scholarly journals Changing to a vegetarian diet reduces the body creatine pool in omnivorous women, but appears not to affect carnitine and carnosine homeostasis: a randomised trial

2018 ◽  
Vol 119 (7) ◽  
pp. 759-770 ◽  
Author(s):  
Laura Blancquaert ◽  
Audrey Baguet ◽  
Tine Bex ◽  
Anneke Volkaert ◽  
Inge Everaert ◽  
...  

AbstractBalanced vegetarian diets are popular, although they are nearly absent in creatine and carnosine and contain considerably less carnitine than non-vegetarian diets. Few longitudinal intervention studies investigating the effect of a vegetarian diet on the availability of these compounds currently exist. We aimed to investigate the effect of transiently switching omnivores onto a vegetarian diet for 6 months on muscle and plasma creatine, carnitine and carnosine homeostasis. In a 6-month intervention, forty omnivorous women were ascribed to three groups: continued omnivorous diet (control,n10), vegetarian diet without supplementation (Veg+Pla,n15) and vegetarian diet combined with dailyβ-alanine (0·8–0·4 g/d) and creatine supplementation (1 g creatine monohydrate/d) (Veg+Suppl,n15). Before (0 months; 0M), after 3 months (3M) and 6 months (6M), a fasted venous blood sample and 24-h urine was collected, and muscle carnosine content was determined by proton magnetic resonance spectroscopy (1H-MRS). Muscle biopsies were obtained at 0M and 3M. Plasma creatine and muscle total creatine content declined from 0M to 3M in Veg+Pla (P=0·013 andP=0·009, respectively), whereas plasma creatine increased from 0M in Veg+Suppl (P=0·004). None of the carnitine-related compounds in plasma or muscle showed a significant time×group interaction effect.1H-MRS-determined muscle carnosine content was unchanged over 6M in control and Veg+Pla, but increased in Veg+Suppl in soleus (P<0·001) and gastrocnemius (P=0·001) muscle. To conclude, the body creatine pool declined over a 3-month vegetarian diet in omnivorous women, which was ameliorated when accompanied by low-dose dietary creatine supplementation. Carnitine and carnosine homeostasis was unaffected by a 3- or 6-month vegetarian diet, respectively.

2021 ◽  
pp. 381-391
Author(s):  
Sandra Marciniak ◽  
Ewa Lange ◽  
Wacław Laskowski

Background. People following a vegetarian diet can obtain all the essential nutrients from a variety of foods. Among the nutrients, protein, iron, calcium, zinc, and vitamins B12 and D3 require special attention. Objective. To assess the knowledge of dietary recommendations among different groups of vegetarians and the diet they follow. Material and methods. The study involved a total of 390 subjects (360 women and 30 men), aged 18–60 years, who were following different vegetarian diets. The study was conducted in November 2020 via Facebook using the Computerassisted web interviewing (CAWI) method. Participation in the study was voluntary and anonymous, and sample selection was intentional (participants were members of groups for vegetarians in Facebook). Statistical analysis was carried out using the Chi2 test, using Statistica 13.3 (at p=0.05). Results. To develop the results, the respondents were divided into 4 groups according to their diet: vegan, pescovegetarian, lactovegetarian, and people following other types of diets. The body mass index of nearly 2/3 of the respondents was within the normal range, and more than 80% of the respondents rated their health as good or very good. An analysis of the frequency of consumption of food products showed that, regardless of the type of vegetarian diet they followed, the participants adhered to the principles of proper nutrition. The respondents who rated their nutritional knowledge as very good were more likely to consume vegetables, fruits, legumes, and whole-grain cereals, and rarely consumed sweet and salty snacks, alcoholic and energizing drinks, or fast food. Vegans more frequently consumed fruits, vegetables, legumes, vegetable fats, and vegetable substitutes for meat and dairy products compared to other vegetarians. In addition to plant products, pesco- and lactovegetarians included selected animal-derived products in their food rations, thus skillfully diversifying the diet. More than 80% of the vegetarians used dietary supplements, mainly vitamins D and B12. Conclusions. Regardless of the type of vegetarian diet followed, the participants seemed to be aware of how to balance their diet and the ingredients that should be supplemented, even though a vast majority of them did not consult a diet specialist.


