scholarly journals Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gabriele Gratton ◽  
Samuel R. Weaver ◽  
Claire V. Burley ◽  
Kathy A. Low ◽  
Edward L. Maclin ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Aging ◽  
Brain Function ◽  
Double Blind ◽  
Acute Study ◽  
Cortical Oxygenation ◽  
Cognitive Challenge ◽  
First Time ◽  
Cocoa Flavanols ◽  
Do So

AbstractCocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive. In a randomized double-blind within-subject acute study in healthy young adults, we link these two lines of research by showing, for the first time, that flavanol intake leads to faster and greater brain oxygenation responses to hypercapnia, as well as higher performance only when cognitive demand is high. Individual difference analyses further show that participants who benefit from flavanols intake during hypercapnia are also those who do so in the cognitive challenge. These data support the hypothesis that similar vascular mechanisms underlie both the peripheral and cerebral effects of flavanols. They further show the importance of studies combining physiological and graded cognitive challenges in young adults to investigate the actions of dietary flavanols on brain function.

scholarly journals Ten Years Evidence-Based High-Tech Acupuncture–A Short Review of Centrally Measured Effects (Part II)

2009 ◽  
Vol 6 (3) ◽  
pp. 305-314 ◽  
Author(s):  
Gerhard Litscher
Keyword(s):  
Brain Function ◽  
Near Infrared ◽  
Short Review ◽  
High Tech ◽  
Acupuncture Points ◽  
Double Blind ◽  
Non Invasive ◽  
Acupuncture Research ◽  
Medical University ◽  
First Time

The assessment of acupuncture-induced effects on brain function is crucial. Ultrasound-assisted brain function monitoring and bioelectrical methods as well as near infrared spectroscopic procedures and functional magnetic resonance investigations form the basis for the latest scientific examination methods for acupuncture research. The laserneedle acupuncture, which was examined scientifically for the first time in Graz, represents a new painless and non-invasive acupuncture method. In this way, individual combinations of acupuncture points can be stimulated simultaneously according to traditional Chinese medicine. In the context of double-blind studies, effects in the brain could be demonstrated in a reproducible manner for the first time. This second part of the short review article summarizes some of the centrally measured effects of acupuncture obtained at the Medical University of Graz within the last 10 years.

scholarly journals Autonomic activity during a daytime nap facilitates working memory improvement

2020 ◽  
Author(s):  
Pin-Chun Chen ◽  
Lauren N. Whitehurst ◽  
Sara C. Mednick
Keyword(s):  
Nervous System ◽  
Young Adults ◽  
Executive Functioning ◽  
Cognitive Aging ◽  
Brain Function ◽  
Parasympathetic Activity ◽  
Deep Sleep ◽  
Autonomic Activity ◽  
Cardiac Parasympathetic Activity

AbstractRecent investigations have implicated the parasympathetic branch of the autonomic nervous system (ANS) in higher-order executive functions. These actions are purported to occur through ANS’s modulation of the prefrontal cortex, with parasympathetic activity during wake associated with working memory ability (WM). Compared with wake, sleep is a period with substantially greater parasympathetic tone. Recent work has reported that sleep may also contribute to improvement in WM. Here, we examined the role of cardiac parasympathetic activity during sleep on WM improvement in healthy young adults. Participants were tested in an operation span task (OSpan) in the morning and evening, and during the inter-test period subjects either experienced a nap or wake. We measured high frequency heart rate variability (HF HRV) as an index of cardiac, parasympathetic activity during both wake and sleep. Participants showed the expected boost in parasympathetic activity during nap, compared with wake, as well as greater WM improvement after a nap compared with an equivalent period awake. Furthermore, parasympathetic activity during sleep, but not wake, was significantly correlated with WM improvement. Together these results indicate that the natural boost in parasympathetic activity during sleep has substantial benefits to gains in prefrontal executive function in young adults. We present a conceptual model illustrating the interaction between sleep, autonomic activity, and prefrontal brain function, and highlight open research questions that will facilitate understanding of the factors that contribute to executive abilities in young adults, as well as in cognitive aging.Significance StatementRecently, the neurovisceral integration model has implicated activity on the parasympathetic branch of the autonomic nervous system (ANS) during wake in executive functioning. Parasympathetic activity peaks during deep sleep, and sleep has been shown to facilitate executive functioning. Yet, the role of parasympathetic activity during sleep for executive functioning is not known. Herein, participants demonstrated increased parasympathetic activity during deep sleep, sleep-dependent WM improvement, and associations between performance gains and parasympathetic activity in sleep, not wake. Our conceptual model illustrates the interaction between sleep, autonomic activity, and prefrontal brain function that may contribute to executive abilities in young adults and to cognitive aging.

