Speaking of Education: Postdoctoral leaning draws broad interest

1993 ◽  
Author(s):  
Joanne E. Callan
Keyword(s):  
Broad Interest

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

scholarly journals Odd Willis coupling induced by broken time-reversal symmetry

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li Quan ◽  
Simon Yves ◽  
Yugui Peng ◽  
Hussein Esfahlani ◽  
Andrea Alù
Keyword(s):  
Time Reversal ◽  
Time Reversal Symmetry ◽  
Acoustic Metamaterials ◽  
Asymmetric Structures ◽  
Sound Control ◽  
Wavefront Shaping ◽  
Scattering Response ◽  
Symmetric Structures ◽  
Signal Routing ◽  
Broad Interest

AbstractWhen sound interacts with geometrically asymmetric structures, it experiences coupling between pressure and particle velocity, known as Willis coupling. While in most instances this phenomenon is perturbative in nature, tailored asymmetries combined with resonances can largely enhance it, enabling exotic acoustic phenomena. In these systems, Willis coupling obeys reciprocity, imposing an even symmetry of the Willis coefficients with respect to time reversal and the impinging wave vector, which translates into stringent constraints on the overall scattering response. In this work, we introduce and experimentally observe a dual form of acoustic Willis coupling, arising in geometrically symmetric structures when time-reversal symmetry is broken, for which the pressure-velocity coupling is purely odd-symmetric. We derive the conditions to maximize this effect, we experimentally verify it in a symmetric subwavelength scatterer biased by angular momentum, and we demonstrate the opportunities for sound scattering enabled by odd Willis coupling. Our study opens directions for acoustic metamaterials, with direct implications for sound control, non-reciprocal scattering, wavefront shaping and signal routing, of broad interest also for nano-optics, photonics, elasto-dynamics, and mechanics.

Insights Into Crowding Effects on Protein Stability From a Coarse-Grained Model

2009 ◽  
Vol 131 (7) ◽  
Author(s):  
Vincent K. Shen ◽  
Jason K. Cheung ◽  
Jeffrey R. Errington ◽  
Thomas M. Truskett
Keyword(s):  
Protein Stability ◽  
Coarse Grained ◽  
Protein Solutions ◽  
Native State ◽  
High Concentration ◽  
Coarse Grained Model ◽  
Excluded Volume Effects ◽  
Thermodynamic Phase ◽  
Broad Interest ◽  
Liquid Liquid Phase Separation

Proteins aggregate and precipitate from high concentration solutions in a wide variety of problems of natural and technological interest. Consequently, there is a broad interest in developing new ways to model the thermodynamic and kinetic aspects of protein stability in these crowded cellular or solution environments. We use a coarse-grained modeling approach to study the effects of different crowding agents on the conformational equilibria of proteins and the thermodynamic phase behavior of their solutions. At low to moderate protein concentrations, we find that crowding species can either stabilize or destabilize the native state, depending on the strength of their attractive interaction with the proteins. At high protein concentrations, crowders tend to stabilize the native state due to excluded volume effects, irrespective of the strength of the crowder-protein attraction. Crowding agents reduce the tendency of protein solutions to undergo a liquid-liquid phase separation driven by strong protein-protein attractions. The aforementioned equilibrium trends represent, to our knowledge, the first simulation predictions for how the properties of crowding species impact the global thermodynamic stability of proteins and their solutions.

RUBBER RECYCLING: CHEMISTRY, PROCESSING, AND APPLICATIONS

2012 ◽  
Vol 85 (3) ◽  
pp. 408-449 ◽  
Author(s):  
Marvin Myhre ◽  
Sitisaiyidah Saiwari ◽  
Wilma Dierkes ◽  
Jacques Noordermeer
Keyword(s):  
Process Safety ◽  
Tire Industry ◽  
Ground Rubber ◽  
Rubber Surface ◽  
Rubber Recycling ◽  
Property Loss ◽  
Recycled Rubber ◽  
Cost Factors ◽  
Broad Interest ◽  
Recycled Material

ABSTRACT For both environmental and economic reasons, there is broad interest in recycling rubber and in the continued development of recycling technologies. The use of postindustrial materials is a fairly well-established and documented business. Much effort over the past decade has been put into dealing with of end-of-life tires from landfills and vacant fields. It is only in the last few years that more business opportunities for recycled rubber have come to the forefront. Reclaiming rubber has gained increasing interest, more so in Europe than in North America. In those areas, much work has been done to refine the processes used. The major form of recycled rubber is still ground rubber. This is produced either by cryogenic, ambient, or wet grinding. The material is then used neat with sulfur/curatives, binders, or cements. The binders are normally moisture curable urethanes, liquid polybutadienes, or latex to produce items such as mats, floor tiles, and carpet undercushion. Recycled rubber is still used as tire derived fuel, but less so than 10 years ago. Another outlet is as an additive to asphalt. Recycled rubber can be used in the plastics industry, for which much development is being done. Large particle size ground rubber or chips are used in civil engineering applications, landscaping, or artificial turf. In terms of applications, most use is outside of the conventional rubber industry. Cost factors are still addressed in the tire industry. As of 2012, approximately 8–10% recycled material is used in tires. The biggest obstacles to further adaption are safety factors and property loss. Better methods are needed for treating or modifying the rubber surface and for regenerating the rubber through devulcanization. Devulcanization gives the highest quality recycled material in terms of processing and properties. However, shortcomings to devulcanization are reduced process safety and odorous chemicals that are required at present.

