North-South Differences in some Indices of Vitamin B6 Nutritional Status in Older British People

1999 ◽  
Vol 69 (6) ◽  
pp. 371-377 ◽  
Author(s):  
Pentieva ◽  
Bates ◽  
Prentice ◽  
Cole
Keyword(s):  
Alcohol Consumption ◽  
Older People ◽  
Pyridoxal Phosphate ◽  
Disease Risk ◽  
Economic Status ◽  
Plasma Concentrations ◽  
Vitamin B ◽  
Nutrition Survey ◽  
The North ◽  
Explanatory Factors

The National Diet and Nutrition Survey, nationally representative for the British population aged 65 years and over, has revealed a north-south geographical gradient, with a decline from south to north of vitamin B6 status indices. The present study further explores the possible explanatory factors (dietary intake of vitamin B6 and riboflavin, alcohol consumption, smoking habits and some other lifestyle determinants) on the difference of vitamin B6 indices – plasma concentrations of pyridoxal phosphate (pPLP) and pyridoxic acid (pPA), between older people living in the north (Scotland, North of England) and the south (Southern England, Wales and Midlands). The results showed that older people living in the northern half of Britain are at greater risk of poor vitamin B6 status, mainly as a result of low intakes of this vitamin, than the people living in the southern half of the country. Riboflavin intake, alcohol consumption, smoking and socio-economic status also correlated with the north-south gradient of pPLP and pPA. Other potential determinants such as use of vitamin B6 supplements, medicines probably affecting vitamin B6 metabolism, were not independent correlates of the north-south gradient in vitamin B6 status indices. This may have important implications for disease-risk geographical gradients in the UK.

scholarly journals Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over

1999 ◽  
Vol 81 (3) ◽  
pp. 191-201 ◽  
Author(s):  
C. J. Bates ◽  
K. D. Pentieva ◽  
A. Prentice ◽  
M. A. Mansoor ◽  
S. Finch
Keyword(s):  
Older People ◽  
Regression Model ◽  
Pyridoxal Phosphate ◽  
Disease Risk ◽  
Public Health Problem ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Phase Reaction ◽  
Nutrition Survey ◽  
Men And Women

Concentrations of pyridoxal phosphate and pyridoxic acid were measured in fasting plasma samples from British men and women aged 65 years and over, participating in a National Diet and Nutrition Survey during 1994–5, selected to be representative of the population of mainland Britain. In this population, the concentration of pyridoxal phosphate declined, whereas pyridoxic acid rose, with increasing age and frailty; however, both status indicators were strongly and directly (with a positive coefficient) correlated with estimates of vitamin B6intake. This was little affected by the inclusion of food energy and protein intakes in the model. Forty-eight percent of the participants living in the community and 75% of those living in institutions had plasma pyridoxal phosphate concentrations below a range considered normal from other studies. In a univariate regression model, plasma pyridoxal phosphate concentrations were inversely correlated with plasma homocysteine concentrations, consistent with the hypothesis that vitamin B6status may influence plasma homocysteine levels, and hence vascular disease risk. However, this relationship was partly attenuated in a multiple regression model including age, sex, domicile and biochemical status indices, including those of folate and vitamin B12. There was evidence that plasma pyridoxal phosphate was sensitive to metabolic conditions associated with inflammation and the acute-phase reaction, and that plasma pyridoxic acid was sensitive to renal function. Thus, neither index is an ideal predictor of vitamin B6status in older people, unless these confounding factors are allowed for. Since poor vitamin B6status may have health implications, e.g. for immune function, cognition, and for essential intermediary metabolic pathways in older people, it needs to be investigated as a possible public health problem.

scholarly journals Biochemical risk indices, including plasma homocysteine, that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of People Aged 65 Years and Over

