Vitamin D Deficiency Linked With Gestational Diabetes

2012 ◽  
Vol 42 (19) ◽  
pp. 3
Author(s):  
MITCHEL L. ZOLER
Author(s):  
Ankita Kumari ◽  
Shaila Mitra ◽  
Harish C Tiwari ◽  
Reena Srivastav

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.


2018 ◽  
Vol 9 ◽  
Author(s):  
Mansour Amraei ◽  
Safoura Mohamadpour ◽  
Kourosh Sayehmiri ◽  
Seyedeh Fatemeh Mousavi ◽  
Ehsan Shirzadpour ◽  
...  

2013 ◽  
Vol 209 (6) ◽  
pp. 560.e1-560.e8 ◽  
Author(s):  
Geum Joon Cho ◽  
Soon-Cheol Hong ◽  
Min-Jeong Oh ◽  
Hai-Joong Kim

2015 ◽  
Vol 59 (5) ◽  
pp. 448-454 ◽  
Author(s):  
Esra Bahar Gur ◽  
Muammer Karadeniz ◽  
Mine Genc ◽  
Fatma Eskicioglu ◽  
Murat Yalcin ◽  
...  

2021 ◽  
Author(s):  
chun yang ◽  
Jing Wu ◽  
Sheng Ge ◽  
Wenguang Sun

Abstract Background This study was to assess vitamin D nutritional status and risk factors among pregnancy of shanghai in China. Methods A cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. All pregnancy was measured for plasma vitamin D, total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL) or very-low-density lipoprotein (VLDL) cholesterol and triglycerides, and completed OGTTs test. Age, height, and weight variables came from their electronic medical records. Criteria for vitamin D status were: <12 ng/ml: severe deficiency; 12–19 ng/ml: deficiency; 20–29 ng/ml: insufficiency; 30–50 ng/ml: normal; and > 50 ng/ml (particularly > 60 ng/ml): possibly leading to adverse effects. Vitamin D was measured from December 2016 to April 2017. Results Our study included 953 pregnant women. The mean vitamin D level of pregnancy was 16.06 (range 10.90 to 20.60) ng/ml,and severe vitamin D deficiency was 31.79%(303); vitamin D deficiency was 40.71 %(388); vitamin D insufficiency was 25.08%(239); normal vitamin D was 2.42%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, gestational diabetes mellitus, and hyperglycemia. Conclusions It is a high prevalence of vitamin D deficiency of Chinese pregnancy in shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, gestational diabetes mellitus and hyperglycemia are risk factors for vitamin D deficiency. Public health strategies should focus on the population of pregnancy in shanghai in China.


2019 ◽  
Vol 6 (2) ◽  
pp. 73-79 ◽  
Author(s):  
T. N Savchenko ◽  
I. A Dergacheva ◽  
Lyudmila A. Ozolinya

According to last research, receptors for vitamin D are found in many organs and tissues. Vitamin D deficiency leads to the development of pathological conditions in children and adults. The non-classical effects of vitamin D are important in modulating congenital and acquired immunity, regulating cell proliferation, in the progress of diabetes, the pathology of the cardiovascular system, and autoimmune diseases. The inverse correlation between the level of 25(OH)D3 and the incidence of cancer has been determined. Vitamin D affects the course of pregnancy, and the decidual and placental tissues synthesize 1.25(OH)2D. Vitamin deficiency is found in pregnant women with preeclampsia and gestational diabetes. Timely diagnosis and adequate correction of the level of vitamin D in the blood reduces the risk of developing diseases.


Author(s):  
Fehmida Parveen Memon ◽  
Ifat Baloch ◽  
Afra Rehman ◽  
Rasheeda Hingoro

Objective: To determine the vitamin D deficiency in pregnant women presented at tertiary care Hospital with gestational diabetes. Methodology: This case control study has been conducted at gynecology department of Liaquat University of Medical and health Sciences, during one year from 2018 to 2019. Women having diagnosed as gestational diabetes, age more than 18 years and equal quantity of non-diabetic pregnant women were included in the study. A 5ml blood sample was taken from each patient and sent to the Hospital diagnostic laboratory to assess the vitamin D level. All the data was collected via self-made proforma. Data was analyzed by using SPSS version 20. Results: Total 80 women with gestational diabetes and of non-gestational diabetes were studied. Mean age of the women was 34.23±12.3 years and mean gestational age was 29.34±5.7 weeks. Vitamin D deficiency was significantly high in women having gestational diabetes (P=0.0001). There was no difference in vitamin D deficiency according to occupation, residence, SES, booking status and parity. Conclusion: Vitamin D deficiency was significantly high in women having gestational diabetes as compared to normal women. By early assessment of vitamin D deficiency and its management can be reduce the risk of gestational diabetes.


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