Dietary fibre intake and common mental disorder: prospective findings from the Whitehall II study

BackgroundThere is suggestive evidence that increased intake of dietary fibre and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are generally associated with decreased colorectal cancer risk. However, the effects on precursors of colorectal cancer, such as adenomatous polyps, are mixed. We present the associations between dietary fibre intake and NSAID use on the presence and type of colorectal polyps in a screening population.MethodsA cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada) was conducted. Dietary fibre intake and NSAID use were assessed using the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire. Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas). Crude and ORs and 95% CIs were estimated using unconditional logistic regression.ResultsThere were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs. Total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres. Ever use of NSAIDs was also inversely associated with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.ConclusionsDietary fibre intake and NSAID use were associated with a decreased risk of having a HRAP at screening.

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Dietary Fibre Intake in Relation to Asthma, Rhinitis and Lung Function Impairment—A Systematic Review of Observational Studies

Nutrients ◽

10.3390/nu13103594 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3594

Author(s):

Emmanouela Sdona ◽

Athina Vasiliki Georgakou ◽

Sandra Ekström ◽

Anna Bergström

Keyword(s):

Systematic Review ◽

Lung Function ◽

Dietary Fibre ◽

Observational Studies ◽

Case Control ◽

Cross Sectional ◽

Fibre Intake ◽

Function Impairment ◽

Dietary Fibre Intake ◽

Lung Function Impairment

A high intake of dietary fibre has been associated with a reduced risk of several chronic diseases. This study aimed to review the current evidence on dietary fibre in relation to asthma, rhinitis and lung function impairment. Electronic databases were searched in June 2021 for studies on the association between dietary fibre and asthma, rhinitis, chronic obstructive pulmonary disease (COPD) and lung function. Observational studies with cross-sectional, case–control or prospective designs were included. Studies on animals, case studies and intervention studies were excluded. The quality of the evidence from individual studies was evaluated using the RoB-NObs tool. The World Cancer Research Fund criteria were used to grade the strength of the evidence. Twenty studies were included in this systematic review, of which ten were cohort studies, eight cross-sectional and two case–control studies. Fibre intake during pregnancy or childhood was examined in three studies, while seventeen studies examined the intake during adulthood. There was probable evidence for an inverse association between dietary fibre and COPD and suggestive evidence for a positive association with lung function. However, the evidence regarding asthma and rhinitis was limited and inconsistent. Further research is needed on dietary fibre intake and asthma, rhinitis and lung function among adults and children.

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Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes

Diabetologia ◽

10.1007/s00125-012-2634-x ◽

2012 ◽

Vol 55 (10) ◽

pp. 2646-2654 ◽

Cited By ~ 40

Author(s):

G. Hindy ◽

E. Sonestedt ◽

U. Ericson ◽

X.-J. Jing ◽

Y. Zhou ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dietary Fibre ◽

Risk Variant ◽

Incident Type ◽

Fibre Intake ◽

Incident Type 2 Diabetes ◽

Dietary Fibre Intake

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MPS 13-02 DIETARY FIBRE INTAKE PREVENTS HYPERTENSION AND IMPROVES RENAL FUNCTION IN A MINERALOCORTICOID-EXCESS MODEL

Journal of Hypertension ◽

10.1097/01.hjh.0000501048.23225.c6 ◽

2016 ◽

Vol 34 (Supplement 1) ◽

pp. e408

Author(s):

Francine Marques ◽

Erin Nelson ◽

Po-Yin Chu ◽

Duncan Horlock ◽

April Fiedler ◽

...