2010 ◽  
Vol 104 (6) ◽  
pp. 893-899 ◽  
Author(s):  
Christopher J. Bates ◽  
Mohammed A. Mansoor ◽  
Kristina D. Pentieva ◽  
Mark Hamer ◽  
Gita D. Mishra
Keyword(s):  
Pyridoxal Phosphate ◽  
Disease Risk ◽  
Plasma Concentrations ◽  
Total Mortality ◽  
Serum Folate ◽  
Baseline Survey ◽  
Vitamin B ◽  
Nutrition Survey ◽  
Risk Predictors ◽  
Vascular Mortality

Predictive power, for total and vascular mortality, of selected indices measured at baseline in the British National Diet and Nutrition Survey (community-living subset) of People Aged 65 Years and Over was tested. Mortality status and its primary and underlying causes were recorded for 1100 (mean age 76·7 (sd7·5) years, 50·2 % females) respondents from the baseline survey in 1994–5 until September 2008. Follow-up data analyses focussed especially on known predictors of vascular disease risk, together with intakes and status indices of selected nutrients known to affect, or to be affected by, these predictors. Total mortality was significantly predicted by hazard ratios of baseline plasma concentrations (persd) of total homocysteine (tHcy) (95 % CI) 1·19 (1·11, 1·27), pyridoxal phosphate 0·90 (0·81, 1·00), pyridoxic acid 1·10 (1·03, 1·19), α1-antichymotrypsin 1·21 (1·13, 1·29), fibrinogen 1·14 (1·05, 1·23), creatinine 1·20 (1·10, 1·31) and glycosylated Hb 1·23 (1·14, 1·32), and by dietary intakes of energy 0·87 (0·80, 0·96) and protein 0·86 (0·77, 0·97). Prediction patterns and significance were similar for primary-cause vascular mortality. The traditional risk predictors plasma total and HDL cholesterol were not significant mortality predictors in this age group, nor were the known tHcy-regulating nutrients, folate and vitamin B12(intakes and status indices). Model adjustment for known risk predictors resulted in the loss of significance for some of the afore-mentioned indices; however, tHcy 1·34 (1·04, 1·73) remained a significant predictor for vascular mortality. Thus, total and primary vascular mortality is predicted by energy and protein intakes, and by biochemical indices including tHcy, independent of serum folate or vitamin B12.

scholarly journals Relationship between alcohol and nutrient intakes and blood status indices of older people living in the UK: further analysis of data from the National Diet and Nutrition Survey of people aged 65 years and over, 1994/5

1998 ◽  
Vol 1 (3) ◽  
pp. 157-167 ◽  
Author(s):  
CM Walmsley ◽  
CJ Bates ◽  
A Prentice ◽  
TJ Cole
Keyword(s):  
Alcohol Consumption ◽  
Older People ◽  
Total Energy ◽  
Grip Strength ◽  
Pyridoxal Phosphate ◽  
Nutrient Intakes ◽  
Nutrition Survey ◽  
Cross Sectional Survey ◽  
Blood Concentrations ◽  
Heavy Alcohol

AbstractObjective:To examine the relationships between alcohol consumption and a range of nutrient intakes and blood status indices in older people.Design:National Diet and Nutrition Survey: cross-sectional survey of nationally representative sample of people aged 65 years or over.Setting:Mainland Britain during 1994/5.Subjects:1198 people (623 males, 575 females) aged 65 years or over, of whom 925 were living in private households and 273 were living in institutions.Results:Intermediate alcohol consumption (particularly 0.1–14 units week−1; 1 unit = 8g) derived from a 4-day diet diary or a 12-month recall questionnaire, was associated with higher intakes of vitamins C, E, B1, iron, calcium, energy from food, carbohydrate and non-starch polysaccharides than heavy alcohol consumption (28 + units week−1) or abstinence, after adjustment for a number of factors (age, sex, domicile, social class, cigarette smoking, self-reported health, grip strength and total energy intake). Intermediate alcohol consumption was also associated with higher blood concentrations (independent of intake) of vitamin C, β-cryptoxanthin, lutein and calcium, with the lowest concentrations being found in heavy alcohol users. The lowest concentrations of serum ferritin were found in light drinkers and the highest levels in heavier alcohol drinkers. Alcohol consumption ranging from 0.1 to > 28 units week−1 was directly correlated with intakes of B vitamins, total energy and fat, with blood concentrations (independent of intake) of lycopene. high density lipoprotein (HDL)-cholesterol, plasma pyridoxal phosphate and retinol, and with blood pressure and grip strength.Conclusions:Compared with abstinence and heavy drinking, light to moderate alcohol consumption in older people is associated with higher intakes of certain nutrients, and higher blood concentrations (independent of intake) of some micronutrient status indices, including antioxidants. The explanation for the latter associations remains unclear and further investigation is recommended. Heavier alcohol consumption is associated with both beneficial and adverse effects with respect to nutrient intakes and health status.

