Cocoa and unripe banana flour beverages improve anthropometric and biochemical markers in overweight women: A randomised double-blind study

2020 ◽  
pp. 1-10
Author(s):  
Fernanda Laurides Ribeiro de Oliveira Lomeu ◽  
Camilla Ribeiro Vieira ◽  
Flávia Della Lucia ◽  
Sandra Maria Oliveira Moraes Veiga ◽  
Hércia Stampini Duarte Martino ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Total Cholesterol ◽  
Dietary Fiber ◽  
Biochemical Markers ◽  
Double Blind Study ◽  
Fat Percentage ◽  
Double Blind ◽  
Overweight Women ◽  
Banana Flour ◽  
Unripe Banana Flour

Abstract. Objectives: The objective of this study was to evaluate the effect of a functional cocoa and unripe banana flour (UBF) beverage intake on the anthropometric and biochemical markers of overweight women. Methods: This prospective, double-blinded, randomized clinical trial involved 60 female volunteers aged between 20 and 50 years. One group received a cocoa beverage (n = 30) and one group received a cocoa and UBF beverage (n = 30), for 6 weeks. The cocoa beverage showed 3.07 total g dietary fiber/serving and 29.55 mg gallic acid equivalentes/portion (GAE/portion). Cocoa and UBF beverage contained 8.48% resistant starch by weight, 4.37 g dietary fiber/full portion and 69.24 mg GAE/portion. Weight, waist circumference, hip circumference, glucose, triglycerides, total cholesterol and fractions were evaluated. Results: The UBF and cocoa beverage reduced waist circumference (−2.03 cm, P < 0.001) and the cocoa beverage reduced total cholesterol (−19.3 mg/dL, P < 0.001) and the LDL/HDL ratio (−0.32, P < 0.001); in addition, both beverages promoted the reduction of body fat percentage (−1.98%, P = 0.001 and −1.15%, P < 0.001 Cocoa/UPF group and Cocoa group respectively). Conclusion: The additional dietary fiber did not further improve health status.

scholarly journals Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2051 ◽  
Author(s):  
Bruna M. Giglio ◽  
Raquel M. Schincaglia ◽  
Alexandre S. da Silva ◽  
Ieda C. S. Fazani ◽  
Paula A. Monteiro ◽  
...  
Keyword(s):  
Body Composition ◽  
Dietary Intake ◽  
Whey Protein ◽  
Total Protein ◽  
Protein Supplementation ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Overweight Women ◽  
Android Fat

Protein supplements are usually used to control body weight, however, the impact of protein quality on body fat attenuation is unknown. We investigated the effects of isocaloric isoproteic supplementation of either whey protein (WG) or hydrolysed collagen supplementation (CG) on dietary intake, adiposity and biochemical markers in overweight women. Methods: In this randomized double-blind study, 37 women, [mean ± SE, age 40.6 ± 1.7 year; BMI (kg/m2) 30.9 ± 0.6], consumed sachets containing 40 g/day of concentrated whey protein (25 g total protein, 2.4 leucine, 1.0 valine, 1.5 isoleucine, n = 17) or 38 g/day of hydrolysed collagen (26 g total protein, 1.02 leucine, 0.91 valine, 0.53 isoleucine, n = 20) in the afternoon snack. The compliance was set at >70% of the total theoretical doses. The dietary intake was evaluated by a 6-day food record questionnaire. At the beginning and after eight weeks of follow-up, body composition was evaluated by using dual-energy X-ray absorptiometry and lipid profile, insulin resistance, C-reactive protein, adiponectin, leptin and nesfastin plasma concentrations were analyzed. Results: Supplements were isocaloric and isoproteic. There were no differences in caloric intake (p = 0.103), protein (p = 0.085), carbohydrate (p = 0.797) and lipids (p = 0.109) intakes. The branched chain amino acids (BCAA) (GC: 1.8 ± 0.1 g vs. WG: 5.5 ± 0.3 g, p < 0.001) and leucine intake (CG: 0.1 ± 0.1 g vs. WG: 2.6 ± 0.1 g, p < 0.001) were higher in WG compared to CG. BMI increased in the CG (0.2 ± 1.1 kg/m2, p = 0.044) but did not change in WG. WG decreased the android fat (−0.1 ± 0.3 kg, p = 0.031) and increased nesfatin concentrations (4.9 ± 3.2 ng/mL, p = 0.014) compared to CG. Conclusions: Whey protein supplementation in overweight women increased nesfatin concentrations and could promote increase of resting metabolic rate as part of body composition improvement programs compared to collagen supplementation for 8 weeks. Additionally, our findings suggest that collagen may not be an effective supplement for overweight women who are attempting to alter body composition.

