scholarly journals Low-carbohydrate diets and prevalence, incidence and progression of coronary artery calcium in the Multi-Ethnic Study of Atherosclerosis (MESA)

2019 ◽  
Vol 121 (4) ◽  
pp. 461-468 ◽  
Author(s):  
Tian Hu ◽  
David R. Jacobs ◽  
Lydia A. Bazzano ◽  
Alain G. Bertoni ◽  
Lyn M. Steffen
Keyword(s):  
Coronary Artery ◽  
Robust Regression ◽  
Epidemiological Studies ◽  
Total Carbohydrate ◽  
Baseline Measure ◽  
Cross Sectional ◽  
Ethnic Study ◽  
Low Carbohydrate ◽  
The Relationship

AbstractThe evidence linking low-carbohydrate diets (LCD) to CVD is controversial, and results from epidemiological studies are inconsistent. We aimed to assess the relationship between LCD patterns and coronary artery Ca (CAC) scores from computed tomography in the Multi-Ethnic Study of Atherosclerosis cohort. Our sample included 5614 men and women free of clinical CVD at baseline (2000–2002), who had a FFQ, a baseline measure and ≥1 measure of CAC during follow-up. We excluded those with implausible energy intake or daily physical activity. The overall, animal-based and plant-based LCD scores were calculated based on intakes of macronutrients. Relative risk regression and robust regression models were used to examine the cross-sectional and longitudinal relationship between LCD score quintile and CAC outcomes, after adjustment for multiple cardiovascular risk factors. The mean age of participants was 63 years. The median intakes of total carbohydrate, fat and protein were 53·7, 30·5 and 15·6 % energy/d, respectively. Among 2892 participants with zero CAC scores at baseline, 264 developed positive scores during 2·4-year follow-up (11–59 months). Among those with positive scores at baseline, the median increase in CAC was 47 units over the course of follow-up. The overall, the animal-based and the plant-based LCD scores were not associated with CAC prevalence, incidence and progression. In conclusion, diets low in carbohydrate and high in fat and/or protein, regardless of the sources of protein and fat, were not associated with higher levels of CAC, a validated predictor of cardiovascular events, in this large multi-ethnic cohort.

Abstract P329: Low-carbohydrate Diets and Incidence, Prevalence, and Progression of Coronary Artery Calcium in the Multi-ethnic Study of Atherosclerosis (mesa)

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Tian Hu ◽  
David Jacobs ◽  
Jennifer Nettleton ◽  
Lyn Steffen ◽  
Alain Bertoni ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Relative Risk ◽  
Coronary Artery Calcium ◽  
Robust Regression ◽  
Total Carbohydrate ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
The Mean

Background: The coronary artery calcium (CAC) score is associated with the risk of coronary heart disease. We aimed to assess the relationship between low-carbohydrate dietary patterns and CAC scores in the MESA cohort. Methods: Our sample included 5,702 men and women who were free of clinical cardiovascular disease and had food frequency questionnaires at baseline (2000-2002), and at least one measure of CAC during follow-up. We excluded those with implausible energy intake (<600 kcal/day or >6000 kcal/day) or daily physical activity (>24 hours). Two low-carbohydrate-diet (LCD) scores were generated: an overall LCD score was calculated based on total carbohydrate, fat, and protein, and a plant-based LCD score was calculated using intakes of unsaturated fat (excluding trans fat) and vegetable protein. CAC scores at exam 1 and at 2 and 3 (18 and 36 months later) were used in multivariable relative risk regression models to examine the association between LCD scores and CAC prevalence and incidence (binary), while robust regression was used to examine CAC progression (continuous). Analyses were adjusted for demographic, socioeconomic, lifestyle, and cardiovascular risk factors. Results: The mean age was 62 years, 48% of participants were male, and 40.8% were White. The mean (SD) levels of carbohydrate intake as a percentage of energy were 64.2 (5.2), 56.1 (4.9), 51.5 (3.7), 47.5 (4.0), and 42.1 (5.6) from the lowest to the highest quintiles of the overall LCD score. There were 2,652 (46.5%) participants who had positive CAC scores at baseline and 252 participants who had newly positive scores for CAC during follow-up. Among those with prevalent CAC at baseline, the median (IQR) of increases in CAC was 47 (132) over follow-ups. For incident CAC, relative risk estimates (95% CI) from Quintile 1 to 5 were 1, 0.73 (0.52, 1.02), 0.65 (0.45, 0.95), 0.90 (0.63, 1.28), 1.05 (0.77, 1.42) for overall LCD scores, and were 1, 1.14 (0.81, 1.61), 0.98 (0.71, 1.37), 1.08 (0.78, 1.49), 1.15 (0.82, 1.62) for plant-based LCD scores, respectively. No significant trend was observed for associations with incident CAC. There was no significant association between any LCD score and CAC prevalence or progression among those with positive CAC scores at baseline. Conclusions: A low-carbohydrate diet, including a plant-based low-carbohydrate diet, was not associated with prevalence, incidence, or progression of CAC among those with prevalent CAC at baseline.

