scholarly journals Adipose tissuetrans-fatty acids and changes in body weight and waist circumference

2013 ◽  
Vol 111 (7) ◽  
pp. 1283-1291 ◽  
Author(s):  
Camilla P. Hansen ◽  
Tina L. Berentzen ◽  
Jane N. Østergaard ◽  
Christina C. Dahm ◽  
Lars I. Hellgren ◽  
...  

Previous studies have suggested that the intake oftrans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of 996 men and women aged 50–64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were totaltrans-octadecenoic acids (18 : 1t), 18 : 1 Δ6-10t, vaccenic acid (18 : 1 Δ11t) and rumenic acid (18 : 2 Δ9c, 11t). Data were analysed using multiple regression with cubic spline modelling. The median proportion of total adipose tissue 18 : 1twas 1·52 % (90 % central range 0·98, 2·19) in men and 1·47 % (1·01, 2·19) in women. No significant associations were observed between the proportions of total 18 : 1t, 18 : 1 Δ6-10t, vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 852
Author(s):  
Pauter ◽  
Fischer ◽  
Bengtsson ◽  
Asadi ◽  
Talamonti ◽  
...  

The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.


2015 ◽  
Vol 15 (2) ◽  
pp. 38-42
Author(s):  
Ch Khorolmaa ◽  
Sh Demberel ◽  
B Battsetseg ◽  
G Gereltsetseg ◽  
S Andrei

Brown adipose tissue in newborn lambs accounts for 4.52% of total body weight, then during postpartum period it intensively decreases, reaching 1.5% after a week, and finally it is gradually adsorbed or replaced with white adipose tissue. Fatty acids composition of lamb brown adipose tissue includes 17 unsaturated fatty acids (53.23%) and 11 saturated ones (46.95%).Mongolian Journal of Agricultural Sciences Vol.15(2) 2015; 38-42


Lipids ◽  
1994 ◽  
Vol 29 (5) ◽  
pp. 319-325 ◽  
Author(s):  
Subodh Atal ◽  
Mary Jane Zamowski ◽  
Samuel W. Cushman ◽  
Joseph Sampugna

2009 ◽  
Vol 91 (2) ◽  
pp. 329-336 ◽  
Author(s):  
Huaidong Du ◽  
Daphne L van der A ◽  
Hendriek C Boshuizen ◽  
Nita G Forouhi ◽  
Nicolas J Wareham ◽  
...  

2012 ◽  
Vol 66 (10) ◽  
pp. 1104-1109 ◽  
Author(s):  
C P Hansen ◽  
T L Berentzen ◽  
J Halkjær ◽  
A Tjønneland ◽  
T I A Sørensen ◽  
...  

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 589-589
Author(s):  
Julie Jones ◽  
Sujatha Rajaram ◽  
Celine Heskey ◽  
Rawiwan Sirirat ◽  
Abigail Clarke ◽  
...  

