scholarly journals Scaling of Technical Systems Using an Object-Based Modelling Approach

2019 ◽  
Vol 1 (1) ◽  
pp. 1603-1612
Author(s):  
Philipp Wolniak ◽  
Bastian Sauthoff ◽  
Roland Lachmayer ◽  
Iryna Mozgova
Keyword(s):  
High Quality ◽  
Initial Development ◽  
Technical Requirements ◽  
Object Based ◽  
Short Period ◽  
Scaling Methods ◽  
Technical Systems ◽  
Cost Efficient ◽  
The Cost ◽  
Modelling Approach

AbstractCompanies that operate and manufacture products in the technical area are exposed to increasingly challenging market situations. The developed products should be individualized to the customers' needs while offering high quality at an acceptable price.The temporal and especially economic claims are constantly growing, forcing the companies to develop a given product that matches the cost-side as well as the technical requirements in a short period of time. Following an initial development, it is often necessary to provide further product variants regarding a modified geometry or performance. A time and cost efficient way is the scaling of the initially developed product.Existing scaling methods focus on uniform geometry changes, not taking into account influences from non-uniform requirement or geometry alterations. Therefore, this article proposes an approach on how to modell and assess the outcome of a scaled assembly, based on the connection of individual scalable components inside an object-based approach.

Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics

2013 ◽  
Vol 31 (2) ◽  
pp. 140-153 ◽  
Author(s):  
José Luis Corchero ◽  
Brigitte Gasser ◽  
David Resina ◽  
Wesley Smith ◽  
Ermenegilda Parrilli ◽  
...  
Keyword(s):  
Protein Therapeutics ◽  
Efficient Production ◽  
High Quality ◽  
High Quality Protein ◽  
Cost Efficient ◽  
The Cost ◽  
Microbial Systems

A Process of Glocalisation? Roman Marble Imports and the Rise of Blocked-Out Capitals in Local Stone

2020 ◽  
pp. 33-45
Author(s):  
Matthias Grawehr
Keyword(s):  
Roman Empire ◽  
Eastern Mediterranean ◽  
High Quality ◽  
White Marble ◽  
Aesthetic Preference ◽  
Local Responses ◽  
Global Trend ◽  
Short Period ◽  
New Type ◽  
Local Materials

In the Augustan Age, a new aesthetic preference was propagated in the Roman Empire – the surface of white marble was valued as it symbolised the strength and superiority of the ‘new age’. Soon, an immense trade in high quality marble over land and sea developed to meet the emergent demand. While the development and scale of this trade is well studied, the repercussions that the new aesthetic preference had on the local architectural traditions in areas where no marble was close at hand is not commonly considered. In this contribution, two developments are traced, taking the Corinthian capital as the leitmotif. First, in the short period between c. 40 and 10 BC, patrons would choose imitation of marble in plaster to meet up with the demands of the new standard and to demonstrate their adherence to the Empire. In the second line of development, a different path was taken – a conscious use of local materials which went hand in hand with the development of a new type of capital, the so-called ‘Nabataean blocked-out’ capital. This combination turned into a new vernacular tradition across large parts of the eastern Mediterranean. Both developments were local responses to a new ‘global’ trend and can therefore be viewed as a phenomenon of glocalisation in the Roman Period.

scholarly journals Comparison of LPWAN Technologies: Cost Structure and Scalability

2021 ◽  
Author(s):  
Mohammad Istiak Hossain ◽  
Jan I. Markendahl
Keyword(s):  
Communication Technology ◽  
Service Providers ◽  
Communication Technologies ◽  
Cost Structure ◽  
Small Scale ◽  
Area Network ◽  
Wide Area Network ◽  
Generic Framework ◽  
Cost Efficient ◽  
The Cost

AbstractSmall-scale commercial rollouts of Cellular-IoT (C-IoT) networks have started globally since last year. However, among the plethora of low power wide area network (LPWAN) technologies, the cost-effectiveness of C-IoT is not certain for IoT service providers, small and greenfield operators. Today, there is no known public framework for the feasibility analysis of IoT communication technologies. Hence, this paper first presents a generic framework to assess the cost structure of cellular and non-cellular LPWAN technologies. Then, we applied the framework in eight deployment scenarios to analyze the prospect of LPWAN technologies like Sigfox, LoRaWAN, NB-IoT, LTE-M, and EC-GSM. We consider the inter-technology interference impact on LoRaWAN and Sigfox scalability. Our results validate that a large rollout with a single technology is not cost-efficient. Also, our analysis suggests the rollout possibility of an IoT communication Technology may not be linear to cost-efficiency.