Sport specific incidence and progression of coronary artery calcification among amateur athletes: a follow-up of the Measuring Athletes Risk of Cardiovascular events (MARC) study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V Aengevaeren ◽  
A Mosterd ◽  
T.L Braber ◽  
H.M Nathoe ◽  
T.M.H Eijsvogels ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Cardiovascular Events ◽  
Coronary Atherosclerosis ◽  
Sport Performance ◽  
Funding Source ◽  
Cross Sectional ◽  
Amateur Athletes ◽  
Entire Cohort

Abstract Background Emerging evidence indicates increased coronary atherosclerosis in amateur athletes. However, previous studies were limited by its cross-sectional design and limited sample size, preventing the exploration of sport specific associations with coronary atherosclerosis. Purpose We aimed to compare the incidence and progression of coronary artery calcification (CAC) between runners, cyclists and other types of athletes using a prospective cohort study with repetitive measurements. Methods Asymptomatic middle-aged men, who previously underwent a sports medical evaluation without abnormalities, were recruited in the Measuring Athlete's Risk of Cardiovascular events (MARC) study (n=318) and were asked to participate in this follow-up study. CT imaging was performed to assess CAC scores. Data was collected between 2012–2014 (i.e. baseline) and 2019–2020 (i.e. follow-up). We categorized participants as runners, cyclists or “other” sports (e.g. water polo, tennis, hockey, etc.) based on their dominant sport performance at baseline. Results We included 260 men in this interim analysis, with an average follow-up time of 6.3±0.5 years. Age (61.4±6.4 years), systolic blood pressure (143±20 mmHg), BMI (25.2±2.8 kg/m2), LDL-cholesterol (3.2±0.9 mmol/L), smoking (0.3 [0–8] pack years) and family history of coronary heart disease (28%) did not differ between runners (n=64), cyclists (n=75) and other athletes (n=121, all p&gt;0.05). CAC was present in 137 (53%) men at baseline, which increased to 181 (70%) at follow-up. CAC scores increased from 1 [0–33] to 33 [0–129]. Cyclists had a lower CAC prevalence and CAC scores compared to individuals performing other sports at follow-up (Figure 1). Of those without CAC at baseline (n=123, 47%), cyclists less often developed CAC during follow-up compared with runners (adjusted OR=0.36 [0.17–0.79], p=0.01). In the entire cohort, CAC progression (ln delta CAC+1) was less prominent in cyclists than runners (adjusted B=−0.75 [−1.39 to −0.11], p=0.02), whereas progression of CAC in participants performing other sports did not differ from the runners. In participants with CAC at baseline, cyclists also had less CAC progression than runners (B=−0.49 [−0.95 to −0.02], p=0.04). Conclusion Cyclists have a lower incidence and less progression of CAC during 6 years of follow-up compared with runners and individuals performing other sports. Figure 1. Sport specific CAC prevalence and scores Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Hartstichting

scholarly journals Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response

2021 ◽  
Vol 22 (7) ◽  
pp. 3728
Author(s):  
Masahiro Hatasa ◽  
Sumiko Yoshida ◽  
Hirokazu Takahashi ◽  
Kenichi Tanaka ◽  
Yoshihito Kubotsu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Basic Research ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Periodontopathic Bacteria ◽  
In Vivo Animal Model ◽  
The Relationship

