especially in older patients and patients treated in the ICU.

Specificity determinants of phosphoprotein phosphatases controlling kinetochore functions

2020 ◽  
Vol 64 (2) ◽  
pp. 325-336 ◽  
Author(s):  
Dimitriya H. Garvanska ◽  
Jakob Nilsson
Keyword(s):  
Spindle Assembly Checkpoint ◽  
Activity Level ◽  
Phosphorylation Sites ◽  
Binding Affinities ◽  
Mitotic Kinases ◽  
Anaphase Onset ◽  
Phosphoprotein Phosphatases ◽  
Linear Motifs ◽  
Temporal And Spatial ◽  
Kinetochore Function

Abstract Kinetochores are instrumental for accurate chromosome segregation by binding to microtubules in order to move chromosomes and by delaying anaphase onset through the spindle assembly checkpoint (SAC). Dynamic phosphorylation of kinetochore components is key to control these activities and is tightly regulated by temporal and spatial recruitment of kinases and phosphoprotein phosphatases (PPPs). Here we focus on PP1, PP2A-B56 and PP2A-B55, three PPPs that are important regulators of mitosis. Despite the fact that these PPPs share a very similar active site, they target unique ser/thr phosphorylation sites to control kinetochore function. Specificity is in part achieved by PPPs binding to short linear motifs (SLiMs) that guide their substrate specificity. SLiMs bind to conserved pockets on PPPs and are degenerate in nature, giving rise to a range of binding affinities. These SLiMs control the assembly of numerous substrate specifying complexes and their position and binding strength allow PPPs to target specific phosphorylation sites. In addition, the activity of PPPs is regulated by mitotic kinases and inhibitors, either directly at the activity level or through affecting PPP–SLiM interactions. Here, we discuss recent progress in understanding the regulation of PPP specificity and activity and how this controls kinetochore biology.

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