scholarly journals Long-chain polyunsaturated fatty acids in breast milk and early weight gain in breast-fed infants

2008 ◽  
Vol 101 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Salome Scholtens ◽  
Alet H. Wijga ◽  
Henriette A. Smit ◽  
Bert Brunekreef ◽  
Johan C. de Jongste ◽  
...  

The long-chain PUFA (LCPUFA) content of an infant's diet might affect early weight gain. In early trials on supplementation of formula feedingn-3 LCPUFA affected weight gain adversely.n-6 LCPUFA are thought to promote adipose tissue development and might be associated with higher weight gain. We studied the association between the naturaln-3 andn-6 LCPUFA content of breast milk of Dutch women and weight and BMI gain of their breast-fed infants in the first year of life. The children in this study were enrolled in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study and were born in 1996–1997 in the Netherlands. Parents reported their child's weight and length in a questionnaire. Of a subgroup of the total population breast-milk samples were collected (n244). The fatty acid composition of breast milk was determined by GLC and expressed as weight percentages. Linear regression was used for data analysis. Mean gain in weight, length and BMI per week from birth to 1 year of age was 119·5 (sd16·1) g, 0·48 (sd0·05) cm and 0·06 (sd0·03) kg/m2, respectively. The associations betweenn-6 andn-3 LCPUFA in breast milk, and infant weight, length and BMI gain were weak and inconsistent. Then-3 andn-6 LCPUFA content in breast milk did not affect weight or BMI gain in the first year of life in breast-fed term infants.

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 921-925
Author(s):  
Alice H. Cushing ◽  
Linda Anderson

During the first year of life a group of babies was prospectively observed for diarrhea and for fecal carriage of heat-labile toxigenic bacteria, with or without colonization factor, and rotavirus. Approximately half of the babies were breast-fed for the first six months of life. There was no difference between groups (breast-fed vs non-breast-fed) in number of babies who had diarrhea during any two-month period. Nor was there any difference between groups in the number of babies who had diarrhea while carrying toxigenic bacteria, with or without colonization factor. Secretory antibody to toxin was found in 37% of colostrum and milk samples. There was a small but insignificant difference in the number of babies who had diarrhea when they carried toxigenic bacteria depending on the presence of antibody in the breast milk they received.


Author(s):  
S. N. Rustamova

Purpose: to investigate the impact of the type of feeding on the incidence and physical development of infants. Material and methods. During a year, 250 children of the first year of life under control received different types of feeding (breast milk and milk formulas, differing in composition). Physical development was assessed according to the generally accepted measurement technique in terms of absolute values, monthly increases in anthropometric indicators and mass-growth indices. Outpatient records of children, protocols of examination of a 1-year-old child were studied. The inclusion criteria for the main group of infants were: breastfeeding for at least 9 months; the age of children up to 1 year. The second comparison group included children who received mixed feeding, which includes probiotics. Results. In the girls of the second group, who received mixed feeding with probiotics (7100.0±95.9 g), the weight gain in the first year was significantly higher than the weight gain in the girls who received breast milk and standard formula - 6671 , 0±72.6 g. and 6733.3±91.8 g, respectively. Despite the fact that there were no significant differences in the medians of body weight and height in children of the main group and the comparison groups, it was found that children in the main group were overweight / obese at the age of 2 months had twice as less indicators than children who received mixed feeding. Breastfed children began to sit without support much earlier, on average at 7.6±0.05 months after birth, and children of the other two groups who are bottle-fed, on average, at 8.0±0.13 and 8,1±0.12 months, respectively (p <0.05). When studying the most common diseases of children over their first year of life, depending on the type of feeding, the following results were found out: acute intestinal infections made up the largest share in both groups, 7.7±2.34% of children in the I group, and 11.7±2.93% of children in the II group (p = 0.3905). Conclusion. The study has demonstrated that breastfeeding in the first year of life reduces the risk of overweight and ensures harmonious physical development, neuropsychic development, cuts down the frequency of infectious diseases, alimentary disorders, functional digestive disorders, and contributes to the normalization of intestinal microflora. It is also important to introduce optimal combinations of feeding methods for young children and adding probiotics.


