scholarly journals Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ran Li ◽  
Yimei Wang ◽  
Jie Du ◽  
Xiangyu Wang ◽  
Ailin Duan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Tumor Targeting ◽  
Target Therapy ◽  
Ph Responsive ◽  
Chemotherapy Drugs ◽  
Tumor Tissues ◽  
Anti Cancer ◽  
Good Technique ◽  
Nanoparticle System

AbstractIn the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs in tumor tissues, and reduce the toxic effects of chemotherapy drugs on normal cells. Hence, great stability was obtained in the biological solution. Moreover, we designed an effective nanoparticle system for the doxorubicin (DOX) delivery targeting the oral squamous cell carcinoma (OSCC) by mediating the HN-1 (TSPLNIHNGQKL) through hydrogen and π–π bonds. DOX@NGO-PEG-HN-1 showed significantly higher cellular uptakes and cytotoxicity in OSCC cells (CAL-27 and SCC-25), compared to free DOX. Moreover, HN-1 showed considerable tumor-targeting and competition inhibition phenomenon. As we expected, the nanocarrier showed pH-responsive drug release. In total, our study represented a good technique to construct OSCC-targeted delivery of nanoparticles and improve the anticancer medicines’ efficiency.

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

2015 ◽  
Vol 357 ◽  
pp. 2077-2086 ◽  
Author(s):  
Congli Wang ◽  
Lizhen Huang ◽  
Shengmei Song ◽  
Bassam Saif ◽  
Yehong Zhou ◽  
...  
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
Anti Cancer

Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24232-24239 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Folate Receptor Targeting

A novel graphene oxide (GO)-based nanocarrier has been designed for the targeting and pH-responsive controlled release of anti-cancer drugs.

scholarly journals Methods of Delivery of Medications for the Treatment of Oncological Diseases

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
N.D Oltarzhevskaja ◽  
G.E. Krichevskij ◽  
M.A. Korovina ◽  
V.I. Shvets ◽  
A.A. Kubatiev
Keyword(s):  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Mass Transfer Rate ◽  
Lesion Site ◽  
Chemotherapy Drugs ◽  
Targeted Transport ◽  
Tumor Tissues ◽  
Oncological Diseases ◽  
Targeted Drug ◽  
Materials Used

The review focuses on the analysis of various methods of obtaining and applying therapeutic materials used for targeted drug delivery to the lesion site of cancer patients. Special attention is paid to creation of targeted drugs by using nanotransporters, obtained by dispersing lipids in water and, in particular, liposomes; efficiencyof such nanotransporters depends the nature of drugs introduced into them (cytostatics). The review also describes methods of targeted transport of cytostatics to tumor tissues. The use of hydrogel therapeutic compositions based on biopolymers polysaccharides for the targeted delivery of chemotherapy drugs introduced into them, allows to control the mass transfer rate of drugs to tumor and to create therapeutic materials with predetermined properties in terms of drug concentration in the lesion site and time prolongation, which reduces toxicity of the treatment and increase its effectiveness.

scholarly journals XYLOGLUCAN CONJUGATED FUNCTIONALIZED GRAPHENE OXIDE AS A NANO CARRIER SYSTEM FOR pH RESPONSIVE TARGETED DRUG DELIVERY OF FUCOIDAN

2021 ◽  
pp. 144-153
Author(s):  
K. SONIA ◽  
D. RAJESH ◽  
S. ARUNA SHARMILI ◽  
K. S. MEENA
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hemolytic Activity ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Potential Candidate ◽  
Functionalized Graphene ◽  
Ph Responsive ◽  
Functionalized Graphene Oxide

Objective: Marine polysaccharides are materializing in the field of biomedicine owing to its promising properties, including high biocompatibility, excellent biodegradability, nontoxic nature, abundance and low cost. Fucoidan (FU), a sulphated marine polysaccharide extracted from brown seaweed, shows a promising application prospect as an anticancer model drug. In order to enhance the stability, biocompatibility and drug loading capacity, xyloglucan was chosen as a targeting ligand, conjugated onto the surface of chitosan functionalized graphene oxide for targeted delivery of fucoidan. Methods: Firstly, Graphene oxide (GO) was prepared by modified Hummer’s method and functionalized with chitosan (CS) via amidation process, further conjugated with xyloglucan (XG). The resulting conjugate, GO-CS-XG, was used to deliver fucoidan through a nanocarrier drug delivery method. The developed GO-CS-XG-FU nanosystem was analyzed for its physiochemical characterization, morphology, hemolytic activity, anti-inflammatory and anticancer activity. Results: The FU loading efficiency and capacity were 75.7% and 83.4%, respectively. XG ligands on the nanoparticle may lead the nanoparticles to actively target cancer cells. Hemolytic activity of the FU-loaded GO-CS-XG nanosystem shows negligible activity, thus making it a potential candidate for biomedical applications. In vitro drug release analysis of FU from GO-CS-XG was lesser at physiological pH but under acidic conditions, it was significantly increased. Results of in vitro cell viability studies indicate that the efficiency of fucoidan was improved upon conjugation with the nanosystem (GO-CS-XG) against human histiocytic lymphoma (U 937) cell line. Conclusion: As a result, we propose a new multifunctional graphene-based targeted platform by using xyloglucan polysaccharide as targeting nanomaterial for pH-responsive anticancer drug delivery with high efficacy.