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship between nonalcoholic fatty liver disease (NAFLD) and periodontal disease has not yet been clarified. Thus, the purpose of this review was to reveal the relationship between NAFLD and periodontal disease based on epidemiological studies, basic research, and immunology. Many cross-sectional and prospective epidemiological studies have indicated that periodontal disease is a risk factor for NAFLD. An in vivo animal model revealed that infection with periodontopathic bacteria accelerates the progression of NAFLD accompanied by enhanced steatosis. Moreover, the detection of periodontopathic bacteria in the liver may demonstrate that the bacteria have a direct impact on NAFLD. Furthermore, Porphyromonas gingivalis lipopolysaccharide induces inflammation and accumulation of intracellular lipids in hepatocytes. Th17 may be a key molecule for explaining the relationship between periodontal disease and NAFLD. In this review, we attempted to establish that oral health is essential for systemic health, especially in patients with NAFLD.

scholarly journals The Relationship Between Reported Pain and Depressive Symptoms Among Adolescents

2018 ◽  
Vol 36 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Sofie Borgman ◽  
Ida Ericsson ◽  
Eva K. Clausson ◽  
Pernilla Garmy
Keyword(s):  
Abdominal Pain ◽  
Back Pain ◽  
Depressive Symptoms ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Scale Scores ◽  
Prevalence Of Pain ◽  
The Relationship

Pain and depressive symptoms are common reasons for adolescents to contact the school nurse. The aim was to describe the prevalence of pain (headache, abdominal pain, and back pain) and depressive symptoms among adolescents and to examine whether there is an association between pain and depressive symptoms. This cross-sectional survey included students ( N = 639) in Sweden (median age: 16 years). Over half of the female participants (56%) and one third of male participants (33%) had weekly headaches, abdominal pain, or back pain. Almost every second girl (48%) and one in four boys (25%) had depressive symptoms (as measured by the Center for Epidemiological Studies Depression Scale, scores ≥ 16). There was a significant association between having pain (headache, abdominal pain, or back pain) and having depressive symptoms. It is of great importance for school nurses to adequately identify and treat the cause of pain and other factors contributing to depression.

The relationship between disability and suicide: prospective evidence from the Ten to Men cohort

2018 ◽  
Vol 41 (4) ◽  
pp. 707-713 ◽  
Author(s):  
Allison Milner ◽  
Anne-Marie Bollier ◽  
Eric Emerson ◽  
Anne Kavanagh
Keyword(s):  
Mental Health ◽  
Logistic Regression ◽  
Regression Model ◽  
Logistic Regression Model ◽  
People With Disabilities ◽  
Cross Sectional ◽  
Longitudinal Cohort ◽  
The Past ◽  
The Relationship

Abstract Background People with disabilities often face a range of social and economic adversities. Evidence suggests that these disadvantages result in poorer mental health. Some research also indicates that people with disabilities are more likely experience thoughts about suicide than people without disability, although most of this research is based on small cross-sectional samples. Methods We explored the relationship between self-reported disability (measured at baseline) and likelihood of reporting thoughts of suicide (measured at follow up) using a large longitudinal cohort of Australian males. A logistic regression model was conducted with thoughts of suicide within the past 12 months (yes or no) as the outcome and disability as the exposure. The models adjusted for relevant confounders, including mental health using the SF-12 MCS, and excluded males who reported thoughts of suicide at baseline. Results After adjustment, there was a 1.48 (95% CI: 0.98–2.23, P = 0.063) increase in the odds of thoughts of suicide among men who also reported a disability. The size of association was similar to that of being unemployed. Conclusions Males reporting disability may also suffer from thoughts of suicide. We speculate that discrimination may be one explanation for the observed association. More research on this topic is needed.