249 Overnight heart rate variability depends on age, gender, and day of the week: a field observation using a smart bed platform

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A100-A101
Author(s):  
Shawn Barr ◽  
Kwanghyun Sohn ◽  
Gary Garcia
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Physiological Stress ◽  
Large Population ◽  
Population Level ◽  
Large Set ◽  
Sleep State ◽  
Cross Sectional ◽  
Day Of The Week ◽  
Broad Interest

Abstract Introduction Heart rate variability (HRV) is commonly used to assess the activity of the autonomic nervous system (ANS). ANS function changes, reflected in HRV, result from factors including lifestyle, aging, cardiorespiratory illnesses, sleep state, and physiological stress. Despite broad interest in HRV, few studies have established normative overnight HRV values for a large population. To better understand population level HRV changes, ecologically-valid, overnight sleep SDNN (standard deviation of all normal heartbeat intervals, lower HRV is reflected by lower SDNN) values have been analyzed for a large sample of Sleep Number 360 smart bed users. Methods Overnight SDNN values were obtained over the course of 18.2M sleep sessions from 379,225 sleepers (48 ± 14.7 sessions/user). 50.9 percent of sleepers were female. The age was normally distributed with mean ± SD of 52.8 ± 12.7 years (range 21 to 84). Heartbeat intervals used to compute SDNN were extracted from a ballistocardiogram (BCG). BCG-based HRV estimation during sleep has previously been validated against ECG-based HRV with an R-square of 0.5. Results Using a Generalized Linear Model, significant cross-sectional associations with SDNN were observed for three variables of interest: age, gender, and day-of-the-week. For sleepers under 50, SDNN declined at a rate of about 2.1 ms/year, then leveled off for sleepers aged 50-65, and increased slightly thereafter. Women under 50 displayed lower, more slowly declining, SDNN values than men, but this trend reversed for sleepers over 50. Throughout the week, SDNN values followed a U-shaped (women) or L-shaped (men) pattern, where values were highest during the weekend and lowest at mid-week. Conclusion Using a smart bed to unobtrusively measure overnight SDNN values for a large set of sleepers in an ecologically valid environment, reveals significant effects of age, gender, and day of the week on overnight SDNN. Support (if any):

The Relationship between Observable Self-Talk and Competitive Junior Tennis Players' Match Performances

1994 ◽  
Vol 16 (4) ◽  
pp. 400-415 ◽  
Author(s):  
Judy L. Van Raalte ◽  
Britten W. Brewer ◽  
Patricia M. Rivera ◽  
Albert J. Petitpas
Keyword(s):  
Sport Psychology ◽  
Descriptive Analysis ◽  
Sport Performance ◽  
Cognitive Factors ◽  
Competitive Sport ◽  
Tennis Players ◽  
Self Talk ◽  
Junior Tennis ◽  
The Relationship ◽  
Broad Interest

In sport psychology, there is broad interest in cognitive factors that affect sport performance. The purpose of this research was to examine one such factor, self-talk, in competitive sport performance. Twenty-four junior tennis players were observed during tournament matches. Their observable self-talk, gestures, and match scores were recorded. Players also described their positive, negative, and other thoughts on a postmatch questionnaire. A descriptive analysis of the self-talk and gestures that occurred during competition was generated. It was found that negative self-talk was associated with losing and that players who reported believing in the utility of self-talk won more points than players who did not. These results suggest that self-talk influences competitive sport outcomes. The importance of "believing" in self-talk and the potential motivational and detrimental effects of negative self-talk on performance are discussed.

PROTESTANTISM AND PROGRESS IN THE YEAR XII: CHARLES VILLERS'SESSAY ON THE SPIRIT AND INFLUENCE OF LUTHER'S REFORMATION(1804)

2012 ◽  
Vol 9 (2) ◽  
pp. 303-329 ◽  
Author(s):  
MICHAEL PRINTY
Keyword(s):  
French Revolution ◽  
Historical Context ◽  
Old Regime ◽  
Social Struggle ◽  
The Reformation ◽  
Relationship Of ◽  
The Relationship ◽  
Broad Interest ◽  
The French Revolution

