Association between C-reactive protein and cognitive deficits in elderly men and women: a meta-analysis

2012 ◽  
Vol 24 (9) ◽  
pp. 1387-1392 ◽  
Author(s):  
Dawson W. Hedges ◽  
Thomas J. Farrer ◽  
Bruce L. Brown
Keyword(s):  
Confidence Interval ◽  
Cognitive Ability ◽  
Cognitive Deficits ◽  
Effect Size ◽  
Cognitive Deficit ◽  
C Reactive Protein ◽  
Elderly Men ◽  
Reactive Protein ◽  
And Gender ◽  
Male Subjects

ABSTRACTBackground: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.Results: While we identified no studies containing only male subjects, the two identified studies containing both female and male subjects (n = 2,525) showed an effect size for cognition of −0.1809 (95% confidence interval, −0.2652 to −0.0967, p = 0.000025) between high and low C-reactive-protein groups. In contrast, the two identified studies containing only female subjects (n = 1,754) showed an effect size for cognition of 0.0345 (95% confidence interval, −0.0594 to 0.1285, not significant).Conclusions: In the context of a small number of source studies and lack of an all-male group, these results suggest that any association between C-reactive protein and cognitive deficits may be stronger in elderly men than in elderly women.

scholarly journals Serum Cathepsin S Is Associated with Serum C-Reactive Protein and Interleukin-6 Independently of Obesity in Elderly Men

2010 ◽  
Vol 95 (9) ◽  
pp. 4460-4464 ◽  
Author(s):  
E. Jobs ◽  
U. Risérus ◽  
E. Ingelsson ◽  
J. Helmersson ◽  
E. Nerpin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Confidence Interval ◽  
Regression Coefficient ◽  
Normal Weight ◽  
Cathepsin S ◽  
C Reactive Protein ◽  
Elderly Men ◽  
Community Based ◽  
Reactive Protein

Objective: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants. Methods: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr. Results: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07–0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01–0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m2, n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr. Conclusions: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.

The characteristics associated with alcohol co-ingestion in patients visited to the emergency department with deliberate self-poisoning: retrospective study

2021 ◽  
Keyword(s):  
Emergency Department ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Self Report ◽  
C Reactive Protein ◽  
Alcohol Group ◽  
Reactive Protein ◽  
History Of

Objective: The aim of this study was to investigate the characteristics associated with alcohol co-ingestion by measuring blood alcohol concentration in patients visited to the emergency department with deliberate self-poisoning. Also, it was to evaluate the accuracy of self-reported alcohol ingestion. Methods: The initial assessment forms, medical records and laboratory tests of patients visited to the ED after DSP between March 2017 and June 2020 were retrospectively reviewed. Based on the patients’ BAC, two groups were formed: the non-alcohol group and the alcohol group. Results: This study included 286 patients (56.6%, n = 162) in the non-alcohol group and 43.4% (n = 124) in the alcohol group. In multivariate logistic analysis, alcohol co-ingestion was independently associated with no history of psychiatric admission (Odds Ratio = 6.222, 95% Confidence Interval = 1.148-33.716, P = 0.034), lactate (mg/dL)(Odds Ratio = 1.961, 95% Confidence Interval = 1.274-3.019, P = 0.002), and C-reactive protein level (mg/dL) (Odds Ratio = 0.003, 95% Confidence Interval = 0.000-0.897, P = 0.046). The receiver operating characteristics analysis of lactate value for the association with alcohol co-ingestion showed a cutoff value of 1.45, with 88.1% sensitivity, 71.6%specificity, and an area under the curve of 0.845. There was no statistically significant difference in emergency department disposition between the two groups. Using the 261 subjects who completed the self-report of alcohol co-ingestion, self-report resulted in 77.6% sensitivity and 76.6% specificity for the assessment of alcohol co-ingestion. The positive and negative predictive values for self-reporting were 72.6% and 81.0%, respectively. Conclusions: Alcohol co-ingestion was associated with no history of psychiatric ward admission, high lactate levels, and low C-reactive protein values in patients who visited the emergency department with deliberate self-poisoning. This study showed that self-reported alcohol co-ingestion was not a substitute for the blood alcohol concentration test.

