Male Infertility and Risk of Nonmalignant Chronic Diseases: A Systematic Review of the Epidemiological Evidence

AbstractThe association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.

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Impact of Coffee/Green Tea/Soft Drink Consumption on the Risk of Hyperuricemia: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18147299 ◽

2021 ◽

Vol 18 (14) ◽

pp. 7299

Author(s):

Joong Seob Lee ◽

Tae Jun Kim ◽

Sung Kwang Hong ◽

Chanyang Min ◽

Dae Myoung Yoo ◽

...

Keyword(s):

Green Tea ◽

Reference Group ◽

Smoking Status ◽

Soft Drink ◽

Sociodemographic Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Soft Drink Consumption ◽

Increased Risk

This cross-sectional study aimed to investigate the association between hyperuricemia and the frequency of coffee, tea, and soft drink consumption, based on data from the Korean Genome and Epidemiology Study (KoGES) (2004–2016). We used the KoGES health examinee data, obtained from urban residents aged ≥ 40 years. Information on the participants’ medical history, nutrition (total calorie, protein, fat, and carbohydrate intake), frequency of alcohol consumption, smoking status, household income, and frequency of coffee/green tea/soft drink intake was collected. A logistic regression model was used to analyze the data. Subgroup analyses were performed according to the participant’s age and sex. Among 173,209 participants, there were 11,750 and 156,002 individuals with hyperuricemia and non-hyperuricemia controls, respectively. In an adjusted model, frequent coffee and green tea consumption did not increase the risk of hyperuricemia, compared to the “no intake” reference group. However, an adjusted odds ratio of hyperuricemia was 1.23 (95% confidence interval, 1.11–1.35, p < 0.001) for participants who reported consuming soft drinks ≥ 3 times per day, compared to the respective “no drink” reference group. Even after adjusting for nutritional and sociodemographic factors, frequent soft drink intake was associated with an increased risk of hyperuricemia. Meanwhile, neither coffee nor green tea intake was associated with an increased risk of hyperuricemia.

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Socio-demographic characteristics and co-occurrence of depressive symptoms with chronic diseases among older adults in China: the China Longitudinal Ageing Social Survey

10.21203/rs.2.12280/v3 ◽

2019 ◽

Author(s):

Zhenjie Wang ◽

Hanmo Yang ◽

Zhanyuan Guo ◽

Bei Liu ◽

Shen Geng

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Chronic Diseases ◽

Odds Ratio ◽

Logistic Regression Model ◽

Depression Scale ◽

Epidemiological Studies ◽

Education Attainment ◽

Cross Sectional ◽

Social Survey

Abstract Background: The aim of the current study is to assess the cross-sectional association of chronic non-communicable diseases (hypertension, diabetes mellitus, arthritis, and cerebrovascular) with depressive symptoms among older adults in China. Methods: Data was obtained from the China Longitudinal Ageing Social Survey (CLASS) conducted in 2014. A total of 7505 participants were included. Depressive symptoms status was assessed by 9-item Center for Epidemiological Studies Depression Scale (CES-D) Associations between depressive symptoms and chronic diseases, adjusting for so, demographics and chronic diseases risk factors were assessed by using logistic regression model. Results: We found negative associations between depressive symptoms and several socioeconomic factors, including education attainment and economic level. Widowed/divorced/ unmarried individuals are more likely to suffer from depressive symptoms. Hypertension (Odds ratio:1.29 [95%CI:1.16, 1.42]), diabetes (1.41 [95%CI:1.19,1.67]), arthritis (1.72 [1.52, 1.96]), and cerebrovascular disease (1.69 [1.41, 2.02]) were found to be associated with depressive symptoms. Conclusions: Most depressive symptoms cases were found to be significantly associated with chronic diseases. Our findings have provided evidence for understanding co-morbid depressive symptoms with chronic diseases, which could help clinicians to evaluate, diagnose and manage depression promptly.