scholarly journals A Study on the Relationship between Iron Reserves and the Intensity of Coronary Artery Stenosisin Angiography Candidates

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Khalil Mahmoodi
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Transferrin Saturation ◽  
Intervention Group ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Coronary Artery Stenos ◽  
The Impact ◽  
The Relationship

Various risk factors including blood iron may create coronary artery diseases and lead to myocardial infarction. There are controversies with regard to the impact of blood iron on myocardial infarction. Therefore, the aim of this paper was to investigate the relationship between iron reserves and the intensity of coronary artery stenos is among angiographic candidates in Zanjan, Iran. This was a cross sectional study. Samples were consisted of patients who were hospitalized for diagnostic coronary angiography in hospitals in an urban area of Iran. A convenient sampling method was used to recruit samples via interviews and laboratory examinations for FBS, iron, TIBC, ferritin, creatinine serum, CBC, cholesterol, HDL and LDL. The samples were divided into control and intervention groups. After coronary angiography, the intervention group was evaluated by four different methods including the extent score, stenos is score, vessel score and Duke CAN Index. The samples were consisted of 89 men (60.1%) and 59 women (39.9%). The levels of ferritin (p=0.003) and iron (p=0.002), and transferrin saturation percent (p=0.002) showed significant differences between males and females (p=0.004)

scholarly journals Correlation between Serum Calcium and Phosphate with Coronary Artery Calcium Scores on Cardiac MSCT Examination

2019 ◽  
Vol 15 (2) ◽  
pp. 120
Author(s):  
Rosita Kai ◽  
Bachtiar Murtala ◽  
Andi Alfian Zainuddin ◽  
Muzakkir Amin ◽  
Muhammad Ilyas
Keyword(s):  
Coronary Artery ◽  
Kidney Function ◽  
Serum Calcium ◽  
Coronary Artery Calcium ◽  
Cross Sectional Study ◽  
Serum Phosphate ◽  
Normal Kidney ◽  
Cross Sectional ◽  
Normal Kidney Function ◽  
The Relationship

Increased serum calcium and phosphate associated with cardiovascular disease in patients with chronic kidney disease, but research on the relationship between coronary artery calcium scores with serum calcium and phosphate in individuals with normal kidney function is lacking. We explore the relationship of serum calcium and phosphate levels with coronary atherosclerosis as assessed by cardiac Multislice Computed Tomography (MSCT) in individuals with normal kidney function. This study aims to assess the correlation of calcium level scores on cardiac MSCT examination with serum calcium and phosphate levels, and assess the association with risk factors for coronary heart disease. This study was a cross-sectional study of 40 subjects who underwent cardiac MSCT examination with normal kidney function, at RSUP Dr. Wahidin Sudirohusodo Makassar during the March-July 2019 period. The results showed an correlation between coronary artery calcium scores with calcium and serum phosphate (serum calcium r = 0.67, serum phosphate r = 0.53, p <0.05).

Abstract 3573: Higher Soluble Thrombomodulin is Associated with Risk of Coronary Artery Calcification: Longitudinal Analysis of the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Dhananjay Vaidya ◽  
Mary Cushman ◽  
Paul Holvoet ◽  
Joseph F Polak ◽  
Robyn L McClelland ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Random Sample ◽  
Robust Regression ◽  
Subclinical Atherosclerosis ◽  
Hormone Replacement ◽  
Lipid Lowering ◽  
Significant Heterogeneity ◽  
Soluble Thrombomodulin ◽  
Increased Risk

