Phenotypic variation in residual food intake of mice at different ages and its relationship with efficiency of growth, maintenance and body composition

1996 ◽  
Vol 63 (1) ◽  
pp. 149-157 ◽  
Author(s):  
J. A. Archer ◽  
W. S. Pitchford
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Phenotypic Variation ◽  
Growth Efficiency ◽  
Maintenance Requirement ◽  
Different Ages ◽  
Selection For ◽  
Young Mice

AbstractFood intake and body weight of 119 mice was measured from 3 to 18 weeks of age. Residual food intake was calculated for each week as the variation in food intake independent of variation in weight gain, weight maintained and sex. Growth efficiency and maintenance requirement were calculated by fitting curves to data from 3 to 18 weeks. The repeatability of residual food intake was low in young mice, but increased as they matured. Growth efficiency was correlated with residual food intake in very young mice. Residual food intake was not correlated with maintenance requirement in young mice, but as mice matured the correlation of residual food intake with maintenance requirement increased to 0·6. Body composition at maturity was correlated with residual food intake and maintenance requirement of mature mice, but a large proportion of the variation in residual food intake and maintenance requirement was independent of body composition. The results suggest that the age at which residual food intake is measured is important if it is to be used as a criterion for selection for efficiency.

scholarly journals Growth, efficiency and body composition of mice selected for post-weaning weight gain on ad libitum or restricted feeding

1986 ◽  
Vol 48 (2) ◽  
pp. 101-109 ◽  
Author(s):  
D. J. S. Hetzel ◽  
F. W. Nicholas
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Growth Efficiency ◽  
Restricted Feeding ◽  
Heritable Variation ◽  
Weaning Weight ◽  
Significant Difference ◽  
Almost All

SummaryAfter seven generations of selection, a line of mice selected for post-weaning (21–42 days) weight gain on full feeding (SF) showed significant increases of 49% in weight gain, 31% in efficiency and 14% in food intake, when compared with its control on full feeding between 21 and 42 days. After day 42, SF mice continued to eat more food and were 28% heavier than control mice at 91 days. Because SF mice were heavier than control mice at almost all ages, they were fatter on an age basis. There was, however, no change in the rate of deposition of fat, protein and ash relative to body weight. On restricted feeding between 21 and 42 days, SF mice showed a non-significant increase in weight gain, and hence in efficiency, of 12%. They deposited more fat than control mice during the feeding period but there was no significant difference when comparisons were made on a weight basis.A contemporary line of mice selected for post-weaning (21–42 days) weight gain on restricted feeding (SR) had significant increases of 12% in weight gain, 17% in efficiency but no significant change in food intake, when compared with its control on full feeding between 21 and 42 days. SR mice were the same weight as control mice at all ages except day 21, when they were significantly lighter due to direct genetic effects rather than maternal effects. SR mice had a lower (P<0·10) rate of fat deposition per unit body weight and became less fat relative to their control as body weight increased. The rate of deposition of other components was not altered by selection. On restricted feeding, SR had a significant increase in weight gain, and hence in efficiency, of 37%. Changes in body composition were similar to those on full feeding.It was concluded that the use of a restricted feeding regime had enabled the exploitation of heritable variation in the partitioning of energy for growth. This variation was independent of genetic variation for appetite and body weight.Overall performance at each level of feeding was best improved by selection on that feeding level. The realized genetic correlation between post-weaning weight gain on full and restricted feeding was estimated to be 0·28 ± 0·08, indicating a very different genetic basis for the same character in the two feeding environments.

scholarly journals Vitamin D and Alcohol Differentially Effect Weight Gain in Older Female Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 541-541
Author(s):  
Brandon McGuire ◽  
Azra Dees ◽  
Anna Ogilvie ◽  
Sue Shapses
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Food Intake ◽  
Glucose Tolerance ◽  
Alcohol Intake ◽  
Caloric Intake ◽  
Increase Body Weight