scholarly journals Cost Analysis of a Novel Method for Ecological Compensation—A Study of the Translocation of Dead Wood

2021 ◽  
Vol 13 (11) ◽  
pp. 6075
Author(s):  
Ola Lindroos ◽  
Malin Söderlind ◽  
Joel Jensen ◽  
Joakim Hjältén
Keyword(s):  
Cost Efficiency ◽  
Dead Wood ◽  
Road Transportation ◽  
Ecological Value ◽  
Ecological Compensation ◽  
Work Time ◽  
Delivery Times ◽  
Novel Method ◽  
Cost Efficient ◽  
The Cost

Translocation of dead wood is a novel method for ecological compensation and restoration that could, potentially, provide a new important tool for biodiversity conservation. With this method, substrates that normally have long delivery times are instantly created in a compensation area, and ideally many of the associated dead wood dwelling organisms are translocated together with the substrates. However, to a large extent, there is a lack of knowledge about the cost efficiency of different methods of ecological compensation. Therefore, the costs for different parts of a translocation process and its dependency on some influencing factors were studied. The observed cost was 465 SEK per translocated log for the actual compensation measure, with an additional 349 SEK/log for work to enable evaluation of the translocation’s ecological results. Based on time studies, models were developed to predict required work time and costs for different transportation distances and load sizes. Those models indicated that short extraction and insertion distances for logs should be prioritized over road transportation distances to minimize costs. They also highlighted a trade-off between costs and time until a given ecological value is reached in the compensation area. The methodology used can contribute to more cost-efficient operations and, by doing so, increase the use of ecological compensation and the benefits from a given input.

Electronic structure of short-period ZnSe/ZnTe superlattices grown by MOVPE at 300ºC

1993 ◽  
Vol 308 ◽  
Author(s):  
N. Briot ◽  
T. Cloitre ◽  
O. Briot ◽  
P. Boring ◽  
B.E. Ponga ◽  
...  
Keyword(s):  
Growth Temperature ◽  
Lattice Mismatch ◽  
Stokes Shift ◽  
Vapour Phase ◽  
Potential Candidate ◽  
High Quality ◽  
Vapour Phase Epitaxy ◽  
Light Emitting Devices ◽  
Short Period ◽  
Movpe Growth

ABSTRACTThe ZnSe-ZnTe combination is a potential candidate for the realisation of visible light-emitting devices. The lattice mismatch between bulk ZnSe and bulk ZnTe is important (∼ 8%). Therefore, their hetero-structures are strained and high quality superlattices will only be grown if having small periods. This prescription can be fulfilled in the case of metal organic vapour phase epitaxy (MOVPE) growth by combining triethylamine dimethyl zinc adduct with di-isopropyl telluride as precursors for the growth of the ZnTe layers. The growth of high quality ZnTe can then be performed at a temperature of 300ºC , close to the best MOVPE-growth temperature for ZnSe (280ºC). Lowering the growth temperature of ZnTe to this value, we could thus obtain sharp interfaces. This work reports on ZnSe-ZnTe superlattices grown on ZnSe and ZnTe buffers deposited on GaAs substrates. We demonstrate that the stokes-shift between the reflectance and photoluminescence features ( ∼ 40 meV ) measured when the thickness of ZnSe layers does not exceed 20 Å, drastically increases for layer thicknesses beyond this critical value. This, we interpret in terms of the onset of plastic relaxation which favours tellurium diffusion in the ZnSe slices. Then photoluminescence spectra broaden ( contributions of trapped-excitons dominate), and observation of free excitons in reflectance become impossible. We have studied in detail the optical properties of the superlattices and compared our findings with the predictions of a multiband envelope function calculation. We show that both zone centre excitons as well as excitons associated with the miniband dispersions (saddle-point excitons) are observed in these superlattices.

scholarly journals Visual multiple cross displacement amplification for the rapid identification of S. agalactiae immediately from vaginal and rectal swabs

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xueqin Cheng ◽  
Zhiqian Dou ◽  
Jing Yang ◽  
Dexi Liu ◽  
Yulong Gu ◽  
...  
Keyword(s):  
Pathogen Detection ◽  
Clinical Specimen ◽  
Rapid Identification ◽  
Sample Collection ◽  
Special Equipment ◽  
Multiple Cross ◽  
Rectal Swabs ◽  
Cost Efficient ◽  
The Cost ◽  
Positive Results

