scholarly journals Free l-glutamate-induced modulation in oxidative and neurochemical profile contributes to enhancement in locomotor and memory performance in male rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Saiqa Tabassum ◽  
Saara Ahmad ◽  
Syeda Madiha ◽  
Sidrah Shahzad ◽  
Zehra Batool ◽  
...  
Keyword(s):  
Memory Performance ◽  
Male Rats ◽  
Neurochemical Profile

scholarly journals Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 682
Author(s):  
Yasmina K. Mahmoud ◽  
Ahmed A. Ali ◽  
Heba M. A. Abdelrazek ◽  
Tahany Saleh Aldayel ◽  
Mohamed M. Abdel-Daim ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Histopathological Examination ◽  
Memory Performance ◽  
Elevated Serum ◽  
Corticosterone Level ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Serum Corticosterone ◽  
Group I ◽  
Ameliorative Effect

The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p < 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

scholarly journals Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

2019 ◽  
Vol 8 ◽  
pp. 1182 ◽  
Author(s):  
Solmaz Khalifeh ◽  
Mehdi Khodamoradi ◽  
Vahid Hajali ◽  
Hamed Ghazvini ◽  
Lelia Eliasy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Memory Performance ◽  
Poor Performance ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Opiate Antagonist

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

scholarly journals Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’s Diseases

2020 ◽  
Vol 10 (3) ◽  
pp. 430-436
Author(s):  
Farnoosh Berahmand ◽  
Golnoush Anoush ◽  
Mir-Jamal Hosseini ◽  
Mahdieh Anoush
Keyword(s):  
Spatial Memory ◽  
Seed Oil ◽  
Neurodegenerative Disorder ◽  
Memory Performance ◽  
Grape Seed ◽  
Treated Group ◽  
Post Treatment ◽  
Male Rats ◽  
Grape Seed Oil ◽  
Male Wistar Rats

Purpose: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, with an increasing prevalence rate, mostly related to cholinergic system. According to the difficulties and complications in management of AD, this study was carried out to evaluate the efficacy of grape seed oil (GSO) on scopolamine (Scop) induced Alzheimer’s in male rats. Methods: 64 healthy male Wistar rats received different treatments such as: normal saline (NS), donepezil (Don), Scop and GSO, according to the previously designed protocol. Morris (MWM) was applied for spatial memory tests. Right after the behavioral tests, the brains were removed and the hippocampus was separated for evaluation of acetylcholine levels as well as cell death and neuro inflammation. Results: The results of the test day indicated that the mean Q2 time was increased in both GSO test groups (P<0.05) and Don treated group (P<0.001).The spectrophotometric findings affirm that both GSO co-treatment and post-treatment were effective in augmenting brain acetylcholine levels (P<0.01 and P<0.05 respectively). The microscopic findings of Hamp;E dyed tissues confirmed the above mentioned results for different treatments except for GSO post treatment, in which the viability of cells were very low. Conclusion: The results implied that supplementation of rats with GSO caused a significant augmentation in spatial memory performance as well as acetylcholine levels and cell viability in the presence of Scop. This effect was comparable to that of Don especially when GSO was used as co-treatment.

Pretreatment with curcumin attenuates anxiety while strengthens memory performance after one short stress experience in male rats

2015 ◽  
Vol 115 ◽  
pp. 1-8 ◽  
Author(s):  
Saida Haider ◽  
Fizza Naqvi ◽  
Zehra Batool ◽  
Saiqa Tabassum ◽  
Sadia Sadir ◽  
...  
Keyword(s):  
Memory Performance ◽  
Male Rats ◽  
Stress Experience

Profound destructive effects of adolescent exposure to vincristine accompanied with some sex differences in motor and memory performance

2012 ◽  
Vol 90 (4) ◽  
pp. 379-386 ◽  
Author(s):  
Mohammad Shabani ◽  
Mohammad Hassan Larizadeh ◽  
Shahrnaz Parsania ◽  
Majid Asadi Shekaari ◽  
Nader Shahrokhi
Keyword(s):  
Motor Coordination ◽  
Cell Damage ◽  
Memory Performance ◽  
Neuronal Cell ◽  
Treated Group ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Probe Test

