scholarly journals A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus

The Lancet ◽  
2004 ◽  
Vol 364 (9437) ◽  
pp. 869-874 ◽  
Author(s):  
BL Rao ◽  
Atanu Basu ◽  
Niteen S Wairagkar ◽  
Milind M Gore ◽  
Vidya A Arankalle ◽  
...  
2007 ◽  
Vol 80 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Babasaheb V. Tandale ◽  
Sanjaykumar S. Tikute ◽  
Vidya A. Arankalle ◽  
Padmakar S. Sathe ◽  
Manohar V. Joshi ◽  
...  

2021 ◽  
Author(s):  
Nidhi Mudgil ◽  
Sidharth Sekhar Mishra ◽  
Anuj Kumar Pandey

UNSTRUCTURED People from 3 districts of Andhra Pradesh, India were struck by a mysterious disease on Saturday December 05th, 2020. Epileptic like symptoms were present and most common differential diagnosis which can be made as of now is to classify them under Acute Encephalitis Syndrome (AES) or some form of heavy metal or insecticide poisoning affecting the Central Nervous System (CNS). To understand the reason behind the sudden illness blood tests, CT (brain) scans and Cerebral Spinal Fluid (CSF) tests were done on patients but all test reports have turned out to be normal. Approximately 600 cases and 1 death are reported till 13th December 2020. Majority of the victims were in the 20- 30 years age groups. All the patients followed the same sequence of events having dizziness, headache, nausea, foam in mouth and epilepsy-like symptoms. Serological, viral markers and radiological findings along with COVID-19 reports were negative/ normal. Symptomatic management was provided, and patient recovered without any neurological abnormality. High levels of Lead and Nickel were found in the blood samples of some patients. This is the first report as it provides preliminary findings of the mysterious disease. More information will provide further clarity about the outbreak


2020 ◽  
Vol 21 (9) ◽  
pp. 3377 ◽  
Author(s):  
Marcella Prete ◽  
Elvira Favoino ◽  
Giacomo Catacchio ◽  
Vito Racanelli ◽  
Federico Perosa

The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.


1964 ◽  
Vol 11 (6) ◽  
pp. 418-420
Author(s):  
W.A. Leonard

It was once suggested that beginning the study of freshman high school algebra is not totally unlike embarking upon the sea of matrimony. Both are milestones in one's life, involving opportunities for excitement, adventure, growth, and rich and lasting reward; but, nonetheless, both tend to necessitate some different approaches to problems, some new ways of thinking, and certainly, in more than a few cases, some amount of adjustment. Without intending to attach social implication to algebra, we as teachers cannot fail to recognize that the first exposure to high school algebra can be a foreboding experience to many elementary school graduates, particularly in the light of the statistical evidence for the high fatality rate of students taking algebra for the first time.


2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 6034-6034
Author(s):  
N. Slimack ◽  
S. M. Belknap ◽  
K. R. Carson ◽  
T. M. Kuzel ◽  
S. Trifilio ◽  
...  

1989 ◽  
Vol 8 (6) ◽  
pp. 507-510 ◽  
Author(s):  
J. Hettiarachchi ◽  
G.C.S. Kodithuwakku

Sri Lanka is a developing agricultural country with a high fatality rate due to self-poisoning with very toxic agrochemicals as the main poisoning agents. A prospective study of 97 consecutive admissions following self-poisoning reveals that easy availability of the agrochemicals together with the lack of knowledge regarding their lethality were the main causative factors determining the choice of poisoning agents. Developing community awareness of the lethality of these substances, educating the farmers with regards to proper storage and disposal of agrochemicals together with stricter legislation regarding their sale and distribution may reduce the incidence of self-poisoning due to these agents with a consequent reduction in mortality due to self-poisoning.


2005 ◽  
Vol 42 (3) ◽  
pp. 495-496 ◽  
Author(s):  
G. Geevarghese ◽  
V. A. Arankalle ◽  
R. Jadi ◽  
P. C. Kanojia ◽  
M. V. Joshi ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Markus Wiedmann ◽  
Thor Skattør ◽  
Arne Stray-Pedersen ◽  
Luis Romundstad ◽  
Ellen-Ann Antal ◽  
...  

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and developed a characteristic syndrome thereafter. The rapid progressive clinical course and high fatality rate of CVT in combination with thrombocytopenia in such a cluster and in otherwise healthy adults is a recent phenomenon. Cerebral autopsy findings were those of venous hemorrhagic infarctions and thrombi in dural venous sinuses, including thrombus material apparently rich in thrombocytes, leukocytes and fibrin. Vessel walls were free of inflammation. Extra-cerebral manifestations included leech-like thrombi in large veins, fibrin clots in small venules and scattered hemorrhages on skin and membranes. CVT with thrombocytopenia after adenovirus vectored COVID-19 vaccination is a new clinical syndrome that needs to be recognized by clinicians, is challenging to treat and seems associated with a high mortality rate.


Author(s):  
Kun Hwang ◽  
Hyung Sun Hong ◽  
Won Young Heo

This study aimed to ascertain whether medical students would enter a closed area where there was a raging epidemic of an infectious disease with a high fatality rate, and includes reasons for the students entering or refusing to enter. Participants included 50 second-year medical students. They were assigned to read a novel entitled 28, written by Youjeong Jeong, and discuss it in groups. Using their book reports, their decisions of whether or not to enter Hwayang, the city from the novel, and the reasons for their decisions were analyzed; we furthermore investigated the factors affecting their decisions. Among the 50 respondents, 18 students (36%) answered that they would enter, and the remaining 32 students (64%) answered that they would not enter the zone. The reasons given for entering were responsibility (44%), sense of ethics (33%), social duty (17%), and sense of guilt (6%). The reasons the students provided for not entering were inefficiency (44%), worry regarding family (28%), needlessness of sacrifice (19%), and safety not ensured (9%). Students who had four or fewer family members were more likely to enter Hwayang than were students who had five or more family members (odds ratio, 1.85). Students who had completed over 100 hours of volunteer work were more likely to enter Hwayang than were students who had volunteered less than 100 hours (odds ratio, 2.04). Owing to their “responsibility” as a doctor, 36% of medical students answered that they would enter an exclusion zone in an infected district with a high fatality rate. However, 64% answered they would not enter because of “inefficiency.” For the medical students it is still a question ‘To enter or not to enter?’


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