scholarly journals Circulating antioxidant defences are decreased in healthy people after a high-fat meal

2008 ◽  
Vol 100 (2) ◽  
pp. 312-316 ◽  
Author(s):  
Fernando Cardona ◽  
Isaac Túnez ◽  
Inmaculada Tasset ◽  
Lourdes Garrido-Sánchez ◽  
Eduardo Collantes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Hdl Cholesterol ◽  
High Fat ◽  
Total Proteins ◽  
Antioxidant Defences ◽  
The Metabolic Syndrome ◽  
Antioxidative Action ◽  
And Oxidative Stress ◽  
Fat Meal

The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal®(60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.

Insulin-Leptin Axis, Cardiometabolic Risk and Oxidative Stress in Elderly with Metabolic Syndrome

2018 ◽  
Vol 126 (07) ◽  
pp. 445-452 ◽  
Author(s):  
Daniela Gradinaru ◽  
Husseina Khaddour ◽  
Denisa Margina ◽  
Anca Ungurianu ◽  
Claudia Borsa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Elderly Subjects ◽  
Control Group ◽  
Oxidative Stress Biomarkers ◽  
The Metabolic Syndrome ◽  
And Oxidative Stress

AbstractInsulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index). Inflammation and oxidative stress biomarkers evaluated were the high-sensitivity C-reactive protein (hsCRP), the advanced oxidation protein products (AOPP), and the serum antioxidant capacity measured as ferric reducing antioxidant potential (FRAP). The metabolic syndrome group showed significantly (p<0.01) lower levels of ILR and not significant (p=0.09) higher values of IAR-index, as compared to the control group. In metabolic syndrome subjects, the IAR-index was significantly positively correlated with uric acid (r=0.313, p<0.05), FRAP (r=0.347, p<0.05) and AOPP (r=0.677, p<0.01), and negatively correlated with HDL-cholesterol (r=− 0.340, p<0.05) as well as with the ratio FRAP/uric acid (r=− 0.315, p<0.05). ILR and IAR-index reflected the biological state of adipose and pancreatic β-cells and seem to depict the adipo-insular axis status related to metabolic and oxidative stress better than individual markers. Therefore, ILR and IAR-index could represent integrated high-potential biomarkers for disease and patient stratification.

Effect Of Exercise Intensity On Postprandial Lipemia And Oxidative Stress Markers After A High-fat Meal

2016 ◽  
Vol 48 ◽  
pp. 818-819
Author(s):  
Renata L. Krüger ◽  
Bruno C. Teixeira ◽  
Juliano B. Farinha ◽  
Rodrigo C. O. Macedo ◽  
Gabriel A. Fonseca ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Intensity ◽  
Postprandial Lipemia ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
And Oxidative Stress ◽  
Fat Meal

Red Wine Consumption Prevents Vascular Oxidative Stress Induced by a High-fat Meal in Healthy Volunteers

2004 ◽  
Vol 74 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Ventura ◽  
Bini ◽  
Panini ◽  
Marri ◽  
Tomasi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Healthy Volunteers ◽  
Red Wine ◽  
Plasma Lipid ◽  
Total Plasma ◽  
High Fat ◽  
Plasma Antioxidant ◽  
Lipid Parameters ◽  
Fat Meal

In order to investigate the effect of red wine on plasma lipid and oxidative stress parameters after a high-fat meal, fifteen healthy volunteers were studied: three days after a high-fat meal with 250 mL of water, they received the same meal with 250 mL of red wine. During both periods, serial blood samples were drawn before and 2, 4, and 8 hours after the meal to evaluate plasma lipids (cholesterol and triglycerides; retinyl palmitate), oxidative stress (D-ROM, and malondialdehyde) and antioxidant (total plasma antioxidant levels and uric acid) parameters. During the meal without wine, plasma lipid parameters increased significantly, whereas plasma total plasma antioxidant levels decreased, and a trend toward reduction of uric acid levels was seen). A similar trend in lipid parameters was observed after the meal with wine; no significant difference in individual lipid parameter trends after a meal with and without wine was observed. Wine ingestion induced higher total plasma antioxidant levels and uric acid; malondialdehyde levels remained constant after wine ingestion. Plasma D-ROM showed a significant postprandial increase in both experiments, but it was significantly lowered after wine ingestion. Our results give evidence of oxidative stress following a fat-rich meal in healthy subjects, suggesting that ingestion of red wine during a high-fat meal significantly reduces oxidative stress without inducing any significant modification in postprandial lipemia.