2012 ◽  
Vol 109 (11) ◽  
pp. 1962-1970 ◽  
Author(s):  
Essi Kainonen ◽  
Samuli Rautava ◽  
Erika Isolauri

Breast milk provides important maturational stimuli to an infant's developing immune system. However, data concerning the role of breast-feeding in reducing the risk of allergic disease remain contradictory. Previous studies have centred on comparative analyses of breast milk and formula compositions. We chose a slightly different angle, whereby we focused on the effects of the chosen diet on the infant himself, comparing the immune development of formula-fed and breast-fed children. The objective of the present study was to determine how the mode of feeding affects infant immunology. Altogether, eighteen formula-fed infants with limited breast-feeding for < 3 months and twenty-nine infants who were exclusively breast-fed for >3 months were included in the study. Concentrations of interferon γ, TNF-α IL-10, IL-5, IL-4 and IL-2 were measured simultaneously from the same serum sample through use of a multiplexed flow cytometric assay at the ages of 1, 3, 6 and 12 months. Transforming growth factor β2 (TGF-β2) was measured using ELISA at the same time points. Serum TNF-α and IL-2 concentrations were significantly higher in formula-fed than in breast-fed infants during the first year of life (ANOVA, P= 0·002). The serum concentrations of TGF-β were significantly lower in formula-fed than in breast-fed infants throughout the first year of life (ANOVA, P≤ 0·0001). Exclusive breast-feeding promotes an anti-inflammatory cytokine milieu, which is maintained throughout infancy. Such an immunological environment limits hyper-responsiveness and promotes tolerisation, possibly prohibiting the onset of allergic disease.


2021 ◽  
Vol 12 ◽  
Author(s):  
Modupe O. Coker ◽  
Hannah E. Laue ◽  
Anne G. Hoen ◽  
Margaret Hilliard ◽  
Erika Dade ◽  
...  

Cesarean-delivered (CD) infants harbor a distinct gut microbiome from vaginally delivered (VD) infants, however, during infancy, the most important driver of infant gut microbial colonization is infant feeding. Earlier studies have shown that breastfeeding is associated with higher levels of health-promoting bacteria such and Bifidobacterium and Bacteroides via modulation of the immune system, and production of metabolites. As the infant gut matures and solid foods are introduced, it is unclear whether longer duration of breast feeding restore loss of beneficial taxa within the intestinal microbiota of operatively delivered infants. Within the New Hampshire Birth Cohort Study, we evaluated the longitudinal effect of delivery mode and infant feeding on the taxonomic composition and functional capacity of developing gut microbiota in the First year of life. Microbiota of 500 stool samples collected between 6 weeks and 12 months of age (from 229 infants) were characterized by 16S ribosomal RNA sequencing. Shotgun metagenomic sequencing was also performed on 350 samples collected at either 6 weeks or 12 months of age. Among infant participants, 28% were cesarean-delivered (CD) infants and most (95%) initiated breastfeeding within the first six months of life, with 26% exclusively breastfed and 69% mixed-fed (breast milk and formula), in addition to complementary foods by age 1. Alpha (within-sample) diversity was significantly lower in CD infants compared to vaginally delivered (VD) infants (P &lt; 0.05) throughout the study period. Bacterial community composition clustering by both delivery mode and feeding duration at 1 year of age revealed that CD infants who were breast fed for &lt; 6 months were more dissimilar to VD infants than CD infants who breast fed for ≥ 6 months. We observed that breastfeeding modified the longitudinal impact of delivery mode on the taxonomic composition of the microbiota by 1 year of age, with an observed increase in abundance of Bacteroides fragilis and Lactobacillus with longer duration of breastfeeding among CD infants while there was an increase in Faecalibacterium for VD infants. Our findings confirm that duration of breastfeeding plays a critical role in restoring a health-promoting microbiome, call for further investigations regarding the association between breast milk exposure and health outcomes in early life.