scholarly journals Relationship between cigarette smoking and nutrient intakes and blood status indices of older people living in the UK: further analysis of data from the National Diet and Nutrition Survey of people aged 65 years and over, 1994/95

1999 ◽  
Vol 2 (2) ◽  
pp. 199-208 ◽  
Author(s):  
CM Walmsley ◽  
CJ Bates ◽  
A Prentice ◽  
TJ Cole
Keyword(s):  
Cigarette Smoking ◽  
Older People ◽  
Pyridoxal Phosphate ◽  
Serum Folate ◽  
Plasma Vitamin ◽  
Nutrient Intakes ◽  
Nutrition Survey ◽  
Cross Sectional Survey ◽  
Micronutrient Status ◽  
Increased Risk

AbstractObjectivesTo examine the relationship between cigarette smoking and a range of nutrient intakes and blood status indices in older people.DesignNational Diet and Nutrition Survey: cross-sectional survey of nationally representative sample of people aged 65 years and over.SettingMainland Britain during 1994/95.Subjects1191 people (619 male, 572 female) aged 65 years and over, of whom 920 were living in private households and 271 were living in institutions.ResultsCigarette smoking was inversely correlated with intakes of antioxidants and other micronutrients after adjustment for age, sex and domicile. Cigarette smoking was also inversely correlated with a number of antioxidant micronutrient status indices including plasma vitamin C and the carotenoids (but not vitamin E status indices), and with other micronutrient status indices, including plasma pyridoxal phosphate, red cell and serum folate, after adjustment for age, sex, domicile and the corresponding nutrient intake. Previous cigarette smoking or cigar/pipe smoking was not generally associated with lower nutrient intakes or status indices, however, both current and previous cigarette smoking was associated with increased concentrations of acute phase indicators. Further adjustment for total energy intake and/or sociodemographic, health and drug usage variables attenuated only a few of the associations observed.ConclusionOlder people who smoke cigarettes are at increased risk of suboptimal antioxidant and other micronutrient intakes and status, but the lower intakes found in cigarette smokers only partly explain their reduced blood indices.

scholarly journals High alcohol consumption in Germany: results of the German National Health Interview and Examination Survey 1998

2004 ◽  
Vol 7 (7) ◽  
pp. 879-884 ◽  
Author(s):  
Martina Burger ◽  
Gert BM Mensink
Keyword(s):  
Alcohol Consumption ◽  
National Health ◽  
Healthy Adult ◽  
Eating Habits ◽  
Economic Status ◽  
Adult Population ◽  
Adult Women ◽  
Nutrition Survey ◽  
Health Interview ◽  
Increased Risk