2021 ◽  
Vol 14 (7) ◽  
pp. 96-101
Author(s):  
Leidiane Lourenço Rodrigues ◽  
Rafaela Martins Santos

The relationship between the vegetarian diet and sports performance is very much investigated since there are many doubts about its results, justified by the main protein source of the diet being of vegetable origin, which, consequently, raises more attention on the levels of some vitamins and minerals, immune function, hormonal relationships and even on the nutritional needs for athletes. Immune functions are also very much emphasized, because they may present small alterations related to prolonged overtraining, causing chronic performance reduction. However, vegetarian diets associated with moderate and regulating workouts have a positive result. Vegetarians have a low level of creatine in their bodies, because this amino acid is more present in animal foods. This may affect a higher performance in supra-maximal workouts; however, a good creatine supplementation is a good alternative. Thus, this study aimed to To understand the effectiveness of vegetarian diet associated with sport performance. This work was an exploratory literature review, with a qualitative approach. Several articles were investigated from 2002 to 2018, in Scielo and Medline databases. However, it was possible to review that the aerobic capacity of vegetarian and omnivorous athletes did not present differences, and with the monitoring of routine tests and a good professional nutritionist, these results can be very well controlled.


2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.


2021 ◽  
pp. 1-16
Author(s):  
Marcin Adamczak ◽  
Stanisław Surma

<b><i>Background:</i></b> Metabolic acidosis in CKD is diagnosed in patients with plasma or venous blood bicarbonate concentration lower than 22 mmol/L. Metabolic acidosis occurs in about 20% of patients with CKD. Metabolic acidosis may lead to dysfunction of many systems and organs as well as CKD progression. Currently, sodium bicarbonate is mainly used for pharmacological treatment of metabolic acidosis in patients with CKD. Veverimer is a new drug dedicated to treatment of metabolic acidosis in patients with CKD. Orally given veverimer binds hydrogen ions in the intestines and subsequently is excreted from the body with feces. Clinical studies have shown that veverimer is effective in increasing serum bicarbonate concentrations in CKD patients with metabolic acidosis. Here, we present review of the epidemiology, pathogenesis, diagnosis, treatment, and prevention of metabolic acidosis in CKD patients. <b><i>Summary:</i></b> Metabolic acidosis is common in patients with CKD and contributes to CKD progression and many complications, which worsen the prognosis in these patients. Currently, sodium bicarbonate is mainly used in metabolic acidosis treatment. The role of the new drug veverimer in the metabolic acidosis therapy needs further studies. <b><i>Key Message:</i></b> The aim of this review article is to summarize the current knowledge concerning the epidemiology, pathogenesis, diagnosis, treatment, and prevention of metabolic acidosis in CKD patients.


2004 ◽  
Vol 96 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Gabriel Laszlo

The measurement of cardiac output was first proposed by Fick, who published his equation in 1870. Fick's calculation called for the measurement of the contents of oxygen or CO2 in pulmonary arterial and systemic arterial blood. These values could not be determined directly in human subjects until the acceptance of cardiac catheterization as a clinical procedure in 1940. In the meanwhile, several attempts were made to perfect respiratory methods for the indirect determination of blood-gas contents by respiratory techniques that yielded estimates of the mixed venous and pulmonary capillary gas pressures. The immediate uptake of nonresident gases can be used in a similar way to calculate cardiac output, with the added advantage that they are absent from the mixed venous blood. The fact that these procedures are safe and relatively nonintrusive makes them attractive to physiologists, pharmacologists, and sports scientists as well as to clinicians concerned with the physiopathology of the heart and lung. This paper outlines the development of these techniques, with a discussion of some of the ways in which they stimulated research into the transport of gases in the body through the alveolar membrane.


From the fact that no carbonic acid gas is given out by venous blood when that fluid is subjected to the action of the air-pump, former experimentalists had inferred that this blood contains no carbonic acid. The author of the present paper contends that this is an erroneous inference; first, by showing that serum, which had been made to absorb a considerable quantity of this gas, does not yield it upon the removal of the atmospheric pressure; and next, by adducing several experiments in proof of the strong attraction exerted on carbonic acid both by hydrogen and by oxygen gases, which were found to absorb it readily through the medium of moistened membrane. By means of a peculiar apparatus, consisting of a double-necked bottle, to which a set of bent tubes were adapted, he ascertained that venous blood, agitated with pure hydrogen gas, and allowed to remain for an hour in contact with it, imparts to that gas a considerable quantity of carbonic acid. The same result had, indeed, been obtained, in a former experiment, by the simple application of heat to venous blood confined under hydrogen gas; but on account of the possible chemical agency of heat, the inference drawn from that experiment is less conclusive than from experiments in which the air-pump alone is employed. The author found that, in like manner, atmospheric air, by remaining, for a sufficient time, in contact with venous blood, on the application of the air-pump, acquires carbonic acid. The hypothesis that the carbon of the blood attracts the oxygen of the air into the fluid, and there combines with it, and that the carbonic acid thus formed is afterwards exhaled, appears to be inconsistent with the fact that all acids, and carbonic acid more especially, impart to the blood a black colour; whereas the immediate effect of exposing venous blood to atmospheric air, or to oxygen gas, is a change of colour from a dark to a bright scarlet, implying its conversion from the venous to the arterial character: hence the author infers that the acid is not formed during the experiment in question, but already exists in the venous blood, and is extracted from it by the atmospheric air. Similar experiments made with oxygen gas, in place of atmospheric air, were attended with the like results, but in a more striking degree and tend therefore to corroborate the views entertained by the author of the theory of respiration. According to these views, it is neither in the lungs, nor generally in the course of the circulation, but only during its passage through the capillary system of vessels, that the blood undergoes the change from arterial to venous; a change consisting in the formation of carbonic acid, by the addition of particles of carbon derived from the solid textures of the body, and which had combined with the oxygen supplied by the arterial blood: and it is by this combination that heat is evolved, as well as a dark colour imparted to the blood. The author ascribes, however, the bright red colour of arterial blood, not to the action of oxygen, which is of itself completely inert as a colouring agent, but to that of the saline ingredients naturally contained in healthy blood. On arriving at the lungs, the first change induced on the blood is effected by the oxygen of the atmospheric air, and consists in the removal of the carbonic acid, which had been the source of the dark colour of the venous blood; and the second consists in the attraction by the blood of a portion of oxygen, which it absorbs from the air, and which takes the place of the carbonic acid. The peculiar texture of the lungs, and the elevation of temperature in warm-blooded animals, concur in promoting the rapid production of these changes.


