RENAL INJURY AND RECOVERY IN PRE-ECLAMPSIA

Affecting 7–10% of pregnancies, pre-eclampsia is, in fact, the most common glomerular disease worldwide. It remains a leading cause of fetal growth restriction, premature birth, as well as infant and maternal morbidity and mortality. Epidemiological studies have identified numerous risk factors for the development of pre-eclampsia including a positive family history, race, nulliparity, advanced maternal age and the presence of pre-existing co morbidities such as kidney disease, hypertension or diabetes mellitus. The incidence of pre-eclampsia has increased by an alarming 40% over the past decade, likely due to the number of women delaying pregnancy and/or becoming pregnant despite the presence of other comorbid conditions.

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Gestational diabetes mellitus and macrosomia: An analysis of secondary data

Journal of Health Technology Assessment in Midwifery ◽

10.31101/jhtam.819 ◽

2018 ◽

Vol 1 (2) ◽

pp. 94-98

Author(s):

Mufdlilah Mufdlilah ◽

Fijri Rachmawati

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Maternal Morbidity ◽

Secondary Data ◽

Case Control ◽

Health Issues ◽

Control Approach ◽

The Past ◽

Maternal Morbidity And Mortality

Excessive fetal weight is considered as a health issues because it increases perinatal and maternal morbidity and mortality. The prevalence of macrosomia worldwide has increased over the past 2 to 3 decades. This study aimed to determine correlation between the incidence of gestational diabetes mellitus and macrosomia among pregnant women. The design of this study was analytical with a case control approach. Data used to analyze the incidence of macrosomia based on secondary data from 2014-2018. This research suggested that diabetes mellitus in pregnancy has a significant relationship with the incidence of macrosomia.

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NEONATAL HEALTH OUTCOME OF PREGNANT WOMEN WITH DIABETES MELLITUS

Journal of Health Technology Assessment in Midwifery ◽

10.31101/jhtam.799 ◽

2019 ◽

Vol 2 (1) ◽

Author(s):

Fijri Rachmawati

Keyword(s):

Diabetes Mellitus ◽

Health Outcome ◽

Pregnant Women ◽

Maternal Morbidity ◽

Secondary Data ◽

Case Control ◽

Neonatal Health ◽

Control Approach ◽

The Past ◽

Maternal Morbidity And Mortality

Excessive fetal weight attracts attention because it increases perinatal and maternal morbidity and mortality. The prevalence of macrosomia worldwide has increased over the past 2 to 3 decades. This study aimed to determine Neonatal Health Outcome of Pregnant Women with Diabetes Mellitus. The design of this study was analytical with a case control approach. Data used to analyze the incidence of macrosomia based on secondary data from 2014-2018. From the research it can be concluded that diabetes mellitus in pregnancy has a significant relationship with the incidence of macrosomia.

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Heterotopic pregnancy: case report of a successful first trimester metacyesis management and a viable third trimester outcome

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20185448 ◽

2018 ◽

Vol 8 (1) ◽

pp. 332

Author(s):

Arvind Kumar Singh ◽

Shazia Khan

Keyword(s):

Case Report ◽

Maternal Morbidity ◽

Assisted Reproductive Technologies ◽

First Trimester ◽

Reproductive Technologies ◽

Heterotopic Pregnancy ◽

Third Trimester ◽

Intrauterine Pregnancy ◽

The Past ◽

Maternal Morbidity And Mortality

Heterotopic pregnancies are rare combined intra and extrauterine pregnancies, the incidence of which has shown an increase over the past decade with the rising trend in assisted reproductive technologies (0.75-1.5%). Authors report a case of a 29 year old primigravida, a post IVF conception who presented at 6 weeks POG with a ruptured tubal and a viable intrauterine pregnancy. She underwent an emergency laparoscopic right salpingectomy and continued with her intrauterine pregnancy successfully till term. The article emphasizes the need of scanning the adnexa carefully in early pregnancy to diagnose and manage heterotopic pregnancy as early as possible to prevent catastrophic haemorrhage and maternal morbidity and mortality later.