Keyword(s):

Renal Function ◽

Dietary Fibre ◽

Fibre Intake ◽

Dietary Fibre Intake

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Association of dietary fibre intake and gut microbiota in adults

British Journal Of Nutrition ◽

10.1017/s0007114518002465 ◽

2018 ◽

Vol 120 (9) ◽

pp. 1014-1022 ◽

Cited By ~ 20

Author(s):

Daniel Lin ◽

Brandilyn A. Peters ◽

Charles Friedlander ◽

Hal J. Freiman ◽

James J. Goedert ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Gut Microbiota ◽

Dietary Fibre ◽

Meta Analysis ◽

Microbiota Composition ◽

Fibre Intake ◽

Dietary Fibre Intake ◽

The Relationship ◽

Gut Microbiota Composition

AbstractIncreasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI), n 75, and New York University (NYU), n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53 (fold change (FC)=1·04, P=0·04), Lachnospira (FC=1·03, P=0·05) and Faecalibacterium (FC=1·03, P=0·06), and lower abundance of Actinomyces (FC=0·95, P=0·002), Odoribacter (FC=0·95, P=0·03) and Oscillospira (FC=0·96, P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii (FC=1·03, P=0·07) and lower abundance of Eubacterium dolichum (FC=0·96, P=0·04) and Bacteroides uniformis (FC=0·97, P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

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The FiberTAG project: Tagging dietary fibre intake by measuring biomarkers related to the gut microbiota and their interest for health

Nutrition Bulletin ◽

10.1111/nbu.12416 ◽

2020 ◽

Vol 45 (1) ◽

pp. 59-65 ◽

Cited By ~ 2

Author(s):

A. M. Neyrinck ◽

J. Rodriguez ◽

S. Vinoy ◽

V. Maquet ◽

J. Walter ◽

...

Keyword(s):

Gut Microbiota ◽

Dietary Fibre ◽

Fibre Intake ◽

Dietary Fibre Intake

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Differences in dietary fibre intake and associated familial factors in a longitudinal study at two time points across adolescence

Public Health Nutrition ◽

10.1017/s1368980019003446 ◽

2019 ◽

Vol 23 (14) ◽

pp. 2539-2547

Author(s):

Olivia G Swann ◽

Monique Breslin ◽

Michelle Kilpatrick ◽

Therese A O’Sullivan ◽

Wendy H Oddy

Keyword(s):

Dietary Fibre ◽

Parental Education ◽

Mixed Model ◽

High Energy ◽

Dietary Guidelines ◽

Food Sources ◽

Familial Factors ◽

Mixed Model Analysis ◽

Fibre Intake ◽

Dietary Fibre Intake

AbstractObjective:Dietary fibre is essential for a healthy diet; however, intake is often inadequate. Understanding of sources of dietary fibre and familial factors associated with intake in adolescents is limited, hampering efforts to increase intake. We aimed to determine adequacy of dietary fibre intake in adolescents, examine how intake changes from mid to late adolescence, identify major food sources and explore associations with familial factors.Design:Dietary fibre intake measured with semi-quantitative FFQ and sources calculated with the AUSNUT database. Familial factors determined by questionnaire.Setting:Western Australian Pregnancy Cohort (Raine) Study.Participants:Generation 2 adolescents from the 14- (n 1626) and 17-year (n 835) follow-ups.Results:Mean intake of dietary fibre did not meet national dietary guidelines other than for females aged 14 years. Mean intake of both sexes was lower at 17 years (23·0 (sd 10·0) g/d) than at 14 years (24·3 (sd 9·0) g/d, P < 0·001). The quantity of dietary fibre consumed per megajoule also decreased (2·6 (sd 0·7) g/MJ at 14 years, 2·5 (sd 0·9) g/MJ at 17 years, P = 0·007). The greatest source of dietary fibre was cereals and grains, followed by fruits, then vegetables. In multivariable mixed-model analysis, female sex, Caucasian race, age 14 years, good family functioning, high level of parental education and high energy intake were independently associated with higher dietary fibre intake.Conclusions:Our study highlights an age range and characteristics of adolescents lacking in dietary fibre, thereby identifying target populations for interventions to improve dietary fibre intake across adolescence, which would lead to better health.

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