The FiberTAG project: Tagging dietary fibre intake by measuring biomarkers related to the gut microbiota and their interest for health

AbstractIncreasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI), n 75, and New York University (NYU), n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53 (fold change (FC)=1·04, P=0·04), Lachnospira (FC=1·03, P=0·05) and Faecalibacterium (FC=1·03, P=0·06), and lower abundance of Actinomyces (FC=0·95, P=0·002), Odoribacter (FC=0·95, P=0·03) and Oscillospira (FC=0·96, P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii (FC=1·03, P=0·07) and lower abundance of Eubacterium dolichum (FC=0·96, P=0·04) and Bacteroides uniformis (FC=0·97, P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

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Guided dietary fibre intake as a means of directing short-chain fatty acid production by the gut microbiota

Journal of the Royal Society of New Zealand ◽

10.1080/03036758.2019.1657471 ◽

2019 ◽

Vol 50 (3) ◽

pp. 434-455 ◽

Cited By ~ 4

Author(s):

Gerald W. Tannock ◽

Yafei Liu

Keyword(s):

Fatty Acid ◽

Gut Microbiota ◽

Dietary Fibre ◽

Acid Production ◽

Short Chain Fatty Acid ◽

Chain Fatty Acid ◽

Short Chain ◽

Fatty Acid Production ◽

Fibre Intake ◽

Dietary Fibre Intake

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Influence of habitual dietary fibre intake on the responsiveness of the gut microbiota to a prebiotic: protocol for a randomised, double-blind, placebo-controlled, cross-over, single-centre study

BMJ Open ◽

10.1136/bmjopen-2016-012504 ◽

2016 ◽

Vol 6 (9) ◽

pp. e012504 ◽

Cited By ~ 5

Author(s):

Genelle Healey ◽

Louise Brough ◽

Chrissie Butts ◽

Rinki Murphy ◽

Kevin Whelan ◽

...

Keyword(s):

Gut Microbiota ◽

Dietary Fibre ◽

Single Centre ◽

Double Blind ◽

Double Blind Placebo ◽

Fibre Intake ◽

Centre Study ◽

Single Centre Study ◽

Dietary Fibre Intake

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Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults

Environmental Microbiology ◽

10.1111/1462-2920.13006 ◽

2015 ◽

Vol 17 (12) ◽

pp. 4954-4964 ◽

Cited By ~ 145

Author(s):

Julien Tap ◽

Jean‐Pierre Furet ◽

Martine Bensaada ◽

Catherine Philippe ◽

Hubert Roth ◽

...

Keyword(s):

Gut Microbiota ◽

Dietary Fibre ◽

Healthy Adults ◽

Fibre Intake ◽

Dietary Fibre Intake

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Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study

British Journal Of Nutrition ◽

10.1017/s0007114517003440 ◽

2018 ◽

Vol 119 (2) ◽

pp. 176-189 ◽

Cited By ~ 43

Author(s):

Genelle Healey ◽

Rinki Murphy ◽

Christine Butts ◽

Louise Brough ◽

Kevin Whelan ◽

...

Keyword(s):

Gut Microbiota ◽

Dietary Fibre ◽

Dietary Intervention ◽

Primary Objective ◽

Individual Variability ◽

Double Blind ◽

Bacterial Gene ◽

Double Blind Placebo ◽

Fibre Intake ◽

Dietary Fibre Intake

AbstractDysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF)v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti®Synergy 1; 16 g/d) or placebo (Glucidex®29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase inBifidobacterium(P=0·001). In the HDF group, the prebiotic intervention led to an increase inBifidobacterium(P<0·001) andFaecalibacterium(P=0·010) and decreases inCoprococcus(P=0·010), Dorea(P=0·043) andRuminococcus(Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.

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Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer

Journal of Epidemiology & Community Health ◽

10.1136/jech-2016-208606 ◽

2017 ◽

Vol 71 (10) ◽

pp. 961-969 ◽

Cited By ~ 5

Author(s):

Eileen Shaw ◽

Matthew T Warkentin ◽

S Elizabeth McGregor ◽

Susanna Town ◽

Robert J Hilsden ◽

...

Keyword(s):

Colorectal Cancer ◽

Dietary Fibre ◽

Cross Sectional Study ◽

Colorectal Polyps ◽

Cross Sectional ◽

Fibre Intake ◽

Screening Population ◽

Lifestyle Questionnaire ◽

Dietary Fibre Intake ◽

Anti Inflammatory

BackgroundThere is suggestive evidence that increased intake of dietary fibre and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are generally associated with decreased colorectal cancer risk. However, the effects on precursors of colorectal cancer, such as adenomatous polyps, are mixed. We present the associations between dietary fibre intake and NSAID use on the presence and type of colorectal polyps in a screening population.MethodsA cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada) was conducted. Dietary fibre intake and NSAID use were assessed using the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire. Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas). Crude and ORs and 95% CIs were estimated using unconditional logistic regression.ResultsThere were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs. Total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres. Ever use of NSAIDs was also inversely associated with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.ConclusionsDietary fibre intake and NSAID use were associated with a decreased risk of having a HRAP at screening.

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Dietary Fibre Intake in Relation to Asthma, Rhinitis and Lung Function Impairment—A Systematic Review of Observational Studies

Nutrients ◽

10.3390/nu13103594 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3594

Author(s):

Emmanouela Sdona ◽

Athina Vasiliki Georgakou ◽

Sandra Ekström ◽

Anna Bergström

Keyword(s):

Systematic Review ◽

Lung Function ◽

Dietary Fibre ◽

Observational Studies ◽

Case Control ◽

Cross Sectional ◽

Fibre Intake ◽

Function Impairment ◽

Dietary Fibre Intake ◽

Lung Function Impairment

A high intake of dietary fibre has been associated with a reduced risk of several chronic diseases. This study aimed to review the current evidence on dietary fibre in relation to asthma, rhinitis and lung function impairment. Electronic databases were searched in June 2021 for studies on the association between dietary fibre and asthma, rhinitis, chronic obstructive pulmonary disease (COPD) and lung function. Observational studies with cross-sectional, case–control or prospective designs were included. Studies on animals, case studies and intervention studies were excluded. The quality of the evidence from individual studies was evaluated using the RoB-NObs tool. The World Cancer Research Fund criteria were used to grade the strength of the evidence. Twenty studies were included in this systematic review, of which ten were cohort studies, eight cross-sectional and two case–control studies. Fibre intake during pregnancy or childhood was examined in three studies, while seventeen studies examined the intake during adulthood. There was probable evidence for an inverse association between dietary fibre and COPD and suggestive evidence for a positive association with lung function. However, the evidence regarding asthma and rhinitis was limited and inconsistent. Further research is needed on dietary fibre intake and asthma, rhinitis and lung function among adults and children.

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