scholarly journals Impetigo Contagiosa. The Association of Certain Types of Staphylococcus Aureus and of Streptococcus Pyogenes with Superficial Skin Infections

1955 ◽  
Vol 53 (4) ◽  
pp. 458-473 ◽  
Author(s):  
M. T. Parker ◽  
A. J. H. Tomlinson ◽  
R. E. O. Williams
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pyogenes ◽  
Skin Infections ◽  
Hospital Infections ◽  
Zone Of Inhibition ◽  
Impetigo Contagiosa ◽  
Solid Media ◽  
Superficial Skin ◽  
Resistant Strains ◽  
Nose And Throat

SummaryIn an investigation of impetigo among troops, carried out in 1941, nearly half of the strains of Staphylococcus aureus isolated from the lesions had the ability to inhibit the growth of corynebacteria on solid media. A much smaller proportion of strains from other superficial lesions and from nose and throat swabs had this ability, and strains from deep suppurative lesions were uniformly negative.Three-quarters of Staph. aureus strains isolated from schoolchildren with impetigo in Lancashire in 1953 and early 1954 were of one variety, which could be denned by its susceptibility to typing phages (‘type 71’).Nearly 90 % of ‘type 71’ staphylococci, and very few others, produced a narrow, sharp zone of inhibition of Corynebacterium diphtheriae mitis on solid media.A small number of other staphylococci, mainly non-typable or unclassifiable strains, produced a wider, hazy zone of inhibition.The majority of the impetigo staphylococci were penicillin-resistant, and most of the resistant strains were members of ‘type 71’. However, ‘type 71’ gave rise to only a small proportion of the penicillin-resistant hospital infections occurring in the same district at the same time.Three-quarters of the Str. pyogenes strains from impetigo lesions belonged to one of two groups of closely related serological types, one of which was rarely encountered in other situations.

scholarly journals Clinical and Bacteriological Aspects of Impetigo Contagiosa

1955 ◽  
Vol 53 (4) ◽  
pp. 495-508 ◽  
Author(s):  
George I. Barrow
Keyword(s):  
Staphylococcus Aureus ◽  
Special Reference ◽  
Streptococcus Pyogenes ◽  
Phage Type ◽  
Nasal Carriage ◽  
Control Groups ◽  
Staph Aureus ◽  
Impetigo Contagiosa ◽  
Resistant Strains

Summary1. The results of an investigation into the clinical, epidemiological and bacteriological features of impetigo contagiosa, with special reference to the type identification of staphylococci and streptococci, are reported and discussed.2. Of 106 impetigo cases studied, Staphylococcus aureus was isolated alone from 86 lesions (81 %), Streptococcus pyogenes alone from 6 (5·6 %), and a mixed growth of Staph. aureus and haemolytic streptococci in 14 instances (13·2 %).3. Of the 100 strains of Staph. aureus isolated from impetigo lesions, 63 were identical in phage type (‘type 71’), and a further 17 were closely related (‘weak 71’).4. Only one representative of ‘type 71’, and 9 of ‘weak 71’, were obtained from 164 strains of Staph. aureus from 200 persons in three control groups.5. Of 90 strains of Staph. aureus from impetigo lesions, 64 (71 %) were resistant to penicillin. Of these penicillin-resistant strains, 54 (84 %) were of ‘type 71’, or close variants.6. Strep, pyogenes was probably causative in at least 6 of the 18 patients yielding this organism from lesions; it was presumed to be a secondary invader in the remainder.7. It is doubtful if nasal carriage is of importance in the epidemiology of impetigo.8. It is concluded that there is a specific ‘type’ of staphylococcus associated with this form of impetigo.

scholarly journals Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

2009 ◽  
Vol 53 (9) ◽  
pp. 4028-4031 ◽  
Author(s):  
Julian G. Hurdle ◽  
Raghunandan Yendapally ◽  
Dianqing Sun ◽  
Richard E. Lee
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Isolates ◽  
Topical Agent ◽  
Skin Infections ◽  
Drug Resistant ◽  
Topical Antibiotics ◽  
Superficial Skin ◽  
Staphylococcal Skin Infections

ABSTRACT The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.