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LIVING AND HEALTH CONDITIONS ASSOCIATED WITH OVERWEIGHT AND OBESITY AMONG ELDERLY

Journal of Frailty & Aging ◽

10.14283/jfa.2015.55 ◽

2015 ◽

pp. 1-9

Author(s):

B.F. DO NASCIMENTO JACINTO DE SOUZA ◽

L. MARÍN-LEON

Keyword(s):

Chronic Diseases ◽

Eating Behaviors ◽

Multinomial Logistic Regression ◽

The Elderly ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Related Factors ◽

Cross Sectional ◽

Increased Risk ◽

Health Related

Background: The epidemiological and nutritional transition processes in the last decades underlie the rising trend of obesity in the elderly and is related to increased risk of chronic non-communicable diseases and decreased functional status. Objective: To analyze the association of demographic, socioeconomic, lifestyle and health-related factors with overweight and obesity in elderly. Design: Cross-sectional study. Setting: Carried out in Campinas-São Paulo, Brazil, in 2011. Participants: 452 non-institutionalized elderly (aged ≥60 years), half were users of a government-run soup kitchen and the other half were neighbors of the same sex. Results:Overweight frequency (BMI ≥25 and <30 kg/m2) was 44.5% and obesity (BMI ≥30 kg/m2) was 21.7%. In the multiple multinomial logistic regression model adjusted for sex, age group and economic class, there was greater chance of overweight among those that reported dyslipidemia; those that reported arthritis/ arthrosis/rheumatism and that once or more per week replaced supper by a snack were more likely to be obese. Elderly who did not leave home daily and reported diabetes had higher chance of overweight and obesity. Conclusions: Overweight and obesity are associated with worse living and health-related conditions, such as physical inactivity, changes in eating behaviors, and chronic diseases. Public health policies should encourage regular physical activity and healthy eating behaviors, focusing on traditional diet, through nutritional education, in order to reduce the prevalence of overweight and obesity and chronic diseases.

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Musculoskeletal Pain and Impact on Performance in Orchestra Musicians and Actors

Medical Problems of Performing Artists ◽

10.21091/mppa.2004.2009 ◽

2004 ◽

Vol 19 (2) ◽

pp. 55-61

Author(s):

K Engquist ◽

P Ørbaek ◽

K Jakobsson

Keyword(s):

Musculoskeletal Pain ◽

Odds Ratio ◽

Reference Group ◽

Study Groups ◽

Physical Work ◽

Prevalence Odds Ratio ◽

Cross Sectional ◽

Body Regions ◽

Increased Risk ◽

The Impact

We studied the prevalence of musculoskeletal pain and its impact on performance in orchestra musicians and in a reference group of actors, who share the mental stress in a performance situation, but without having the physical work load from an instrument. Swedish musicians (n = 103) from symphony and chamber orchestras and actors (n = 106) participated in a cross-sectional questionnaire study. Musculoskeletal pain was assessed by a further developed Standardized Nordic Questionnaire. The impact of pain on performance (pain affecting playing capacity, decreased playing time, and change of technique) and trouble-related sick leave also was assessed. Pain intensity was assessed by visual analogue scales. Musculoskeletal pain in the neck and shoulders was the most frequently reported problem, with similar prevalence among musicians and actors, around 25% for present pain and 20% for chronic pain (1-year prevalence). Around 10% of the musicians and 5% of the actors reported pain in the hands. Oral pain was reported by 12% of the musicians and 18% of the actors. The number of affected body regions and the intensity of pain were similar in the study groups. The musicians had an increased risk for pain affecting playing capacity. For the neck, the prevalence odds ratio (POR) was 3.0 (95%CI 1.2-7.2; adjusted for age and gender). String instrumentalists had higher risk estimates than nonstring instrumentalists. A gender difference was not observed. Pain in the oral region affecting playing capacity was less common in musicians, with a prevalence odds ratio of 0.4 (95%CI 0.1-0.8). Even though the prevalence of musculoskeletal pain was similar in the two groups of performing artists, the consequences for the work situation were more serious among musicians.

