scholarly journals Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’

2009 ◽  
Vol 68 (2) ◽  
pp. 122-126 ◽  
Author(s):  
Conleth F. Feighery ◽  
Ross McManus
Keyword(s):  
Autoimmune Disease ◽  
Coeliac Disease ◽  
Genetic Markers ◽  
Pathogenic Mechanisms ◽  
The Past ◽  
Inflammatory Pathways ◽  
Insight Into ◽  
Made In

Over the past 20 years major advances have been made in the diagnosis and understanding of pathogenic mechanisms relating to coeliac disease. Recently-identified genetic markers support the immunological–inflammatory nature of the disease. It is hoped that these newly-identified genes will assist further dissection of the inflammatory pathways in coeliac disease and give insight into why certain individuals develop intolerance to dietary gluten.

Formation, translocation and resolution of Holliday junctions during homologous genetic recombination

1995 ◽  
Vol 347 (1319) ◽  
pp. 21-25 ◽  
Keyword(s):  
Molecular Mechanisms ◽  
Genetic Recombination ◽  
Holliday Junctions ◽  
The Novel ◽  
E Coli ◽  
The Past ◽  
Endonucleolytic Cleavage ◽  
Insight Into ◽  
Made In

Over the past three or four years, great strides have been made in our understanding of the proteins involved in recombination and the mechanisms by which recombinant molecules are formed. This review summarizes our current understanding of the process by focusing on recent studies of proteins involved in the later steps of recombination in bacteria. In particular, biochemical investigation of the in vitro properties of the E. coli RuvA, RuvB and RuvC proteins have provided our first insight into the novel molecular mechanisms by which Holliday junctions are moved along DNA and then resolved by endonucleolytic cleavage.

Post-1990 Documentary

2015 ◽  
Keyword(s):  
Film Industry ◽  
Political Systems ◽  
Traditional Media ◽  
The Past ◽  
Wide Range ◽  
Production Distribution ◽  
Global Understanding ◽  
Exhibition Strategies ◽  
Insight Into ◽  
Made In

This book presents in-depth case studies focusing on the major aspects of post-1990 documentary practices and styles. The book questions the meanings of ‘independence’ for documentaries made in the post-1990 context, a period of unrivalled disruption and creativity in the field. Written from a wide range of academic perspectives, the book sheds new light on historical, theoretical, and empirical issues pertaining to the independent documentary, in order to better comprehend the radical transformations of the form over the past twenty years. The book focuses on works and practitioners existing at the margins of the traditional media, the mainstream film industry, and the prevailing economic and socio-political systems. In doing so, it addresses an important gap in the global understanding of documentary practices and styles. The book provides critical and detailed insight into contemporary independent documentary makers and their varied works, practices and uses and offers a variety of perspectives and interpretations of under studied contemporary subject matters and styles, as well as production, distribution, and exhibition strategies.

An exon-centric perspective1Canadian Society of Molecular Biosciences (CSMB) Senior Investigator Award

2012 ◽  
Vol 90 (5) ◽  
pp. 603-612 ◽  
Author(s):  
Benjamin J. Blencowe
Keyword(s):  
Alternative Splicing ◽  
Computational Methods ◽  
Large Datasets ◽  
Regulatory Mechanisms ◽  
The Past ◽  
Human Genes ◽  
Insight Into ◽  
Remarkable Progress ◽  
Discrete Networks ◽  
Made In

During the past ten years, remarkable progress has been made in our understanding of the complexity and regulation of alternative splicing. The generation of large datasets of quantitative alternative splicing profiling information has revealed that transcripts from at least 95% of multi-exon human genes undergo alternative splicing, and that thousands of exons in mammalian transcriptomes are subject to striking regulatory patterns. Together with advanced computational methods, these datasets have enabled the inference of a predictive code for tissue-dependent alternative splicing. This code has further provided new insight into splicing regulatory mechanisms. Collectively, these approaches are revealing the existence of discrete networks of exons that are coordinately regulated in diverse biologically normal and disease contexts. A major challenge ahead is to systematically determine the functions of exons comprising these exon networks as well as the factors and mechanisms responsible for their regulation. This perspective provides an account of progress in these areas and also discusses future avenues of exon-centric exploration.

