scholarly journals Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

2011 ◽  
Vol 14 (5) ◽  
pp. 882-888 ◽  
Author(s):  
Barbara J Stewart-Knox ◽  
Gordon Rae ◽  
Ellen EA Simpson ◽  
Chris McConville ◽  
Jacqueline O’Connor ◽  
...  
Keyword(s):  
Negative Affect ◽  
Older People ◽  
Intervention Study ◽  
Controlled Trial ◽  
Positive And Negative Affect ◽  
Age Group ◽  
Post Intervention ◽  
Double Blind ◽  
Zinc Gluconate ◽  
Older Europeans

AbstractObjectiveOlder people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans.SubjectsHealthy volunteers (n 387) aged 55–87 years were recruited.SettingVolunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70–87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55–70 years.DesignMood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention.ResultsMixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55–70 years or the ≥70 years age group.ConclusionsThese results suggest that zinc does not benefit mood in healthy older people.

scholarly journals Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial

2021 ◽  
Author(s):  
Michael Berk ◽  
Bruno Agustini ◽  
Robyn L. Woods ◽  
Mark R. Nelson ◽  
Raj C. Shah ◽  
...  
Keyword(s):  
Older People ◽  
Controlled Trial ◽  
Double Blind ◽  
Term Management

scholarly journals Improving Mental Performance in an Athletic Population with the Use of Ārepa®, a Blackcurrant Based Nootropic Drink: A Randomized Control Trial

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 316
Author(s):  
Natalie Gibson ◽  
Dane Baker ◽  
Alice Sharples ◽  
Andrea Braakhuis
Keyword(s):  
Controlled Trial ◽  
Training Session ◽  
Rugby League ◽  
Pine Bark ◽  
Post Intervention ◽  
Double Blind ◽  
Dietary Polyphenols ◽  
Bioactive Ingredients ◽  
Post Trial ◽  
And Control

A range of dietary bioactive ingredients have claimed to improve mental clarity and reduce fatigue, including blackcurrant, pine bark, and l-theanine. These active ingredients provide a good source of dietary polyphenols which could be useful in reducing mental fatigue in a sports setting. The aim of the investigation was to test the effect of Ārepa® a blackcurrant-based nootropic-drink also containing pine-bark and l-theanine (BC+), on mental clarity in a sport setting. Twenty-three rugby league players completed a cross-over design, randomized, double-blind, controlled trial. Intervention and control phases lasted 7 days, with a washout in between. Cognition was assessed pre and post intervention following a standardized training session. Our study found the total score, accuracy, and average time per response scores improved significantly more after drinking the BC+ drink (p = 0.001, 0.003, and 0.043 respectively). The BC+ improved the perception that participants were reliable (p = 0.02) and less distracted (p = 0.03), while placebo supplementation increased participant perception they could control their nervousness (p = 0.03). Thematic analysis of post-trial questionnaire indicated participants found the BC+ sour, most reported no side effects, and opinion on which drink was more effective was not unanimous. The results indicate that the BC+ drink may be useful for athletes.

scholarly journals Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants

2020 ◽  
Vol 124 (4) ◽  
pp. 374-385
Author(s):  
Fiona C. Malcomson ◽  
Naomi D. Willis ◽  
Iain McCallum ◽  
Long Xie ◽  
Arthur C. Ouwehand ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Resistant Starch ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
Rectal Mucosa ◽  
Crypt Cell ◽  
Post Intervention ◽  
Double Blind ◽  
Healthy Participants

AbstractThere is strong evidence that foods containing dietary fibre protect against colorectal cancer, resulting at least in part from its anti-proliferative properties. This study aimed to investigate the effects of supplementation with two non-digestible carbohydrates, resistant starch (RS) and polydextrose (PD), on crypt cell proliferative state (CCPS) in the macroscopically normal rectal mucosa of healthy individuals. We also investigated relationships between expression of regulators of apoptosis and of the cell cycle on markers of CCPS. Seventy-five healthy participants were supplemented with RS and/or PD or placebo for 50 d in a 2 × 2 factorial design in a randomised, double-blind, placebo-controlled trial (the Dietary Intervention, Stem cells and Colorectal Cancer (DISC) Study). CCPS was assessed, and the expression of regulators of the cell cycle and of apoptosis was measured by quantitative PCR in rectal mucosal biopsies. SCFA concentrations were quantified in faecal samples collected pre- and post-intervention. Supplementation with RS increased the total number of mitotic cells within the crypt by 60 % (P = 0·001) compared with placebo. This effect was limited to older participants (aged ≥50 years). No other differences were observed for the treatments with PD or RS as compared with their respective controls. PD did not influence any of the measured variables. RS, however, increased cell proliferation in the crypts of the macroscopically-normal rectum of older adults. Our findings suggest that the effects of RS on CCPS are not only dose, type of RS and health status-specific but are also influenced by age.