scholarly journals Effect of Unripe Banana Flour on Gut-Derived Uremic Toxins in Individuals Undergoing Peritoneal Dialysis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 646
Author(s):  
Laila Santos de Andrade ◽  
Fabiana Andréa Hoffmann Sardá ◽  
Natalia Barros Ferreira Pereira ◽  
Renata Rodrigues Teixeira ◽  
Silvia Daniéle Rodrigues ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Crossover Trial ◽  
Serum Levels ◽  
Total Serum ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Waxy Corn Starch ◽  
Banana Flour ◽  
Secondary Outcomes ◽  
Unripe Banana Flour

In chronic kidney disease (CKD), the accumulation of gut-derived metabolites, such as indoxyl sulfate (IS), p-cresyl sulfate (pCS), and indole 3-acetic acid (IAA), has been associated with the burden of the disease. In this context, prebiotics emerge as a strategy to mitigate the accumulation of such compounds, by modulating the gut microbiota and production of their metabolites. The aim of this study was to evaluate the effect of unripe banana flour (UBF—48% resistant starch, a prebiotic) on serum concentrations of IS, pCS, and IAA in individuals undergoing peritoneal dialysis (PD). A randomized, double-blind, placebo-controlled, crossover trial was conducted. Forty-three individuals on PD were randomized to sequential treatment with UBF (21 g/day) and placebo (waxy corn starch—12 g/day) for 4 weeks, or vice versa (4-week washout). The primary outcomes were total and free serum levels of IS, pCS, and IAA. Secondary outcomes were 24 h urine excretion and dialysis removal of IS, pCS, and IAA, serum inflammatory markers [high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α)], serum lipopolysaccharide LPS, and dietary intake. Of the 43 individuals randomized, 26 completed the follow-up (age = 55 ± 12 years; 53.8% men). UBF did not promote changes in serum levels of IS (p = 0.70), pCS (p = 0.70), and IAA (p = 0.74). Total serum IS reduction was observed in a subgroup of participants (n = 11; placebo: median 79.5 μmol/L (31–142) versus UBF: 62.5 μmol/L (31–133), p = 0.009) who had a daily UBF intake closer to that proposed in the study. No changes were observed in other secondary outcomes. UBF did not promote changes in serum levels of IS or pCS and IAA; a decrease in IS was only found in the subgroup of participants who were able to take 21g/day of the UBF.

scholarly journals The Effect of Ergogenic Supplements and Mediterranean Diet on Cycling Performance. Differences According to Duration and Intensity.

2017 ◽  
Vol 2 (1) ◽  
pp. 23
Author(s):  
Sousana Papadopoulou ◽  
Elpiniki Kroustalloudi ◽  
Ioannis Pagkalos ◽  
Anna Kokkinopoulou ◽  
Maria Hassapidou
Keyword(s):  
Time Trial ◽  
Bioelectrical Impedance ◽  
Energy Drinks ◽  
Ergogenic Aids ◽  
Double Blind Study ◽  
Fat Percentage ◽  
Caffeine Consumption ◽  
Double Blind ◽  
Supplement Use ◽  
Validated Questionnaire

Aims: To record the prevalence and the type of supplement use among cyclists and to estimate the effect of caffeine, carbohydrates, energy drinks and meddiet score on 200m and 4km cycling time-trial performances in a Greek sample.Methods: Fifty male cycling athletes aged 32±20 years participated in a randomized, double-blind study. The subjects were submitted to anthropometric measurements and body composition was assessed with bioelectrical impedance. All participants completed the meddiet Score questionnaire and a validated questionnaire about their ergogenic aids’ preference. The athletes performed two cycling trials (200m and 4km) and their records were taken down and were evaluated according to their consumption of caffeine, carbohydrates and energy drinks and their meddiet score. For the statistical analysis SPSS, v20 was used.Results: Greek cyclists had a mean BMI value of 23.65±2.74 and a mean body fat percentage of 15.82±8.33. Endurance and speed performances were improved with caffeine consumption when compared to no consumption (7.42±3.92min vs 12.5±3.16min, p<0.001 and 20.75±15.69sec vs 34.07±16.25sec, p<0.05, respectively), as well as with energy drinks’ consumption (8.77±4.15min vs 13.25±2.47min, p<0.001 and 20.35±14.08sec vs 39.14±14.38sec, p<0.001, respectively). Carbohydrates’ intake improved performance in the endurance test (7.60±3.72min vs 12.86±2.92min, p<0.001), but did not have a positive influence in the speed test (25.73±18.68sec vs 33.08±15.95sec, p>0.05).Conclusions: Ergogenic aids had a positive effect on the athletic performance in terms of speed and endurance in cyclists. 

scholarly journals Differences of lipid profile, body fat percentage, and waist circumference between childbearing age women acceptors of depot medroxy progesterone acetate contraceptive injection with non-acceptors in Padang City 2017