Increasingly Intelligent Micromachines

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Tian-Yun Huang ◽  
Hongri Gu ◽  
Bradley J. Nelson
Keyword(s):  
State Of The Art ◽  
Autonomous Systems ◽  
Annual Review ◽  
Publication Date ◽  
Significant Progress ◽  
The Past ◽  
Water Cleaning ◽  
Information Media ◽  
Insight Into ◽  
Made In

Intelligent micromachines, with dimensions ranging from a few millimeters down to hundreds of nanometers, are miniature systems capable of performing specific tasks autonomously at small scales. Enhancing the intelligence of micromachines to tackle the uncertainty and variability in complex microenvironments has applications in minimally invasive medicine, bioengineering, water cleaning, analytical chemistry, and more. Over the past decade, significant progress has been made in the construction of intelligent micromachines, evolving from simple micromachines to soft, compound, reconfigurable, encodable, multifunctional, and integrated micromachines, as well as from individual to multiagent, multiscale, hierarchical, self-organizing, and swarm micromachines. The field leverages two important trends in robotics research—the miniaturization and intelligentization of machines—but a compelling combination of these two features has yet to be realized. The core technologies required to make such tiny machines intelligent include information media, transduction, processing, exchange, and energy supply, but embedding all of these functions into a system at the micro- or nanoscale is challenging. This article offers a comprehensive introduction to the state-of-the-art technologies used to create intelligence for micromachines and provides insight into the construction of next-generation intelligent micromachines that can adapt to diverse scenarios for use in emerging fields. Expected final online publication date for the Annual Review of Control, Robotics, and Autonomous Systems, Volume 5 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Implementasi Aplikasi Mobile Peta NKRI (Negara Kesatuan Republik Indonesia) Berbasis Android Menggunakan Metode Prototype

2021 ◽  
Vol 2 (4) ◽  
pp. 288-292
Author(s):  
Adika May Sari ◽  
Desri Yani ◽  
Desy Suryani
Keyword(s):  
Mobile Applications ◽  
Mobile Application ◽  
Ordinary People ◽  
School Students ◽  
Interactive Games ◽  
The Past ◽  
Indonesian Archipelago ◽  
The World ◽  
Insight Into ◽  
Made In

Android technology is developing very rapidly, it is proven that everything can be done easily. Indonesia is the largest archipelagic country in the world. The alternative name for Indonesia is called Nusantara. With its many islands, Indonesia has 34 provinces. Therefore, the author makes an android-based application program about the map of the State of Indonesia. Where the method used is the prototype method. With Android studio programming language. This mobile application makes it easy for users to view a map of the Indonesian archipelago which consists of 34 provinces. This application is intended for school students, but ordinary people can also use it. In the past we could only see maps of the islands and provinces using books. With the development of mobile applications, an Android-based application for the NKRI map was made. In this application, users can view a map of Indonesia, and can use other features such as interactive games, questions about the map of Indonesia to add insight into the map of Indonesia

The penitential motif in Cynewulf's Fates of the Apostles and in his epilogues

1977 ◽  
Vol 6 ◽  
pp. 105-119 ◽  
Author(s):  
Robert C. Rice
Keyword(s):  
The Past ◽  
Basic Theme ◽  
Vercelli Book ◽  
Insight Into ◽  
Scholarly Attention ◽  
Made In

In the past few years a real advance has been made in the appreciation of Cynewulf's shortest signed poem, the Fates of the Apostles, extant in the Vercelli Book. For most of the century and more since this poem was first published critical opinion has been almost unanimously unfavourable about its literary merit and until recently scholarly attention has been limited mainly to textual and source investigations. Today, however, illuminating studies, such as those by James L. Boren and Constance B. Hieatt, have made us aware of the poem's subtleties of image and structure. In particular, now that we have begun to apprehend the depth of the poem's meaning, I believe that we can use this understanding to gain further insight into the thematic concerns of Cynewulf's other three signed poems. This can be achieved, I suggest, through recognizing how the basic theme of the Fates reappears as a motif linking Cynewulf's epilogues.

Past, Present, and Future of Measles, Mumps, and Rubella Virus Vaccines

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 149-153
Author(s):  
Maurice R. Hilleman
Keyword(s):  
Measles Virus ◽  
Lessons Learned ◽  
Measles Vaccine ◽  
Rubella Vaccine ◽  
The Past ◽  
Viral Vaccine ◽  
The World ◽  
Insight Into ◽  
Festive Occasion ◽  
Made In