In the Labyrinth

2017 ◽  
Author(s):  
Andrew McNeillie
Keyword(s):  
The Right ◽  
First Time ◽  
Do So

It is now widely acknowledged, and far beyond Ireland, that Tim Robinson’s two volumes jointly known as Stones of Aran (‘Pilgrimage’ and ‘Labyrinth’) are modern classics, exemplary in every way of how to write about place and to do so with a formal, literary accomplishment that more than earns the right to nod at Ruskin’s own classic. In 2012, Robinson went back to Árainn, the largest of the three islands, for the first time in nearly ten years. He did so at the urging of Andrew McNeillie, with whom he spent two and a half days revisiting old haunts. This chapter makes account of the occasion and uses, in the process, a unique document provided by Robinson as an experiment in annotating his work. This prompts McNeillie to investigate some of his own annotations and footnotes to Aran.

Reconstituting the International, 1918–1923

2017 ◽  
Author(s):  
Talbot C. Imlay
Keyword(s):  
Seismic Events ◽  
Great War ◽  
Bolshevik Revolution ◽  
Meaning And Purpose ◽  
Post War ◽  
The Impact ◽  
First Time ◽  
The Great War ◽  
Do So ◽  
Lengthy Process

This chapter examines the post-war efforts of European socialists to reconstitute the Socialist International. Initial efforts to cooperate culminated in an international socialist conference in Berne in February 1919 at which socialists from the two wartime camps met for the first time. In the end, however, it would take four years to reconstitute the International with the creation of the Labour and Socialist International (LSI) in 1923. That it took so long to do so is a testimony to the impact of the Great War and to the Bolshevik revolution. Together, these two seismic events compelled socialists to reconsider the meaning and purpose of socialism. The search for answers sparked prolonged debates between and within the major parties, profoundly reconfiguring the pre-war world of European socialism. One prominent stake in this lengthy process, moreover, was the nature of socialist internationalism—both its content and its functioning.

scholarly journals Breast Cancer Cell Re-Dissemination from Lung Metastases—A Mechanism for Enhancing Metastatic Burden

2021 ◽  
Vol 10 (11) ◽  
pp. 2340
Author(s):  
Lucia Borriello ◽  
John Condeelis ◽  
David Entenberg ◽  
Maja H. Oktay
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Metastatic Disease ◽  
Breast Cancer Cells ◽  
Lung Metastases ◽  
Primary Tumors ◽  
Metastatic Burden ◽  
First Time ◽  
Do So

Although metastatic disease is the primary cause of mortality in cancer patients, the mechanisms leading to overwhelming metastatic burden are still incompletely understood. Metastases are the endpoint of a series of multi-step events involving cancer cell intravasation, dissemination to distant organs, and outgrowth to metastatic colonies. Here we show, for the first-time, that breast cancer cells do not solely disseminate to distant organs from primary tumors and metastatic nodules in the lymph nodes, but also do so from lung metastases. Thus, our findings indicate that metastatic dissemination could continue even after the removal of the primary tumor. Provided that the re-disseminated cancer cells initiate growth upon arrival to distant sites, cancer cell re-dissemination from metastatic foci could be one of the crucial mechanisms leading to overt metastases and patient demise. Therefore, the development of new therapeutic strategies to block cancer cell re-dissemination would be crucial to improving survival of patients with metastatic disease.

It Is Your Decision to Date Interracially: The Influence of Family Approval on the Likelihood of Interracial/Interethnic Dating

2021 ◽  
pp. 0192513X2199413
Author(s):  
Byron Miller ◽  
Savanah Catalina ◽  
Sara Rocks ◽  
Kathryn Tillman
Keyword(s):  
College Students ◽  
Young Adults ◽  
Romantic Relationships ◽  
Family Members ◽  
Individual Level ◽  
Interracial Romance ◽  
Using Data ◽  
Do So

Although attitudes toward interracial romantic relationships (IRRs) have generally improved over the years, many Americans still disapprove of their family members being in IRRs. Prior studies have examined correlates of individual-level attitudes about interracial romance, but less is known about whether family members’ attitudes are directly associated with young people’s decisions to date interracially. Using data collected from 790 romantically involved college students at two large public four-year universities, we find that young adults who believe their siblings, parents, and grandparents approve of IRRs have greater odds of dating interracially. Compared to Whites, Blacks and Hispanics are more likely to be interracially involved but their decision to do so is much less dependent on the approval of their parents and grandparents. We also find young adults are more likely to date interracially if they have five or more relatives with IRR experience themselves. The findings and their implications are discussed.