AbstractObjective:To analyse the alcohol consumption behaviour of the German adult population, with a focus on the characteristics of persons drinking more than the tolerable upper alcohol intake level (TUAL) of 10–12 g day−1 for healthy adult women and 20–24 g day−1 for healthy adult men.Design and setting: For the German National Health Interview and Examination Survey 1998, a representative sample of free-living adults was drawn. A total of 7124 participants were interviewed comprehensively about their sociodemographic background, lifestyle and eating habits including alcohol consumption.Subjects:A sub-sample of 4030 women and men, 18–79 years old, who were involved in the integrated German Nutrition Survey.Results:About 16% of women and 31% of men had mean alcohol consumption above the TUAL. Among other factors, the inclination to exceed the TUAL was related to middle-age, high socio-economic status, smoking and use of soft drugs. Among both women and men, a high proportion of persons drinking above the TUAL was observed among those consuming low amounts of soft drinks, fruit, poultry, milk products, bread and cake/biscuits. Women preferred to drink wine, whereas men preferred to drink beer.Conclusions:Many Germans have an alcohol consumption level above the TUAL and thus are supposed to be at increased risk for alcohol-associated diseases.

scholarly journals Association between alcohol consumption and dietary supplement intake of students from the University of Sarajevo

2019 ◽  
Author(s):  
Nafija Serdarević ◽  
Arzija Pašalić ◽  
Eldina Smječanin ◽  
Vedran Đido ◽  
Refet Gojak ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Economic Status ◽  
Cost Effective ◽  
Vitamin B ◽  
Chi Square ◽  
Drinking Habits ◽  
The University ◽  
Supplement Intake

Introduction: Dietary supplements are an important source of vitamins and minerals that may help prevent several disease-causing biological pathways involved in one-carbon metabolism, including the suppression of cell proliferation, oxidative stress, nitric oxide synthesis, and angiogenesis. The present study aimed to assess the association between the intake of folate, Vitamin B6, Vitamin B12, and minerals and the consumption of alcohol among university students. Methods: This study was participated by students aged 19-22 years from the University of Sarajevo between 2017 and 2018. Using a questionnaire, we interviewed in a week them to collect information regarding age, socio-economic status, alcohol consumption, and dietary supplement intake. Then, we investigated the association between the baseline intake of folate, B vitamins, and minerals and that of alcohol consumption. Results: Most students consumed Vitamin B supplements (32%) and folic acid (10%). Dietary multivitamins and minerals were less prevalent in more than a year, accounting for 186 (23.9%) and 174 (24.3%) students, respectively, than those in less than a year. In a year, <20% of students consumed multivitamins 129 (16.6%) and minerals 116 (15.3%). Meanwhile, 256 (27.1%) students consumed alcohol. The Chi-square test of independence showed that drinking habits and the intake of such dietary supplements had no association (p > 0.05). Conclusion: An extremely low percentage of the participating students in Canton Sarajevo used dietary supplements of Vitamin B, folate, multivitamins, and minerals. Moreover, alcohol consumption and dietary supplement intake were not associated. Further research is needed to establish the best cost-effective public health system to achieve a sufficient intake of dietary supplements.

scholarly journals Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of Young People Aged 4–18 Years, and a comparison with the Survey of People Aged 65 Years and Over

2002 ◽  
Vol 87 (1) ◽  
pp. 71-79 ◽  
Author(s):  
C. J. Bates ◽  
M. A. Mansoor ◽  
Jan Gregory ◽  
Kristina Pentieva ◽  
Ann Prentice
Keyword(s):  
Young People ◽  
Disease Risk ◽  
Serum Vitamin ◽  
Public Health Intervention ◽  
Serum Folate ◽  
Vitamin B ◽  
Nutrition Survey ◽  
Vitamin Status ◽  
Risk Indices ◽  
B Vitamin