Sensitivity to Antibacterials of Staphylococcus Aureus Isolated from Skin Infections: A Comparison of Two Hospitals

1997 ◽  
Vol 25 (1) ◽  
pp. 8-13 ◽  
Author(s):  
S Nishijima ◽  
S Namura ◽  
M Nakagawa ◽  
I Kurokawa ◽  
S Kawabata
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Use ◽  
Skin Infections ◽  
Resistant Strains

We compared the sensitivities to antibacterials of Staphylococcus aureus strains isolated from skin infections in two hospitals of different sizes. There were differences between the two hospitals in the proportions of the strains isolated that were resistant to certain drugs, and these differences may be related to the patterns of drug use at each hospital. The differences in the patterns of drug use at each hospital may be due to the types of infections encountered and/or the ages of the patients, both of which differed greatly. The proportions of resistant strains may also be related to differences in the proportions of in-patients.

scholarly journals Postantibiotic Suppression of Growth of Erythromycin A-Susceptible and -Resistant Gram-Positive Bacteria by the Ketolides Telithromycin (HMR 3647) and HMR 3004

2000 ◽  
Vol 44 (6) ◽  
pp. 1749-1753 ◽  
Author(s):  
Wendy J. Munckhof ◽  
Glenn Borlace ◽  
John D. Turnidge
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Streptococcus Pyogenes ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Resistant Strains ◽  
Erythromycin A

ABSTRACT We investigated the in vitro postantibiotic effects (PAEs) of the ketolides telithromycin (HMR 3647) and HMR 3004 and analyzed the results using the sigmoid E max model. Mean maximum telithromycin PAEs against erythromycin A-susceptible strains of Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae were 3.7, 8.9, and 9.7 h, respectively, while maximum PAEs for erythromycin A-resistant strains were much shorter. Mean maximum HMR 3004 PAEs were 3.2 to 4.4 h for all species.

scholarly journals Uçucu Yağların Staphylococcus aureus Üzerine Etkisi

2014 ◽  
Vol 2 (5) ◽  
pp. 228 ◽  
Author(s):  
Seda Ozdikmenli ◽  
Nukhet Nilüfer Zorba
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Products ◽  
Essential Oils ◽  
Current Knowledge ◽  
Hospital Infections ◽  
Antibiotic Resistant ◽  
The World ◽  
Food Applications ◽  
Resistant Strains

Diseases caused by Staphylococcus aureus are widespread through the world in spite of developing technology. S. aureus is an important pathogen causing food intoxications besides hospital infections by its antibiotic resistant strains. Nowadays, there has been worldwide increasing concern on usage of natural products to control microorganisms. One of these natural products is essential oils. They are produced from plants especially from spices and composed of many components and volatiles. This review summarizes informative literature on essential oils and their mode of antimicrobial action. In addition, current knowledge on in vitro researches on antibacterial activity of essential oils and food applications to control S. aureus has been discussed.

scholarly journals The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus

2019 ◽  
Vol 20 (19) ◽  
pp. 4761 ◽  
Author(s):  
Anna Golda ◽  
Paulina Kosikowska-Adamus ◽  
Aleksandra Kret ◽  
Olena Babyak ◽  
Kinga Wójcik ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Infectious Agent ◽  
Epidemiological Data ◽  
Human Keratinocytes ◽  
Multidrug Resistant ◽  
Skin Infections ◽  
Promising Alternative ◽  
Methicillin Resistant ◽  
Cytoprotective Activity ◽  
Superficial Skin

