scholarly journals Meal irregularity and cardiometabolic consequences: results from observational and intervention studies

2016 ◽  
Vol 75 (4) ◽  
pp. 475-486 ◽  
Author(s):  
Gerda K. Pot ◽  
Suzana Almoosawi ◽  
Alison M. Stephen
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Cardiometabolic Risk ◽  
Intervention Studies ◽  
Cardiometabolic Risk Factors ◽  
Obese Women ◽  
Cross Sectional ◽  
Meal Patterns ◽  
The Metabolic Syndrome ◽  
The Impact

Studying irregular meal patterns fits in with the latest research focusing not only on what people eat but also when they eat, also called chrono-nutrition. Chrono-nutrition involves studying the impact of nutrition on metabolism via circadian patterns, including three aspects of time: (ir)regularity, frequency and clock time. The present paper aimed to narratively review research on irregular meal patterns and cardiometabolic consequences. Only few cross-sectional studies and prospective cohort studies were identified, and most of these suggested that eating meals irregularly is associated with a higher risk of the metabolic syndrome and cardiometabolic risk factors, including BMI and blood pressure. This was supported by two randomised controlled intervention studies showing that consuming meals regularly for 2 weeks v. an irregular meal pattern, led to beneficial impact on cardiometabolic risk factors as lower peak insulin, lower fasting total and LDL-cholesterol, both in lean and obese women. In conclusion, the limited evidence on meal regularity and cardiometabolic consequences supports the hypothesis that consuming meals irregularly is adversely associated with cardiometabolic risk. However, it also highlights the need for more large-scale studies, including detailed dietary assessment to further advance the understanding of the impact of chrono-nutrition on public health.

scholarly journals The Epidemiological Boehringer Ingelheim Employee Study—Part I: Impact of Overweight and Obesity on Cardiometabolic Risk

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Kerstin Kempf ◽  
Stephan Martin ◽  
Carmen Döhring ◽  
Klaus Dugi ◽  
Carolin Wolfram von Wolmar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Cardiometabolic Risk ◽  
Intima Media Thickness ◽  
Roc Curves ◽  
Overweight And Obesity ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Increased Risk

Objective.Obesity-dependent diseases cause economic burden to companies. Large-scale data for working populations are lacking. Prevalence of overweight and obesity in the Boehringer Ingelheim (BI) Employee cohort and the relationship between body mass index (BMI) and cardiometabolic risk factors and diseases were estimated.Design and Methods.Employees (≥38 years, employed in Ingelheim ≥2 years;n=3151) of BI Pharma GmbH & Co. KG were invited by the medical corporate department to participate in intensive health checkups. Cross-sectional analysis of baseline data collected through 2006–2011 was performed.Results.90% of eligible subjects participated (n=2849). Prevalences of overweight and obesity were 40% and 18% and significantly higher in men and participants ≥50 years. Cardiometabolic risk factor levels and prevalences of cardiometabolic diseases significantly increased with BMI and were higher in overweight and obese participants. Cut-points for increased risk estimated from ROC curves were≈25 kg/m2for hypertension, hypercholesterolemia, arteriosclerosis, and hypertriglyceridemia and 26.7–28.0 kg/m2for the metabolic syndrome, insulin resistance, hyperinsulinemia, increased intima media thickness, and type 2 diabetes.Conclusion.This is the first large-scale occupational health care cohort from a single company. Cardiometabolic risk factors and diseases accumulate with increasing BMI. Occupational weight reduction programs seem to be reasonable strategies.

scholarly journals Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness

Neurology ◽  
2019 ◽  
Vol 93 (11) ◽  
pp. e1045-e1057 ◽  
Author(s):  
Si Eun Kim ◽  
Jin San Lee ◽  
Sookyoung Woo ◽  
Seonwoo Kim ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cortical Thickness ◽  
Cardiometabolic Risk ◽  
Brain Aging ◽  
Normal Weight ◽  
Cardiometabolic Risk Factors ◽  
Obese Women ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Age Related

ObjectiveTo investigate whether cardiometabolic factors were associated with age-related differences in cortical thickness in relation to sex.MethodsIn this cross-sectional study, we enrolled 1,322 cognitively normal elderly (≥65 years old) individuals (774 [58.5%] men, 548 [41.5%] women). We measured cortical thickness using a surface-based analysis. We analyzed the associations of cardiometabolic risk factors with cortical thickness using multivariate linear regression models after adjusting for possible confounders and interactions with age.ResultAmong women, hypertension (β = −1.119 to −0.024, p < 0.05) and diabetes mellitus (β = −0.920, p = 0.03) were independently associated with lower mean cortical thickness. In addition, there was an interaction effect between obesity (body mass index [BMI] ≥27.5 kg/m2) and age on cortical thickness in women (β = −0.324 to −0.010, p < 0.05), suggesting that age-related differences in cortical thickness were more prominent in obese women compared to women with normal weight. Moreover, low education level (<6 years) was correlated with lower mean cortical thickness (β = −0.053 to −0.046, p < 0.05). Conversely, among men, only being underweight (BMI ≤18.5 kg/m2, β = −2.656 to −0.073, p < 0.05) was associated with lower cortical thickness.ConclusionsOur findings suggest that cortical thickness is more vulnerable to cardiometabolic risk factors in women than in men. Therefore, sex-specific prevention strategies may be needed to protect against accelerated brain aging.

scholarly journals Trends in known and undiagnosed diabetes, HbA1c levels, cardiometabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys: the population-based Tromsø Study 1994–2016

