Phenotypic antimicrobial resistance patterns in Pseudomonas aeruginosa and Acinetobacter: results of a Multicenter Intensive Care Unit Surveillance Study, 1995-2000

Pseudomonas aeruginosa is one of the gram-negative bacteria that causes infection in the Intensive Care Unit (ICU) which is easily resistant. Patients infected with carbapenem-resistant P. aeruginosa are predicted to have a poor prognosis. This study aims to know the resistance profile of meropenem-resistant P. aeruginosa in the ICU. The results of this study can be used as a measure on the success of antimicrobial resistance control, infection control programs and become a reference for empirical therapy in the ICU. This study used a cross-sectional retrospective descriptive research method and was carried out at the Clinical Microbiology Laboratory of Sanglah Hospital Denpasar for three years, from 2018 to 2020. The results showed 38 of the 93 isolates of P. aeruginosa in the ICU were resistant to meropenem and were derived from sputum and urine. The percentage of meropenem-resistant P. aeruginosa isolates was higher in the multi-drug-resistant group and mostly came from sputum specimens. In 2018, Non-MDR meropenem-resistant P. aeruginosa isolates was that 100% sensitive to all other antibiotics used to treat P. aeruginosa infections, including; ceftazidime, cefepime, ciprofloxacin, gentamicin, amikacin, and piperacillin-tazobactam. In 2019 no meropenem-resistant P. aeruginosa isolates were found. In 2020, its sensitivity to antibiotics ceftazidime and piperacillin-tazobactam was 20.0%, ciprofloxacin 60.0% and to antibiotics gentamicin and amikacin 100%. MDR meropenem-resistant P. aeruginosa isolates in 2018 were still sensitive to ceftazidime (15.4%) and amikacin (69.2%) antibiotics, while in 2019 they were only sensitive to amikacin (37.5%). In 2020, P. aeruginosa isolates were sensitive to the antibiotics ceftazidime and cefepime (11.1%), piperacillin-tazobactam (22.2%), and amikacin (88.9%). Amikacin may be the choice of treatment for MDR meropenem-resistant P. aeruginosa.

Download Full-text

Device - Associated Infections and Antimicrobial Resistance Patterns of Isolated Pathogens in Surgical Intensive Care Unit at Ain Sham University Hospital = العدوى المرتبطة بالأجهزة الطبية و أنماط مقاومة العزلات الممرضة للمضادات الحيوية في الرعاية المركزة للجراحة بمستشفى جامعة عين شمس

The Egyptian Journal of Medical Microbiology ◽

10.12816/0025916 ◽

2014 ◽

Vol 23 (4) ◽

pp. 17-26 ◽

Cited By ~ 1

Author(s):

Maha Salah El-Din Hamdy ◽

Marwa Shabban ◽

Ahmed Kamal Mohamed

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Antimicrobial Resistance ◽

University Hospital ◽

Surgical Intensive Care Unit ◽

Surgical Intensive Care ◽

Resistance Patterns

Download Full-text

Emergence of antimicrobial resistance to Pseudomonas aeruginosa in the intensive care unit: association with the duration of antibiotic exposure and mode of administration

Annals of Intensive Care ◽

10.1186/s13613-017-0296-z ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 20

Author(s):

Erlangga Yusuf ◽

Bruno Van Herendael ◽

Walter Verbrugghe ◽

Margareta Ieven ◽

Emiel Goovaerts ◽

...

Keyword(s):

Intensive Care Unit ◽

Pseudomonas Aeruginosa ◽

Intensive Care ◽

Antimicrobial Resistance ◽

Antibiotic Exposure ◽

Mode Of Administration

Download Full-text

Bloodstream infections in a medical–surgical intensive care unit: incidence, aetiology, antimicrobial resistance patterns of Gram-positive and Gram-negative bacteria

Clinical Microbiology and Infection ◽

10.1111/j.1469-0691.2009.02863.x ◽

2009 ◽

Vol 15 (10) ◽

pp. 943-946 ◽

Cited By ~ 5

Author(s):

I. Erdem ◽

A. Ozgultekin ◽

A. Sengoz Inan ◽

D. Ozturk Engin ◽

S. Senbayrak Akcay ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Antimicrobial Resistance ◽

Bloodstream Infections ◽

Surgical Intensive Care Unit ◽

Gram Negative Bacteria ◽

Surgical Intensive Care ◽

Gram Positive ◽

Gram Negative ◽

Resistance Patterns

Download Full-text

Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital

Antibiotics ◽

10.3390/antibiotics10101221 ◽

2021 ◽

Vol 10 (10) ◽

pp. 1221

Author(s):

Giancarlo Pérez-Lazo ◽

Susan Abarca-Salazar ◽

Renata Lovón ◽

Rocío Rojas ◽

José Ballena-López ◽

...

Keyword(s):

Intensive Care Unit ◽

Pseudomonas Aeruginosa ◽

Intensive Care ◽

Bacterial Resistance ◽

Antibiotic Consumption ◽

Antimicrobial Consumption ◽

Carbapenem Resistant ◽

Resistance Patterns ◽

Medical Wards ◽

Eskape Pathogens

A descriptive design was carried out studying the correlation between antimicrobial consumption and resistance profiles of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) in a Peruvian hospital, including the surgical, clinical areas and the intensive care unit (ICU) during the time period between 2015 and 2018. There was a significant correlation between using ceftazidime and the increase of carbapenem-resistant Pseudomonas aeruginosa isolations (R = 0.97; p < 0.05) and the resistance to piperacillin/tazobactam in Enterobacter spp. and ciprofloxacin usage (R = 0.97; p < 0.05) in the medical wards. The Pseudomonas aeruginosa resistance to piperacillin/tazobactam and amikacin in the intensive care unit (ICU) had a significant reduction from 2015 to 2018 (67% vs. 28.6%, 65% vs. 34.9%, p < 0.001). These findings give valuable information about the rates and dynamics in the relationship between antibiotic usage and antimicrobial resistance patterns in a Peruvian hospital and reinforce the need for continuous support and assessment of antimicrobial stewardship strategies, including microbiological indicators and antimicrobial consumption patterns.

Download Full-text