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Neighbourhood socioeconomic status and overweight/obesity: a systematic review and meta-analysis of epidemiological studies

BMJ Open ◽

10.1136/bmjopen-2018-028238 ◽

2019 ◽

Vol 9 (11) ◽

pp. e028238 ◽

Cited By ~ 7

Author(s):

Shimels Hussien Mohammed ◽

Tesfa Dejenie Habtewold ◽

Mulugeta Molla Birhanu ◽

Tesfamichael Awoke Sissay ◽

Balewgizie Sileshi Tegegne ◽

...

Keyword(s):

Systematic Review ◽

Socioeconomic Status ◽

Observational Studies ◽

Data Extraction ◽

Meta Analysis ◽

Epidemiological Studies ◽

Cochrane Library ◽

Eligibility Criteria ◽

Cross Sectional ◽

Neighbourhood Socioeconomic Status

ObjectiveLow neighbourhood socioeconomic status (NSES) has been linked to a higher risk of overweight/obesity, irrespective of the individual’s own socioeconomic status. No meta-analysis study has been done on the association. Thus, this study was done to synthesise the existing evidence on the association of NSES with overweight, obesity and body mass index (BMI).DesignSystematic review and meta-analysis.Data sourcesPubMed, Embase, Scopus, Cochrane Library, Web of Sciences and Google Scholar databases were searched for articles published until 25 September 2019.Eligibility criteriaEpidemiological studies, both longitudinal and cross-sectional ones, which examined the link of NSES to overweight, obesity or BMI, were included.Data extraction and synthesisData extraction was done by two reviewers, working independently. The methodological quality of included studies was assessed using the Newcastle-Ottawa Scale for the observational studies. The summary estimates of the relationships of NSES with overweight, obesity and BMI statuses were calculated with random-effects meta-analysis models. Heterogeneity was assessed by Cochran’s Q and I2 statistics. Subgroup analyses were done by age categories, continents, study designs and NSES measures. Publication bias was assessed by visual inspection of funnel plots and Egger’s regression test.ResultA total of 21 observational studies, covering 1 244 438 individuals, were included in this meta-analysis. Low NSES, compared with high NSES, was found to be associated with a 31% higher odds of overweight (pooled OR 1.31, 95% CI 1.16 to 1.47, p<0.001), a 45% higher odds of obesity (pooled OR 1.45, 95% CI 1.21 to 1.74, p<0.001) and a 1.09 kg/m2 increase in mean BMI (pooled beta=1.09, 95% CI 0.67 to 1.50, p<0.001).ConclusionNSES disparity might be contributing to the burden of overweight/obesity. Further studies are warranted, including whether addressing NSES disparity could reduce the risk of overweight/obesity.PROSPERO registration numberCRD42017063889

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Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population

British Journal Of Nutrition ◽

10.1017/s0007114516002580 ◽

2016 ◽

Vol 116 (5) ◽

pp. 853-863 ◽

Cited By ~ 14

Author(s):

Biao Zhou ◽

Xuefen Su ◽

Danting Su ◽

Fangfang Zeng ◽

Maggie Haitian Wang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Animal Studies ◽