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

2022 ◽  
Author(s):  
Mary Beth Wire ◽  
Soo Youn Jun ◽  
In-Jin Jang ◽  
Seung-Hwan Lee ◽  
Jun Gi Hwang ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Phase 1 ◽  
Infusion Site ◽  
Healthy Male ◽  
C Reactive Protein ◽  
Phase 1 Study ◽  
Reactive Protein ◽  
Male Subjects ◽  
Common Teaes ◽  
Dose Proportional

Thirty-two healthy male subjects (8 per cohort) were randomized 6:2 to active:placebo. LSVT-1701, an anti-staphylococcal lysin, was administered intravenously as a 6 mg/kg single dose and as 1.5, 3, and 4.5 mg/kg twice daily for 4 days. LSVT-1701 exposure increased in a greater than dose proportional manner and did not accumulate. Treatment-emergent adverse events (TEAEs) were predominantly of mild intensity. The most common TEAEs were chills, pyrexia, headache, infusion site events, cough, rhinorrhea, and increases in C-reactive protein.

scholarly journals Race and Gender Differences in C-Reactive Protein Levels

2005 ◽  
Vol 46 (3) ◽  
pp. 464-469 ◽  
Author(s):  
Amit Khera ◽  
Darren K. McGuire ◽  
Sabina A. Murphy ◽  
Harold G. Stanek ◽  
Sandeep R. Das ◽  
...  
Keyword(s):  
Gender Differences ◽  
C Reactive Protein ◽  
Race And Gender ◽  
Protein Levels ◽  
Reactive Protein ◽  
And Gender

Interpretation of circulating C-reactive protein levels in adults: Body Mass Index and gender are a must

2003 ◽  
Vol 29 (2) ◽  
pp. 133-138 ◽  
Author(s):  
L Piéroni ◽  
JP Bastard ◽  
A Piton ◽  
L Khalil ◽  
B Hainque ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
And Gender

scholarly journals Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein

2018 ◽  
Vol 8 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Kazuhiro Dan ◽  
Toru Miyoshi ◽  
Makoto Nakahama ◽  
Tomofumi Mizuno ◽  
Kenzo Kagawa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Percutaneous Coronary Intervention ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Coronary Angiography ◽  
Confidence Interval ◽  
Coronary Intervention ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Percutaneous Coronary

Background: Chronic kidney disease (CKD) and inflammation play critical roles in atherosclerosis. There is limited evidence regarding the relationship between CKD and patients receiving second-generation drug-eluting stents for coronary artery disease. Objective: This study aimed to investigate the effect of CKD on cardiovascular and renal events in patients undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents (EES). Methods: We analyzed 504 consecutive patients with stable angina pectoris and significant coronary artery stenosis treated with EES. CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 before coronary angiography. The primary outcome was the occurrence of major adverse renal and cardiovascular events (MARCE) including cardiac death, revascularization, heart failure, cerebral infarction, worsening renal function > 25% from baseline, and renal replacement therapy at 1 year. Results: Patients were divided into the a MARCE (n = 126) and a non-MARCE (n = 378) group. The incidence of CKD was 51% in all subjects (including those on hemodialysis) and was significantly higher in the MARCE group than in the non-MARCE group (p = 0.00001). Multivariate logistic regression analysis identified that CKD was independently associated with MARCE (adjusted odds ratio 2.03, 95% confidence interval 1.21–3.39, p = 0.007). Patients were divided into four groups based on CKD and C-reactive protein (CRP) level prior to initial coronary angiography. Cox proportional hazards analysis revealed that patients with CKD and high CRP (≥0.3 mg/dL) had the worst prognosis (hazard ratio 4.371, 95% confidence interval 2.634–7.252, p = 0.00001) compared to patients without CKD and with low CRP. Conclusion: CKD combined with CRP predicted more clinical events in patients undergoing PCI with EES.

scholarly journals Can the simplified magnetic resonance index of activity be used to evaluate the degree of activity in Crohn's disease?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yongli Tao ◽  
Hong Li ◽  
Han Xu ◽  
Wen Tang ◽  
Guohua Fan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Confidence Interval ◽  
Sedimentation Rate ◽  
Fecal Calprotectin ◽  
Left Colon ◽  
C Reactive Protein ◽  
Right Colon ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Highly Correlated

Abstract Background and aims A simplified magnetic resonance index of activity (MaRIAs) was recently proposed. Our aim was to verify whether MaRIAs can accurately assess the activity degree of CD. Methods We retrospectively analyzed the MRI, ileocolonoscopy, fecal calprotectin (FC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) data of 93 CD patients. With the SES-CD as the gold standard, MaRIAs’ accuracy, the correlation of MaRIAs and SES-CD, FC, ESR, CRP, and interevaluator reliability were assessed. Results MaRIAs ≥ 1 detected segments with active CD with 90.80% specificity and 81.37% sensitivity (area under the curve was 0.91, 95% confidence interval 0.87–0.94). MaRIAs score of 2 or more detected severe lesions with 88.89% specificity and 95.12% sensitivity (AUC was 0.96, 95% confidence interval was 0.94–0.98). The MaRIAs score showed a high correlation with the SES-CD in the terminal ileum, transverse colon, right colon, and left colon (r = 0.85, 0.91, 0.88, 0.86, P < 0.001) and a moderate correlation with the SES-CD in the rectum (r = 0.74, P < 0.001). The global MaRIAs score was highly correlated with the global SES-CD (r = 0.90, P < 0.001). The global MaRIAs score was positively correlated with the fecal calprotectin (FC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) (r = 0.77, r = 0.64, and r = 0.68). The intragroup correlation coefficient (ICC) of the two physicians was nice in the terminal ileum, the right colon, the transverse colon, the left colon and was moderately good in the rectum. Conclusion MaRIAs can accurately evaluate the disease activity level of CD and are highly correlated with SES-CD and biomarkers. The interrater reliability of the two physicians was moderately good to nice.