2019 ◽  
Vol 7 (3) ◽  
pp. 800
Author(s):  
Utami Ariyasra ◽  
Mohamad Reza ◽  
Dessy Arisanty ◽  
Nur Indrawaty Lipoeto
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Childbearing Age ◽  
Significant Difference

Background: A hormonal contraception which considered ideal is depot medroxy progesteron acetat. There are large number of acceptors choose this contraception because this contraception is considered safe, effective, and can be used after labor. The possible side effect which can occur are increase of lipid profile, body fat percentage, and waist circumference. The purpose of this study is to see the differences between lipid profile, body fat percentage, and the waist circumference of women of childbearing age who use depot medroxy progesteron acetat injection compared with non-acceptors.Methods: This study was observational study with a cross sectional comparative approach and was conducted at the Regional Technical Services Unit (UPTD) at Regional Health Laboratory in West Sumatera Province from December 2017 until June 2018. The samples were 46 DMPA acceptors and 46 non-acceptors. The sampling method used random sampling technique. The measurements of lipid profile was conducted with colorimetric enzymatic method, which is GPO-PAP for triglycerides, and CHOD-PAP for total cholesterol, HDL and LDL. The percentage of body fat examination was conducted using Bioelectrical Impedance Analysis (BIA). The obtained data were analyzed by using t-test. Abnormal data were confirmed by Mann-whitney non-parametric test with p<0.05.Results: The results showed a significant difference between DMPA acceptors and non-acceptors (p<0.05). In total cholesterol (p = 0.000), LDL (p = 0.000), triglycerides (p = 0.000), body fat percentage (p = 0.007), body mass index (p = 0.004), and waist circumference (p = 0.001). But, in HDL there was no significant difference between DMPA acceptors and non-acceptors with p value = 0.302 (p>0.05). There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and the circumference of waist in both DMPA acceptors and non acceptors. There were no significant difference in HDL levels between DMPA acceptors and non acceptors.Conclusions: There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and waist circumference between DMPA acceptors and non-acceptors. There was no significant difference in HDL between DMPA acceptors and non-acceptors.

scholarly journals The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3298
Author(s):  
Mariangela Rondanelli ◽  
Antonella Riva ◽  
Giovanna Petrangolini ◽  
Pietro Allegrini ◽  
Luisa Bernardinelli ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Total Cholesterol ◽  
Multiple Testing ◽  
Protein A ◽  
Density Lipoprotein ◽  
Metabolic Parameters ◽  
Lipoprotein Cholesterol ◽  
Metabolic Effects ◽  
Multiple Testing Correction ◽  
Double Blind

Impaired fasting glucose (IFG) is a condition that precedes diabetes and increases the risk of developing it. Studies support the hypoglycemic effect of Cynarascolymus (Cs) extracts due to the content of chlorogenic acid, which is a potent inhibitor of glucose 6-phosphate translocase and of dicaffeoylquinic acid derivatives that modulate the activity of alpha-glucosidase. Given this background, we investigated whether a new highly standardized Cs extract could improve glycemic control, insulin sensitivity and other metabolic parameters (total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) Triglycerides, Apolipo protein B (ApoB), Apolipo protein A (ApoA), waist circumference, visceral adipose tissue (VAT) by dual-energy X-ray absorptiometry (DXA) in overweight subjects with newly diagnosed IFG. Fifty-four subjects (females/males 26/28, mean ± SD age 51.5 ± 6.2) were randomly assigned to the supplemented group (n = 27) and placebo (n = 27). After multiple testing correction, statistically significant interactions between time and group were observed for the primary endpoint glycemia (β = 0.36, p < 0.0001) and for the secondary endpoints HDL (β = −0.10, p < 0.0001), total cholesterol/HDL (β = 0.27, p < 0.0001), LDL (β = 0.15, p = 0.005), LDL/HDL (β = 0.23, p = 0.001), insulin (β = 1.28, p = 0.04), glycated hemoglobin (β = 0.21, p = 0.0002), A1c-derived average glucose (β = 0.34, p = 0.0002), ApoB (β = 6.00, p = 0.01), ApoA (β = −4.50, p = 0.04), ApoB/ApoA (β = 0.08, p = 0.003), waist circumference (β = 1.89, p = 0.05), VATβ = 222.37, p = 0.005). In conclusion, these results confirm that Cs supplementation has a significant effect on metabolic parameters in IFG patients.

scholarly journals 100 Olanzapine/Samidorphan for Schizophrenia: Weight Gain and Metabolic Outcomes in Phase 3 ENLIGHTEN-2 and Subsequent Long-Term, Open-Label Safety Study

CNS Spectrums ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 265-265
Author(s):  
Christoph U. Correll ◽  
John W. Newcomer ◽  
Bernard Silverman ◽  
Lauren DiPetrillo ◽  
Christine Graham ◽  
...  
Keyword(s):  
Weight Gain ◽  
Waist Circumference ◽  
Metabolic Parameters ◽  
Opioid Antagonist ◽  
Metabolic Parameter ◽  
Double Blind Study ◽  
Open Label ◽  
Phase 3 ◽  
Double Blind

