scholarly journals An alternative approach to nucleic acid memory

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
George D. Dickinson ◽  
Golam Md Mortuza ◽  
William Clay ◽  
Luca Piantanida ◽  
Christopher M. Green ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Error Correction ◽  
Data Storage ◽  
Super Resolution ◽  
Information Storage ◽  
Advantages And Disadvantages ◽  
Information Density ◽  
Alternative Approach ◽  
Correction Scheme ◽  
Storage Technologies

AbstractDNA is a compelling alternative to non-volatile information storage technologies due to its information density, stability, and energy efficiency. Previous studies have used artificially synthesized DNA to store data and automated next-generation sequencing to read it back. Here, we report digital Nucleic Acid Memory (dNAM) for applications that require a limited amount of data to have high information density, redundancy, and copy number. In dNAM, data is encoded by selecting combinations of single-stranded DNA with (1) or without (0) docking-site domains. When self-assembled with scaffold DNA, staple strands form DNA origami breadboards. Information encoded into the breadboards is read by monitoring the binding of fluorescent imager probes using DNA-PAINT super-resolution microscopy. To enhance data retention, a multi-layer error correction scheme that combines fountain and bi-level parity codes is used. As a prototype, fifteen origami encoded with ‘Data is in our DNA!\n’ are analyzed. Each origami encodes unique data-droplet, index, orientation, and error-correction information. The error-correction algorithms fully recover the message when individual docking sites, or entire origami, are missing. Unlike other approaches to DNA-based data storage, reading dNAM does not require sequencing. As such, it offers an additional path to explore the advantages and disadvantages of DNA as an emerging memory material.

scholarly journals A Review of Machine Learning Algorithms for Cloud Computing Security

Electronics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1379
Author(s):  
Umer Ahmed Butt ◽  
Muhammad Mehmood ◽  
Syed Bilal Hussain Shah ◽  
Rashid Amin ◽  
M. Waqas Shaukat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cloud Computing ◽  
Data Storage ◽  
Response Times ◽  
Edge Computing ◽  
Machine Learning Algorithms ◽  
Information Storage ◽  
Future Research ◽  
Computer Algorithms ◽  
Advantages And Disadvantages

Cloud computing (CC) is on-demand accessibility of network resources, especially data storage and processing power, without special and direct management by the users. CC recently has emerged as a set of public and private datacenters that offers the client a single platform across the Internet. Edge computing is an evolving computing paradigm that brings computation and information storage nearer to the end-users to improve response times and spare transmission capacity. Mobile CC (MCC) uses distributed computing to convey applications to cell phones. However, CC and edge computing have security challenges, including vulnerability for clients and association acknowledgment, that delay the rapid adoption of computing models. Machine learning (ML) is the investigation of computer algorithms that improve naturally through experience. In this review paper, we present an analysis of CC security threats, issues, and solutions that utilized one or several ML algorithms. We review different ML algorithms that are used to overcome the cloud security issues including supervised, unsupervised, semi-supervised, and reinforcement learning. Then, we compare the performance of each technique based on their features, advantages, and disadvantages. Moreover, we enlist future research directions to secure CC models.

scholarly journals Improved read/write cost tradeoff in DNA-based data storage using LDPC codes

2019 ◽  
Author(s):  
Shubham Chandak ◽  
Kedar Tatwawadi ◽  
Billy Lau ◽  
Jay Mardia ◽  
Matthew Kubit ◽  
...  
Keyword(s):  
Error Correction ◽  
Data Storage ◽  
Coding Theory ◽  
Ldpc Code ◽  
Block Length ◽  
Synthesis Process ◽  
Sequencing Errors ◽  
Insertion And Deletion ◽  
Erasure Correction ◽  
Storage Technologies

AbstractWith the amount of data being stored increasing rapidly, there is significant interest in exploring alternative storage technologies. In this context, DNA-based storage systems can offer significantly higher storage densities (petabytes/gram) and durability (thousands of years) than current technologies. Specifically, DNA has been found to be stable over extended periods of time which has been demonstrated in the analysis of organisms long since extinct. Recent advances in DNA sequencing and synthesis pipelines have made DNA-based storage a promising candidate for the storage technology of the future.Recently, there have been multiple efforts in this direction, focusing on aspects such as error correction for synthesis/sequencing errors and erasure correction for handling missing sequences. The typical approach is to use separate codes for handling errors and erasures, but there is limited understanding of the efficiency of this framework. Furthermore, the existing techniques use short block-length codes and heavily rely on read consensus, both of which are known to be suboptimal in coding theory.In this work, we study the tradeoff between the writing and reading costs involved in DNA-based storage and propose a practical scheme to achieve an improved tradeoff between these quantities. Our scheme breaks with the traditional separation framework and instead uses a single large block-length LDPC code for both erasure and error correction. We also introduce novel techniques to handle insertion and deletion errors introduced by the synthesis process. For a range of writing costs, the proposed scheme achieves 30-40% lower reading costs than state-of-the-art techniques on experimental data obtained using array synthesis and Illumina sequencing.The code, data, and Supplementary Material is available at https://github.com/shubhamchandak94/LDPC_DNA_storage.