Plasma total homocysteine (tHcy), cysteine and cysteinyl-glycine were measured in a representative sample of 922 young people aged 4–18 years, participating in the National Diet and Nutrition Survey in mainland Britain in 1997. Both tHcy and cysteine increased markedly with age; cysteinyl-glycine less so. Neither tHcy nor cysteine differed between genders; cysteinyl-glycine was higher in males. tHcy concentrations were lowest in the winter; cysteine and cysteinyl-glycine varied only slightly with season. In respondents aged >15 years, tHcy was higher in smokers, but in respondents aged 7–11 years, tHcy was higher in those whose mothers smoked. tHcy was inversely correlated with serum folate, serum vitamin B12and vitamin B6status, but neither cysteine nor cysteinyl-glycine shared these relationships. The relationships between tHcy and B-vitamin status indices ran parallel with those of the 65 years and over survey, but at much lower tHcy concentrations for any given B-vitamin concentration. Age-adjusted tHcy was not correlated with anthropometric indices, blood pressure, haematology, plasma creatinine, urea or cholesterol, but was directly correlated with fasting triacylglycerol. We conclude that disease-risk indices, like tHcy and perhaps cysteine, if established during early life, may be modulated by diet and lifestyle, thereby providing an opportunity for public health intervention.

scholarly journals North–south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

2012 ◽  
Vol 110 (2) ◽  
pp. 363-374 ◽  
Author(s):  
Simone J. P. M. Eussen ◽  
Roy M. Nilsen ◽  
Øivind Midttun ◽  
Steinar Hustad ◽  
Noortje IJssennagger ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Central Europe ◽  
Plasma Concentrations ◽  
B Vitamins ◽  
Northern Europe ◽  
Vitamin B ◽  
Southern Europe ◽  
European Regions ◽  
The North ◽  
Prospective Investigation

Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10·4 nmol/l; women, 10·7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north–south gradient. Vitamin B2 concentrations were highest in Northern Europe (men, 22·2 nmol/l; women, 26·0 nmol/l) and decreased towards Southern Europe (Ptrend< 0·001). Vitamin B6 concentrations were highest in Central Europe in men (77·3 nmol/l) and highest in the North among women (70·4 nmol/l), with decreasing concentrations towards Southern Europe in women (Ptrend< 0·001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.

Tryptophan metabolism and vitamin B6 nutritional status in patients with schistosomiasis mansoni and in infected mice

Parasitology ◽  
1992 ◽  
Vol 104 (3) ◽  
pp. 433-441 ◽  
Author(s):  
E. N. M. Njagi ◽  
D. A. Bender ◽  
G. B. A. Okelo
Keyword(s):  
Vitamin B6 ◽  
Pyridoxal Phosphate ◽  
Reference Range ◽  
Plasma Concentrations ◽  
Test Dose ◽  
Tryptophan Metabolism ◽  
Vitamin B ◽  
Abnormal Response ◽  
Hydroxyindoleacetic Acid ◽  
Activation Coefficient

Patients infected with Schistosoma mansoni showed an abnormal response to a test dose of tryptophan, with little increase in the urinary excretion of kynurenine, hydroxykynurenine, xanthurenic and kynurenic acids, N1-methyl nicotinamide, methyl pyridone carboxamide, 5-hydroxytryptamine or 5-hydroxyindoleacetic acid. In contrast to previous reports, this is different from the pattern of tryptophan metabolism seen in vitamin B6 deficiency. Furthermore, the patients' plasma concentrations of pyridoxal phosphate were within the reference range, and supplementation for 5 days with 20 mg vitamin B6/day did not affect tryptophan metabolism. Treatment with a single dose of Praziquantel resulted in a substantial restoration of normal tryptophan metabolism. In mice infected with S. mansoni there was a similar impairment of tryptophan metabolism, as shown by considerably reduced formation of 14CO2 after the administration of a tracer dose of [14C]tryptophan. Again, the administration of vitamin B6 supplements did not correct tryptophan metabolism in the mice. Treatment with Praziquantel resulted in substantial restoration of the production of 14CO2 from [14C]tryptophan. There was no evidence of vitamin B6 deficiency (as determined by erythrocyte aspartate aminotransferase activation coefficient) associated with infection in the mice, although there was a redistribution of pyridoxal phosphate between tissues, with a reduction in the concentration of liver, spleen and kidney, and an increase in skeletal muscle.

Economic Status of Older People

1954 ◽  
Vol 27 (2) ◽  
pp. 119
Author(s):  
John R. Stark
Keyword(s):  
Older People ◽  
Economic Status
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