Depression and monocyte dysfunction: a follow-up study

SummarySeveral studies have reported immune cellular and humoral dysfunction during depression. We specifically focused on the study of the monocyte as it has a key role in the activation of the immune response. To examine the association between severity of depressive symptoms and values of monocyte parameters (HLA-DR, CD35, phagocytic activity and vimentin filaments), we used a longitudinal design and assessed monocyte markers at intake and at follow-up 12 weeks after discharge from the hospital in 49 depressed patients. Seventy percent of patients showed pretreatment a marked monocyte dysfunction (82.5% had at least one parameter altered). After treatment, alterations in immunological variables were significantly associated (P < 0.05) with depression scores higher than 15. The findings indicate that the monocyte dysfunction is temporally associated with the state of depression. Before and after treatment the immunoreactive vimentin filaments significantly increased (P < 0.01) after incubation of monocytes with naloxone, suggesting that an increased opioid activity might account for the monocyte dysfunction.

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Impact of COVID-19 on child malnutrition, obesity in women and household food insecurity in underserved urban settlements in Sri Lanka: a prospective follow up study

Public Health Nutrition ◽

10.1017/s1368980021001841 ◽

2021 ◽

pp. 1-24

Author(s):

Renuka Jayatissa ◽

Himali Herath ◽

Amila Gayan Perera ◽

Thulasika Thejani Dayaratne ◽

Nawmali Dhanuska De Alwis ◽

...

Keyword(s):

Sri Lanka ◽

Food Insecurity ◽

Child Malnutrition ◽

Nutrition Status ◽

Household Food Insecurity ◽

Follow Up Study ◽

Household Food ◽

Before And After ◽

Urban Settlements

Abstract Objectives: To determine changes and factors associated with child malnutrition, obesity in women and household food insecurity before and after the first wave of COVID-19 pandemic. Design: A prospective follow up study. Setting: In 2019, the baseline Urban Health and Nutrition Study (UHNS-2019) was conducted in 603 households, which were selected randomly from 30 clusters to represent underserved urban settlements in Colombo. In the present study, 35% of households from the UHNS-2019 cohort were randomly selected for repeat interviews, one year after the baseline study and 6 months after COVID-19 pandemic in Sri Lanka. Height/length and weight of children and women were re-measured, household food insecurity was reassessed, and associated factors were gathered through interviewer administered questionnaires. Differences in measurements at baseline and follow-up studies were compared. Participants: A total of 207 households, comprising 127 women and 109 children were included. Results: The current prevalence of children with wasting and overweight was higher in the follow-up study than at baseline UHNS-2019 (18.3%vs13.7%;p=0.26 and 8.3%vs3.7%;p=0.12 respectively). There was a decrease in prevalence of child stunting (14.7%vs11.9%;p=0.37). A change was not observed in overall obesity in women, which was around 30.7%. Repeated lockdown was associated with a significant reduction in food security from 57% in UHNS-2019 to 30% in the current study (p<0.001). Conclusions: There was an increase in wasting and overweight among children while women had a persistent high prevalence of obesity. This population needs suitable interventions to improve nutrition status of children and women to minimise susceptibility to COVID-19.

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Prospective Associations Between Home Practice and Depressive Symptoms in Mindfulness-Based Cognitive Therapy for Recurrent Depression: A 15 Months Follow-Up Study

Cognitive Therapy and Research ◽

10.1007/s10608-020-10108-1 ◽

2020 ◽

Author(s):

Marleen J. ter Avest ◽

Corina U. Greven ◽

Marloes J. Huijbers ◽

Tom F. Wilderjans ◽

Anne E. M. Speckens ◽

...