scholarly journals Secret messaging with endogenous chemistry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eamonn Kennedy ◽  
Joseph Geiser ◽  
Christopher E. Arcadia ◽  
Peter M. Weber ◽  
Christopher Rose ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Error Correction ◽  
Data Storage ◽  
Turbo Codes ◽  
Chemical Information ◽  
Information Density ◽  
Chemical Fingerprints ◽  
Secret Keys ◽  
Molecular Information ◽  
Analytical Tools

AbstractData encoded in molecules offers opportunities for secret messaging and extreme information density. Here, we explore how the same chemical and physical dimensions used to encode molecular information can expose molecular messages to detection and manipulation. To address these vulnerabilities, we write data using an object’s pre-existing surface chemistry in ways that are indistinguishable from the original substrate. While it is simple to embed chemical information onto common objects (covers) using routine steganographic permutation, chemically embedded covers are found to be resistant to detection by sophisticated analytical tools. Using Turbo codes for efficient digital error correction, we demonstrate recovery of secret keys hidden in the pre-existing chemistry of American one dollar bills. These demonstrations highlight ways to improve security in other molecular domains, and show how the chemical fingerprints of common objects can be harnessed for data storage and communication.

Deoxyribonucleic Acid as a Tool for Digital Information Storage: An Overview

2019 ◽  
Vol 15 (01) ◽  
pp. 1-8
Author(s):  
Ashish C Patel ◽  
C G Joshi
Keyword(s):  
Data Storage ◽  
Dna Sequences ◽  
Consensus Sequence ◽  
Random Access ◽  
Information Storage ◽  
Digital Data ◽  
Digital Information ◽  
Multiple Sequence ◽  
Digital World ◽  
Digital File

Current data storage technologies cannot keep pace longer with exponentially growing amounts of data through the extensive use of social networking photos and media, etc. The "digital world” with 4.4 zettabytes in 2013 has predicted it to reach 44 zettabytes by 2020. From the past 30 years, scientists and researchers have been trying to develop a robust way of storing data on a medium which is dense and ever-lasting and found DNA as the most promising storage medium. Unlike existing storage devices, DNA requires no maintenance, except the need to store at a cool and dark place. DNA has a small size with high density; just 1 gram of dry DNA can store about 455 exabytes of data. DNA stores the informations using four bases, viz., A, T, G, and C, while CDs, hard disks and other devices stores the information using 0’s and 1’s on the spiral tracks. In the DNA based storage, after binarization of digital file into the binary codes, encoding and decoding are important steps in DNA based storage system. Once the digital file is encoded, the next step is to synthesize arbitrary single-strand DNA sequences and that can be stored in the deep freeze until use.When there is a need for information to be recovered, it can be done using DNA sequencing. New generation sequencing (NGS) capable of producing sequences with very high throughput at a much lower cost about less than 0.1 USD for one MB of data than the first sequencing technologies. Post-sequencing processing includes alignment of all reads using multiple sequence alignment (MSA) algorithms to obtain different consensus sequences. The consensus sequence is decoded as the reversal of the encoding process. Most prior DNA data storage efforts sequenced and decoded the entire amount of stored digital information with no random access, but nowadays it has become possible to extract selective files (e.g., retrieving only required image from a collection) from a DNA pool using PCR-based random access. Various scientists successfully stored up to 110 zettabytes data in one gram of DNA. In the future, with an efficient encoding, error corrections, cheaper DNA synthesis,and sequencing, DNA based storage will become a practical solution for storage of exponentially growing digital data.

Realization of NAND FLASH Control Glueless Interface Circuit

2014 ◽  
Vol 1008-1009 ◽  
pp. 659-662
Author(s):  
Hai Ke Liu ◽  
Shun Wang ◽  
Xin Gna Kang ◽  
Jin Liang Wang
Keyword(s):  
Error Correction ◽  
Code Generation ◽  
Nand Flash ◽  
Timing Control ◽  
Interface Circuit ◽  
Advantages And Disadvantages ◽  
Operation Sequence ◽  
Control Interface

The article realization of NAND FLASH control glueless interface circuit based on FPGA,comparing the advantages and disadvantages of the NAND Flash and analysising the function of control interface circuit. The control interface circuit can correct carry out the SRAM timing-input block erase, page reads, page programming, state read instructions into the required operation sequence of NAND Flash, greatly simplifies the NAND FLASH read and write timing control. According to the ECC algorithm,the realization method of ECC check code generation,error search,error correction is described.The function of operate instructions of the NAND Flash control interface circuit designed in this paper is verified on Xillinx Spartan-3 board, and the frequency can reach 100MHz.