Abstract Objectives Serum calcidiol is inversely associated with BMI in obese individuals and murine research has shown that vitamin D deficient diets (VDD) increase body weight. Alcohol intake doesn't necessarily increase body weight despite its caloric density but has been associated with VDD. The objective of this study was to determine the effect of vitamin D deficiency with or without alcohol on body weight, body composition, glucose tolerance, and energy expenditure in seven-month-old female mice. Methods Seven-month-old female retired breeder C57BL/6J mice (n = 40) were weight-matched and randomized to one of four diets: control (normal purified AIN-93 diet), vitamin D deficient (VDD, 0 intake of vitamin D), alcohol (Alc, 10% ethanol), or vitamin D deficient and alcohol (VDD + Alc). Mice were fed ad libitum for 8 weeks. Body weight and food intake were recorded weekly and body composition was measured at baseline and final time points using EchoMRI. Glucose tolerance and energy expenditure (EE) were assessed by an oral glucose tolerance test (OGTT) and Oxymax/CLAMS unit at week 8. Results Body weight at baseline was 27.4 ± 1.8 g and did not differ between groups. Mice drinking alcohol had a decreased food intake (p &lt; 0.001). When liquid calories were accounted for, total caloric intake did not differ between groups. Weight gain throughout the study increased more in the VDD groups (p &lt; 0.05). Increases in weight were 0.81 ± 2.9, 0.82 ± 2.0, 2.0 ± 1.7, and 3.6 ± 2.9 g, in the control, Alc, VDD, and VDD + Alc groups, respectively (p &lt; 0.05). Lean body mass was also increased due to VDD (p &lt; 0.05). The total fat mass did not differ significantly between groups, however, VDD groups gained more fat mass over time (p &lt; 0.05). Two-way ANOVA showed an interaction between vitamin D and alcohol for EE (p &lt; 0.05). Positive incremental area under the curve (IAUC) for blood glucose was decreased due to alcohol intake (p &lt; 0.05). Conclusions In conclusion, alcohol intake decreased blood glucose and food intake, but there was no effect on total caloric intake, body weight or body composition. VDD led to greater increases in body weight and soft tissue compartments compared to other groups that were not explained by caloric intake or EE. Understanding mechanisms that are causing excess weight gain due to VDD is currently a focus in the lab. Funding Sources USDA-NIFA (NJAES).

scholarly journals Influence of High and Low Saturated Fatty Acid-Based Diets on Weight and Body Composition of Albino Rats (Rattusnorvegicus)

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Abere DV
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Fatty Acid ◽  
Weight Gain ◽  
Food Intake ◽  
Saturated Fatty Acid ◽  
Body Weight Gain ◽  
Control Diet ◽  
Balance Model ◽  
Albino Rats

The study investigated the effect of feeding high and low saturated fatty acid based diets to feed female albino rats (Rattusnorvegicus) with a view to evaluating the effects of the fatty diets on the feeding patterns, weight and body composition of the rats. Seven months old female Rattus norvegicus were used for the experiment. The weights of the rats were taken for twelve weeks using Salter balance (Model 250). Four experimental diets were formulated which were made up of 2.5 and 5.0 g of margarine (blue band), 2.5 and 5.0 g canola oil each mixed with the basal diet. The control diet was grower feed and the resultant experimental diets were fed to the experimental rats kept in cages at the rate of 12 rats per cage. The rats were fed with the diets at the rate of 3% of body weight for a period of twelve weeks. The highest weight gain was recorded in the group fed with 5.0 g margarine, followed by 5.0 g canola, 2.5 g margarine, 2.5 g canola and least in the rats fed the control.The mean weight gain of the rats fed with 5.0 g margarine and 5.0 g canola were significantly different (p<0.05) from the mean weight of 2.5 g margarine, 2.5 g canola and the control. The food intake of the rats fed 5.0 g margarine and 5.0 g canola was also significantly different (p<0.05) from the food intake of rats fed 2.5 g margarine, 2.5 g canola and the control. The proximate composition of the carcass of the rats fed the different experimental diets showed that fat content of the rats fed 5.0 g margarine was higher than in the rats fed the other diets. The histology of the liver of rats fed 5.0 g margarine and 5.0 g canola showed greater fat accumulation in the rat’s liver compared to rats fed 2.5 g margarine, 2.5 g canola as well as the control. Rats with the highest body weight gain were considered obesity-prone; those with the lowest body weight were regarded as obesity-resistant while others were considered intermediate. The study concluded that the kind of fat consumed contributes to the weight gained by the rats.

