scholarly journals Development of a new approach to diagnosis of the early fluorosis forms by means of FTIR and Raman microspectroscopy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pavel Seredin ◽  
Dmitry Goloshchapov ◽  
Yuri Ippolitov ◽  
Jitraporn Vongsvivut
Keyword(s):  
Early Stage ◽  
Type B ◽  
Surface Layers ◽  
Human Teeth ◽  
New Approach ◽  
Mean Values ◽  
Infrared Microspectroscopy ◽  
The Mean ◽  
Apatite Lattice ◽  
Preventive Diagnostics

AbstractThis study is aimed at investigating the features of mineralization of the enamel apatite at initial stages of fluorosis development. Samples of teeth with intact and fluorotic enamel in an early stage of the disease development (Thylstrup–Fejerskov Index = 1–3) were studied by Raman scattering and FTIR using Infrared Microspectroscopy beamline at Australian Synchrotron equipment. Based on the data obtained by optical microspectroscopy and calculation of the coefficient R [A-type/B-type], which represents the ratio of carbonation fraction of CO32−, replacing phosphate or hydroxyl radicals in the enamel apatite lattice, the features of mineralization of enamel apatite in the initial stages of development of the pathology caused by an increased content of fluorine in the oral cavity were established. Statistical analysis of the data showed significant differences in the mean values of R [A-type/B-type] ratio between the control and experimental groups for surface layers (p < 0.01). The data obtained are potentially significant as benchmarks in the development of a new approach to preventive diagnostics of the development of initial and clinically unregistered stages of human teeth fluorosis, as well as personalized control of the use of fluoride-containing caries-preventive agents.

A new simpler approach to measure the strength of toe plantar flexion requiring no mechanical restraint with a light-weight device

2021 ◽  
pp. 095441192110029
Author(s):  
Yuko Komuro ◽  
Yuji Ohta
Keyword(s):  
Plantar Flexion ◽  
Mean Value ◽  
Simple Approach ◽  
Light Weight ◽  
New Approach ◽  
Mean Values ◽  
Mechanical Restraint ◽  
Significant Difference ◽  
Ankle Joints ◽  
The Mean

Conventionally, the strength of toe plantar flexion (STPF) is measured in a seated position, in which not only the target toe joints but also the knee and particularly ankle joints, are usually restrained. We have developed an approach for the measurement of STPF which does not involve restraint and considers the interactions of adjacent joints of the lower extremities. This study aimed to evaluate this new approach and comparing with the seated approach. A thin, light-weight, rigid plate was attached to the sole of the foot in order to immobilize the toe area. Participants were 13 healthy young women (mean age: 24 ± 4 years). For measurement of STPF with the new approach, participants were instructed to stand, raise the device-wearing leg slightly, plantar flex the ankle, and push the sensor sheet with the toes to exert STPF. The sensor sheet of the F-scan II system was inserted between the foot sole and the plate. For measurement with the seated approach, participants were instructed to sit and push the sensor with the toes. They were required to maintain the hip, knee, and ankle joints at 90°. The mean values of maximum STPF of the 13 participants obtained with each approach were compared. There was no significant difference in mean value of maximum STPF when the two approaches were compared (new: 59 ± 23 N, seated: 47 ± 33 N). The coefficient of variation of maximum STPF was smaller for data obtained with the new approach (new: 39%, seated: 70%). Our simple approach enables measurement of STPF without the need for the restraints that are required for the conventional seated approach. These results suggest that the new approach is a valid method for measurement of STPF.

scholarly journals Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers

2009 ◽  
Vol 36 (8) ◽  
pp. 1800-1802 ◽  
Author(s):  
BARRY BRESNIHAN ◽  
ELIZA PONTIFEX ◽  
ROGIER M. THURLINGS ◽  
MARJOLEIN VINKENOOG ◽  
HANI EL-GABALAWY ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Early Stage ◽  
Medical Center ◽  
Biological Effects ◽  
Pearson Correlation ◽  
University Hospital ◽  
Mean Values ◽  
The Mean