The development and application of new media technology in news communication industry

2021 ◽  
pp. 002072092199659
Author(s):  
Hong Guo
Keyword(s):  
New Media ◽  
Data Storage ◽  
News Media ◽  
Modern Society ◽  
Information Storage ◽  
Media Technology ◽  
Communication Industry ◽  
Media Technologies ◽  
Tv News ◽  
New Media Technologies

Many new media technologies have emerged in modern society. The application of new media technologies has impacted traditional TV news media, which not only faces great challenges, but also brings some lessons for the development of TV news media. New media technology relies on powerful information processing technology and data storage technology to develop and grow continuously. Compared with traditional news, new media technology has more powerful information storage capacity and dissemination capacity. Firstly, this paper briefly introduces the concept of new media technology, summarizes the typical characteristics of new media technology, and analyzes the existing problems in the application of new media technology in the news communication industry based on the necessity of applying new media technology. Finally, some Suggestions are put forward based on this, hoping to provide some reference for the development of news communication industry.

The Use of Mesoporous Systems for Preparation of One-Dimensional Ordered Magnetic Nanowires

2003 ◽  
Vol 788 ◽  
Author(s):  
Andrei A. Eliseev ◽  
Kirill S. Napolskii ◽  
Dmitry F. Gorozhankin ◽  
Alexei V. Lukashin ◽  
Yuri D. Tretyakov ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Data Storage ◽  
Magnetic Measurements ◽  
Decomposition Temperature ◽  
Silica Matrix ◽  
Information Storage ◽  
Molar Ratio ◽  
Magnetic Nanowires ◽  
One Dimensional ◽  
Novel Variant

ABSTRACTHere we report the synthesis and investigation of iron and iron oxide nanowire arrays using mesoporous silica as a host material. In the present work a novel variant of synthesis of ordered magnetic nanowires in the mesoporous silica matrix was suggested. The method is based on the incorporation of a hydrophobic metal compound into the hydrophobic part of silica-surfactant composite. The amount of iron intercalated into the mesoporous matrix was measured by chemical analysis. In all samples it corresponds well to with the molar ratio SiO2: Fe = 9:1. To provide crystallinity of nanowires additional thermal treatment was performed. Thus prepared nanocomposites were characterized by TEM, ED, SAXS, SANS, BET and magnetic measurements. The anisotropy parameters of nanowires were determined using two non-correlated methods: temperature dependence of magnetic susceptibility and small angle polarized neutron scattering. It was found that the particle length increases with the increasing of the decomposition temperature of the metal complex. Obviously it deals with crystallization and growth of metal particles inside the pores at a constant diameter of a single particle. For iron containing sample annealed at 375 °C (form factor of nanowire is about 40), the coercive force at room temperature was found to be 145 Oe at saturation magnetization of 1.2 emu/g, which is not far from modern information storage. It was shown that particles shape and size are in good agreement with that of the pores. Particles are uniform and well ordered in the silica matrix. Thus, the suggested method leads to one-dimensional anisotropic nanostructures which could find an application as high-density data storage magnetic media.

A Research of GIS Software Application Based on Cloud Computing

2014 ◽  
Vol 513-517 ◽  
pp. 2107-2110 ◽  
Author(s):  
Zhi Jian Diao ◽  
Song Guo
Keyword(s):  
Cloud Computing ◽  
Data Storage ◽  
Information Storage ◽  
Application Layer ◽  
Cloud Infrastructure ◽  
Network Resource ◽  
Software Application ◽  
Computing Model ◽  
Two Layer Model ◽  
Gis Software

Cloud computing is a novel network-based computing model, in which the cloud infrastructure is constructed in bottom level and provided as the support environment for the applications in upper cloud level. The combination of clouding computing and GIS can improve the performance of GIS, and it can also provide a new prospect of GIS information storage, processing and utilization. By integrating cloud computing and GIS, this paper presented a cloud computing based GIS model based on two features of cloud computing: data storage and transparent custom service. The model contains two layers: service layer and application layer. With this two-layer model, GIS can provide stable and efficient services to end users by optimized network resource allocation of underlying data and services in cloud computing.

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