Abstract Objectives We sought to assess the effect of daily consumption of macadamia nuts as 15% of calories on body weight, BMI, waist circumference, percent body fat and skeletal muscle mass in overweight/obese men and women with elevated cardiometabolic risk. Methods Utilizing a randomized crossover design, we randomized 38 subjects to consume macadamia nuts daily as 15% of calories for 8 weeks (intervention) and their usual diet for 8 weeks (control), with a 2-week washout. Three subjects dropped out early; n = 35 for analysis. Subjects were healthy men and postmenopausal women with a BMI of 25–39, a waist circumference of >101.6 cm for men and >88.9 cm for women, and one additional cardiovascular risk factor (fasting plasma glucose >100 mg/dL, triglycerides ≥150 mg/dl, total cholesterol >200 mg/dL, LDL-C > 100 mg/dL, blood pressure ≥130/85 mmHg or taking anti-hypertensive medication). Macadamia nuts were provided in pre-weighed daily portions as 15% of calories calculated using the Mifflin-St. Jeor equation. Percent body fat and skeletal muscle mass (kg) were determined by bioelectrical impedance analysis. A mixed model analysis was performed with treatment, sequence, phase, and baseline values as fixed-effect terms and subjects as a random-effects term. Results Compared to control, consumption of macadamia nuts led to a mean weight change of –348 g (84.13 vs. 83.78 kg; P = 0.15) a mean BMI change of –0.15 kg/m2 (30.61 vs. 30.47 kg/m2; P = 0.12), and a mean waist circumference change of 0.17 cm (107.41 vs. 107.58 cm; P = 0.61). Percent body fat increased by an average of 0.26% after eating nuts (42.70 vs. 42.96%; P = 0.16). Skeletal muscle mass was slightly but significantly lower after eating nuts with a mean change of –0.237 kg (26.33 vs. 26.09 kg; P = 0.017). Conclusions Daily consumption of high-fat macadamia nuts for eight weeks in overweight and obese individuals did not change anthropometrics including body weight, BMI, waist circumference, and % body fat. Skeletal muscle mass was slightly lowered but likely not clinically relevant. Funding Sources Hort Innovation, Sydney, Australia.


2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Xian-Yong Ma ◽  
Wei Qiao Qiu ◽  
Caren E. Smith ◽  
Laurence D. Parnell ◽  
Zong-Yong Jiang ◽  
...  

Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in theBDNFgene with dietary intake for obesity traits in the Boston Puerto Rican Health Study.BDNFrs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242) with the GG genotype had higher BMI (P=0.009), waist circumference (P=0.002), hip (P=0.002), and weight (P=0.03) than GA or AA carriers (n=94). They had twice the risk of being overweight (BMI≥25) relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, andP=0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n=595) with the GG genotype had significantly lower BMI (P=0.009), hip (P=0.029), and weight (P=0.027) than GA or AA carriers (n=216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, andP=0.024). In summary,BDNFrs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.


1974 ◽  
Vol 60 (3) ◽  
pp. 517-NP ◽  
Author(s):  
J. P. THAPLIYAL ◽  
S. C. GUPTA ◽  
R. K. GARG

SUMMARY Thyroidectomy decreased the body weight and the height of the cells lining the sex-segment of the kidney of the Chequered Water-snake, Natrix piscator maintained at 30 °C; at 40 °C the liver, kidney and gonad were also affected. At the higher temperature, thyroidectomy influenced significantly protein, carbohydrate and lipid metabolism. At 30 °C, only a decrease in the rate of esterification of the free fatty acids in the liver and of their release from the adipose tissue was observed. The difference in the effect of thyroidectomy at 30 and 40 °C is explained by suggesting that thyroid activity was low in animals maintained at the lower temperature and high in those kept at the higher temperature.


2009 ◽  
Vol 55 (3) ◽  
pp. 13-16 ◽  
Author(s):  
D. A. Tanyanskiy ◽  
E M. Firova ◽  
L. V. Shatilina ◽  
A. D. Denisenko

The purpose of the study was to reveal a possible role of adipokines, biologically active adipose tissue proteins (leptin and adiponectin) and nonesterified fatty acids in generating insulin resistance (IR). One hundred and fifty-seven patients (90 females and 67 males) aged 57.5±9.2 years were enrolled in the study. According to the HOMA index for IR, the patients were divided into 3 equal groups. The examinees with a high HOMA index were found to have elevated levels of fatty acids, leptin and decreased concentrations of adiponectin. At the same time according to the linear regression analysis, all these indices are its independent determinants. However, analysis of the data in the groups of patients with different body weight revealed that the increased concentrations of fatty acids and leptin may play a role in the development of IR in subjects with obesity while the higher level of fatty acids and lower adiponectin may be involved in patients without noticeable obesity. Thus, it may be assumed that leptin, adiponectin and nonesterified fatty acids may affect the development of IR; however, their contribution depends on the degree of adiposity.


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