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e041846
Author(s):  
Petja Lyn Langholz ◽  
Tom Wilsgaard ◽  
Inger Njølstad ◽  
Rolf Jorde ◽  
Laila Arnesdatter Hopstock
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Population Based ◽  
Cardiometabolic Risk Factors ◽  
Undiagnosed Diabetes ◽  
Cross Sectional ◽  
Treatment Target ◽  
The Metabolic Syndrome ◽  
Hba1c Levels

ObjectivesThe aim of this study was to investigate time trends in known and undiagnosed diabetes, glycated haemoglobin (HbA1c) levels and other cardiometabolic risk factors in the general population as well as treatment target achievement among those with diabetes.Design and settingRepeated cross-sectional surveys in the population-based Tromsø Study.MethodsWe used age-adjusted generalised estimating equation models to study trends in self-reported and undiagnosed (HbA1c ≥6.5%) diabetes, cardiometabolic risk factors and the metabolic syndrome in 27 281 women and men aged 40–84 years examined in up to four surveys of the Tromsø Study between 1994 and 2016. Further, we analysed trends in diabetes treatment target achievement.ResultsDuring 1994–2016, diabetes prevalence increased in women (2.3% to 4.6%) and men (2.4% to 5.8%) and in all age groups, while the proportion of undiagnosed diabetes in women (32% to 17%) and men (37% to 24%) decreased. Blood pressure and total cholesterol decreased, while waist circumference increased in participants with and without diabetes, leading to a relatively stable prevalence of the metabolic syndrome throughout the study period. There was a marginal increase in HbA1c levels among participants without diabetes. Only half of those with diabetes achieved the treatment target of HbA1c ≤7.0%.ConclusionIn the last two decades, diabetes prevalence increased, while the proportion of undiagnosed diabetes declined. The prevalence of the metabolic syndrome remained stable throughout, driven by opposing trends with an increase in obesity and a decrease in other cardiometabolic risk factors. HbA1c treatment target achievement did not improve.

scholarly journals Normalization of Muscle Strength Measurements in the Assessment of Cardiometabolic Risk Factors in Adolescents

2021 ◽  
Vol 18 (16) ◽  
pp. 8428
Author(s):  
Tiago Rodrigues de Lima ◽  
Xuemei Sui ◽  
Diego Augusto Santos Silva
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Body Size ◽  
Muscle Strength ◽  
Fat Mass ◽  
Cardiometabolic Risk ◽  
Cross Sectional Study ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
The Impact

Muscle strength (MS) has been associated with cardiometabolic risk factors (CMR) in adolescents, however, the impact attributed to body size in determining muscle strength or whether body size acts as a confounder in this relationship remains controversial. We investigated the association between absolute MS and MS normalized for body size with CMR in adolescents. This was a cross-sectional study comprising 351 adolescents (44.4% male; 16.6 ± 1.0 years) from Brazil. MS was assessed by handgrip and normalized for body weight, body mass index (BMI), height, and fat mass. CMR included obesity, high blood pressure, dyslipidemia, glucose imbalance, and high inflammation marker. When normalized for body weight, BMI, and fat mass, MS was inversely associated with the presence of two or more CMR among females. Absolute MS and MS normalized for height was directly associated with the presence of two or more CMR among males. This study suggests that MS normalized for body weight, BMI, and fat mass can be superior to absolute MS and MS normalized for height in representing lower CMR among females. Absolute MS and MS normalized for height were related to higher CMR among males.

scholarly journals Effects of Nine-Month Lifestyle Intervention on Cardiometabolic Risk Factors: Sex Differences in Obese Individuals

Obesities ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Florent Besnier ◽  
Anil Nigam ◽  
Martin Juneau ◽  
Valérie Guilbeault ◽  
Elise Latour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Composition ◽  
Sex Differences ◽  
Body Mass ◽  
Cardiometabolic Risk ◽  
Interval Training ◽  
Cardiometabolic Risk Factors ◽  
Obese Women ◽  
Baseline Values ◽  
High Intensity Interval

Limited data is available on the sex differences and individual responses of cardiometabolic parameters adjusted with potential confounders (i.e. sex, age, baseline values) after a longer term Mediterranean diet (MedD) and high intensity interval training (HIIT) in obese subjects. The objective of this study was to compare the effects of nine-month MedD counseling and supervised HIIT on cardiometabolic risk factors and individual responses in obese women (n = 99) and obese men (n = 35). Body composition (body mass, fat mass, lean body mass, waist circumference), cardiorespiratory fitness (METs), and cardiometabolic risk factors (blood pressure, blood sample variables) were measured at baseline and after nine months of a program combining MedD and HIIT two to three times a week. When adjusted with sex, age, and baseline values, obese women similarly improved their body composition, METs, and cardiometabolic risk factors vs. obese men. The proportion of responders according to clinical cutoff levels were the same in obese women and men. A longer MedD and HIIT intervention similarly improves body composition, cardiometabolic risk factors, and individual responses in obese women and men, even after adjustment of confounders (sex, age, baseline value).

scholarly journals Association of intraocular pressure with the metabolic syndrome and novel cardiometabolic risk factors

Eye ◽  
2009 ◽  
Vol 24 (6) ◽  
pp. 1037-1043 ◽  
Author(s):  
Y C Chang ◽  
J-W Lin ◽  
L C Wang ◽  
H M Chen ◽  
J J Hwang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Intraocular Pressure ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
The Metabolic Syndrome
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