Objective.To determine whether the correlation between the mean change in disease activity and the mean change in synovial sublining (sl) CD68 expression could be demonstrated across different academic centers.Methods.Synovial biopsies obtained at arthroscopy from patients with rheumatoid arthritis before and 160 days after rituximab therapy were selected and coded. Paired sections were processed independently at Amsterdam Medical Center (AMC) and at St. Vincent’s University Hospital (SVUH), Dublin. Digital image analysis (DIA) was employed at both centers to quantify sublining CD68 expression.Results.After analysis of CD68sl expression at centers in 2 different countries, high levels of intracenter and intercenter agreement were observed. For the pooled sections stained at AMC, the correlation between 2 investigators was R = 0.942, p = 0.000, and for sections stained at SVUH, R = 0.899, p = 0.001. Similarly, the intracenter correlations for ΔCD68sl expression after treatment were R = 0.998, p = 0.000, for sections stained at AMC and R = 0.880, p = 0.000, for sections stained at SVUH. The intercenter correlation for the pooled scores of sections stained at AMC was R = 0.85, p = 0.000, and for the sections stained at SVUH, R = 0.62, p = 0.001. The consistent correlation between ΔDAS (Disease Activity Score) and ΔCD68sl expression across different studies (Pearson correlation = 0.895, p < 0.001) was confirmed. The standardized response mean values for ΔCD68sl, calculated from analyses at both AMC and SVUH, were consistently 0.5 or greater, indicating a moderate to high potential to detect change.Conclusion.The correlation between mean ΔDAS and mean ΔCD68sl expression was confirmed across 2 centers. Examination of serial biopsy samples can be used reliably to screen for interesting biological effects at the site of inflammation at an early stage of drug development.

A new approach to the measurement of the quantitative effects of inherent and environmental factors on the composition of the milk of individual cows and of herds, with particular reference to lactose content

1968 ◽  
Vol 35 (1) ◽  
pp. 91-105 ◽  
Author(s):  
J. P. Walsh ◽  
J. A. F. Rook ◽  
F. H. Dodd
Keyword(s):  
Quantitative Estimation ◽  
Relative Importance ◽  
New Approach ◽  
Mean Values ◽  
Stage Of Lactation ◽  
Bulk Milk ◽  
Wide Range ◽  
The Mean ◽  
The Difference ◽  
Effect Of Age

Summary(1) A tentative scheme is proposed for the quantitative estimation of the effects of various factors on one major milk constituent, lactose, from analyses of the milk of individual cows within herds. The potential lactose content in the milk of individual cows is predicted from the observed potassium-to-lactose ratio in the milk, and the difference between the predicted potential and the actual lactose content is partitioned into fractions that are attributed to effects due to age, inter-quarter difference and changes with stage of lactation. The scheme was applied to 2 commercial herds, one (herd A) producing milk of low and the other (herd B) milk of normal SNF content.(2) Lactation mean values for fat, SNF and lactose contents of the milk of individual cows showed a wide range of the same order in each of the 2 herds. Of the mean difference in SNF percentage of 0·30 between the herds, 0·14, or 47%, was due to a difference in lactose content.(3) The predicted potential milk lactose content of the cows in the 2 herds ranged from 5·04 to 5·66 (g/100 g milk water). Herd mean values were 5·394 for herd A and 5·244 for herd B.(4) Herd mean values for the effect on the lactose content (g/100 g milk water) of age, of changes with stage of lactation and of inter-quarter difference were −0·127, −0·080, and 0·073 respectively in herd A, and −0·197, −0·058 and −0·078, respectively, in herd B.(5) The relative importance of the various factors in accounting for differences between the herds in the lactose content of their bulk milk were: predicted potential lactose content 61%, effect of age 28%, effect of changes with stage of lactation 9% and effect of inter-quarter difference 2%.(6) The errors attached to the estimation of potential milk lactose content and the effects of age, of changes with stage of lactation and of inter-quarter difference are discussed.

scholarly journals Exchangeable cations in Finnish soils

1965 ◽  
Vol 37 (2) ◽  
pp. 148-161
Author(s):  
Ulla Marttila
Keyword(s):  
Fine Sand ◽  
Exchange Capacity ◽  
Exchangeable Cations ◽  
Base Saturation ◽  
Clay Soils ◽  
Organic Soils ◽  
Surface Layers ◽  
Mean Values ◽  
Calcium Magnesium ◽  
The Mean