1967 ◽  
Vol 46 (2) ◽  
pp. 307-315 ◽  
Author(s):  
E. DON STEVENS ◽  
D. J. RANDALL

1. Changes in blood pressure in the dorsal aorta, ventral aorta and subintestinal vein, as well as changes in heart rate and breathing rate during moderate swimming activity in the rainbow trout are reported. 2. Blood pressures both afferent and efferent to the gills increased during swimming and then returned to normal levels within 30 min. after exercise. 3. Venous blood pressure was characterized by periodic increases during swimming. The pressure changes were not in phase with the body movements. 4. Although total venous return to the heart increased during swimming, a decreased blood flow was recorded in the subintestinal vein. 5. Heart rate and breathing rate increased during swimming and then decreased when swimming ceased. 6. Some possible mechanisms regulating heart and breathing rates are discussed.


2019 ◽  
Vol 13 (2) ◽  
pp. 72-86
Author(s):  
Depi Lukitasari

Background. During hospitalization large number of invasive procedure recived by patient and preceived as threatening and anxiety experience. One of the invasive procedures that commonly done is the venous blood extraction. The children in preschool age preceived venous blood extraction as something that endanger the integrity of the body and lead to anxiety experience. To reduce the anxiety during the venous blood extraction, a nurse could perform a clay theraphy. The aim of this research is to ascertain the effect of clay therapy toward scoreof anxiety in preschool age children that undergoing venous blood extraction in RSUD Al-Ihsan.Methode. The study was quasi-experiment with nonequivalent control group posttest only. A total of 34 children who recieve venous blood extraction was assigned into 2 group, 17 children in control and 17 children in intevention. The children anxiety level measured using anxiety observation sheet before the procedure complete. Data were analyzed used independent t test for bivariate and logistik regresion for multivariate. Result Findings. The results  show a significat difference in anxiety score between control group and intervention group with p-value 0,001 < α 0.05 which means there is impact of clay therapy to level anxiety in preschool age children undergoing invasive procedure in RSUD Al-Ihsan. Conclusion. This research indicate that clay therapy may be used to reduce anxiety in children that undergoing venous blood extraction.


2011 ◽  
Vol 6 (3) ◽  
pp. 250-267 ◽  
Author(s):  
Kate Marsh ◽  
Carol Zeuschner ◽  
Angela Saunders

There is now a significant amount of research that demonstrates the health benefits of vegetarian and plant-based diets, which have been associated with a reduced risk of obesity, diabetes, heart disease, and some types of cancer as well as increased longevity. Vegetarian diets are typically lower in fat, particularly saturated fat, and higher in dietary fiber. They are also likely to include more whole grains, legumes, nuts, and soy protein, and together with the absence of red meat, this type of eating plan may provide many benefits for the prevention and treatment of obesity and chronic health problems, including diabetes and cardiovascular disease. Although a well-planned vegetarian or vegan diet can meet all the nutritional needs of an individual, it may be necessary to pay particular attention to some nutrients to ensure an adequate intake, particularly if the person is on a vegan diet. This article will review the evidence for the health benefits of a vegetarian diet and also discuss strategies for meeting the nutritional needs of those following a vegetarian or plant-based eating pattern.


Author(s):  
Abinand Manorama ◽  
Tamara Reid Bush

Pressure ulcers have been a concern in healthcare settings, with more than 50% of bedridden or wheelchair-bound patients being affected [1]. Pressure ulcers typically occur on a region of the body that experiences forces from an external structure (e.g. bed, wheelchair). Researchers believe that such forces cause a decrease in blood flow, which results in tissue necrosis, causing pressure ulcers [2].


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