Fat deposition in Hereford and Friesian steers: 3. Growth efficiency and fat mobilization

1983 ◽  
Vol 100 (2) ◽  
pp. 277-284 ◽  
Author(s):  
T. G. Truscott ◽  
J. D. Wood ◽  
N. G. Gregory ◽  
I. C. Hart
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Plasma Concentrations ◽  
Growth Efficiency ◽  
Hormonal Control ◽  
The Body ◽  
Food Utilization ◽  
Body Type ◽  
Maintenance Requirement ◽  
Fat Mobilization

SUMMARYFood utilization in relation to growth of body components, and fat mobilization and its hormonal control in vivo, were examined in 15 Hereford and 15 Friesian steers which were slaughtered at 20 months of age. Changes in body composition between 6 and 20 months were calculated from the body composition of these animals and from an additional four and two steers from each breed slaughtered at 6 and 13 months of age, respectively.The Friesians consumed more food overall (14%) and grew more rapidly (14%), but their intake in relation to metabolic body weight was not different from that of the Herefords. Although the Friesians deposited more protein in relation to lipid there was no breed difference in food conversion ratio, and maintenance requirement relative to empty-body weight0·75 was estimated to be 7% greater in the Friesians than the Herefords. Friesians therefore had a lower efficiency of conversion of food energy to body energy. It is speculated that the higher maintenance requirement of the Friesians was due to a faster rate of protein deposition and a higher proportion of visceral organs with an associated higher rate of protein turnover.Changes in plasma concentrations of free fatty acids (FFA), insulin, growth hormone (GH), adrenaline and noradrenaline were examined in response to fasting at 12 and 20 months of age. Inaddition plasma concentrations of glucose, thyroxine (T4) and triiodothyronine (T3) were measured at 20 months of age.At both ages, FFA concentration increased almost linearly with duration of fasting and was not different between breeds. It was therefore unrelated to fat partitioning and a poor index of breed differences in metabolic and body type. Within breeds, the rate at which FFA concentration increased during fasting was correlated with estimated maintenance requirement (r = 0·53). This suggests a different relationship between FFA utilization and maintenance requirement in the two breeds.During fasting at 12 months of age, Friesians had higher concentrations of plasma GH and noradrenaline. At 20 months of age they had higher concentiations of glucose, insulin and catecholamines. There was no obvious hormonal explanation for the observed differences in body composition or growth efficiency. Correlations between indices of fat partitioning and maintenance requirement were low, suggesting no direct link between the two traits.

Food Intake, Body Weight Gain, and Body Composition of the Young Obese (ob/ob) Mouse

1977 ◽  
Vol 107 (9) ◽  
pp. 1715-1723 ◽  
Author(s):  
Pi-Yao Lin ◽  
Dale R. Romsos ◽  
Gilbert A. Leveille
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain

Food efficiency in relation to estimated growth of body components in cattle

1975 ◽  
Vol 20 (3) ◽  
pp. 315-335 ◽  
Author(s):  
L. S. Monteiro
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Linear Model ◽  
Unit Weight ◽  
Fat Percentage ◽  
Non Linear ◽  
The Difference ◽  
Maintenance Requirements

SUMMARYA model is proposed to establish a functional relationship between food intake, weight gain and body composition during growth, based on the differential energy requirements for fat, fat-free tissues and contents of the digestive tract. If constant specific nutrient requirements are assumed for fat and fat-free tissues, these requirements can be directly estimated from changes in food intake and body composition during growth. By introducing an allometric function relating changes in fat-free tissue to changes in body weight, the model is extended to include situations where direct measures of body composition are not available. This enabled the model to be fitted to data on food intake, body weight and growth rate up to 2 years of age in Friesians and Jerseys fed ad libitum on a complete diet. The nonlinear model is contrasted with a linear relationship where food intake i s related to body weight and weight gain. The linear model was unable to account for the changes in food intake over the whole period of growth. The non-linear model allowed a gradual decline n i maintenance requirements per unit weight and indicated an increase in the net conversion coefficient of food into gain, consistent with an increase from early to late growth in proportion of fat deposited.For the period studied the Jerseys were less efficient in transforming food into weight gain than Friesians. On the non-linear model, about half of the difference was attributable to the higher metabolic rate per unit weight of Jerseys, the remainder to poorer utilization of nutrients for weight gain. If, as the model indicated the conversion coefficients of food into body constituents were the same in the two breeds, the difference in efficiency may be attributable to a higher proportion of fat in the overall gain of Jerseys. The pattern of estimated fat deposition also differed in the two breeds with Jerseys appearing to be less mature in fat percentage at all stages.