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Incidence of insulin-dependent diabetes mellitus: An epidemiological study

Problems of Endocrinology ◽

10.14341/probl12150 ◽

1994 ◽

Vol 40 (4) ◽

pp. 61-64

Author(s):

Ye. V. Trofimenko ◽

N. B. Lebedev ◽

N. V. Gubanov ◽

Ye. N. Zlobina ◽

I. I. Dedov

Keyword(s):

Diabetes Mellitus ◽

Insulin Dependent Diabetes Mellitus ◽

Epidemiological Studies ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

The Past ◽

The World ◽

The Usa ◽

Insulin Dependent ◽

Therapeutic Measures

Insulin-dependent diabetes mellitus (T1DM) is one of the most important problems of our time. This disease plays a significant role in the structure of chronic childhood pathology, leads to severe complications that invalidate a person, and significantly increases mortality at a young age. The study of the incidence of T1DM (the number of new cases of T1DM in a certain population within 1 year) allows you to get answers to a number of questions on its etiology and pathogenesis, to solve the problems of the need to allocate material resources for the organization of preventive and therapeutic measures. Information on the incidence of T1DM in the world applies in most cases to people under the age of 15 years, data for the age group up to 1820 years of age are less common. Epidemiological studies in various countries show an increase in the incidence of T1DM in children. This is shown by the example of Norway, the USA, Finland, Denmark from the 20s of our century, England - from the 50s and other countries over the past 20 years. It is possible to reliably distinguish a true increase in the incidence from an improvement in the detection of diabetes only on the basis of standardized epidemiological studies for certain periods of time. Many countries have compiled national childhood diabetes registries. Thus, in a number of countries standardized information on sex and age was obtained on the incidence of children with T1DM for at least 10 years, divided into 5-year periods. According to these data, the incidence rate has increased in the vast majority of countries over the past 10-20 years. It is noteworthy that the change, namely, an increase in the incidence of type 1 diabetes mellitus in children, is uneven. In some regions of the world, this indicator remained virtually unchanged over fairly long periods of time.

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Impact of diabetes on maternal-fetal outcomes in Manitoba: Relationship with ethnic and environmental factors

Clinical & Investigative Medicine ◽

10.25011/cim.v31i6.4919 ◽

2008 ◽

Vol 31 (6) ◽

pp. 338 ◽

Cited By ~ 14

Author(s):

Naji Aljohani ◽

Brenda M Rempel ◽

Sora Ludwig ◽

Margaret Morris ◽

Mary Cheang ◽

...

Keyword(s):

Diabetes Mellitus ◽

First Nations ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Advanced Maternal Age ◽

Fetal Outcomes ◽

Rural Living ◽

Type 2 Dm ◽

The Impact

Purpose: To examine the impact of gestational diabetes mellitus (GDM) on maternal-fetal outcomes in Manitoba. Methods: The rates of macrosomia, stillbirth, cesarean section (C/S) and shoulder dystocia (S/D) in 324,605 births in Manitoba during 1985-2004, and their relationships with diabetes and demographical factors were analyzed. Results: The incidence of macrosomia, stillbirth, C/S and S/D were 15.3%, 0.57%, 16.0%, and 1.2%, respectively. The rates of macrosomia were elevated in mothers with GDM, type 2 DM (T2DM), rural living, First Nations (FN) status, or ?35 years of age. Increased rates of stillbirth were associated with women with T2DM, FN status or ?35 years, but not those with GDM. C/S and S/D were increased in women with GDM or T2DM. FN status in combination with GDM increased the risk of S/D. Conclusions: GDM, T2DM, advanced maternal age, FN status or rural living affected pregnancy outcomes in Manitoba.

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Pregnancy in advanced age of mothers and fathers

Obstetrics Gynecology and Reproduction ◽

10.17749/2313-7347/ob.gyn.rep.2021.231 ◽

2021 ◽

Vol 15 (4) ◽

pp. 415-418

Author(s):

C. Dadak

Keyword(s):

Diabetes Mellitus ◽

Maternal Age ◽

Placenta Previa ◽

Advanced Maternal Age ◽

Paternal Age ◽

Advanced Age ◽

Vitro Fertilization ◽

Mothers And Fathers ◽

Ectopic Pregnancies

There is a higher incidence of infertility, chromosomal aberrations, poor results of in vitro fertilization, ectopic pregnancies, spontaneous abortion, preeclampsia, placenta previa, gestational diabetes mellitus, caesarean section, chronic diseases with higher rates of admission into intensive care units, and a higher rate of maternal mortality among women who delay pregnancy into advanced age. This is mainly due to socioeconomic causes as well as the increased use of contraceptives. Problems due to advanced maternal age arise also with egg donations. Only chromosome aberrations are related to the age of the donor. Paternal age also appears to play a significant role in the outcome of the pregnancy. However, opinions vary in the literature available. Counseling the couples should be addressed.