Hdl Cholesterol ◽

Epidemiological Studies ◽

Inverse Association ◽

Chinese Adults ◽

Related Data ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Low Hdl

AbstractAnimal studies have suggested that Mn might be associated with some components of the metabolic syndrome (MetS). A few epidemiological studies have assessed dietary Mn intake and its association with the risk of the MetS and its components among Chinese adults. In this study, we assessed daily dietary Mn intake and its relationship with MetS risk among Chinese adults in Zhejiang Province using data from the 5th Chinese National Nutrition and Health Survey (2010–2012). A total of 2111 adults were included. Dietary Mn intake was assessed using 3-d 24-h dietary recalls; health-related data were obtained by questionnaire surveys, physical examinations and laboratory assessments. The mean intake of Mn was 6·07 (sd 2·94) mg/d for men (n 998) and 5·13 (sd 2·65) mg/d for women (n 1113). Rice (>42 %) was the main food source of Mn. The prevalence of the MetS was 28·0 % (590/2111). Higher Mn intake was associated with a decreased risk of the MetS in men (Q4 v. Q1 OR 0·62; 95 % CI 0·42, 0·92; Ptrend=0·043) but an increased risk in women (Q4 v. Q1 OR 1·56; 95 % CI 1·02, 2·45; Ptrend=0·078). In addition, Mn intake was inversely associated with abdominal obesity (Ptrend=0·016) and hypertriacylglycerolaemia (Ptrend=0·029) in men, but positively associated with low HDL-cholesterol in both men (Ptrend=0·003) and women (Ptrend<0·001). Our results suggest that higher Mn intakes may be protective against the MetS in men. The inverse association between Mn intake and the MetS in women might be due to the increased risk for low HDL-cholesterol.

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Metabolic Syndrome Components and the Risk of Pulmonary Nodules: A Cross‐sectional Study in Northern China

10.21203/rs.3.rs-142645/v1 ◽

2021 ◽

Author(s):

Chengshui Chen ◽

Mingyang Zhu ◽

Xueyu Chen ◽

Yong Zhou ◽

Xiaocheng Zhang ◽

...

Keyword(s):

Lung Cancer ◽

Metabolic Syndrome ◽

Pulmonary Nodules ◽

Heart Association ◽

Northern China ◽

Epidemiological Studies ◽

Cross Sectional Study ◽

Chinese Adults ◽

Cross Sectional ◽

Increased Risk

Abstract Objective: The components of metabolic syndrome have been shown to be associated with lung cancer. Pulmonary nodules (PNs), early predictors of lung cancer, have become common incidental findings with the widespread use of low-dose computed tomography (LDCT) but few epidemiological studies have been performed. The present study aimed to determine the association between MetS and/or its components with PNs in Chinese adults.Methods:A total of 3,340 participants (51.4% women) aged 18 years or older were included from the Jidong communities. MetS was defined by the criteria from the American Heart Association, and National Heart, Lung, and Blood Institute (AHA/NHLBI). PNs were detected using LDCT. Results:The prevalence rate of PNs was 19.2% in participants with MetS, while 12.8% in healthy controls (P<0.001). The odds ratio (OR) and 95% confidence internal (CI) for PNs in participants with elevated blood pressure (≥130/85 mmHg or on drugs for treatment of hypertension) was OR = 1.23, 95% CI: 1.01–1.51. Compared to individuals without MetS components, the ORs (95% CI) for PNs development among those with 1, 2, and ≥3 MetS components were 1.25 (0.94–1.67), 1.10 (0.82–1.48), and 1.43 (1.08–1.89), respectively (P for trend =0.04). Moreover, individuals with MetS had an approximately 30% increased risk of PNs than those who did not meet the MetS diagnostic criteria (number of MetS components<3) ( OR = 1.29, 95% CI: 1.03–1.61). Conclusion:The present study suggested that PNs was associated with abnormal MetS components in Chinese adults. Individuals with MetS might have a higher PNs risk than those without MetS.

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Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20190107 ◽

2019 ◽

Vol 77 (9) ◽

pp. 654-668 ◽

Cited By ~ 1

Author(s):

Leandro Boson Gambogi ◽

Henrique Cerqueira Guimarães ◽

Leonardo Cruz De Souza ◽

Paulo Caramelli

Keyword(s):