scholarly journals Correlation between Interleukin-6 (IL-6), High Sensitivity C-Reactive Protein (hsCRP), Endothelin-1 (ET-1), Asymmetric Dimethylarginine (ADMA) and Insulin Resistance (HOMA-IR) in Central Obese Men

2011 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Andri Hidayat ◽  
Andi Wijaya ◽  
Harun Alrasyid
Keyword(s):  
Insulin Resistance ◽  
Endothelial Dysfunction ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Causal Pathways ◽  
Resistance State ◽  
Male Subjects

BACKGROUND: Many studies have shown that obesity was closely related to insulin resistance via several pathways such as inflammation, oxidative stress, lipolysis, and endothelial dysfunction. This study was carried out to observe the correlation between inflammation (IL-6 and hsCRP), lipolysis process (ET-1), and endothelial dysfunction (ADMA) and insulin resistance (HOMA-IR) in centrally obese men.METHODS: This was a cross sectional study on 62 male subjects aged 30–60 years old with waist circumference (WC) >90 cm. IL-6, ET-1 and ADMA levels were measured using ELISA method, while hsCRP and insulin were measured using chemiluminescence method. All blood testings were conducted in Prodia Clinical Laboratory.RESULTS: The results showed that WC was significantly correlated with hsCRP (r=0.294, p=0.022 ), ET-1 (r=0.257, p=0.047 ) and ADMA (r=0.338, p=0.009). We also found a significant correlation between hsCRP with HOMA-IR (r=0.324, p=0.021), ADMA with HOMA-IR (r=0.280, p=0.045), and IL-6 with hsCRP (r=0.437, p=0.003).CONCLUSIONS: hsCRP and ADMA have significant correlation with HOMA-IR in centrally obese men. HOMA-IR significantly increases in subjects with ADMA above median and either IL-6 or hsCRP above median, as compared to those in the other groups. Inflammation and endothelial dysfunction are important causal pathways of insulin resistance state in centrally obese men.KEYWORDS: obesity, IL-6, hsCRP, ET-1, ADMA, HOMA-IR

scholarly journals Early Vascular Aging and Risk Factors Among a Population Aged 50 and Below in Kailuan Study

2020 ◽  
Vol 33 (9) ◽  
pp. 887-887
Author(s):  
Meng-yi Zheng ◽  
Quan-hui Zhao ◽  
Ying-chi Liu ◽  
Yong-jian Song ◽  
Mao-xiang Zhao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Confidence Interval ◽  
Pulse Wave ◽  
Adult Population ◽  
High Sensitivity ◽  
Vascular Aging ◽  
Resting Heart Rate ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Background To examine the frequency of early vascular aging and risk factors in an adult population with age ≤50 years old in Kailuan. Methods A total of 21,952 subjects aged ≤50 years without previous history of cardiovascular and cerebrovascular diseases and having completed brachial-ankle pulse wave velocity test in 2010–2016 were recruited. The mean plus 2 standard deviations (mean + 2SD) of brachial-ankle pulse wave velocity in 1,813 healthy population without hypertension, diabetes, dyslipidemia, and smoking were calculated and used as the reference value for early vascular aging. The stepwise regression multivariate logistic regression model was used to analyze the influencing factors for early vascular aging in different age and gender groups. Results The average detection rate of early vascular aging in this population was 15.0% with 12.9% in 30 years or less, 14.8% between 30 and 40 years, and 15.6% between 40 and 50 years. Furthermore, age, male, resting heart rate, high sensitivity C-reactive protein, smoking, hypertension, and diabetes were risk factors for early vascular aging with odds ratio values (95% confidence interval) of 1.02 (1.01–1.03), 2.51 (2.10–3.00), 1.04 (1.03–1.04), 1.09 (1.05–1.13), 1.11 (1.04–1.20), 1.05 (1.00–1.11), 3.55 (3.13–4.03), and 1.69 (1.38–2.08), respectively. The risk factors for early vascular aging in women with gestational hypertension were 4.27 times higher than those in women without (95% confidence interval 1.34–13.53). Conclusions The frequency of early vascular aging is 15.0% in adult population ≤50 years old. Risk factors for early vascular aging include age, male, resting heart rate, high sensitivity C-reactive protein, smoking, hypertension, diabetes, and in women, the pregnancy-induced hypertension.

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