An attempt was made to study the cation exchange capacity, the percentage base saturation and the amounts of the most common cations in the different types and depths of the Finnish soils on the basis of a material of 100 soil samples from various parts of the country. The exchangeable cations were leached from the soil with neutral 1N ammonium acetate. Calcium, magnesium, potassium, sodium and hydrogen were determined and the exchange capacity was calculated as the sum of all these cations. In the different soil types the mean values of the CEC were the following: organic soils 92.1 me per 100 g of soil, non-Litorina clays 28.9 », Litorina clays 27.9 », loam and silt soils 16.9 », sand and fine sand soils 14.5 ». The highest values of the percentage base saturation, on an average 85 % were obtained in the Glacial clay soils and the lowest ones in the organic soils, 34%, and in the Litorina clay soils, 36 %. BS % was generally greater in the deeper than in the surface layers. The contents of clay (

scholarly journals Prevalence and Levels of Forward Head Posture among School Going Children

2021 ◽  
Vol 5 (1) ◽  
pp. 022-025
Author(s):  
Hemendra Chandoliya ◽  
Varsha Chorsiya ◽  
Dhananjay Kaushik
Keyword(s):  
Cervical Spine ◽  
Early Stage ◽  
Research Work ◽  
Plumb Line ◽  
Early Screening ◽  
School Students ◽  
Forward Head Posture ◽  
Mean Values ◽  
Head Posture ◽  
The Mean

Introduction: Exposure of overloaded bag packs and early usage of digital gadgets amongst school going children alters the cervical spine posture. The present research work intends to study the prevalence of forward head posture in school going children. The study also elucidates the ranges to consider for mild, moderate and severe forward head posture prevalence. Methods: A total of 100 school students (50 males and 50 females) were recruited for cross-sectional study. Assessment of forward head posture was done using plumb line. The students were made to stand at a point marked 25 cm distance away from the plumb line. The researcher, from the side view, using a meter scale, measured the distance between the tragus of the ear and plumb line and record it. The weight of the school bag was measured using the weighing machine and the time for which gadgets were used was recorded as per the subject/parents feedback. Results: The mean values for age, height, weight and BMI are 13.67 ± 0.55 years, 158.56 ± 7.71 cms, 46.47 ± 10.50 kgs and 18.40 ± 3.48 kg /m2 respectively. The mean values for gadgets time use, distance plumb line and weight bag are 130.50 ± 67.07 min, 1.96 ± 1.19 cm and 4.32 ± 1.70 kgs respectively. About ~27% children having mild or no FHP (less than or equal to 1 cm), ~37% children having moderate FHP (ranging between 1.01 cm to 2.49 cm) and ~36% children found to have severe FHP (more than or equal to 2.5 cm). Conclusion: The study showed that the FHP is developing at early stage in the school going children and it has the potential of altering cervical spine biomechanics. Early screening is much essential aspect to prevent FHP. The ergonomic based awareness programs should be organized to sensitize children about the right posture and to indulge them in physical activity.

scholarly journals Mean Values of Certain Multiplicative Functions and Artin's Conjecture on Primitive Roots

2014 ◽  
Vol Volume 37 ◽  
Author(s):  
Sankar Sitaraman
Keyword(s):  
Dirichlet Series ◽  
Mean Value ◽  
Multiplicative Functions ◽  
New Approach ◽  
Mean Values ◽  
Artin's Conjecture ◽  
International Audience ◽  
The Mean ◽  
Primitive Roots

International audience We discuss how one could study asymptotics of cyclotomic quantities via the mean values of certain multiplicative functions and their Dirichlet series using a theorem of Delange. We show how this could provide a new approach to Artin's conjecture on primitive roots. We focus on whether a fixed prime has a certain order modulo infinitely many other primes. We also give an estimate for the mean value of one such Dirichlet series.

scholarly journals Simple Amplitudes for ϕ3 Feynman ladder graphs

1997 ◽  
Vol 12 (11) ◽  
pp. 811-819
Author(s):  
R. Hong Tuan
Keyword(s):  
Infinite Number ◽  
Simple Form ◽  
Mean Value ◽  
New Approach ◽  
Mean Values ◽  
Regge Behavior ◽  
Gaussian Representation ◽  
Feynman Graphs ◽  
The Mean ◽  
Ladder Graphs

Recently, we proposed a new approach for calculating Feynman graphs amplitude using the Gaussian representation for propagators which was proven to be exact in the limit of graphs having an infinite number of loops. Regge behavior was also found in a completely new way and the leading Regge trajectory calculated. Here we present symmetry arguments justifying the simple form used for the polynomials in the Feynman parameters [Formula: see text], where [Formula: see text] is the mean-value for these parameters, appearing in the amplitude for the ladder graphs. (Taking mean-values is equivalent to the Gaussian representation for propagators.)