scholarly journals A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa

2008 ◽  
Vol 11 (12) ◽  
pp. 1397-1406 ◽  
Author(s):  
Karen E Charlton ◽  
Krisela Steyn ◽  
Naomi S Levitt ◽  
Nasheeta Peer ◽  
Deborah Jonathan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
South African ◽  
Controlled Trial ◽  
Control Diet ◽  
Diet Group ◽  
Post Intervention ◽  
Intervention Effect ◽  
Double Blind ◽  
Cation Content ◽  
The Impact

AbstractObjectiveTo assess the impact of a food-based intervention on blood pressure (BP) in free-living South African men and women aged 50–75 years, with drug-treated mild-to-moderate hypertension.MethodsA double-blind controlled trial was undertaken in eighty drug-treated mild-to-moderate hypertensive subjects randomised to an intervention (n40) or control (n40) arm. The intervention was 8-week provision of six food items with a modified cation content (salt replacement (SOLO™), bread, margarine, stock cubes, soup mix and a flavour enhancer) and 500 ml of maas (fermented milk)/d. The control diet provided the same quantities of the targeted foods but of standard commercial composition and 500 ml/d of artificially sweetened cooldrink.FindingsThe intervention effect estimated as the contrast of the within-diet group changes in BP from baseline to post-intervention was a significant reduction of 6·2 mmHg (95 % CI 0·9, 11·4) for systolic BP. The largest intervention effect in 24 h BP was for wake systolic BP with a reduction of 5·1 mmHg (95 % CI 0·4, 9·9). For wake diastolic BP the reduction was 2·7 mmHg (95 % CI −0·2, 5·6).ConclusionsModification of the cation content of a limited number of commonly consumed foods lowers BP by a clinically significant magnitude in treated South African hypertensive patients of low socio-economic status. The magnitude of BP reduction provides motivation for a public health strategy that could be adopted through lobbying of the food industry by consumer and health agencies.

scholarly journals Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial

2005 ◽  
Vol 34 (3) ◽  
pp. 256-261 ◽  
Author(s):  
Marion E. T. McMurdo ◽  
Linda Y. Bissett ◽  
Rosemary J. G. Price ◽  
Gabby Phillips ◽  
Iain K. Crombie
Keyword(s):  
Urinary Tract ◽  
Older People ◽  
Urinary Tract Infections ◽  
Controlled Trial ◽  
Cranberry Juice ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Tract Infections

scholarly journals Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: A double-blind, randomized, placebo-controlled trial

2020 ◽  
Author(s):  
Hadi Bazyar ◽  
Ahmad Zare Javid ◽  
Hossein Bavi Behbahani ◽  
Fardin Moradi ◽  
Bahman Moradi Poode ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Intervention Group ◽  
Control Group ◽  
Post Intervention ◽  
Anthropometric Indices ◽  
Double Blind ◽  
Conicity Index

Abstract Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for eight weeks. Mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHR) were evaluated in all the patients pre- and post-intervention.Results: Melatonin supplementation for eight weeks significantly decreased the mean levels of MAP, PP, weight, BMI, WC, HC, BAI, AVI, conicity index, and WHR post-intervention (p<0.05). Also, the median changes of MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p<0.05). A significant increase (p<0.001) was observed in the mean levels of ABSI in the intervention group. The median changes of ABSI were significantly greater in the intervention group compared with the control group (p<0.001).Conclusions: Consumption of melatonin supplement may be effective in controlling arterial pressure and anthropometric indices (as predictors of obesity) in T2DM patients.Trial registration: This trial was registered in the Iranian Registry of Clinical Trials website at 2019/5/17. (IRCT20190303042905N1).

scholarly journals Improving executive, behavioural and socio-emotional competences in very preterm young adolescents through a mindfulness-based intervention: study protocol and feasibility

2021 ◽  
Author(s):  
Vanessa Siffredi ◽  
Maria Chiara Liverani ◽  
Mariana Magnus Smith ◽  
Djalel Eddine Meskaldji ◽  
Françoise Stuckelberger-Grobéty ◽  
...  
Keyword(s):  
Study Protocol ◽  
Intervention Study ◽  
Controlled Trial ◽  
Emotional Difficulties ◽  
Young Adolescents ◽  
Attendance Rate ◽  
Post Intervention ◽  
Very Preterm ◽  
Link Type ◽  
Randomised Controlled