Background. A prior cross sectional study reported that higher soluble thrombomodulin (sTM) was associated with subclinical atherosclerosis only in the presence of higher soluble intercellular adhesion molecule-1, sICAM-1. We evaluated this interaction longitudinally with regard to coronary artery calcium (CAC) in the MESA cohort. Methods: MESA is a multi-center longitudinal study with baseline measurements of endothelial biomarkers in a random sample (n=1000) of the baseline cohort. In the random sample, 374 men and 496 women had CT measurement for CAC (Agatston score) at baseline and a median follow-up of 2.9 years. Among those with no baseline CAC (n=490), we estimated the relative risk of detectable CAC at follow-up using general linear models with Gaussian error and robust standard errors. Among those with detectable baseline CAC (n=380), change in CAC on follow-up was modeled using robust regression that down-weights outliers. Models with log(sTM) as predictor were adjusted for follow-up time, sex, ethnicity and baseline age, BMI, smoking, diabetes, systolic blood pressure, total cholesterol, use of BP or lipid-lowering medications and for hormone replacement (HRT) in women in separate models. Interactions between sTM and sICAM-1, sex and ethnicity was assessed. Results: The median [interquartile range] of sTM was 38 [28 to 47] ng/mL for persons with incident detectable CAC, and 30 [23 to 41] ng/mL in those without (rank sum p <0.001). On adjustment, a 2-fold higher sTM at baseline (e.g., from 23 to 46 ng/mL) was associated with a 1.36-fold increased risk of detectable CAC on follow-up (95% CI: 1.03, 1.79, p=0.031). Among those with baseline detectable CAC, the rank correlation between sTM level and change in CAC score was 0.10 (p = 0.042), however, on adjustment, a 2-fold higher sTM was associated with a non-significant 0.86 Agatston units greater CAC change (p = 0.84). Higher sICAM-1 did not modify the association of sTM with CAC incidence (interaction p = 0.15) or change (interaction p = 0.26). There was no significant heterogeneity by sex, or ethnicity, or confounding by HRT in women. Conclusion: High circulating levels of sTM were independently associated with incident calcification of the coronary arteries.

Abstract 5108: Microalbuminuria is Associated with Progression of Coronary Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Andrew P DeFilippis ◽  
Holly J Kramer ◽  
Ronit Katz ◽  
Nathan Wong ◽  
Alain Bertoni ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Albumin Creatinine Ratio ◽  
Ethnic Study ◽  
Median Increase ◽  
Increased Risk ◽  
History Of ◽  
Relationship Of ◽  
The Relationship ◽  
Progression Of Atherosclerosis

Background: Microalbuminuria (MA) is associated with an increased risk of cardiovascular disease (CVD) but the mechanism by which microalbuminuria imparts this increased risk is not known. In this study we assessed the relationship between MA and the development and progression of atherosclerosis by measuring the incidence of new CAC and the progression of existing CAC in individuals free of clinical CVD. Methods : The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of 6,814 participants free of clinical CVD at entry who underwent assessment of coronary artery calcification (CAC) by computerized tomography at baseline. Overall, 6,775 individuals had data available on urinary albumin creatinine ratio (UACR); 1,109 individuals were excluded for missing data or macroalbuminuria (UACR≥300 mg/g). Incident CAC was defined as detectable CAC at follow-up among those with CAC=0 at baseline, and absolute CAC score change among those with CAC>0 at baseline. Relative risk (RR) regression adjusted for covariates; and multivariable adjusted median regression was employed to assess the independent relationship of MA with CAC incidence and progression. Results : Of the 5,666 subjects (mean age 62±10 years, 48% males), baseline MA was seen in 424 (7%) participants, who were more likely to have CAC compared to those with normal UACR (62% vs. 48%, p<0.0001). During a mean follow-up of 2.4±0.8 years, those with MA were more likely to develop CAC (28% vs. 15%, p<0.0001) and they had a higher absolute median increase in CAC (47 vs. 29 Agatston Units, p<0.0001). After adjustment for age, gender, ethnicity, site, follow-up duration, diabetes, hypertension, smoking, family history of heart attack, total cholesterol, lipid lowering medications and body mass index; MA was associated with incident CAC (RR 1.65; 95%CI 1.41–2.48) among those with CAC=0 at baseline. Among those with CAC>0 at baseline, MA was associated with a median increase in CAC of 7.93 (95%CI 0.38 –15.47) Agatston Units in multivariable adjusted analyses (variables noted above). Conclusion : MA is independently associated with development of incident CAC and progression of CAC in an asymptomatic multi-ethnic population, and may in part explain its associated increased risk of CVD.

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