scholarly journals Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response

2021 ◽  
Vol 22 (7) ◽  
pp. 3728
Author(s):  
Masahiro Hatasa ◽  
Sumiko Yoshida ◽  
Hirokazu Takahashi ◽  
Kenichi Tanaka ◽  
Yoshihito Kubotsu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Basic Research ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Periodontopathic Bacteria ◽  
In Vivo Animal Model ◽  
The Relationship

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship between nonalcoholic fatty liver disease (NAFLD) and periodontal disease has not yet been clarified. Thus, the purpose of this review was to reveal the relationship between NAFLD and periodontal disease based on epidemiological studies, basic research, and immunology. Many cross-sectional and prospective epidemiological studies have indicated that periodontal disease is a risk factor for NAFLD. An in vivo animal model revealed that infection with periodontopathic bacteria accelerates the progression of NAFLD accompanied by enhanced steatosis. Moreover, the detection of periodontopathic bacteria in the liver may demonstrate that the bacteria have a direct impact on NAFLD. Furthermore, Porphyromonas gingivalis lipopolysaccharide induces inflammation and accumulation of intracellular lipids in hepatocytes. Th17 may be a key molecule for explaining the relationship between periodontal disease and NAFLD. In this review, we attempted to establish that oral health is essential for systemic health, especially in patients with NAFLD.

scholarly journals The Relationship Between Reported Pain and Depressive Symptoms Among Adolescents

2018 ◽  
Vol 36 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Sofie Borgman ◽  
Ida Ericsson ◽  
Eva K. Clausson ◽  
Pernilla Garmy
Keyword(s):  
Abdominal Pain ◽  
Back Pain ◽  
Depressive Symptoms ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Scale Scores ◽  
Prevalence Of Pain ◽  
The Relationship

Pain and depressive symptoms are common reasons for adolescents to contact the school nurse. The aim was to describe the prevalence of pain (headache, abdominal pain, and back pain) and depressive symptoms among adolescents and to examine whether there is an association between pain and depressive symptoms. This cross-sectional survey included students ( N = 639) in Sweden (median age: 16 years). Over half of the female participants (56%) and one third of male participants (33%) had weekly headaches, abdominal pain, or back pain. Almost every second girl (48%) and one in four boys (25%) had depressive symptoms (as measured by the Center for Epidemiological Studies Depression Scale, scores ≥ 16). There was a significant association between having pain (headache, abdominal pain, or back pain) and having depressive symptoms. It is of great importance for school nurses to adequately identify and treat the cause of pain and other factors contributing to depression.

scholarly journals Influence of Psychological Stress on Periodontal Diseases

2020 ◽  
Vol 2 (1) ◽  
pp. 1-5
Author(s):  
Larissa Marques Storto Soares ◽  
Ana Emilia Farias Pontes ◽  
Fernanda de Oliveira Bello Corrêa ◽  
Cleverton Corrêa Rabelo
Keyword(s):  
Risk Factor ◽  
Periodontal Disease ◽  
Psychological Stress ◽  
Psychological Factors ◽  
Positive Relationship ◽  
Periodontal Diseases ◽  
Psychosocial Factor ◽  
Research Needs ◽  
The Relationship

Introduction: The association between periodontal disease and stress has been questioned for a almost a century, however, it still represents an unexplored field of research with several orphaned questions of conclusive answers. Objective: To evaluate the relationship between periodontal disease and stress. Methodology: Searches were performed with descriptors related to periodontal diseases and psychological factors in the following databases: Pubmed, Embase, Lilacs. Were identified and included studies that deal with the relationship between stress and periodontal disease and /or that emphasize the role of this psychosocial factor in the progression of periodontal disease. Conclusion: Most studies have shown a positive relationship between periodontal disease and stress, however, further research needs to be developed to confirm stress as a risk factor for periodontal disease

scholarly journals Low-carbohydrate diets and prevalence, incidence and progression of coronary artery calcium in the Multi-Ethnic Study of Atherosclerosis (MESA)