Author(s):  
Saida Nuraddin Rustamaova ◽  

Evaluation of the type of nutrition, which is one of the important components that ensure the physical growth, development and health of a child in the first year of life, and that forms metabolic processes at an older age, has been the subject of research and discussion of domestic and foreign scientists over the past decades. Purpose — to study the influence of the nature of feeding on the incidence and physical development of infants. Materials and methods. During the year, 250 children (118 girls and 132 boys) of the first year of life were under observation, who received various types of feeding (breast milk and milk formulas, differing in composition). The main (I) group (n=130) included children (62 girls and 68 boys) who were breastfed; and in the comparison group — children receiving artificial feeding: in group II (n=60) (27 girls and 33 boys) received a standard mixture with a prebiotic; in group III (n=60) (29 girls and 31 boys) — a standard mixture without a prebiotic. Physical development was assessed according to the generally accepted measurement technique in terms of absolute values, monthly increases in anthropometric indicators and mass-growth indices. Outpatient records of children, protocols of examination of a 1-year-old child were studied (accounting and reporting documentation was analyzed). The criteria for inclusion in the main group of infants were: breastfeeding for at least 9 months; the age of children from up to 1 year of age. The second comparison group included children who were fed mixed with the addition of probiotic means. Results. In girls of the second group, who were artificially fed with the addition of a probiotic — 7100.0±95.9 g, the weight gain in the first year of life was significantly higher than the weight gain of girls who received breast milk and standard formula — 6671.0±72.6 g and 6733.3±91.8 g, respectively. Despite the fact that there were no significant differences in the medians of body weight and height in children of the main group and the comparison groups, it was found that children in the main group were overweight/obese at 12 months had two or more times less indicators than children who received artificial nutrition. Children who are breastfed began to sit independently much earlier, on average 7.6±0.05 months after birth, and children of the other two groups who are bottle-fed, on average, 8.0±0.13 and 8.1±0.12 months, respectively (p<0.05). When studying the structure of the most common diseases of children in the first year of life, depending on the type of feeding, it was revealed that the greatest percentage both in group I (group) and in group II (claim) are children with acute intestinal infections — in group I (group 1)) group in 7.7±2.34% of children, in subgroup II (claim) in 11.7±2.93% of children (p=0.3905). Conclusions. The results obtained indicate a positive effect of breastfeeding on anthropometric indicators and the formation of basic skills in young children. The incidence of infectious diseases (ARI and OCI) revealed in children who received breast milk, compared with children who are bottle-fed, indicates that breastfeeding has the ability to create conditions for reducing the incidence of diseases in young children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: types of feeding, physical development, motor skills, morbidity, children under 1 year old.


2001 ◽  
Vol 120 (5) ◽  
pp. A209-A209
Author(s):  
G RIEZZO ◽  
R CASTELLANA ◽  
T DEBELLIS ◽  
F LAFORGIA ◽  
F INDRIO ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.


2004 ◽  
Vol 58 (10) ◽  
pp. 1429-1431 ◽  
Author(s):  
A Kerssen ◽  
I M Evers ◽  
H W de Valk ◽  
G H A Visser

PEDIATRICS ◽  
1976 ◽  
Vol 57 (2) ◽  
pp. 294-295
Author(s):  
Justin D. Call

"Breast-Feeding: Second Thoughts" by Gerrard,1 sets forth epidemiologic and immunological data on human and other mammalian species showing that colostrum and breast milk actively protect the infant from enterocolitis and respiratory infections when breast-feeding is begun immediately after birth and continued through at least most of the first year of life. Gerrard hypothesizes that breast-feeding provides a smooth transition for the baby from being entirely dependent on the mother for nutritional and immunological requirements to being completely independent from her.


2017 ◽  
Vol 15 (1-2) ◽  
pp. 19
Author(s):  
J.H.P. Jonxis

Malnutrition in the first year of life may cause permanent damage to the individual. There may be a permanent retardation in growth if the malnutrition is a serious one and the food intake is severely insufficient over a longer, period. Specially when malnutrition occurs in the first months after birth, it may cause damage to the central nervous system.As long as the breast-fed child gets enough breastmilk, it is unlikely that serious problems  arise. The declinein feeding in many developing countries is a serious problem, especially because the alternatives for human milk are not always available, owing to economic factors. In the, countries of the Western world there exists just, the opposite problem owing to partial over-nutrition abnormalities in fat metabolism may occur, which may influence the health of the individual later on in life.


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