No correlation of serum cholesterol levels with measures of violence in patients with schizophrenia and non-psychotic disorders

1999 ◽  
Vol 14 (6) ◽  
pp. 346-348 ◽  
Author(s):  
T. Steinert ◽  
M. Woelfle ◽  
R.P. Gebhardt
Keyword(s):  
Serum Cholesterol ◽  
Animal Studies ◽  
Psychotic Disorders ◽  
Epidemiological Studies ◽  
Psychiatric Admission ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
The Social ◽  
Icd 10 ◽  
Overt Aggression Scale

SummaryEpidemiological studies, animal studies, and clinical studies yielded conflicting results concerning a supposed association between increased risk for suicide and violence, and low serum cholesterol levels. Until now, no data has been available for patients with schizophrenia, a disorder with a well-known increased risk of violence. Correlations of serum cholesterol levels at admission and measures of violence were investigated in 103 consecutively admitted patients (44 males, 59 females) of a general psychiatric admission unit. Seventy subjects were diagnosed as suffering from schizophrenia or schizoaffective disorder (ICD-10 F 20, F25), and 33 were diagnosed as suffering from non-psychotic disorders (mainly personality disorders). The level of total exhibited violence during the inpatient treatment period was measured in each patient by the Modified Overt Aggression Scale (MOAS), the Social Dysfunction and Aggression Scale (SDAS), the Staff Observation Aggression Scale (SOAS), and the Violence Scale (VS). Correlations of all violence measures were high (0.75–0.90), but no correlation was found with cholesterol levels, neither for psychotic nor for non-psychotic subjects, neither for men nor for women. The hypothesis of associations of violence and cholesterol levels is not supported by the data.

An Assessment of Serum Cholesterol level and BMI in Women: Study in Several Private Chambers in Mymensingh

2019 ◽  
Vol 8 (2) ◽  
pp. 4-9
Author(s):  
Nahid Bintay Ansary ◽  
Arup Ratan Paul ◽  
Md Mahamudur Rahman ◽  
Maria Hussain ◽  
Rubiat Naznin
Keyword(s):  
Cardiovascular Disease ◽  
Health Status ◽  
Cholesterol Level ◽  
Serum Cholesterol ◽  
Serum Cholesterol Level ◽  
Normal Weight ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
The Mean ◽  
Study Participants

The increased risk of cardiovascular disease associated with higher serum cholesterol levels in middle-aged persons has been established, but there have been few studies conducted regarding the issues in Mymensingh. For evaluation of serum cholesterol and BMI in women of Mymensingh, across-sectional studywas conducted in several private chambers in the districts of Mymensingh, Bangladesh during the period from January 2017 to December 2017. A total of 48 Female patients participated in the study. In the study, participants were aged between 18 to 29 years of age. The study suggested that the serum cholesterol was below 4.99 were 15(31.25%), 5.00 to 6.49 were 13(26.08%) and above 6.50 were 20 (41.67%), the Mean ± SD was 4.45 (0.76). The health status according to BMI showed that 12.50% (n=6) of the participants were underweight <18.49, majority 50.00% (n=24) of the population were from normal weight range (18.5-24.9), 16.67% (n=8) of the participants were overweight and 20.83 %( n=10) of the participants were obese >30. The Mean ± SD was 18.93± (3.68). Measurement of BMI and Serum Cholesterol levels can help doctors to treat patients properly for reducing the burden of death in our country. CBMJ 2019 July: Vol. 08 No. 02 P: 4-9

scholarly journals Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis

2018 ◽  
Vol 212 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Antti Mustonen ◽  
Solja Niemelä ◽  
Tanja Nordström ◽  
Graham K. Murray ◽  
Pirjo Mäki ◽  
...  
Keyword(s):  
Substance Use ◽  
General Population ◽  
Birth Cohort ◽  
Psychotic Disorders ◽  
Temporal Order ◽  
Population Based ◽  
Cannabis Use ◽  
Prodromal Symptoms ◽  
Increased Risk ◽  
Icd 10