AbstractStreptococcus agalactiae (S. agalactiae) is an important pathogen that can lead to neonatus and mother infection. The current existing techniques for the identification of S. agalactiae are limited by accuracy, speed and high-cost. Therefore, a new multiple cross displacement amplification (MCDA) assay was developed for test of the target pathogen immediately from vaginal and rectal swabs. MCDA primers screening were conducted targeting S. agalactiae pcsB gene, and one set of MCDA primers with better rapidity and efficiency was selected for establishing the S. agalactiae-MCDA assay. As a result, the MCDA method could be completed at a constant temperature of 61 °C, without the requirement of special equipment. The detection limit is 250 fg (31.5 copies) per reaction, all S. agalactiae strains displayed positive results, but not for non-S. agalactiae strains. The visual MCDA assay detected 16 positive samples from 200 clinical specimen, which were also detected positive by enrichment/qPCR. While the CHROMagar culture detected 6 positive samples. Thus, the MCDA assay is prefer to enrichment/qPCR and culture for detecting S. agalactiae from clinical specimen. Particularly, the whole test of MCDA takes about 63.1 min, including sample collection (3 min), DNA preparation (15 min), MCDA reaction (45 min) and result reporting (6 s). In addition, the cost was very economic, with only US$ 4.9. These results indicated that our S. agalaciae-MCDA assay is a rapid, sensitive and cost-efficient technique for target pathogen detection, and is more suitable than conventional assays for an urgent detection, especially for 'on-site' laboratories and resource-constrained settings.

REFORM OF LEGAL REGULATION OF REMOTE WORK AS A STIMULATION FOR ENTREPRENEURSHIP DEVELOPMENT IN RUSSIA

2020 ◽  
pp. 136-143
Author(s):  
Maria A. Andrianova ◽  
Keyword(s):  
Labor Law ◽  
Legal Regulation ◽  
Remote Work ◽  
High Quality ◽  
Quality Work ◽  
Entrepreneurship Development ◽  
Short Period ◽  
The World ◽  
Work Done ◽  
Usual Order

The pandemic has created many difficulties for entrepreneurs around the world, including in Russia. As you know, difficulties, disrupting the usual order, can give impetus for radical changes that would not have a chance to be realized in times of peace and prosperity. It seems that remote mode is not suitable for all forms of employment, but if initially the employer assumes such an opportunity, the main problem is not the lack of the ability to control the employee, but ensuring effective communication with him and the ability to timely obtain the results of high-quality work done. It is noted that this goal can be achieved with the help of greater detail in local regulations of the order and conditions of interaction between the employee and the employer. One of the most promising consequences of the pandemic has been the reform of the legal regulation of remote work. In a very short period of time, remote work in Russia from an unviable rudiment has become one of the most progressive institutions, which has every chance of making all labor law more flexible and effective. Such labor law will undoubtedly become one of the incentives for the development of entrepreneurship in Russia.

scholarly journals Current Diagnosis and Management of Cervical Spondylotic Myelopathy

2017 ◽  
Vol 7 (6) ◽  
pp. 572-586 ◽  
Author(s):  
Joshua Bakhsheshian ◽  
Vivek A. Mehta ◽  
John C. Liu
Keyword(s):  
Natural History ◽  
Cervical Spondylotic Myelopathy ◽  
Early Recognition ◽  
Clinical Manifestations ◽  
High Quality ◽  
Diagnosis And Management ◽  
Imaging Characteristics ◽  
Cervical Sagittal Alignment ◽  
Long Term Follow Up ◽  
The Cost

Study Design: Review. Objectives: Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options. Methods: The authors performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives. Results: The clinical presentation and natural history of CSM is variable, alternating between quiescent and insidious to stepwise decline or rapid neurological deterioration. For mild CSM, conservative options could be employed with careful observation. However, surgical intervention has shown to be superior for moderate to severe CSM. The success of operative or conservative management of CSM is multifactorial and high-quality studies are lacking. The optimal surgical approach is still under debate, and can vary depending on the number of levels involved, location of the pathology and baseline cervical sagittal alignment. Conclusions: Early recognition and treatment of CSM, before the onset of spinal cord damage, is essential for optimal outcomes. The goal of surgery is to decompress the cord with expansion of the spinal canal, while restoring cervical lordosis, and stabilizing when the risk of cervical kyphosis is high. Further high-quality randomized clinical studies with long-term follow up are still needed to further define the natural history and help predict the ideal surgical strategy.

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