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ECLAMPSIA

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.04.2293 ◽

2018 ◽

Vol 21 (04) ◽

pp. 628-632

Author(s):

Sumaira Rauf Qureshi ◽

Sana Zaheer ◽

Shehla Raza Channa

Keyword(s):

Maternal Age ◽

Maternal Morbidity ◽

Post Partum ◽

Mode Of Delivery ◽

Obstetrics And Gynecology ◽

Vaginal Route ◽

Maternal Complications ◽

Prompt Treatment ◽

Maternal Morbidity And Mortality ◽

One Year

Objective: To determine the maternal morbidity and mode of delivery in eclampticpatients. Study design: Descriptive studies (cases series). Duration of study: One year from1.3.2012 to 28.2.2013. Setting: Dept of Obstetrics and Gynecology Unit-III Liaquat UniversityHospital Hyderabad. Patients and methods: This study included 97 eclamptic patients. The mainvariables of interest were maternal age, parity, booking status, gestational age, mode of deliveryand maternal complications like HELLP syndrome, pulmonary edema, post partum hemorrhage,renal failure, neurological deficit and ICU admission. Result: During the study period 2839obstetrical patients were admitted with 97 cases being eclamptic give an incidence of 3.4%.Majority were unbooked 94.8%, Primigravida 58.8% and ≤ 25 years of age 68%. Complicationswere seen in n 50.51% and 12.4% patients have more than one complications. Vaginal route wasmode of delivery in 53.60% and cesarean section was in 44.32% patients. Conclusions:Eclampsia still responsible for significant maternal morbidity and mortality. Eclampsia can onlybe successfully managed by early detection and prompt treatment of pre-eclampsia

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Placentas From Women of Advanced Maternal Age

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2019-0481-oa ◽

2020 ◽

Vol 144 (10) ◽

pp. 1254-1261

Author(s):

Vanda F. Torous ◽

Drucilla J. Roberts

Keyword(s):

Socioeconomic Factors ◽

High Frequency ◽

Maternal Age ◽

Comparison Group ◽

Advanced Maternal Age ◽

Placental Pathology ◽

Pathologic Examination ◽

Group 14 ◽

The Past ◽

Significant Difference

Context.— The percentage of pregnant women with advanced maternal age (AMA) has increased during the past several decades due to various socioeconomic factors and advances in assisted reproduction. These pregnancies are associated with adverse maternal and fetal outcomes. However, the underlying placental pathology has not been well described. Objective.— To investigate the placental histopathology associated with AMA pregnancies. Design.— Placental pathology from 168 AMA women 35 years or older at delivery was reviewed. The cases were subdivided into 2 age subgroups, ages 35 to 39 and 40 or older, as well as a “pure AMA” subgroup where the only indication for placental examination was AMA. A group of 60 consecutive non-AMA placentas was also identified and used as comparison. The spectrum of histologic features in each case was catalogued. Results.— Of the overall AMA cases, meconium deposition was seen in 55% (93 of 168), chorangiosis in 40% (68 of 168), and acute chorioamnionitis in 36% (60 of 168). Fetal vascular malperfusion was also seen with high frequency (30%; 50 of 168). Two histologic alterations found to be significantly different between the 35 to 39 and greater than 40 age subgroups were fetal vascular malperfusion (11% [7 of 65] versus 42% [43 of 103]; P = .001) and delayed villous maturation (1.5% [1 of 65] versus 13% [13 of 103]; P = .02). The pure AMA subgroup showed no statistically significant differences compared with the overall AMA group. Chronic deciduitis was the only statistically significant difference between the overall AMA group and the non-AMA comparison group (14% [23 of 168] versus 30% [18 of 60]; P = .02). Conclusions.— Our findings, particularly the high frequency of fetal vascular malperfusion, suggest that AMA should be an independent indication for placental pathologic examination.

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