This article examines Charles Villers'sEssay on the Spirit and Influence of Luther's Reformation(1804) in its intellectual and historical context. Exiled from France after 1792, Villers intervened in important French and German debates about the relationship of religion, history, and philosophy. The article shows how he took up a German Protestant discussion on the meaning of the Reformation that had been underway from the 1770s through the end of the century, including efforts by Kantians to seize the mantle of Protestantism for themselves. Villers's essay capitalized on a broad interest in the question of Protestantism and its meaning for modern freedom around 1800. Revisiting the formation of the narrative of Protestantism and progress reveals that it was not a logical progression from Protestant theology or religion but rather part of a specific ideological and social struggle in the wake of the French Revolution and the collapse of the Old Regime.

scholarly journals Officina medici philosophi schola est. Terapia słowami (casus Erazma z Rotterdamu)

2019 ◽  
Vol 67 (3) ◽  
pp. 7
Author(s):  
Justyna Dąbrowska-Kujko
Keyword(s):  
Early Modern ◽  
Medical Terminology ◽  
Philosophical Literature ◽  
Modern Age ◽  
Ancient Literature ◽  
The Subject ◽  
The Rich ◽  
Rhetorical Discourse ◽  
Broad Interest

The article is devoted to the relationships of rhetoric, philosophy and medicine. The first part concerns the Greek (especially sophistic) roots of dependencies occurring between these domains, processes of penetration of the medical topics into ancient literature and principles of mutual interactions. The purpose of this presentation is to show the ground and find the justification for the fact that medical terminology and medical threads are frequent in the rhetorical discourse of the early modern age, especially in humanistic philosophical literature, focused on verbal therapy and convinced of the healing dimension of the word. The case of Erasmus of Rotterdam was considered particularly interesting for these diagnoses, hence the work of this humanist has been the subject of research in this work. Therefore, attention was drawn to the rich representation of medical motifs in the works of Erasmus, the presence in the author’s texts of imaging, terminology and medical topics, broad interest in the field of medicine, which is reflected in references to Galen’s work and translation of his writings by Erasmus. The most important and the most interesting, however, turned out to be the text in which the medical nomenclature became an aesthetic and ideological component, influenced the shape of the entire discourse, its argumentative platform, influenced the persuasive fabric of the work and at the same time participated in building its philosophical pronunciation. Lingua – the apologetic work of Erasmus with clearly didactic meaning, and at the same time strongly permeated by the epideictic manners of the sophistic diatribe – belongs to this kind of writings.

scholarly journals Pedagogical Explorations of an Open- Source Architecture Paradigm in Emerging Design Technologies

2016 ◽  
Author(s):  
Kihong Ku ◽  
◽  
Christian Jordan ◽  
Jim Doerfler ◽  
◽  
...  
Keyword(s):  
Open Source ◽  
Architectural Design ◽  
Visual Programming ◽  
Participatory Culture ◽  
Learning Networks ◽  
Physical Computing ◽  
Personal Learning ◽  
Open Source Hardware ◽  
Open Source Communities ◽  
Broad Interest

Open-Source Architecture is an emerging paradigm advocating peer-to-peer collectivity, inclusiveness and participatory culture in architectural design. These conditions support a broad interest at the intersection of education, research and practice in emerging design technologies exploring formal complexity, performance, biomimicry and responsiveness. In the last decade, rich participatory, open-source communities, open-source software, and open-source hardware, created by and designed for the fields of parametric and algorithmic design, visual programming, and physical computing have emerged with resulting opportunities for change in architectural education. We discuss pedagogical approaches that introduce pathways for open-source cultures in architectural design and personal learning networks for professional development.

scholarly journals Recent Advances in Photocatalytic Transformation of Carbohydrates Into Valuable Platform Chemicals

2021 ◽  
Vol 3 ◽  
Author(s):  
Huan Chen ◽  
Kun Wan ◽  
Fangjuan Zheng ◽  
Zhuo Zhang ◽  
Hongyu Zhang ◽  
...  
Keyword(s):  
Solar Energy ◽  
Scientific Community ◽  
Value Added ◽  
Reaction Pathways ◽  
Future Perspective ◽  
Reaction Conditions ◽  
Catalytic Systems ◽  
Selective Transformation ◽  
Platform Chemicals ◽  
Broad Interest

In response to the less accessible fossil resources and deteriorating environmental problems, catalytic conversion of the abundant and renewable lignocellulosic biomass to replace fossil resources for the production of value-added chemicals and fuels is of great importance. Depolymerization of carbohydrate and its derivatives can obtain a series of C5-C6 monosaccharides (e.g., glucose and xylose) and their derived platform compounds (e.g., HMF and furfural). Selective transformation of lignocellulose using sustainable solar energy via photocatalysis has attract broad interest from a growing scientific community. The unique photogenerated reactive species (e.g., h+, e−, •OH, •O2−, and 1O2), novel reaction pathways as well as the mild reaction conditions make photocatalysis a “dream reaction.” This review is aimed to provide an overview of the up-to-date contributions achieved in the selective photocatalytic transformation of carbohydrate and its derivatives. Photocatalytic methods, properties and merits of different catalytic systems are well summarized. We then put forward future perspective and challenges in this field.

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