Vincristine, an anticancer drug, is known to induce neuronal cell damage. We have elucidated the alteration in performance of the hippocampus and cerebellum following chronic vincristine treatment (0.2 mg·(kg body mass)–1·week–1) in male and female rats. Intraperitoneal injection of vincristine in adolescent rats caused impairment of motor and cognitive behavior. In the probe test, the length of path traveled and percent swimming time for vincristine-treated rats in the correct quadrant was significantly less than for the saline-treated (control) groups. The path length and time latency at the 2nd and 3rd blocks of trials for the male vincristine-treated group was significantly higher than that for the female saline- and the vincristine-treated rats. In the rod test, vincristine exposure impaired the motor coordination in both male and female rats. Exposure to vincristine caused a significant decrease in hanging time in male rats, compared with the saline- and the vincristine-treated female rats, while there were no differences between the female vincristine-treated rats and the saline-treated rats of both sexes. The rearing frequency, total distance moved, and velocity for both male and female rats were dramatically affected by exposure to vincristine. We have observed that the hippocampal and cerebellar functions of male and female rats were profoundly affected by exposure to vincristine, especially the male rats, suggesting a sexual dimorphism in the developing central nervous system that is affected by chemicals such as anticancer drugs.

scholarly journals Effets comparés du traitement à l’alcool des rattes gestantes et allaitantes sur les performances mnésiques de leurs progénitures

2020 ◽  
Vol 14 (6) ◽  
pp. 2028-2036
Author(s):  
Prisca Joëlle Djoman Doubran ◽  
Koffi Mathias Yao ◽  
Niemtiah Ouattara
Keyword(s):  
Alcohol Consumption ◽  
Spontaneous Alternation ◽  
Memory Performance ◽  
Public Health Problem ◽  
Male Rats ◽  
Distilled Water ◽  
Consommation D’Alcool ◽  
Significant Drop ◽  
Lactating Mothers ◽  
Different Doses

La consommation d’alcool par les mères gestantes ou allaitantes est un problème de santé publique qui a un impact chez la mère et le nourrisson. Les dommages causés chez le nouveau-né peuvent affecter la mémoire. L’objectif de cette étude est de comparer les effets de la prise d’alcool par des rattes durant les périodes de la gestation et/ou de la lactation sur les performances mnésiques des ratons. De ce fait, treize (13) lots de six (6) rattes nullipares sont accouplés avec des rats mâles à raison de deux femelles pour un mâle. Elles ont ensuite reçu quotidiennement de l’eau distillée (lot 0) ou différentes doses d’alcool (0,1 ; 0,3 ; 0,5 et 0,8 g/L de sang) durant les périodes de gestation (groupes 1-4), de lactation (groupes 5-8) et du début de la gestation jusqu’à la fin de la lactation (groupes 9-12). Les performances mnésiques des ratons issus de chaque lot sont évaluées grâce à un labyrinthe en T. Les résultats ont montré que l’alcool a favorisé une baisse significative des pourcentages d’alternance spontanée des ratons (P < 0,05). Cependant, les doses de 0,5 et 0,8 g/L de sang ont les plus fortes baisses avec 26 et 30% durant la gestation, et 10 et 8% pendant l’allaitement (P < 0,0001). En conclusion, l’alcool a des effets délétères plus prononcés sur la mémoire lorsqu’il est consommé durant la période de la gestation.Mots clés : Performances mnésiques, Labyrinthe en T, Alternance spontanée.   English Title: Comparative effects of alcohol treatment of pregnant and lactating rats on the memory performance of their offspring Alcohol consumption by pregnant and lactating mothers is a public health problem that has an impact on mothers and newborn. Damage to the newborn can affect memory. The aim of this study is to compare the effects of alcohol consumption by rats during gestation and / or lactation on the memory performance of pups. Therefore, thirteen (13) lots of six (6) nulliparous rats are mated with male rats, two females for one male. They received daily distilled water (lot 0) or different doses of alcohol (0.1, 0.3, 0.5 and 0.8 g / L of blood) during gestation periods (groups 1 -4), lactation (groups 5-8) and from the start of gestation until the end of lactation (groups 9-12). The memory performance of each pup is evaluated using a T-maze. The results showed that the alcohol favored a significant drop in the percentages of spontaneous alternation of the pups (P <0.05). However, the doses of 0.5 and 0.8 g / L of blood have the largest decreases with 26 and 30% during gestation, and 10 and 8% during breastfeeding (P <0.0001). In conclusion, alcohol has more pronounced deleterious effects on memory when it is consumed during the gestation period.Keywords: Memory performance, T-maze, Spontaneous alternation  

