scholarly journals Childhood infections and common carotid intima media thickness in adolescence

2018 ◽  
Vol 147 ◽  
Author(s):  
A. C. Prins-van Ginkel ◽  
P. C. J. Bruijning-Verhagen ◽  
A. H. Wijga ◽  
M. L. Bots ◽  
U. Gehring ◽  
...  
Keyword(s):  
Parental Education ◽  
Inflammatory Responses ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Population Based ◽  
Childhood Infections ◽  
Media Thickness ◽  
Mite Allergy ◽  
Atherosclerotic Process

AbstractAtherosclerotic changes can be measured as changes in common carotid intima media thickness (CIMT). It is hypothesised that repeated infection-associated inflammatory responses in childhood contribute to the atherosclerotic process. We set out to determine whether the frequency of infectious diseases in childhood is associated with CIMT in adolescence. The study is part of the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) population-based birth cohort. At age 16 years, common CIMT was measured. We collected general practitioner (GP) diagnosed infections and prescribed antibiotics. Parent-reported infections were retrieved from annual questionnaires. Linear regression analysis assessed the association between number of infections during the first 4 years of life and common CIMT. Common CIMT measurement, GP and questionnaire data were available for 221 participants. No association was observed between the infection measures and CIMT. In a subgroup analysis, significant positive associations with CIMT were observed in participants with low parental education for 2–3 or ⩾7 GP diagnosed infections (+26.4 µm, 95% CI 0.4–52.4 and +26.8 µm, 95% CI 3.6–49.9, respectively) and ⩾3 antibiotic prescriptions (+35.5 µm, 95%CI 15.8–55.3). Overall, early childhood infections were not associated with common CIMT in adolescence. However, a higher number of childhood infections might contribute to the inflammatory process of atherosclerosis in subgroups with low education, this needs to be confirmed in future studies.

Carotid Intima-Media Thickness and Cognitive Function in Elderly Women: A Population-Based Study

2007 ◽  
Vol 28 (4) ◽  
pp. 207-213 ◽  
Author(s):  
Pirjo Komulainen ◽  
Miia Kivipelto ◽  
Timo A. Lakka ◽  
Maija Hassinen ◽  
Eeva-Liisa Helkala ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Elderly Women ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Population Based ◽  
Population Based Study ◽  
Media Thickness

scholarly journals Carotid intima-media thickness and coronary artery Disease

2018 ◽  
Vol 15 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Murari Prasad Barakoti
Keyword(s):  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ultrasound Measurement ◽  
Media Thickness ◽  
Atherosclerotic Burden ◽  
Future Events ◽  
Artery Disease ◽  
Atherosclerotic Process ◽  
A Site

It is known from the post-mortem studies of accidental death that atherosclerotic process begins in childhood and gradually progresses over decades. Only when the process leads to flow limiting stenosis as a gradual narrowing or when a thrombus forms at a site of plaque due to rupture or erosion, then the clinical cardiovascular event is manifested. Although only a certain percentage of people with underlying atherosclerosis become manifest, the greater degree of subclinical atherosclerosis is associated with greater chance of future events. The event could be sudden cardiac death at its extreme. The ultrasound measurement of carotid intima-media thickness (CIMT) has withstood test of time as an important technique of measuring atherosclerotic burden. It has been more than three decades to know the value of CIMT in the risk prediction.NepaleseHeart Journal 2018; 15(1): 9-15

Abstract P298: Relationship Of Plasma Asymmetrical Dimethylarginine To Carotid Intima-media Thickness In General Japanese Population: The ERA-JUMP And The SESSA

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Shin-ya Nagasawa ◽  
Katsuyuki Miura ◽  
Akira Fujiyoshi ◽  
Aya Kadota ◽  
Takayoshi Ohkubo ◽  
...  
Keyword(s):  
Linear Regression ◽  
Regression Models ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Population Based ◽  
Linear Regression Models ◽  
Media Thickness ◽  
Plasma Adma ◽  
Relationship Of