ABSTRACTBackground(VPT) children and adolescents exhibit executive, behavioural and socio-emotional difficulties that persists into adulthood. Previous research suggests that mindfulness-based intervention (MBI) may specifically target the development of theses competences. The objective of the current study is to describe the study protocol and to evaluate the feasibility of a clinical trial on a MBI program to enhance executive, behavioural and socio-emotional competences in a cohort of VPT young adolescents.Methods164 VPT young adolescents from 10 to 14 years old, born before 32 gestational weeks, were invited to participate in an MBI program of 8 weekly sessions in groups of up to 8 participants, lasting 1h30. Participant were enrolled in a randomised controlled trial (RCT) or in a pre-post intervention designs depending of their availability. Satisfaction and attendance measures of the MBI were collected using self-reported questionnaires and registration of attendance.ResultsOf the 63 participants who were enrolled in the study (38.2% of families invited to participate), 52 (82.5%) completed all assessments. Once enrolled, acceptability was high as shown by the high attendance rate in the sessions and the feedback evaluation questionnaire.DiscussionTo our knowledge, this is the first study to investigate the feasibility of an MBI study in VPT born young adolescents. Our findings suggest that an MBI study is feasible and show a high acceptability among participants. The use of an RCT design in our study constitutes the gold standard for testing the efficacy of such intervention in VPT young adolescents. If effective, the MBI program could potentially be a valuable tool for improving executive, behaviour and socio-emotional competences in the vulnerable VPT population.Trial registrationClinicalTrials, NCT04638101. Registered 19 November 2020 - Retrospectively registered, https://clinicaltrials.gov/show/NCT04638101.

scholarly journals The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3037 ◽  
Author(s):  
Anna I. Petridou ◽  
Eleftheria T. Zagora ◽  
Petros Petridis ◽  
George S. Korres ◽  
Maria Gazouli ◽  
...  
Keyword(s):  
Oxidized Ldl ◽  
Controlled Trial ◽  
Controlled Clinical Trial ◽  
Antioxidant Compounds ◽  
Antioxidant Supplementation ◽  
Post Intervention ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Antioxidant ◽  
Post Measure

Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The objective of the present study was to assess the effects of antioxidant supplementation in tinnitus patients. This is a randomized, double-blind, placebo-controlled clinical trial. Patients (N = 70) were randomly allocated to antioxidant supplementation (N = 35) or to placebo (N = 35) for a total of 3 months. Demographic, anthropometric, clinical, and nutritional data were collected. Serum total antioxidant capacity (TAC), oxidized LDL (oxLDL), and superoxide dismutase (SOD), tinnitus loudness, frequency, and minimum masking level (MML), and scores in Tinnitus Handicap Inventory questionnaire (THI), Tinnitus Functional Index (TFI), and Visual Analogue Scale (VAS) were evaluated at baseline and follow-up. Tinnitus loudness and MML significantly decreased from baseline to post measure (p < 0.001) only in the antioxidant group, the overall change being significantly different between the two groups post-intervention (p < 0.001). THI and VAS decreased only in the antioxidant group. Differences in changes in serum TAC, SOD, and oxLDL post-intervention were insignificant. In conclusion, antioxidant therapy seems to reduce the subjective discomfort and tinnitus intensity in tinnitus patients.

Effect of Zinc Supplementation on Observed Activity in Low Socioeconomic Indian Preschool Children

PEDIATRICS ◽  
1996 ◽  
Vol 98 (6) ◽  
pp. 1132-1137
Author(s):  
Sunil Sazawal ◽  
Margaret Bentley ◽  
Robert E. Black ◽  
Pratibha Dhingra ◽  
Sherly George ◽  
...  
Keyword(s):  
Preschool Children ◽  
Zinc Supplementation ◽  
Controlled Trial ◽  
Control Group ◽  
Activity Levels ◽  
Double Blind ◽  
Activity Increase ◽  
Zinc Gluconate ◽  
Low Socioeconomic ◽  
Activity Rating

Objectives. To investigate whether supplementation of zinc in preschool children is associated with improvement in observed activity levels. Methods. On 2 consecutive days, we performed 5-hour observations with momentary time sampling (instant activity every 10 minutes) in children selected from an ongoing double-blind, randomized trial of zinc supplementation. The study was conducted in Kalkaji, a low-socioeconomic urban population of New Delhi with high diarrheal incidence and rates of malnutrition. A total of 93 children (48 zinc and 45 control) 12 to 23 months of age from an ongoing community-based, randomized, controlled trial received supplements for at least 1 month before study; 71% had received supplementation for more than 120 days. Zinc gluconate (10 mg of elemental zinc) was given daily, with both zinc and control groups receiving vitamins A, B1, B2, B6, D3, and E and niacinamide in addition. Results. Outcomes were percentages of time spent in each of five activity levels and two groups representing high and low movement and overall rating by two activity scores. Children in the zinc group spent 72% more time performing activities in the high-movement group. Among the zinc-supplemented children, the activity rating by the children's activity rating score was 12% higher and by the energy expenditure score was 8.3% higher than in the control group. Conclusions. In conclusion, zinc supplementation, given along with selected vitamins, was associated with significantly greater activity levels in children. The relationship between the activity increase and locomotor development needs to be investigated, as do the long-term implications of zinc supplementation in terms of developmental status and school performance.

Sign in / Sign up

Export Citation Format

Share Document