Mental Illness ◽

Frontotemporal Dementia ◽

Cognitive Performance ◽

Frontotemporal Lobar Degeneration ◽

English Language ◽

Case Reports ◽

Eligibility Criteria ◽

Cross Sectional ◽

Schizophrenic Patients ◽

The Relationship

ABSTRACT Objectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities. Methods: We performed a systematic review investigating what has already been published regarding the relationship between bvFTD and SMI. Studies were selected from PubMed and LILACS databases, including those published up to February 12, 2018. The search strategy included the following terms: “frontotemporal dementia” plus “bipolar”, OR “frontotemporal dementia” plus “schizophrenia”, OR “frontotemporal dementia” plus “schizoaffective”. Publications without abstracts, case reports with absent genetic or histopathological confirmation, reviews and non-English language papers were excluded across the search process. Results: The search on PubMed retrieved 186 articles, of which 42 met eligibility criteria. On the LILACS database, none met the requirements. Generally, three major research aims were identified: 1) to look for frontotemporal lobar degeneration-associated genetic abnormalities in patients with prior SMI; 2) to compare the cognitive profile between patients affected by neurodegenerative disorders and schizophrenic patients; 3) to highlight the association between bvFTD and preceding psychiatric conditions and/or distinguish them both. The investigated mutations were found infrequently in the studied SMI samples. Cross-sectional studies comparing cognitive performance between bvFTD and psychiatric disorders mostly found no remarkable differences. There were only a few case reports identifying definite frontotemporal lobar degeneration in patients with previous psychiatric diagnoses. Conclusions: The available evidence demonstrates how fragile the current understanding is regarding the association between bvFTD and prior SMI.

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Socio-demographic characteristics and co-occurrence of depressive symptoms with chronic diseases among older adults in China: the China Longitudinal Ageing Social Survey

10.21203/rs.2.12280/v5 ◽

2019 ◽

Author(s):

Zhenjie Wang ◽

Hanmo Yang ◽

Zhanyuan Guo ◽

Bei Liu ◽

Shen Geng

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Chronic Diseases ◽

Odds Ratio ◽

Logistic Regression Model ◽

Depression Scale ◽

Epidemiological Studies ◽

Education Attainment ◽

Cross Sectional ◽

Social Survey

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Carriage of ESBL-producing Enterobacterales in wastewater treatment plant workers and surrounding residents - The AWARE Study

10.1101/2021.06.25.21259524 ◽

2021 ◽

Author(s):

Daloha Rodriguez-Molina ◽

Fanny Berglund ◽

Hetty Blaak ◽

Marcela Popa ◽

Carl-Fredrik Flach ◽

...

Keyword(s):

Wastewater Treatment ◽

The Netherlands ◽

Wastewater Treatment Plant ◽

Reference Group ◽

Treatment Plant ◽

Cross Sectional Study ◽

Sensitivity Analyses ◽

Cross Sectional ◽

Increased Risk ◽

Close Proximity

Purpose. To investigate whether wastewater treatment plant (WWTP) workers and residents living in close proximity to a WWTP have elevated carriage rates of ESBL-producing Enterobacterales, as compared to the general population. Methods. From 2018 to 2020, we carried out a cross-sectional study in Germany, the Netherlands, and Romania among WWTP workers (N=344), nearby residents (living ≤ 300 meters away from WWTPs; N=431) and distant residents (living ≥ 1000 meters away = reference group; N=1165). We collected information on potential confounders via questionnaire. Culture of participants' stool samples was performed with ChromID®-ESBL agar plates and species identification with MALDI-TOF-MS. We used logistic regression to estimate the odds ratio (OR) for carrying ESBL-producing E. coli (ESBL- EC). Sensitivity analyses included stratification by country and interaction models using country as secondary exposure. Results. Prevalence of ESBL-EC was 11% (workers), 29% (nearby residents), and 7% (distant residents), and higher in Romania (28%) than in Germany (7%) and the Netherlands (6%). Models stratified by country showed that within the Romanian population, WWTP workers are about twice as likely (aOR = 2.34, 95% CI: 1.22-4.5) and nearby residents about three times as likely (aOR = 3.17, 95% CI: 1.8-5.59) to be ESBL-EC carriers, when compared with distant residents. Conclusions. In stratified analyses by country, we found an increased risk for carriage of ESBL-EC in Romanian workers and nearby residents. This effect was higher for nearby residents than for workers, which suggests that, for nearby residents, factors other than the local WWTP could contribute to the increased carriage.

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