Objective: Asymmetrical dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is known as a mediator of endothelial cell dysfunction. Some clinical studies have found evidence that increased plasma ADMA levels are associated with a higher risk of cerebrovascular events. However, studies on the relationship of plasma ADMA to subclinical atherosclerosis have been scarce. We evaluated the association of ADMA with carotid intima-media thickness (IMT) in population-based samples in Japan. Methods: Population-based Japanese samples composed of 313 men aged 40-49 (40s men) from the ERA-JUMP and 732 men aged 60-79 (60s+70s men) from the SESSA were examined with physical examinations, life-style questionnaires, laboratory assessment and IMT using standardized methods. Plasma samples were stored at -80°C, and concentration of ADMA was determined using a validated high-throughput liquid chromatographic-tandem mass spectrometric assay. The IMTs of the right and left common carotid arteries, the carotid bulbs, and the internal carotid arteries were examined. Statistical associations were evaluated using multiple linear regression models with adjustment for age, body mass index, systolic blood pressure, LDL-cholesterol, HDL-cholesterol, fasting blood glucose, smoking, alcohol intake, medications for hypertension, hyperlipidemia, or diabetes, and estimated glomerular filtration rate (eGFR) . Results: The average concentrations and standard deviation (SD) of plasma ADMA in men aged 40-49 and 60-79 were 0.39 ± 0.06 and 0.43 ± 0.06 μmol/L, respectively. The mean and SD of IMT in men aged 40-49 and 60-79 were 0.61 ± 0.07 and 0.91 ± 0.20 mm, respectively. Higher level of ADMA was significantly and positively associated with proportion of current smoking both in 40s and 60s+70s men (correlation coefficient: both p <0.001). It was also significantly and positively associated with eGFR in 60s+70s men (p <0.001) but not associated with eGFR in 40s men (p = 0.429). In full adjusted linear regression models, 1 SD increase in ADMA was associated with 0.14mm increase in IMT in 40s men (p=0.01) but only 0.04mm increase in IMT in 60s+70s men (p=0.26). Conclusions: Higher level of ADMA was associated with more IMT independently of traditional risk factors and renal function in young adult men, but not in elderly men.

scholarly journals Association of Carotid Intima Media Thickness With Metabolic Syndrome Among Low-Income Middle-Aged and Elderly Chinese: A Population-Based Cross-Sectional Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Qiaoxia Yang ◽  
Qiuxing Lin ◽  
Dandan Guo ◽  
Hanhua Wang ◽  
Jie Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Linear Regression ◽  
Low Income ◽  
Elderly Population ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Middle Aged ◽  
Media Thickness ◽  
The Relationship

Background: We aimed to evaluate the relationship between metabolic syndrome (MetS) including its components and carotid intima media thickness (CIMT) in a low-income Chinese population aged ≥45 years.Methods: The participants underwent a general health screening and B-mode carotid ultrasonography that measured CIMT. The diagnosis of MetS and its components was based on the modified International Diabetes Federation Criteria for the Asian Population. The univariate and multivariable linear regression analyses were used to evaluate the relationship between MetS and CIMT.Results: A total of 3,583 participants (mean age, 60 years) was included in the analyses (41.4% male and 58.6% female); more than 50% of the participants were diagnosed with MetS. In the multivariable linear regression analysis, the mean CIMT was 0.009 mm greater in the participants with MetS than in those without MetS (β = 0.009; 95% CI, 0.003–0.014; P &lt; 0.05). Moreover, a high number of MetS components was associated with greater CIMT values; for example, CIMT increased by 0.007 and 0.015 mm for the individuals diagnosed with 3–4 and 5 MetS components, respectively. Among the MetS components, elevated blood pressure (β = 0.022; 95% CI, 0.015–0.029; P &lt; 0.001) and abdominal obesity (β = 0.008; 95% CI, 0.001–0.015; P &lt; 0.001) were positively correlated with CIMT. However, the increased triglyceride levels were negatively associated with CIMT (β = −0.008; 95% CI: −0.015 to −0.002; P = 0.012), especially among the elderly population.Conclusions: The risk of carotid atherosclerosis increased in the presence of multiple MetS components in a low-income, middle-aged, and elderly population. Accordingly, more detailed management strategies are essential for the early prevention and intervention of atherosclerosis in this low-income population with MetS, in China.

scholarly journals Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2631 ◽  
Author(s):  
Serafi Cambray ◽  
Merce Ibarz ◽  
Marcelino Bermudez-Lopez ◽  
Manuel Marti-Antonio ◽  
Milica Bozic ◽  
...  
Keyword(s):  
Linear Regression ◽  
Cardiovascular Health ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Atherosclerotic Cardiovascular Disease ◽  
Effect Modifier ◽  
Media Thickness ◽  
Lipid Parameters

Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with worse cardiovascular outcomes. Magnesium (Mg) is a divalent cation whose homeostasis is altered in CKD. Furthermore, Mg levels have been associated with cardiovascular health. The present study aims to understand the relationships of Mg and lipid parameters with atherosclerosis in CKD. In this analysis, 1754 participants from the Observatorio Nacional de Atherosclerosis en Nefrologia (NEFRONA) cohort were included. Carotid intima media thickness (cIMT) was determined in six arterial territories, and associated factors were investigated by linear regression. cIMT correlated positively with being male, Caucasian, a smoker, diabetic, hypertensive, dyslipidemic and with increased age, BMI, and triglyceride levels, and negatively with levels of HDL cholesterol. First-order interactions in linear regression analysis showed that Mg was an effect modifier on the influence of lipidic parameters. Thus, cIMT predicted values were higher when triglycerides or LDL levels were high and Mg levels were low. On the contrary, when Mg levels were high, this effect disappeared. In conclusion, Mg acts as an effect modifier between lipidic parameters and atherosclerotic cardiovascular disease. Therefore, Mg levels, together with lipidic parameters, should be taken into account when assessing atherosclerotic risk.

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