BackgroundThe association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.AimsTo examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.MethodThe sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15–16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.ResultsThe risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0–13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1–8.0).ConclusionsAdolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.Declaration of interestNone.

scholarly journals Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population

2016 ◽  
Vol 116 (5) ◽  
pp. 853-863 ◽  
Author(s):  
Biao Zhou ◽  
Xuefen Su ◽  
Danting Su ◽  
Fangfang Zeng ◽  
Maggie Haitian Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Animal Studies ◽  
Hdl Cholesterol ◽  
Epidemiological Studies ◽  
Inverse Association ◽  
Chinese Adults ◽  
Related Data ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Low Hdl

AbstractAnimal studies have suggested that Mn might be associated with some components of the metabolic syndrome (MetS). A few epidemiological studies have assessed dietary Mn intake and its association with the risk of the MetS and its components among Chinese adults. In this study, we assessed daily dietary Mn intake and its relationship with MetS risk among Chinese adults in Zhejiang Province using data from the 5th Chinese National Nutrition and Health Survey (2010–2012). A total of 2111 adults were included. Dietary Mn intake was assessed using 3-d 24-h dietary recalls; health-related data were obtained by questionnaire surveys, physical examinations and laboratory assessments. The mean intake of Mn was 6·07 (sd 2·94) mg/d for men (n 998) and 5·13 (sd 2·65) mg/d for women (n 1113). Rice (>42 %) was the main food source of Mn. The prevalence of the MetS was 28·0 % (590/2111). Higher Mn intake was associated with a decreased risk of the MetS in men (Q4 v. Q1 OR 0·62; 95 % CI 0·42, 0·92; Ptrend=0·043) but an increased risk in women (Q4 v. Q1 OR 1·56; 95 % CI 1·02, 2·45; Ptrend=0·078). In addition, Mn intake was inversely associated with abdominal obesity (Ptrend=0·016) and hypertriacylglycerolaemia (Ptrend=0·029) in men, but positively associated with low HDL-cholesterol in both men (Ptrend=0·003) and women (Ptrend<0·001). Our results suggest that higher Mn intakes may be protective against the MetS in men. The inverse association between Mn intake and the MetS in women might be due to the increased risk for low HDL-cholesterol.

scholarly journals Delayed parenthood and its influence on offspring health: What have we learned from the mouse model

2021 ◽  
Author(s):  
Federica Zacchini ◽  
Silvestre Sampino ◽  
Marta Zietek ◽  
Alan Chan
Keyword(s):  
Mouse Model ◽  
Animal Studies ◽  
Current Knowledge ◽  
Epidemiological Studies ◽  
Reproductive Outcome ◽  
Parental Age ◽  
Biological Mechanisms ◽  
Increased Risk ◽  
Delayed Parenthood ◽  
Offspring Health

Abstract Delayed parenthood is constantly increasing worldwide due to various socio-economic factors. In the last decade, a growing number of epidemiological studies have suggested a link between advanced parental age and an increased risk of diseases in the offspring. Also, poor reproductive outcome has been described in pregnancies conceived by aged parents. Similarly, animal studies showed that aging negatively affects gametes, early embryonic development, pregnancy progression and the postnatal phenotype of resulting offspring. However, how and to what extent parental age is a risk factor for the health of future generations is still subject to debate. Notwithstanding the limitation of an animal model, the mouse model represents a useful tool to understand not only the influence of parental age on offspring phenotype but also the biological mechanisms underlying the poor reproductive outcome and the occurrence of diseases in the descendants. The present review aims at i) providing an overview of the current knowledge from mouse model about the risks associated with conception at advanced age (e.g. neurodevelopmental and metabolic disorders), ii) highlighting the candidate biological mechanisms underlying this phenomenon, and iii) discussing on how murine-derived data can be relevant to humans.

