CROSS SECTIONAL STUDY OF PATIENTS WITH ACUTE CORONARY SYNDROME REQUIRING LONG TERM ORAL ANTICOAGULATION THERAPY: RESULTS FROM NATIONAL INPATIENT SAMPLE

The prevalence of Acute Coronary Syndrome (ACS) is increasing in both developed and developing countries. Uncontrolled risk factors such as smoking, hypertension, and fewer activities are the main causes of ACS recurrence within 30 days after the acute presentation. This study aims to analyze risk factors related to the recurrence rate of ACS patients in Pakraman and non-Pakraman villages in Buleleng Regency, Bali Province. Observational analytics with Cross-Sectional Study are used in this study involving 130 patients within 1 month. Data is collected through two (2) stages using a questionnaire. The bivariate analysis shows that both smoking groups (p = 0.003 and p = 0.008) and hypertension groups (p = 0.02 and p = 0.01) are associated with ACS recurrence, while physical activity groups are not related (p = 0.455 and p = 0.565). Logistic regression results show that smoking (5.633) is highly associated with ACS recurrence in Pakraman villages, while hypertension (4.784) is highly associated with ACS recurrence in non-Pakraman villages. ACS handling is important in the acute period and in the long-term to prevent the risk of recurrence.

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Are patients on oral anticoagulation therapy aware of its effects? A cross-sectional study from Karachi, Pakistan

BMC Research Notes ◽

10.1186/s13104-020-05119-w ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Ibrahim Zahid ◽

Syed Wajih Ul Hassan ◽

Nida Sehar Bhurya ◽

Sheena Nadeem Alam ◽

Choudhary Ahmed Hasan ◽

...

Keyword(s):

Oral Anticoagulation ◽

Anticoagulation Therapy ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Oral Anticoagulation Therapy

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Relationship of health literacy and adherence to oral anticoagulation therapy in patients with atrial fibrillation: a cross‐sectional study

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-021-02432-4 ◽

2021 ◽

Author(s):

Frederico Bartolazzi ◽

Antônio Luiz Pinho Ribeiro ◽

Waleska Jaclyn Freitas Nunes de Sousa ◽

Mayara Sousa Vianna ◽

José Luiz Padilha da Silva ◽

...

Keyword(s):

Atrial Fibrillation ◽

Health Literacy ◽

Oral Anticoagulation ◽

Anticoagulation Therapy ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Oral Anticoagulation Therapy ◽

Relationship Of

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Impact of smoking history on the association between Eicosapentaenoic acid to arachidonic acid ratio and acute coronary syndrome: A multicenter cross-sectional study

Tobacco Induced Diseases ◽

10.18332/tid/84973 ◽

2018 ◽

Vol 16 (March) ◽

pp. 1-6

Author(s):

Yuji Nishizaki ◽

Kazunori Shimada ◽

Shigemasa Tani ◽

Takayuki Ogawa ◽

Jiro Ando ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Arachidonic Acid ◽

Eicosapentaenoic Acid ◽

Cross Sectional Study ◽

Smoking History ◽

Sectional Study ◽

Cross Sectional ◽

Coronary Syndrome ◽

Acid Ratio

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Chest discomfort at night and risk of acute coronary syndrome: cross-sectional study of telephone conversations

Family Practice ◽

10.1093/fampra/cmaa005 ◽

2020 ◽

Vol 37 (4) ◽

pp. 473-478 ◽

Cited By ~ 1

Author(s):

Loes T Wouters ◽

Dorien L Zwart ◽

Daphne C Erkelens ◽

Noël S Cheung ◽

Esther de Groot ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Risk Ratio ◽

Patient Characteristics ◽

Final Diagnosis ◽

Cross Sectional Study ◽

Sectional Study ◽

Chest Discomfort ◽

Cross Sectional ◽

Adjusted Risk ◽

Coronary Syndrome

Abstract Background During telephone triage, it is difficult to assign adequate urgency to patients with chest discomfort. Considering the time of calling could be helpful. Objective To assess the risk of acute coronary syndrome (ACS) in certain time periods and whether sex influences this risk. Methods Cross-sectional study of 1655 recordings of telephone conversations of patients who called the out-of-hours services primary care (OHS-PC) for chest discomfort. Call time, patient characteristics, symptoms, medical history and urgency allocation of the triage conversations were collected. The final diagnosis of each call was retrieved at the patient’s general practice. Absolute numbers of patients with and without ACS were plotted and risks per hour were calculated. The risk ratio of ACS at night (0 to 9 am) was calculated by comparing to the risk at other hours and was adjusted for gender and age. Results The mean age of callers was 58.9 (standard deviation ±19.5) years, 55.5% were women and, in total, 199 (12.0%) had an ACS. The crude risk ratio for an ACS at night was 1.80 (confidence interval 1.39–2.34, P < 0.001): 2.33 (1.68–3.22, P < 0.001) for men and 1.29 (0.83–1.99, P = 0.256) for women. The adjusted risk ratio for ACS of all people at night was 1.82 (1.07–3.10, P = 0.039). Conclusions Patients calling the OHS-PC for chest discomfort between 0 and 9 am have almost twice a higher risk of ACS than those calling other hours, a phenomenon more evident in men than in women. At night, dispatching ambulances more ‘straightaway’ could be considered for these patients with chest discomfort. Trial number NTR7331.