Effects of Two Combined Exercise Designs Associated With High-Fat Meal Consumption on Postprandial Lipemia, Insulinemia, and Oxidative Stress

2018 ◽  
Vol 32 (5) ◽  
pp. 1422-1430
Author(s):  
Juliano B. Farinha ◽  
Carlos Ernani O. Macedo ◽  
Josianne Rodrigues-Krause ◽  
Renata L. Krüger ◽  
Francesco P. Boeno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Postprandial Lipemia ◽  
High Fat ◽  
Combined Exercise ◽  
And Oxidative Stress ◽  
Fat Meal ◽  
Meal Consumption

Impact of Meal Ingestion Rate and Caffeine Coingestion on Postprandial Lipemia and Oxidative Stress Following High-Fat Meal Consumption

2016 ◽  
Vol 6 (3) ◽  
pp. 108-116 ◽  
Author(s):  
Laura Brooks Crone ◽  
Emily Beatty ◽  
Ryan G. Moran ◽  
Matthew Butawan ◽  
Richard J. Bloomer
Keyword(s):  
Oxidative Stress ◽  
Ingestion Rate ◽  
Postprandial Lipemia ◽  
High Fat ◽  
Meal Ingestion ◽  
And Oxidative Stress ◽  
Fat Meal ◽  
Meal Consumption

Supplements of l-arginine attenuate the effects of high-fat meal on endothelial function and oxidative stress

2008 ◽  
Vol 127 (3) ◽  
pp. 337-341 ◽  
Author(s):  
Chih-Chan Lin ◽  
Wei-Chuan Tsai ◽  
Ju-Yi Chen ◽  
Yi-Heng Li ◽  
Li-Jen Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
High Fat ◽  
And Oxidative Stress ◽  
Fat Meal

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers

2019 ◽  
Vol 22 (7) ◽  
pp. 496-501
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Parisa Falsafi ◽  
Hamidreza Abolsamadi ◽  
Mohammad T. Goodarzi ◽  
Jalal Poorolajal
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Free Radicals ◽  
Antioxidant Capacity ◽  
Cigarette Smoke ◽  
Total Antioxidant Capacity ◽  
The Body ◽  
Total Antioxidant ◽  
The Mean ◽  
And Oxidative Stress

Background: Cigarette smoke free radicals can cause cellular damage and different diseases. All the body fluids have antioxidants which protect against free radicals. Objective: The aim of this study was to evaluate salivary total antioxidant capacity and peroxidase, uric acid and malondialdehyde levels in smokers and a nonsmoking control group. Methods: Unstimulated saliva was collected from 510 males. A total of 259 subjects were current smokers and 251 were non-smokers. The levels of salivary total antioxidant capacity, uric acid, peroxidase and malondialdehyde were measured using standard procedures. Data were analyzed with t test and ANOVA. Results: The smokers were younger and dental hygiene index was higher than healthy nonsmoking controls. The mean total antioxidant capacity in smokers and nonsmokers was 0.13±0.07 and 0.21±011, respectively (P=0.001). Smokers had significantly lower peroxidase and uric acid levels than healthy controls. In addition, the mean malondialdehyde levels in the smokers and nonsmokers were 4.55 ±2.61 and 2.79 ±2.21, respectively (P=0.001). Conclusion: Cigarette smoke produces free radical and oxidative stress, causing many side effects. Salivary antioxidant levels decreased and malondialdehyde levels increased in smokers, indicating the high oxidative stress among smokers compared to nonsmokers. Cigarette smoke had deleterious effects on main salivary antioxidants levels.

scholarly journals Galangin Resolves Cardiometabolic Disorders through Modulation of AdipoR1, COX-2, and NF-κB Expression in Rats Fed a High-Fat Diet

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 769
Author(s):  
Patoomporn Prasatthong ◽  
Sariya Meephat ◽  
Siwayu Rattanakanokchai ◽  
Juthamas Khamseekaew ◽  
Sarawoot Bunbupha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Tissue ◽  
Sprague Dawley ◽  
High Fat ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Cardiometabolic Disorders ◽  
Cox 2 ◽  
Factor Α ◽  
And Oxidative Stress

Galangin is a natural flavonoid. In this study, we evaluated whether galangin could alleviate signs of metabolic syndrome (MS) and cardiac abnormalities in rats receiving a high-fat (HF) diet. Male Sprague–Dawley rats were given an HF diet plus 15% fructose for four months, and they were fed with galangin (25 or 50 mg/kg), metformin (100 mg/kg), or a vehicle for the last four weeks. The MS rats exhibited signs of MS, hypertrophy of adipocytes, impaired liver function, and cardiac dysfunction and remodeling. These abnormalities were alleviated by galangin (p < 0.05). Interleukin-6 and tumor necrosis factor-α concentrations and expression were high in the plasma and cardiac tissue in the MS rats, and these markers were suppressed by galangin (p < 0.05). These treatments also alleviated the low levels of adiponectin and oxidative stress induced by an HF diet in rats. The downregulation of adiponectin receptor 1 (AdipoR1) and cyclooxygenase-2 (COX-2) and the upregulation of nuclear factor kappa B (NF-κB) expression were recovered in the galangin-treated groups. Metformin produced similar effects to galangin. In conclusion, galangin reduced cardiometabolic disorders in MS rats. These effects might be linked to the suppression of inflammation and oxidative stress and the restoration of AdipoR1, COX-2, and NF-κB expression.

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