Methylphenidate reduces orienting bias in healthy individuals

2021 ◽  
pp. 026988112199688
Author(s):  
Leehe Peled-Avron ◽  
Hagar Gelbard Goren ◽  
Noa Brande-Eilat ◽  
Shirel Dorman-Ilan ◽  
Aviv Segev ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Asymmetric Effect ◽  
Healthy Individuals ◽  
Double Blind ◽  
Spatial Orienting ◽  
Individual Trait ◽  
Neurological Patients ◽  
Dopamine Signaling ◽  
First Time ◽  
Neural Effect

Background: Healthy individuals show subtle orienting bias, a phenomenon known as pseudoneglect, reflected in a tendency to direct greater attention toward one hemispace. Accumulating evidence indicates that this bias is an individual trait, and attention is preferentially directed contralaterally to the hemisphere with higher dopamine signaling. Administration of methylphenidate (MPH), a dopamine transporter inhibitor, was shown to normalize aberrant spatial attention bias in psychiatric and neurological patients, suggesting that the reduced orienting bias following administration of MPH reflects an asymmetric effect of the drug, increasing extracellular dopamine in the hemisphere with lower dopamine signaling. Aim: We predicted that, similarly to its effect on patients with brain pathology, MPH will reduce the orienting bias in healthy subjects. Methods: To test this hypothesis, we examined the behavioral effects of a single dose (20 mg) of MPH on orienting bias in 36 healthy subjects (18 females) in a randomized, double-blind placebo-controlled, within-subject design, using the greyscales task, which has been shown to detect subtle attentional biases in both patients and healthy individuals. Results/outcomes: Results demonstrate that healthy individuals vary in both direction and magnitude of spatial orienting bias and show reduced magnitude of orienting bias following MPH administration, regardless of the initial direction of asymmetry. Conclusions/interpretations: Our findings reveal, for the first time in healthy subjects, that MPH decreases spatial orienting bias in an asymmetric manner. Given the well-documented association between orienting bias and asymmetric dopamine signaling, these findings also suggest that MPH might exert a possible asymmetric neural effect in the healthy brain.

scholarly journals Young Spanish Adults and Disinformation: Do They Identify and Spread Fake News and Are They Literate in It?

Publications ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 2
Author(s):  
Aida María de Vicente de Vicente Domínguez ◽  
Ana Beriain Beriain Bañares ◽  
Javier Sierra Sierra Sánchez
Keyword(s):  
Young Adults ◽  
Information Literacy ◽  
Quantitative Method ◽  
Spanish Population ◽  
Fake News ◽  
Know How ◽  
Literacy Training ◽  
Structured Questionnaire ◽  
Do So

The infodiet of young Spanish adults aged 18 to 25 was analysed to determine their attitude towards fake news. The objectives were: to establish whether they have received any training in fake news; to determine whether they know how to identify fake information; and to investigate whether they spread it. The study employed a descriptive quantitative method consisting of a survey of 500 representative interviews of the Spanish population aged between 18 and 25 through a structured questionnaire. The results indicate that they are aware of the importance of training, although generally they do not know of any course and when they do, they do not tend to enroll on one either due to lack of interest or time. These young adults feel that they know how to identify fake content and, moreover, that they know how to do so very well. However, they do not use the best tools. While they do not always verify information, they mainly suspect the credibility of information when it is meaningless. However, they do not tend to spread fake information. We conclude that media information literacy training (MILT) is necessary in educational centres that focuses on the main issues identified.

Some Palaeoliths from South Arabia

1954 ◽  
Vol 19 (2) ◽  
pp. 189-218 ◽  
Author(s):  
G. Caton-Thompson
Keyword(s):  
Geographical Society ◽  
South Arabia ◽  
First Time ◽  
Do So

The material here described was found in the Hadhramaut by Elinor Gardner and myself between November 1937 and March 1938. My personal investigation of the Palaeolithic Age was limited by pre-Islamic excavations, and I am therefore indebted to her for the gathering of most of the specimens in situ in terrace gravels, and to her detailed study of their positions.The collection consists mainly of groups from four fairly widely separated localities; the physiography of these has already been outlined in a comprehensive paper published in the Geographical Journal. Whenever appropriate to the purpose of this account, which is to place for the first time on illustrated record all we observed about the palaeoliths, I have reused in this different context illustrations of Quaternary environment which appeared in that Journal. With thanks I acknowledge the permission of the Royal Geographical Society to do so.

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