Articulatory Behavior Pre and Post Full-Mouth Tooth Extraction and Alveoloplasty

1980 ◽  
Vol 23 (3) ◽  
pp. 630-645 ◽  
Author(s):  
Gerald Zimmermann ◽  
J.A. Scott Kelso ◽  
Larry Lander
Keyword(s):  
Control Subject ◽  
High Speed ◽  
Tooth Extraction ◽  
Kinematic Parameters ◽  
Experimental Conditions ◽  
Mean Values ◽  
Articulatory Movements ◽  
The Mean ◽  
Experimental Subjects ◽  
Normal Speech

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveoloplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the Control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

Comparative Study of Intranasal, Subcutaneous and Intravenous Administration of Desamino-D-Arginine Vasopressin (DDAVP)

1986 ◽  
Vol 55 (01) ◽  
pp. 108-111 ◽  
Author(s):  
M Köhler ◽  
P Hellstern ◽  
C Miyashita ◽  
G von Blohn ◽  
E Wenzel
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Factor Xii ◽  
Additional Advantage ◽  
Mean Values ◽  
Routes Of Administration ◽  
The Mean ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

SummaryThis study was performed to evaluate the influence of different routes of administration on the efficacy of DDAVP treatment. Ten healthy volunteers received DDAVP intranasally (i.n.), subcutaneously (s.c.) and intravenously (i.v.) in a randomized cross-over trial. Factor XII and high molecular weight (HMW)-kininogen levels increased only slightly after DDAVP administration. The mean increase of factor VIII: C was 3.1 (i. v.), 2.3 (s. c.), and 1.3 (i.n.) - fold over baseline. Ristocetin cofactor (von Willebrand factor antigen) increased 3.1 (2.5), 2.0 (2.3) and 1.2 (1.2) - fold over baseline mean values after i.v., s.c. and i.n. DDAVP, respectively. The half-disappearance time of factor VIII and von Willebrand factor (vWF) after DDAVP ranged from five (factor VIII: C) to eight hours (vWF). The mean increase of fibrinolytic activity was more pronounced after i.v. DDAVP. The antidiuretic effect was moderate with no apparent differences between the routes of application. This study provides further evidence that both i.v. and s.c. DDAVP administration result in an appropriate and reliable stimulation of haemostasis. An additional advantage of s. c. administration is its suitability for home treatment.

Comparative Study of effectiveness of mobilization with movement (MWM) and End range mobilization (ERM) techniques in frozen shoulder

2018 ◽  
Vol 4 (4) ◽  
pp. 519-522
Author(s):  
Jeyakumar S ◽  
Jagatheesan Alagesan ◽  
T.S. Muthukumar
Keyword(s):  
Range Of Motion ◽  
Frozen Shoulder ◽  
Type I ◽  
Mean Values ◽  
Functional Activities ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Frozen shoulder is disorder of the connective tissue that limits the normal Range of motion of the shoulder in diabetes, frozen shoulder is thought to be caused by changes to the collagen in the shoulder joint as a result of long term Hypoglycemia. Mobilization is a therapeutic movement of the joint. The goal is to restore normal joint motion and rhythm. The use of mobilization with movement for peripheral joints was developed by mulligan. This technique combines a sustained application of manual technique “gliding” force to the joint with concurrent physiologic motion of joint, either actively or passively. This study aims to find out the effects of mobilization with movement and end range mobilization in frozen shoulder in Type I diabetics. Materials and Methods: 30 subjects both male and female, suffering with shoulder pain and clinically diagnosed with frozen shoulder was recruited for the study and divided into two groups with 15 patients each based on convenient sampling method. Group A patients received mobilization with movement and Group B patients received end range mobilization for three weeks. The outcome measurements were SPADI, Functional hand to back scale, abduction range of motion using goniometer and VAS. Results: The mean values of all parameters showed significant differences in group A as compared to group B in terms of decreased pain, increased abduction range and other outcome measures. Conclusion: Based on the results it has been concluded that treating the type 1 diabetic patient with frozen shoulder, mobilization with movement exercise shows better results than end range mobilization in reducing pain and increase functional activities and mobility in frozen shoulder.

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