2019 ◽  
Vol 121 (4) ◽  
pp. 461-468 ◽  
Author(s):  
Tian Hu ◽  
David R. Jacobs ◽  
Lydia A. Bazzano ◽  
Alain G. Bertoni ◽  
Lyn M. Steffen
Keyword(s):  
Coronary Artery ◽  
Robust Regression ◽  
Epidemiological Studies ◽  
Total Carbohydrate ◽  
Baseline Measure ◽  
Cross Sectional ◽  
Ethnic Study ◽  
Low Carbohydrate ◽  
The Relationship

AbstractThe evidence linking low-carbohydrate diets (LCD) to CVD is controversial, and results from epidemiological studies are inconsistent. We aimed to assess the relationship between LCD patterns and coronary artery Ca (CAC) scores from computed tomography in the Multi-Ethnic Study of Atherosclerosis cohort. Our sample included 5614 men and women free of clinical CVD at baseline (2000–2002), who had a FFQ, a baseline measure and ≥1 measure of CAC during follow-up. We excluded those with implausible energy intake or daily physical activity. The overall, animal-based and plant-based LCD scores were calculated based on intakes of macronutrients. Relative risk regression and robust regression models were used to examine the cross-sectional and longitudinal relationship between LCD score quintile and CAC outcomes, after adjustment for multiple cardiovascular risk factors. The mean age of participants was 63 years. The median intakes of total carbohydrate, fat and protein were 53·7, 30·5 and 15·6 % energy/d, respectively. Among 2892 participants with zero CAC scores at baseline, 264 developed positive scores during 2·4-year follow-up (11–59 months). Among those with positive scores at baseline, the median increase in CAC was 47 units over the course of follow-up. The overall, the animal-based and the plant-based LCD scores were not associated with CAC prevalence, incidence and progression. In conclusion, diets low in carbohydrate and high in fat and/or protein, regardless of the sources of protein and fat, were not associated with higher levels of CAC, a validated predictor of cardiovascular events, in this large multi-ethnic cohort.

scholarly journals Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 953 ◽  
Author(s):  
Eric Francelino Andrade ◽  
Débora Ribeiro Orlando ◽  
Amanda Melo Sant’Anna Araújo ◽  
James Newton Bizetto Meira de Andrade ◽  
Diana Vilela Azzi ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Alveolar Bone ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Preclinical Studies ◽  
Research Reporting ◽  
Resveratrol Treatment ◽  
Manual Search ◽  
Inflammatory Conditions

Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.

scholarly journals Does systemic oral administration of curcumin effectively reduce alveolar bone loss associated with periodontal disease? A systematic review and meta-analysis of preclinical in vivo studies

2020 ◽  
Vol 75 ◽  
pp. 104226
Author(s):  
Juliana Simeão Borges ◽  
Luiz Renato Paranhos ◽  
Gabriela Leite de Souza ◽  
Felipe de Souza Matos ◽  
Ítalo de Macedo Bernardino ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Oral Administration ◽  
Alveolar Bone ◽  
Meta Analysis ◽  
Alveolar Bone Loss ◽  
In Vivo Studies

scholarly journals How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies

Medicina ◽  
2020 ◽  
Vol 56 (8) ◽  
pp. 374 ◽  
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta
Keyword(s):  
Dna Methylation ◽  
Epidemiological Studies ◽  
Dietary Factors ◽  
Negative Effects ◽  
Cross Sectional ◽  
The Past ◽  
Large Size ◽  
Future Challenges ◽  
Public Health Strategies ◽  
The Relationship

Over the past decades, DNA methylation has been proposed as a molecular mechanism underlying the positive or negative effects of diet on human health. Despite the number of studies on this topic is rapidly increasing, the relationship between dietary factors, changes in DNA methylation and health outcomes remains unclear. In this review, we summarize the literature from observational studies (cross-sectional, retrospective, or prospective) which examined the association of dietary factors (nutrients, foods, and dietary patterns) with DNA methylation markers among diseased or healthy people during the lifetime. Next, we discuss the methodological pitfalls by examining strengths and limitations of published studies. Finally, we close with a discussion on future challenges of this field of research, raising the need for large-size prospective studies evaluating the association between diet and DNA methylation in health and diseases for appropriate public health strategies.