The hazards of operational diving in heavily oil-polluted water

1991 ◽  
Vol 77 (3) ◽  
pp. 159-164
Author(s):  
K. A. Peterson ◽  
S. J. Portouw
Keyword(s):  
Thyroid Cancer ◽  
Skin Cancer ◽  
Crude Oil ◽  
Chronic Exposure ◽  
Animal Studies ◽  
Epidemiological Studies ◽  
Polluted Water ◽  
Toxic Dose ◽  
Increased Risk ◽  
Low Levels

AbstractThe war in the Gulf and the resultant massive oil spill has prompted an assessment of the health hazards to naval divers operating in oil-fouled environments. A review of current literature and discussions with experts in the field was undertaken to assess these hazards. With the assistance of Kuwait Petroleum, an assay of the content of average Kuwait crude was obtained. The risks of contact with crude oil and its vapours via the skin, inhalation and ingestion have been assessed. Contact dermatitis is the most likely sequel. A chemical pneumonitis from oil inhalation is possible but extremely unlikely. A health risk from ingestion of crude oil is equally unlikely since no toxic effect is thought to occur below a consumption of 5 ml/kg (350 ml for an average diver). Trace metals were found to be at a level of less than 1/10 of the minimal toxic dose for all but vanadium. No increased risk of skin cancer can be found in animal studies of crude oil. Epidemiological studies have recorded no increased risk of bladder or thyroid cancer in petroleum workers, but an increase in lung, nasal cavity, sinus and skin cancer has been shown following chronic exposure to low levels of petroleum vapour. No medical indication was found for modification of existing operational procedures, although, since the toxicity of some components of crude oil is unknown, the use of improved equipment to avoid contact should be studied.

scholarly journals Transition to schizophrenia in acute and transient psychotic disorders

2014 ◽  
Vol 204 (4) ◽  
pp. 299-305 ◽  
Author(s):  
Filippo Queirazza ◽  
David M. Semple ◽  
Stephen M. Lawrie
Keyword(s):  
Psychotic Disorders ◽  
Age At Onset ◽  
Diagnostic Category ◽  
Male Gender ◽  
Validity And Reliability ◽  
Routinely Collected Data ◽  
Younger Age ◽  
Increased Risk ◽  
Icd 10 ◽  
Using Data

BackgroundThe diagnostic category of acute and transient psychotic disorders (ATPD) was introduced in ICD-10. Subsequent studies have called into question its validity and reliability.AimsTo determine the pattern of diagnostic revision to schizophrenia in first-ever diagnosed ATPD.MethodUsing data drawn from the Scottish Morbidity Record, we estimated incidence and diagnostic change in first-ever diagnosed ATPD in Scottish hospitals between January 1997 and December 2010 (n= 2923).ResultsThe average incidence of ATPD was 4.1 per 100 000 population per year. Diagnostic stability was estimated at 53.9% over an average of approximately 4 years of observation. The most common diagnostic shift was to schizophrenia (12.6%), over an average of 1.7 years. Estimates of the transition risks for schizophrenia were 80% at 2.8 years and 90% at 4.6 years. Longer first admission to hospital, younger age at onset and male gender were associated with increased risk and earlier development of schizophrenia.ConclusionsRoutinely collected data suggest that approximately one in eight individuals with first-ever diagnosed ATPD will develop schizophrenia within 3–5 years. Those at high risk of transition may benefit from monitoring for possible diagnostic change.

Association between parent mental health and paediatric TBI: epidemiological observations from the 1987 Finnish Birth Cohort

2018 ◽  
Vol 25 (4) ◽  
pp. 283-289 ◽  
Author(s):  
Michael Lowery Wilson ◽  
Olli Tenovuo ◽  
Mika Gissler ◽  
Simo Saarijärvi
Keyword(s):  
Mental Health ◽  
Mood Disorders ◽  
Psychotic Disorders ◽  
Brain Injuries ◽  
Maternal Mental Health ◽  
Traumatic Brain Injuries ◽  
Parental Mental Illness ◽  
Behavioural Disorders ◽  
Increased Risk ◽  
Icd 10