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Frequency of CYP2C19*2 Allele in Patients with Acute Coronary Syndrome: A Cross-sectional Study from Central Kerala, India

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/51247.15524 ◽

2021 ◽

Author(s):

Christina Ann George ◽

Shibu Thadathil Sreedharan ◽

Smitha Kalarikkal Satheesan ◽

Sindhu Panakkaparambil Surendranath

Keyword(s):

Acute Coronary Syndrome ◽

Cross Sectional Study ◽

Government Medical College ◽

Sectional Study ◽

Therapy Failure ◽

Cross Sectional ◽

Medical College ◽

Coronary Syndrome ◽

Variant Genotype ◽

Study Population

Introduction: Ischaemic Heart Diseases (IHD) are increasing at an alarming rate globally. Pharmacotherapy, the mainstay of management of IHD, has Dual Antiplatelet Therapy (DAPT) at its crux. DAPT, comprising of clopidogrel and aspirin, is used often for 12 months in medically managed Acute Coronary Syndrome (ACS). Clopidogrel being a prodrug, needs to be activated after ingestion, mainly by Cytochrome family of enzymes, for the desired pharmacological effects. Abnormal enzymes that convert clopidogrel to its active form can reduce the effectiveness of the drug. Therefore, Single Nucleotide Polymorphisms (SNPs) of the enzymes involved, would predispose the patient to therapy failure and recurrence of the illness. This study aims at identifying the presence of a genetic variant associated with clopidogrel responsiveness in patients with ACS. Aim: To estimate the frequency of CYP2C19*2 allele in patients with ACS presenting to Government Medical College, Thrissur, Kerala, India. Materials and Methods: Present study was a cross-sectional study done among 60 patients who presented to Government Medical College, Thrissur with ACS, between June 2018 to June 2019. Having obtained informed consent from the participants blood samples were collected in Ethylene diamine tetra-acetic Acid (EDTA) tubes. Samples were used to look for presence of CYP2C19*2 allele by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Out of 60 patients 38 were males and 22 were females. Most common age group was 61-65 years. The frequency of CYP2C19*2 allele was 41% in the study population and the variant genotype (AA/AG) was present in 62%. Conclusion: The variant genotype was found to be present in a high frequency in the study population implying the high risk for therapy failure in the study population. This asserts the need to probe the matter further, as the gene is also implicated in the metabolism of several other drugs. The introduction of pharmacogenomic testing prior to initiation of therapy may be therefore recommended for better treatment outcome. However, to validate the same, further studies with larger sample size may be necessary.

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Depression in Acute Coronary Syndrome Patients: A Cross-sectional Study in Malaysia

Iranian Journal Of Health Sciences ◽

10.18502/jhs.v8i3.4310 ◽

2020 ◽

Author(s):

Wan Nor Asyikeen Wan Adnan ◽

Siti Azrin Ab Hamid ◽

Zatul Rathiah Sulong ◽

Mohd Hashairi Fauzi

Keyword(s):

Acute Coronary Syndrome ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Female Gender ◽

Cross Sectional Study ◽

Ischemic Heart ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Coronary Syndrome

Background and purpose: Linked with high mortality rate, depression is common among acute coronary syndrome (ACS) patients. The current study sought to identify the factors associated with depression among ACS patients in Malaysia. Materials and Methods: A cross-sectional study was conducted on 400 ACS patients in two Malaysian hospitals: Hospital Universiti Sains Malaysia (USM), Kelantan and Hospital Sultanah Nur Zahirah (HSNZ), Terengganu. ACS patients were included if they were above 18 years of age, able to read and/or write in Bahasa Melayu language and had informed consent. Patients were excluded if they were intubated, had an altered mental status, mental retardation and had psychological problems prior to ACS. Depression in this study was defined as having dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest or involvement, anhedonia, and inertia among ACS patients. A questionnaire was distributed to all 400 ACS patients. Simple and multiple logistic regressions were used for data analysis. Results: The mean (standard deviation) age of ACS patients was 60.4 (11.3) years at Hospital USM and 61.2 (10.4) years at HSNZ. Nearly all of the depressive-ACS patients were Malay (79.4%), 85.9% were male, and 79.7% were married. Approximately 87.7% of depressive-ACS patients had ischemic heart disease, 87.1% had stroke, 83.4% had hyperlipidaemia, 81.8% had diabetes mellitus, and 80.7% had hypertension. The factors associated with depression were female gender (adjusted odd ratio (OR): 2.48, 95% confidence interval (CI): 1.50, 4.10, p<0.001) and ischemic heart disease (adjusted OR: 2.44, 95% CI: 1.41, 4.25, p=0.002). Conclusion: The results showed that female gender and ischemic heart disease were the most significant associated factors of depression among ACS patients.

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