Endometrial cancer and physical activity

2018 ◽  
Vol 8 (1) ◽  
pp. 202-206
Author(s):  
R. Terlikowski ◽  
Z. Łada ◽  
MA. Strzyż-Skalij ◽  
K. Kryński ◽  
M. Osmólska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Endometrial Cancer ◽  
Risk Factor ◽  
Epidemiological Studies ◽  
Objective Measures ◽  
Practical Reasons ◽  
Metabolic Equivalent ◽  
Metabolic Equivalent Of Task ◽  
The Relationship ◽  
Reduced Risk

Physical activity (PA) is an important modifiable risk factor for endometrial cancer (EC). PA has been studied using diverse measures including metabolic equivalent of task MET, duration, frequency and subjective levels, but for practical reasons most of epidemiological studies use questionnaires rather than objective measures to document PA. Moderate-intense daily PA has a protective effect and have a 20-40% reduced risk of EC. In this rewiev complex and variable behaviour, and the ability of epidemiological studies to determine the relationship between PA and EC has been discussed.

ASBMT Risk Group and CD 34+ Dose Predicted for the Development of aGVHD in Allogeneic MRD Transplants When the Donors Who Received a Combined Mobilization and In Vivo TCD Regimen Using rhg-CFS and Dexamethasone.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 5006-5006
Author(s):  
Khaleel K. Ashraf ◽  
Arabella B. Tilden ◽  
Yufeng Li ◽  
Sameer Gupta ◽  
Lawrence S. Lamb ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Risk Factor ◽  
Median Survival ◽  
Chronic Gvhd ◽  
Multivariable Analysis ◽  
Multivariable Logistic Regression Analysis ◽  
Factors Affecting ◽  
Cd 34 ◽  
The Relationship

Abstract We looked at factors affecting the development of acute and chronic GVHD in a cohort of 118 patients who underwent allogeneic matched sibling transplantation between 09/1998 to 05/2006 at the UAB BMT program. Donors were mobilized with rhg-CSF (10–16mcg/kg/day x4) and received dexamethasone 10mg/m2/day x3 days to effect in vivo T cell depletion (TCD). Total CD3 and CD34 cell dose were divided in to 4 quartiles (See table below). We then analyzed the influence of CD3+ and CD34+ dose quartiles on aGVHD, cGVHD, engraftment, TRM and relapse. (see table) Acute GVHD: Univariate Logistic regression indicated that the development of aGVHD is negatively associated with quartiles (q25–q50) interval of CD3 dose (p=0.0418). However this relationship was not independent of risk factor and CD34 dose. After using Multivariable Logistic regression analysis with adjustments for age, race and sex, we found that ASBMT risk factor and CD34 quartiles dose are strong predictors of aGVHD: patients who had high risk are about three times more likely to have aGVHD (OR=2.829, 95% CI 1.142–7.020, p=0.0250). The higher the CD34 dose also predisposed to higher incidence of aGVHD (p=0.0432). Median Survival: Patients who received the CD3 (P=0.00141) and CD34 (P=0.0270) in the q25–q50 quartile did better with improved median survival. Relapse and CD 3 quartiles: Using the - 2 log (LR) test shows the relapse free interval was longer if the CD3 dose is between q25 and q50 (p=0.0058); there was no relation between CD34 and relapse. TRM: Not associated with CD3 or CD 34 dose. WBC engraftment: Multivariable analysis indicated that the relationship is mainly an age effect. After adjusted for risk factor, GVHD status, CD3 or CD34 dose, the engraftment day is still significantly related to age at BMT (p=0.0252). No associations are observed for the relationship between engraftment day and GVHD risk. cGVHD: Neither CD34 dose (p=0.5339) nor CD3 (p=0.4209) dose were statistically associated with incidence and severity of cGVHD. To summarize, higher CD34 dose and higher risk ASBMT category predicted for higher incidence of aGVHD; neither CD3 nor CD 34 dose predicted for the development of cGVHD. Age was the single most important predictor of WBC engraftment. CD3+ and CD34 Quartiles Quartile <25 25–50 50–75 >75 CD3 X10E8 <2.5 2.53–3.60 3.60–5.30 >5.30 CD34 X10E6 <4.92 4.92–7.79 7.79–11.2 >11.2