BackgroundThis study examined whether parental mental illness has implications for child risk for traumatic brain injuries (TBI).MethodData on 60 069 Finnish children born in 1987 and their parents were examined for demographic and mental health-related variables in relationship with paediatric TBI. Altogether, 15 variables were derived from the cohort data with ICD-10 F-codes being available for mental health diagnoses for all parents. Bivariate and multivariate analyses were carried out using inpatient and outpatient diagnoses of child TBI.ResultsPaternal disorders due to psychoactive substance use (F10–F19) was associated with an increased inpatient TBI (OR=1.51; CI=1.07 to 2.14). Mood disorders (F30–F39) were associated with higher rates of outpatient TBI (OR=1.42; CI=1.06 to 1.90). Paternal personality and behavioural disorders (F60–F69) were linked with a twofold increase in risk across both categories of child TBI (OR=2.35; CI=1.41 to 3.90) and (OR=2.29; CI=1.45 to 3.61), respectively. Among the maternal mental health factors associated with child TBI, schizophrenia and other non-mood psychotic disorders (F20–F29) were associated with an increase in inpatient traumatic brain injuries (iTBI) (OR=1.78; 1.22 to 2.59). Mothers having mood disorders (F30–F39) were more likely to have had a child who experienced an iTBI (OR=1.64; CI=1.20 to 2.22). Mothers with personality and behavioural disorders (F60–F69) were also found to have had children with an increased risk for iTBI (OR=2.30; CI=1.14 to 3.65).ConclusionTaken together, these data should call attention to methods and strategies designed to augment and support caregiving environments with modalities that can foster mutually supportive households in cooperation with parents who have been diagnosed with a mental disorder.

Relative prevalence of 10 types of pharmacodynamic interactions in psychiatric treatment

2019 ◽  
Vol 55 (2) ◽  
pp. 82-104 ◽  
Author(s):  
Paul A Zarkowski
Keyword(s):  
Animal Studies ◽  
Psychiatric Treatment ◽  
Epidemiological Studies ◽  
Healthcare Database ◽  
Pharmacodynamic Interaction ◽  
Factors Affecting ◽  
Pharmacodynamic Interactions ◽  
Increased Risk ◽  
Mental Health Centers ◽  
Relative Prevalence

Objective To assess the relative prevalence and factors affecting the prescription of medication combinations with a theoretical efficacy limiting pharmacodynamic interaction, defined as two medications with opposing indications and side effects or antagonistic action at the primary receptor of mechanism of action. Method One hundred sixteen combinations were identified for 10 types of pharmacodynamic interactions. PubMed was searched for each combination to assess the quality of evidence either supporting clinical use or verifying reduced efficacy. Micromedex was searched to determine the presence of warnings to prescribers of reduced efficacy. The prevalence in clinical practice was determined by computer review of the Genoa Healthcare database for all prescribers at 10 participating community mental health centers. The expected prevalence was calculated as the product of the probability of each medication prescribed alone and was compared with the actual prevalence of the combination using the test of proportions. Results The frequency of prescription of eight combinations met the Bonferroni corrected level of significance of p < 0.001. Four were combinations of amphetamine and D2 antagonists and each were prescribed less often than chance, p = 0.0001 consistent with epidemiological studies and multiple animal studies verifying an efficacy limiting interaction. Despite epidemiological studies indicating increased risk of accidents, alprazolam and amphetamine were prescribed more often than chance, p = 0.0001. Micromedex generated warnings for efficacy limiting interactions for five other combinations, but with no subsequent change in prescription frequency. Conclusions Neither presence of medical evidence nor warnings from Micromedex consistently affect the prescription of combinations with pharmacodynamic efficacy limiting interactions.

Male Infertility and Risk of Nonmalignant Chronic Diseases: A Systematic Review of the Epidemiological Evidence

2017 ◽  
Vol 35 (03) ◽  
pp. 282-290 ◽  
Author(s):  
Jens Bonde ◽  
Michael Eisenberg ◽  
Aleksander Giwercman ◽  
Katia Hærvig ◽  
Susie Rimborg ◽  
...  
Keyword(s):  
Male Infertility ◽  
Chronic Diseases ◽  
Animal Studies ◽  
Reference Group ◽  
Case Reports ◽  
Epidemiological Studies ◽  
Epidemiological Evidence ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Increased Risk

AbstractThe association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.

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