A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain

Increasing in ambient temperature inside the cage could lead to heat stress in broilers. This research was conducted to find out effects of heat stress on body weight gain, heterophile-lymphocite ratio and body temperature in chicken broiler. Twenty broilers aged 20 days (strain Cobb) were randomly divided into 2 groups. The first group was treated with no heat stress, the second one was caged in 33±1 0C temperature for 4 hours per day for 14 days. The results indicated that heat stress reduced body weight gain, increased body temperature, and changed behavior, but no effect on feed conversion ratio (FCR) and heterophile-lymphocyte ratio. It suggested that the heat stress caused detrimental effects on broiler chicken.

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Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle

Clinical Science ◽

10.1042/cs20200173 ◽

2020 ◽

Vol 134 (13) ◽

pp. 1659-1673

Author(s):

Anwar Khan ◽

Sherouk Fouda ◽

Ali Mahzari ◽

Stanley M.H. Chan ◽

Xiu Zhou ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Cigarette Smoking ◽

Mrna Expression ◽

Glucose Intolerance ◽

Insulin Action ◽

Insulin Signalling ◽

Body Weight Gain ◽

Hormone Sensitive Lipase ◽

Reduced Body

Abstract Cigarette smoking (CS) is known to reduce body weight and this often masks its real effect on insulin action. The present study tested the hypothesis that CS can divert lipid deposition to muscles to offset the supposed benefit of reduced body weight gain on insulin signalling in this major site for glucose tolerance (or insulin action). The study was conducted in mice exposed to chronic CS followed by either a chow (CH) diet or a high-fat (HF) diet. CS increased triglyceride (TG) levels in both plasma and muscle despite a reduced body weight gain and adiposity. CS led to glucose intolerance in CH-fed mice and they retained the glucose intolerance that was induced by the HF diet. In adipose tissue, CS increased macrophage infiltration and the mRNA expression of TNFα but suppressed the protein expression of adipose triglyceride lipase and PPARγ. While CS increased hormone-sensitive lipase and suppressed the mRNA expression of leptin, these effects were blunted in HF-fed mice. These results imply that CS impairs insulin signalling in skeletal muscle via accumulated intramuscular lipids from lipolysis and lipodystrophy of adipose tissues. This may explain why smokers may not benefit from insulin sensitising effects of reduced body weight gain.

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Clinically important body weight gain following total hip arthroplasty: a cohort study with 5-year follow-up

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2012.09.010 ◽

2013 ◽

Vol 21 (1) ◽

pp. 35-43 ◽

Cited By ~ 7

Author(s):

D.L. Riddle ◽

J.A. Singh ◽

W.S. Harmsen ◽

C.D. Schleck ◽

D.G. Lewallen

Keyword(s):

Body Weight ◽

Cohort Study ◽

Weight Gain ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Body Weight Gain ◽

Total Hip

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Effects of estradiol and progesterone on food intake, body weight, and carcass adiposity in weanling rats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1981.240.5.e499 ◽

1981 ◽

Vol 240 (5) ◽

pp. E499-E503 ◽

Cited By ~ 7

Author(s):

S. M. Schwartz ◽

G. N. Wade

Keyword(s):

Body Weight ◽

Adipose Tissue ◽

Weight Gain ◽

Food Intake ◽

Body Weight Gain ◽

Estradiol Benzoate ◽

Female Rats ◽

Reduce Food Intake ◽

Reduced Body ◽

Adipose Tissue Lipoprotein Lipase

The effects of estradiol and progesterone on food intake, body weight, carcass adiposity, and adipose tissue lipoprotein lipase (LPL) activity were investigated in weanling female rats. Treatment with estradiol benzoate (EB) reduced body weight gain in ovariectomized (OVX) weanlings as it does in adults. However, other responses to EB were attenuated or absent in weanlings. EB treatment did not reduce food intake, carcass adiposity, or adipose tissue LPL activity. This impaired responsiveness to EB may be due to decreased levels of cytoplasmic estrogen receptors in liver and adipose tissue (but not hypothalamus) in weanlings. On the other hand, responsiveness to progesterone was adultlike in weanlings. Treatment of OVX, EB-primed weanlings with progesterone increased food intake, body weight gain, and carcass adiposity. This adultlike responsiveness to progesterone was associated with adultlike levels of adipose tissue progestin receptors. However, progesterone treatment did not increase adipose tissue LPL activity in weanlings, indicating that changes in LPL activity are not necessary for progesterone-induced obesity.

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1348 Night shift work, body weight gain and obesity occurrence: preliminary results with 3 years of follow-up

10.1136/oemed-2018-icohabstracts.397 ◽

2018 ◽

Author(s):

Lap Ah Tse ◽

Zhimin Li ◽

LiuZhuo Zhang ◽

Miaomiao Sun ◽

Feng Wang

Keyword(s):

Body Weight ◽

Weight Gain ◽

Shift Work ◽

Body Weight Gain ◽

Night Shift ◽

Night Shift Work ◽

Preliminary Results

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Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility

Journal of Endocrinology ◽

10.1677/joe.1.06150 ◽

2005 ◽

Vol 186 (1) ◽

pp. 203-211 ◽

Cited By ~ 48

Author(s):

Simon Klebanov ◽

Clinton M Astle ◽

Olga DeSimone ◽

Vitaly Ablamunits ◽

David E Harrison

Keyword(s):

Body Weight ◽

Adipose Tissue ◽

Weight Gain ◽

Insulin Sensitivity ◽

Therapeutic Potential ◽

Body Weight Gain ◽

Hormone Replacement ◽

Tolerance Test ◽

Reduced Body ◽

Insulin Tolerance

Adipose tissue affects metabolism by secreting various adipokines. Lipodystropic mice benefit both from leptin replacement therapy and from transplantation of normal fat. Leptin-deficient Lepob/Lepob (ob/ob) mice can also be treated with leptin. Surprisingly, there have been no reports of successful treatment of obese ob/ob mice by transplantation of normal white adipose tissue (WAT). If WAT transplantation is ineffective in treating insulin resistance and diabetes in obese individuals, its applicability may be limited in humans as such abnormalities are usually associated with obesity. In the current study, we tested whether WAT transplantation might prevent, and even reverse, abnormalities characteristic of ob/ob mice. To assess the preventive potential, 6-week-old ob/ob mice were transplanted, subcutaneously, with gonadal fat pads from normal mice. Profound effects on multiple physiological phenotypes were achieved despite leptin levels below 25% of those in control mice. WAT from one donor reduced body weight gain, and WAT from 4 or 8 donors prevented obesity in ob/ob mice. Nonfasting insulin levels and insulin tolerance test were normalized. Corticosterone elevation was also prevented. Finally, WAT from 4 donors restored fertility in ob/ob females. The effects of WAT transplantation were long-lasting, with body weight gain suppressed for at least 40 weeks. To assess the therapeutic potential, obese 13-month-old ob/ob mice with a long history of leptin deficiency were used. Their body weight decreased by approximately 50% when transplanted with WAT from 8 donors. As in young recipients, transplantation greatly reduced nonfasting insulin, suggesting normalized insulin sensitivity. Thus, WAT transplantation was effective for both prevention and therapy. In the future, WAT transplantation may become a useful alternative to hormone replacement in treating not only lipodystropy, but also certain types of obesity.

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