Assessment of long-term effects of smoke from wildfires on white rats

2020 ◽  
Vol 60 (11) ◽  
pp. 720-722
Author(s):  
Elizaveta S. Andreeva
Keyword(s):  
Cognitive Abilities ◽  
Memory Performance ◽  
Recovery Period ◽  
White Male ◽  
Reproductive Function ◽  
Male Rats ◽  
Long Term Effects ◽  
Wildfire Smoke ◽  
White Rats

Introduction. The study of the effects of wildfire smoke on the reproductive function is the most important scientific problem at the present stage. The aim of study is to study the behavior and cognitive abilities of sexually mature offspring obtained from white male rats exposed to the smoke of wildfires. Materials and methods. Experiments were carried out on 30 white male rats and 60 adult male of their offspring. The duration of exposure was 4 weeks, 4 hours/day. To obtain progeny exposed males were mated with intact females immediately after the exposure and in long-term period after exposure. Examination of adult progeny was performed using the "open field", Morris water maze, and histological examination of brain tissue. Results. Behavioral and cognitive alterations in offspring of male rats exposed to wildfire smoke were obtained: significant decrease in motor activity and research on higher level of negative emotional state, impaired spatial memory performance. Individuals from offspring obtained in a long-term period after exposure to smoke showed a normalization of the studied parameters to background values. Conclusions. The long-term consequences of exposure to the smoke of wildfires were revealed, manifested in the offspring of the first generation in the form of impaired behavior and cognitive abilities. The recovery period after prolonged smoke intoxication, which is 60 days and is comparable in duration with the duration of spermatogenesis in rats, is important for reducing the risk of developing CNS disorders in offspring.

Effect of Centella asiatica Ethanol Extract in Spatial Working Memory on Adult Male Rats

2018 ◽  
Vol 24 (8) ◽  
pp. 6109-6111 ◽  
Author(s):  
Auliyani Andam Suri ◽  
Astri Handayani ◽  
Adibah Ferhad ◽  
Siti Farida ◽  
Sri Redjeki
Keyword(s):  
Working Memory ◽  
Adult Male ◽  
Wistar Rats ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Centella Asiatica ◽  
Ethanol Extract ◽  
Male Rats ◽  
Normal Adult ◽  
Male Adult

Cognitive decline can be started at early adult. It may be prevented with administration of Centella asiatica (CeA). CeA already known has some medicinal values for the brain such as to increase dendritic growth, to improve cognitive function and memory performance in rats after chronic stress. Objective: This study is aimed to investigate effect CeA ethanol extract on spatial working memory of normal adult male rats. Eighteen normal adult male Wistar rats were divided into three groups: control/aquadest group and two groups treated with different doses (mg/kg) of CeA: 300 (CeA300) and 600 (CeA600). Ethanol extract of CeA were administrated orally for 28 consecutive days with weekly weight-adjusted dose. Memory performance was tested using Y-Maze before, on 14th days of treatment and after treatment. Data were analyzed using Kruskal-Wallis test and continued with Mann-Whitney test. Result: Treatment groups showed a better spatial working memory performance than control group, but there were no significant result between CeA300 and CeA600 groups (p < 0.05). Ethanol extract of CeA prevents spatial working memory decline on normal male adult Wistar rats. The optimum dosage of CeA might be 300 mg/kg of body weight.

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