Abstract:Background:Opioid antagonists may mitigate medication-associated weight gain and/or metabolic dysregulation. ENLIGHTEN-2 evaluated a combination of olanzapine and the opioid antagonist samidorphan (OLZ/SAM) vs olanzapine for effects on weight gain and metabolic parameters over 24 weeks in adults with stable schizophrenia.METHODS:This phase 3, double-blind study (ClinicalTrials.gov: NCT02694328) enrolled adults 18–55 yo with stable schizophrenia, randomized 1:1 to once-daily OLZ/SAM or olanzapine. Co-primary endpoints were percent change from baseline in body weight and proportion of patients with ≥10% weight gain at week 24. Waist circumference and fasting metabolic parameters were also measured. Completers could enter a 52-week open-label safety extension.RESULTS:561 patients were randomized: 550 were dosed, 538 had ≥1 post-baseline weight assessment, and 352 (64%) completed; 10.9% discontinued due to AEs. At week 24, least squares mean (SE) percent weight change from baseline was 4.21 (0.68)% with OLZ/SAM and 6.59 (0.67)% with olanzapine (difference, −2.38 [0.76]%; P=0.003). Fewer patients treated with OLZ/SAM (17.8%) had ≥10% weight gain vs olanzapine (29.8%; odds ratio=0.50; P=0.003). The change from baseline in waist circumference was significantly smaller with OLZ/SAM (P<0.001). Common AEs (≥10%) with OLZ/SAM and olanzapine were weight increased (24.8%, 36.2%), somnolence (21.2%, 18.1%), dry mouth (12.8%, 8.0%), and increased appetite (10.9%, 12.3%), respectively. Metabolic parameter changes were generally small and remained stable with long-term OLZ/SAM treatment.DISCUSSION:OLZ/SAM treatment limited weight gain associated with olanzapine. Metabolic parameter changes were generally small, similar between groups over 24 weeks, and remained stable over an additional 52 weeks of open-label OLZ/SAM treatment.Funding Acknowledgements:This study was funded by Alkermes, Inc.

Clinical application of a cocoa and unripe banana flour beverage for overweight women with abdominal obesity: Prospective, double-blinded and randomized clinical trial

2017 ◽  
Vol 41 (3) ◽  
pp. e12372 ◽  
Author(s):  
Camilla Ribeiro Vieira ◽  
Fernanda Laurides Ribeiro de Oliveira Lomeu ◽  
Maria Eliza de Castro Moreira ◽  
Hércia Stampini Duarte Martino ◽  
Roberta Ribeiro Silva
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Clinical Application ◽  
Abdominal Obesity ◽  
Overweight Women ◽  
Banana Flour ◽  
Unripe Banana Flour ◽  
Double Blinded

scholarly journals Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects

2006 ◽  
Vol 95 (5) ◽  
pp. 968-975 ◽  
Author(s):  
A. Greyling ◽  
C De Witt ◽  
W Oosthuizen ◽  
J. C. Jerling
Keyword(s):  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Specific Effect ◽  
Double Blind Study ◽  
Lipid Levels ◽  
Primary Alcohols ◽  
Double Blind ◽  
Beneficial Effects ◽  
Plant Sources

Policosanol is a mixture of higher aliphatic primary alcohols that is extracted from purified sugar cane wax or a variety of other plant sources, and has been shown to have beneficial effects on serum lipid concentrations. The objective of this study was to investigate the effects of a policosanol supplement (Octa-60) on lipid profiles of hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Nineteen hypercholesterolaemic and familial hypercholesterolaemic subjects completed this randomised, placebo-controlled, double-blind study. The subjects received either a daily dose of 20 mg policosanol or placebo for 12 weeks. After a wash-out period of 4 weeks, the interventions were crossed over. Lipid levels were measured at baseline and at the end of each intervention period. No significant differences in total cholesterol and LDL-cholesterol from baseline to end or between policosanol and placebo were seen in the hypercholesterolaemic or familial hypercholesterolaemic groups. There were small reductions in total cholesterol and LDL-cholesterol from baseline to end in the hypercholesterolaemic group, but these changes did not differ significantly from the changes with the placebo, indicating that the observed decrease in cholesterol in the policosanol group was not due to the specific effect of policosanol treatment. The differences in response may be ascribed to the differences in composition of the higher aliphatic primary alcohols in the previously used products, compared with the local policosanol supplement. An intake of 20 mg/d policosanol for 12 weeks had no significant effect on serum lipid levels in hypercholesterolaemic and heterozygous familial hypercholesterolaemic patients when compared with placebo intake.

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