Staphylococcus aureus is a major infectious agent responsible for a plethora of superficial skin infections and systemic diseases, including endocarditis and septic arthritis. Recent epidemiological data revealed the emergence of resistance to commonly used antibiotics, including increased numbers of both hospital- and community-acquired methicillin-resistant S. aureus (MRSA). Due to their potent antimicrobial functions, low potential to develop resistance, and immunogenicity, antimicrobial peptides (AMPs) are a promising alternative treatment for multidrug-resistant strains. Here, we examined the activity of a lysine-rich derivative of amphibian temporin-1CEb (DK5) conjugated to peptides that exert pro-proliferative and/or cytoprotective activity. Analysis of a library of synthetic peptides to identify those with antibacterial potential revealed that the most potent agent against multidrug-resistant S. aureus was a conjugate of a temporin analogue with the synthetic Leu-enkephalin analogue dalargin (DAL). DAL-PEG-DK5 exerted direct bactericidal effects via bacterial membrane disruption, leading to eradication of both planktonic and biofilm-associated staphylococci. Finally, we showed that accumulation of the peptide in the cytoplasm of human keratinocytes led to a marked clearance of intracellular MRSA, resulting in cytoprotection against invading bacteria. Collectively, the data showed that DAL-PEG-DK5 might be a potent antimicrobial agent for treatment of staphylococcal skin infections.

scholarly journals In VitroAntibacterial Spectrum ofSodium Seleniteagainst Selected Human Pathogenic Bacterial Strains

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Firoz Alam ◽  
Mohammed M. Safhi ◽  
Sivakumar Sivagurunathan Moni ◽  
Aamena Jabeen
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Bacillus Subtilis ◽  
Streptococcus Pyogenes ◽  
Sodium Selenite ◽  
Antibacterial Properties ◽  
Human Pathogens ◽  
Bacterial Strains ◽  
Zone Of Inhibition ◽  
Klebsiella Planticola

The objective of this investigation was to predict the antibacterial properties ofsodium seleniteagainst selected human pathogens. A group of six human bacterial pathogens includingStaphylococcus aureus,Streptococcus pyogenes,Bacillus subtilis,Escherichia coli,Pseudomonas aeruginosa, andKlebsiella planticolawere utilized for screening. The spectrum of activity was qualified based on zone of inhibition. Our study demonstrated thatsodium seleniteexhibits a strong spectrum of activity againstBacillus subtilis,Staphylococcus aureus,Escherichia coli, andKlebsiella planticola.The spectrum of activity was compared with standard ciprofloxacin disc (5 μg/disc) and observed to have satisfactory effect.

Further Experience with Augmentin in the Treatment of Skin Infections

1982 ◽  
Vol 27 (1_suppl) ◽  
pp. S35-S38 ◽  
Author(s):  
G. Millard
Keyword(s):  
Staphylococcus Aureus ◽  
General Practice ◽  
Side Effects ◽  
Streptococcus Pyogenes ◽  
Toxin Production ◽  
Mixed Infections ◽  
Leg Ulcers ◽  
Skin Infections ◽  
Clostridium Difficile Toxin ◽  
Lactamase Inhibitor

Thirty-two patients with skin infections were treated with Augmentin, a combination of amoxycillin with the β-lactamase inhibitor clavulanic acid. These infections were primary skin sepsis (7), infected eczema (11), infected trauma (10) and leg ulcers (4). The majority of cases were caused by amoxycillin-resistant Staphylococcus aureus either alone or in combination with Streptococcus pyogenes. Thirty patients (94%) responded to treatment with only one withdrawal (for side effects). Side effects were limited to nausea (9%) diarrhoea (9%) and rash (3%). No patient with diarrhoea showed evidence of Clostridium difficile toxin production in the stools. Augmentin appears to be a safe, useful, effective antibiotic for the treatment of skin infections in general practice and in hospital. It may prove of particular value when mixed infections of penicillin-resistant staphylococci and Streptococcus pyogenes are present.

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