Food intake, growth and body composition in Australian Merino sheep selected for high and low weaning weight. 1. Food intake, food efficiency and growth

1985 ◽  
Vol 40 (1) ◽  
pp. 55-70 ◽  
Author(s):  
J. M. Thompson ◽  
J. R. Parks ◽  
Diana Perry
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Conversion Efficiency ◽  
Growth Curves ◽  
Growth Efficiency ◽  
Food Conversion ◽  
Weaning Weight ◽  
Regular Oscillation ◽  
Selection For ◽  
Food Conversion Efficiency

ABSTRACTChanges in the pattern of food intake, food conversion efficiency and growth from weaning to maturity, were examined in 35 rams and ewes from flocks of Merino sheep selected for high (weight-plus) and low (weight-minus) weaning weight and from a randomly bred control flock. The sheep were individually fed a pelleted ration ad libitum for at least 72 weeks and up to 90 weeks post weaning. Weekly food intake was described as an increasing exponential function of age with a linearly declining asymptote, about which a regular oscillation occurred, and weekly body-weight gain was described as an increasing exponential function of weekly food intake, about which a regular oscillation also occurred.The oscillations in weekly food intake had a period of about 52 weeks and appeared to be largely associated with seasonal variations in temperature, with an increased food intake during winter and a decreased food intake during summer. The oscillations in both the food-intake and body-weight functions were of similar phase and period and it was suggested that the body-weight oscillations were due to variation in gut-fill, a result of the seasonal oscillations in food intake.Selection for weaning weight changed the shape and magnitude of the food-intake curve, with the weight-plus having a greater rate of food intake (i.e. appetite) in the early stages of growth and a greater asymptote than the weight-minus animals. Selection for high and low weaning weight also resulted in an increase and a decrease in mature weight. Both strains had a similar growth efficiency, although when calculated as gross food conversion efficiency the weight-plus were higher than the weight-minus animals at the same body weight, whereas there was no difference between strains at the same age.The rams had both a higher asymptote and a slower rate of decline in food intake than the ewes. Rams had a higher mature weight than the ewes, although ewes had a slightly greater growth efficiency. However, when calculated as gross food conversion efficiency, ewes tended to be lower than rams, when compared either at the same age, or at the same body weight.When the food-intake curves were standardized for differences in mature size, strain differences in the magnitude of the food-intake curves were reduced, although differences in the shape were still apparent. Shape differences in the food-intake curves were reflected in the shape of the standardized growth curves, with the weight-plus maturing at a faster rate than the weight-minus animals. There was little difference between the sexes in the initial shape of the food-intake curve, although at later ages ewes had a lower food intake than rams. There was little difference between the sexes in the shape of the standardized growth curves.

MAINTENANCE ENERGY REQUIREMENT OF THE ROOSTER AND INFLUENCE OF PLANE OF NUTRITION ON METABOLIZABLE ENERGY

1970 ◽  
Vol 50 (2) ◽  
pp. 363-369 ◽  
Author(s):  
J. GUILLAUME ◽  
J. D. SUMMERS
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Energy Requirement ◽  
Metabolizable Energy ◽  
Maintenance Energy ◽  
Maintenance Requirement ◽  
Average Value ◽  
Maintenance Energy Requirement ◽  
Energy Maintenance

Arnould’s method can be applied to the adult rooster to estimate the energy maintenance requirement, although estimation of the weight gain requirement is inaccurate with this method. The average value obtained of 117 kcal metabolizable energy per kg body weight per day for maintenance requirement agrees well with previously reported estimates but is higher than values reported for the laying hen. Maintenance requirement for energy appears to be very variable, the coefficient of variation being 13% which equals that found for basal metabolism. Maintenance requirement is correlated neither with body weight nor with endogenous N excretion. It is concluded that metabolic and endogenous energy should be taken into account for correcting metabolizable energy values when food intake is close to maintenance requirement, especially with adult birds.

Influence of selection for body weight at different ages on growth of Turkeys

1963 ◽  
Vol 4 (1) ◽  
pp. 71-82 ◽  
Author(s):  
H. Abplanalp ◽  
F. X. Ogasawara ◽  
V. S. Asmundson
Keyword(s):  
Body Weight ◽  
Different Ages ◽  
Selection For
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