It is a real pleasure for me to speak on this memorable occasion. Dr Saul Krugman is now entering his ninth decade while enjoying the world status of senior statesman! Saul and I have collaborated often during the last three of these decades. In the studies of new vaccines in our laboratories, our first clinical probes were made in cooperative studies with the late Dr Joseph Stokes and his colleagues and successors at the Children's Hospital of Philadelphia. Following such initial phase, Dr Krugman received the vaccines for expanded clinical studies. Hence, he has been an indispensible clinical partner in most of the new viral vaccine developments in our laboratories during the past 30 years. In discussions with Dr Wade Parks, I was advised that I might speak on any subject I choose. I chose to talk about the measles-mumps-rubella vaccine (M-M-R), a topic that has occupied Dr Krugman for nearly three decades and that is receiving renewed attention in the worlds of pediatrics and public health at the present time. This being a festive occasion, I feel I should keep it light. Therefore, I want to emphasize the science, but also to recount some of the less well-known "behind-the-scenes" activities that led to the creation and birth of M-M-R. There were lessons learned that might provide historic insight into problems that can be avoided in the future. MEASLES Measles vaccine began when the late Dr John Enders and Dr Samuel Katz and their coworkers developed and tested their Edmonston strain of attenuated live measles virus.1

scholarly journals Case Study: The International Criminal Tribunal for the Former Yugoslavia’s Court Transcripts in Bosnian/Croatian/Serbian—Part 1: Needs, Feasibility, and Output Assessment

2021 ◽  
Vol 15 (2) ◽  
pp. 37-48
Author(s):  
Besmir Fidahić
Keyword(s):  
International Criminal ◽  
International Criminal Tribunal ◽  
Historical Record ◽  
Former Yugoslavia ◽  
The Past ◽  
Court Record ◽  
Totalitarian Regimes ◽  
Insight Into ◽  
Made In

International Criminal Tribunal for the Former Yugoslavia (ICTY) remains the most important organization for the past, the present, and the future of the former Yugoslavia. Faced with a country that always lived under totalitarian regimes with very little insight into actions of the groups and individuals who reaped unthinkable havoc on each other at the end of the twentieth century, the ICTY set undisputable historical record about events that took place during the 1991–1999 wars and put the country on an excellent track towards transformation for the better. But even 28 years since the establishment of the ICTY, the former Yugoslavia remains the hotbed of nationalism, ethnic divisions, genocide denial, and genocide justification. Court transcripts belong to the category of the permanent court record. The ICTY court transcripts have only been made in English and French, but not in Bosnian/Croatian/Serbian (B/C/S), the languages of the former Yugoslavia. This paper is going to examine the needs for the ICTY court transcripts in the B/C/S, could they have been made in the B/C/S from the very beginning of the institution and whether the existing ICTY court transcripts in the B/C/S are up to par for any of its audiences.

Laryngeal Manifestations of Autoimmune Diseases

2020 ◽  
Vol 5 (2) ◽  
pp. 439-456
Author(s):  
Jenny L. Pierce
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Patient Outcomes ◽  
Correct Diagnosis ◽  
Upper Airway ◽  
Clinical Implications ◽  
Laryngeal Function ◽  
The Past ◽  
Referral Practices ◽  
Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

Recovery boiler sootblowers: History and technological advances

TAPPI Journal ◽  
2015 ◽  
Vol 14 (1) ◽  
pp. 51-60
Author(s):  
HONGHI TRAN ◽  
DANNY TANDRA
Keyword(s):  
Cfd Modeling ◽  
Computing Systems ◽  
The Past ◽  
Technological Advances ◽  
Recovery Boilers ◽  
Computational Fluid Dynamics Cfd ◽  
Recovery Boiler ◽  
Steam Parameters ◽  
Insight Into ◽  
Deposit Removal

Sootblowing technology used in recovery boilers originated from that used in coal-fired boilers. It started with manual cleaning with hand lancing and hand blowing, and evolved slowly into online sootblowing using retractable sootblowers. Since 1991, intensive research and development has focused on sootblowing jet fundamentals and deposit removal in recovery boilers. The results have provided much insight into sootblower jet hydrodynamics, how a sootblower jet interacts with tubes and deposits, and factors influencing its deposit removal efficiency, and have led to two important innovations: fully-expanded sootblower nozzles that are used in virtually all recovery boilers today, and the low pressure sootblowing technology that has been implemented in several new recovery boilers. The availability of powerful computing systems, superfast microprocessors and data acquisition systems, and versatile computational fluid dynamics (CFD) modeling capability in the past two decades has also contributed greatly to the advancement of sootblowing technology. High quality infrared inspection cameras have enabled mills to inspect the deposit buildup conditions in the boiler during operation, and helped identify problems with sootblower lance swinging and superheater platens and boiler bank tube vibrations. As the recovery boiler firing capacity and steam parameters have increased markedly in recent years, sootblowers have become larger and longer, and this can present a challenge in terms of both sootblower design and operation.

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