Disproportionately high fatality rate of women compared to men in patients with gemcitabine-associated lung injury: Preliminary findings from RADAR

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 6034-6034
Author(s):  
N. Slimack ◽  
S. M. Belknap ◽  
K. R. Carson ◽  
T. M. Kuzel ◽  
S. Trifilio ◽  
...  
2020 ◽  
Vol 21 (9) ◽  
pp. 3377 ◽  
Author(s):  
Marcella Prete ◽  
Elvira Favoino ◽  
Giacomo Catacchio ◽  
Vito Racanelli ◽  
Federico Perosa

The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.


The Lancet ◽  
2004 ◽  
Vol 364 (9437) ◽  
pp. 869-874 ◽  
Author(s):  
BL Rao ◽  
Atanu Basu ◽  
Niteen S Wairagkar ◽  
Milind M Gore ◽  
Vidya A Arankalle ◽  
...  

1964 ◽  
Vol 11 (6) ◽  
pp. 418-420
Author(s):  
W.A. Leonard

It was once suggested that beginning the study of freshman high school algebra is not totally unlike embarking upon the sea of matrimony. Both are milestones in one's life, involving opportunities for excitement, adventure, growth, and rich and lasting reward; but, nonetheless, both tend to necessitate some different approaches to problems, some new ways of thinking, and certainly, in more than a few cases, some amount of adjustment. Without intending to attach social implication to algebra, we as teachers cannot fail to recognize that the first exposure to high school algebra can be a foreboding experience to many elementary school graduates, particularly in the light of the statistical evidence for the high fatality rate of students taking algebra for the first time.


1989 ◽  
Vol 8 (6) ◽  
pp. 507-510 ◽  
Author(s):  
J. Hettiarachchi ◽  
G.C.S. Kodithuwakku

Sri Lanka is a developing agricultural country with a high fatality rate due to self-poisoning with very toxic agrochemicals as the main poisoning agents. A prospective study of 97 consecutive admissions following self-poisoning reveals that easy availability of the agrochemicals together with the lack of knowledge regarding their lethality were the main causative factors determining the choice of poisoning agents. Developing community awareness of the lethality of these substances, educating the farmers with regards to proper storage and disposal of agrochemicals together with stricter legislation regarding their sale and distribution may reduce the incidence of self-poisoning due to these agents with a consequent reduction in mortality due to self-poisoning.


2021 ◽  
Vol 12 ◽  
Author(s):  
Markus Wiedmann ◽  
Thor Skattør ◽  
Arne Stray-Pedersen ◽  
Luis Romundstad ◽  
Ellen-Ann Antal ◽  
...  

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and developed a characteristic syndrome thereafter. The rapid progressive clinical course and high fatality rate of CVT in combination with thrombocytopenia in such a cluster and in otherwise healthy adults is a recent phenomenon. Cerebral autopsy findings were those of venous hemorrhagic infarctions and thrombi in dural venous sinuses, including thrombus material apparently rich in thrombocytes, leukocytes and fibrin. Vessel walls were free of inflammation. Extra-cerebral manifestations included leech-like thrombi in large veins, fibrin clots in small venules and scattered hemorrhages on skin and membranes. CVT with thrombocytopenia after adenovirus vectored COVID-19 vaccination is a new clinical syndrome that needs to be recognized by clinicians, is challenging to treat and seems associated with a high mortality rate.


Author(s):  
Kun Hwang ◽  
Hyung Sun Hong ◽  
Won Young Heo

This study aimed to ascertain whether medical students would enter a closed area where there was a raging epidemic of an infectious disease with a high fatality rate, and includes reasons for the students entering or refusing to enter. Participants included 50 second-year medical students. They were assigned to read a novel entitled 28, written by Youjeong Jeong, and discuss it in groups. Using their book reports, their decisions of whether or not to enter Hwayang, the city from the novel, and the reasons for their decisions were analyzed; we furthermore investigated the factors affecting their decisions. Among the 50 respondents, 18 students (36%) answered that they would enter, and the remaining 32 students (64%) answered that they would not enter the zone. The reasons given for entering were responsibility (44%), sense of ethics (33%), social duty (17%), and sense of guilt (6%). The reasons the students provided for not entering were inefficiency (44%), worry regarding family (28%), needlessness of sacrifice (19%), and safety not ensured (9%). Students who had four or fewer family members were more likely to enter Hwayang than were students who had five or more family members (odds ratio, 1.85). Students who had completed over 100 hours of volunteer work were more likely to enter Hwayang than were students who had volunteered less than 100 hours (odds ratio, 2.04). Owing to their “responsibility” as a doctor, 36% of medical students answered that they would enter an exclusion zone in an infected district with a high fatality rate. However, 64% answered they would not enter because of “inefficiency.” For the medical students it is still a question ‘To enter or not to enter?’


Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 103
Author(s):  
Sangmi Lee

Intestinal microbiota exerts protective effects against the infection of various bacterial pathogens, including Listeria monocytogenes, a major foodborne pathogen whose infection can lead to a disease (listeriosis) with a high fatality rate. As a strategy to mitigate the action of the intestinal microbiota, pathogens often produce antimicrobial proteinaceous compounds such as bacteriocins. In this review, we summarize the information currently available for the well-characterized L. monocytogenes bacteriocin listeriolysin S, with the emphasis on its intriguing mode of action as a virulence factor, which promotes the infection of L. monocytogenes by changing the composition of the intestinal microbiota. We then discuss another intriguing L. monocytogenes bacteriocin Lmo2776 that specifically inhibits the inflammogenic species, Prevotella copri, in the intestinal microbiota, reducing superfluous inflammation while weakening virulence. In addition, we describe relatively less studied phage tail-like Listeria bacteriocins (monocins) and elaborate on the possibility that these monocins could be involved in enhancing pathogenicity. In spite of the burgeoning interest in the roles played by the intestinal microbiota against the L. monocytogenes infection, our understanding on the virulence factors affecting the intestinal microbiota is still lacking, calling for further studies on bacteriocins that could function as novel virulence factors.


2014 ◽  
Vol 663 ◽  
pp. 175-184
Author(s):  
Chong Woi Joon

Nowadays, most of the passenger cars are equipped with anti-locking brake system (ABS) in order to provide better safety protection to vehicle occupants. Despite its advantages, it has been reported in the public domain that the ABS could be one of the causes in fatal frontal/rollover crashes on dry roads. This paper is first attempting to reveal the shortcomings of ABS that lead to high fatality rate. Then, in order to overcome these ABS shortcomings, a potential system called pre crash wheel-locking braking (PWLB) system is conceptually proposed. The PWLB system works by locking both front and rear wheels simultaneously that based on speed and distance between the leading and the following vehicles. With this PWLB concept it is expected that braking effect during the vehicle crash up to 2.5 meter before reaching to the occupants can be maintained. As a result, it can provide maximum braking force and improve ability to steer to the vehicle before crashing with the leading vehicle.


2019 ◽  
Vol 11 (502) ◽  
pp. eaau5485 ◽  
Author(s):  
Jeffery K. Taubenberger ◽  
John C. Kash ◽  
David M. Morens

The 2018–2019 period marks the centennial of the “Spanish” influenza pandemic, which caused at least 50 million deaths worldwide. The unprecedented nature of the pandemic’s sudden appearance and high fatality rate serve as a stark reminder of the threat influenza poses. Unusual features of the 1918–1919 pandemic, including age-specific mortality and the high frequency of severe pneumonias, are still not fully understood. Sequencing and reconstruction of the 1918 virus has allowed scientists to answer many questions about its origin and pathogenicity, although many questions remain. This Review summarizes key findings and still-to-be answered questions about this deadliest of human events.


1995 ◽  
Vol 6 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Karl Weiss ◽  
Louise Poirier ◽  
Sylvain Varin ◽  
Claire Beliveau ◽  
Michel Laverdière

The first Canadian case of hepatitis E is described in a patient who travelled to Asia for a six-month period and spent most of his time in India. Hepatitis E shares some similarities with hepatitis A, notably the mode of transmission and the absence of chronic course. However, a few important differences have been noted, including a higher mortality rate and a high fatality rate in pregnant women. Hepatitis E is very common in developing countries and should be suspected more often in individuals with gastrointestinal complaints returning from endemic areas.


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