scholarly journals GAMBARAN DISFUNGSI EREKSI DAN HUBUNGAN DIABETES MELITUS DAN HIPERTENSI TERHADAP KEJADIAN DISFUNGSI EREKSI PADA PENDERITA STROKE DI POLI NEUROLOGI RSUP PROF. DR. R. D. KANDOU MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Richie Irvanto Ciandra ◽  
Corry N. Mahama ◽  
Melke J. Tumboimbela
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Erectile Dysfunction ◽  
Erectile Function ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Risk Of Disease ◽  
The Relationship ◽  
Diabetes Melitus

ABSTRACT: Stroke is a big health problem in all industrial nations. In Indonesia, the prevalence of stroke keeps on increasing with each passing year. In addition to physical complaints suffered, sexual function may affect the patient’s. Erectile dysfunction is a problem that often arises in stroke patients. Purpose: This research is aimed in understanding describe of erectile dysfunction and the relationship between the risk factor namely diabetes mellitus and hypertension among stroke patients. Methods: The research method used is analytic descriptive with cross sectional approach. The study subjects were 40 men stroke patients, recruited by consecutive sampling in Polyclinic Neurology RSUP Prof. Dr. R. D. Kandou Manado during the period of November to December 2013. The measurement of erectile dysfunction used International Index of Erectile function/IIEF-5. Conclusion: Stroke patients who experience erectile dysfunction by 85%, with the highest amount on mild erectile dysfunction and mild to moderate erectile dysfunction at  35% dan 32,5%. Age most experienced erectile dysfunction are in the age group 35-44 years and >75 years. Low levels of education may suffer from erectile dysfunction is higher than the high education level. And the insiden of erectile dysfunction among stroke patients having risk factor of diabetes mellitus were higher than haven’t (OR=2,391). While hypertension risk factors correlated with a reduced risk of disease (OR=0,771). Keywords: Stroke, erectile dysfunction, diabetes mellitus, hypertension   ABSTRAK: Stroke merupakan masalah kesehatan yang besar di negara-negara industri, prevalensi stroke di Indonesia terus meningkat dari tahun ke tahun. Selain keluhan fisik yang diderita, keadaan fungsi seksual dapat mempengaruhi penderita. Disfungsi ereksi merupakan masalah yang sering timbul pada pasien stroke. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran disfungsi ereksi dan hubungan diabetes melitus dan hipertensi terhadap kejadian disfungsi ereksi pada pasien stroke. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 40 pasien stroke laki-laki yang diambil secara consecutive sampling di Poliklinik Neurologi RSUP Prof. Dr. R. D. Kandou Manado selama bulan November - Desember 2013. Pengukuran disfungsi ereksi menggunakan International Index of Erectile Function/IIEF-5. Simpulan: Pasien stroke yang mengalami disfungsi ereksi sebesar 85% dengan jumlah terbanyak pada disfungsi ereksi ringan dan disfungsi ereksi ringan sampai sedang sebesar 35% dan 32,5%. Umur terbanyak mengalami disfungsi ereksi terletak pada kelompok umur 35-44 tahun dan >75 tahun. Tingkat pendidikan rendah dapat mengalami disfungsi ereksi lebih tinggi daripada yang tingkat pendidikannya tinggi. Dan insiden disfungsi ereksi diantara pasien stroke yang mempunyai faktor resiko diabetes melitus adalah lebih tinggi daripada yang tidak mempunyai faktor resiko tersebut (OR=2,391). Sedangkan faktor resiko hipertensi berkorelasi dengan berkurangnya resiko penyakit (OR=0,771). Kata Kunci: Stroke, disfungsi ereksi, diabetes melitus, hipertensi

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