Keyword(s):

Depressive Symptoms ◽

Cognitive Therapy ◽

Home Practice ◽

Recurrent Depression ◽

Follow Up Study

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A Six-month Follow-up Study of Maternal Anxiety and Depressive Symptoms among Japanese

Journal of Epidemiology ◽

10.2188/jea.18.84 ◽

2008 ◽

Vol 18 (2) ◽

pp. 84-87 ◽

Cited By ~ 11

Author(s):

Yuki Sato ◽

Tadaaki Kato ◽

Naoko Kakee

Keyword(s):

Depressive Symptoms ◽

Maternal Anxiety ◽

Follow Up Study

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Workplace bullying and depressive symptoms among employees in Germany: prospective associations regarding severity and the role of the perpetrator

International Archives of Occupational and Environmental Health ◽

10.1007/s00420-019-01492-7 ◽

2019 ◽

Vol 93 (4) ◽

pp. 433-443 ◽

Cited By ~ 1

Author(s):

Stefanie Lange ◽

Hermann Burr ◽

Uwe Rose ◽

Paul Maurice Conway

Keyword(s):

Depressive Symptoms ◽

Workplace Bullying ◽

Longitudinal Design ◽

Panel Study ◽

Patient Health ◽

A Prospective Study ◽

Nonsignificant Effect ◽

Degree Of Severity

Abstract Objectives The aim of this study was to investigate the effect of self-reported workplace bullying on depressive symptoms in a prospective study among a representative sample of employees from Germany. We focused specifically on the role of the perpetrator (co-workers and superiors), which was never done before in a longitudinal design. Methods We used data from a nation-wide representative panel study with a 5-year follow-up (N = 2172). Data on bullying exposure were obtained separately for different perpetrators (co-workers and superiors) and degree of severity (severe bullying, i.e., at least weekly). Depressive symptoms were assessed with the Patient Health Questionnaire (PHQ). We used logistic regression analyses to examine the effect of workplace bullying at baseline on depressive symptoms at follow-up. Results After adjusting for baseline depressive symptoms, severe bullying by co-workers significantly increased the 5-year risk of depressive symptoms (OR = 2.50). Severe bullying by superiors had a nonsignificant effect. Conclusions Workplace bullying is a risk factor for depressive symptoms among employees in Germany. The type of perpetrator seems to be an important factor to consider, as indicated by the elevated risk of depressive symptoms when bullying is perpetrated by co-workers.

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Socioeconomic position and mental health care use before and after first redeemed antidepressant and time until subsequent contact to psychologist or psychiatrists: a nationwide Danish follow-up study

Social Psychiatry and Psychiatric Epidemiology ◽

10.1007/s00127-020-01908-7 ◽

2020 ◽

Author(s):

Aake Packness ◽

Sonja Wehberg ◽

Lene Halling Hastrup ◽

Erik Simonsen ◽

Jens Søndergaard ◽

...

Keyword(s):

Mental Health ◽

Health Care ◽

Mental Health Care ◽

Socioeconomic Position ◽

Health Care Use ◽

Follow Up Study ◽

Before And After ◽

Mental Health Care Use

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Whether Keratectasia Area Shown in Corneal Topography Is Appropriate for Evaluating the Effect of Corneal Cross-Linking for Keratoconus: A 12-Month Follow-Up Study

BioMed Research International ◽

10.1155/2019/1762537 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Jia Wang ◽

Zhiwei Li ◽

Huankai Zhang ◽

Ning Gao ◽

Guoying Mu

Keyword(s):

Endothelial Cell ◽

Linear Regression ◽

Early Stage ◽

Morphological Changes ◽

Corneal Thickness ◽

Corneal Topography ◽

Cross Linking ◽

Follow Up Study ◽

Before And After

Purpose. To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results. Linear regression model revealed the KEA, Kmax, K1, and K2 decreased after CXL in model y = 0.9622 -0.02408 x (P<0.05), y = 0.9982 -0.003469 x(P<0.05), y = 0.9977 + -0.001347 x(P<0.05), y = 0.9992 + -0.001779 x(P<0.05) (y represents KEA, Kmax, K1, or K2; x represents time (month)). The KEA is significantly decreased in early stage (before month 3) (P<0.05); however, the Kmax, K1, and K2 have no significant decrease in early stage (P= 0.09, 0.19, 0.32). Conclusions. The KEA is more sensitive than K-value in describing the morphological changes of cornea after CXL, especially in early stage after treatment.

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