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 89299-89308 ◽  
Author(s):  
Congli Wang ◽  
Bo Li ◽  
Weifen Niu ◽  
Shasha Hong ◽  
Bassam Saif ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Layer By Layer ◽  
Innovative Drug ◽  
Assembly Method ◽  
Modified Graphene Oxide ◽  
Anti Cancer ◽  
Modified Graphene ◽  
Effective Layer

β-Cyclodextrin modified graphene oxide–magnetic (MGC) nanocomposite as an innovative drug carrier was the first to be developed via an effective layer-by-layer-assembly method.

Lung cancer immunochemotherapy: Codelivery of EGFR tki and PTX via an immunostimulatory dual functional nanocarrier.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15177-e15177
Author(s):  
Dingwei Diao ◽  
Kaican Cai ◽  
Xiguang Liu ◽  
Jianjun Yang
Keyword(s):  
Lung Cancer ◽  
Antitumor Activity ◽  
Targeted Delivery ◽  
Target Therapy ◽  
Drug Loading ◽  
Control Group ◽  
Immune Microenvironment ◽  
Chemotherapy Drugs ◽  
Dual Functional ◽  
Tumor Immune Microenvironment

e15177 Background: Immuno-target therapy combines a target therapy agent with an immune modulating agent and represents an attractive approach to improve cancer therapy.However, the success of it is hampered by the lack of a strategy to effectively co deliver the two therapeutics to the tumours.Here we report an improved dual functional nanocarrier (PEG5k-Fmoc-NLG2) to load Gefitinib for improved cancer Immuno target therapy.PEG5K-Fmoc-NLG2 is a prodrug that can inhibited IDO enzyme activity in vitro,while IDO1 inhibition reversed T cell suppression mediated by IDO expressing mouse cancer cells. Methods: Gefitinib loaded in carrier was prepared via a film hydrationmethod,the physicochemical properties of micelles was determined by TEM and particle size test.The cytotoxicity of the drug was detected by MTT assay. 3LL lung cancer was inoculated in mice and different drugs was injected through the tail vein to compare the anti tumor effect of drug loading micells with existing targeted drug gefitinib and CTLA4 antibody; tumor tissue proteins were extracted to clarify changes in pEGFR expressionexpression; flow cytometry will be finished to observe tumor immune microenvironment changes. Results: 1. Gefitinib loaded micelle maintain the similar size with blank PEG5k-fmoc-NLG2 micelles that is around 20nm.The drug-loaded micelles produced uniformed size and morphology. which further confirmed the size of micelles was around 20nm. 2. PTX and Gefitinib loaded in PEG5k-fmoc-NLG2 exhibited significantly enhanced tumor cell killing effect than the free drug on both A549 and 3LL cell lines. 3. The antitumor efficacy of different drugs loaded in the carrier were tested in a murine lung cancer model (3LL). All treatment showed significant better antitumor activity compared to the control group, Gefitinib/PEG5k-Fmoc-NLG2 plus CTLA4 antibody exhibited the best antitumor effect. Antitumor activity of gefitinib loaded in carrier was comparable with free gefitinib alone. 4. With various treatments the expression of p-EGFR protein level varied. Basically, compare with free gefitinib alone, the carrier loaded gefitinib was more effective in the inhibition of EGFR phosphorylation. Conclusions: We have shown that targeted delivery of PTX and Gefitinib via a immunostimulatory nanocarrier effectively improved drugs antitumor activity. More study about tumor immune microenvironment are required. Such strategy can be employed in novel therapy combining chemotherapy drugs and immunemodulating agents such as PD-1 and CTLA4.

scholarly journals pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs

2018 ◽  
Vol 3 (1) ◽  
pp. 150-158 ◽  
Author(s):  
Gokhan Yilmaz ◽  
Emine Guler ◽  
Caner Geyik ◽  
Bilal Demir ◽  
Melek Ozkan ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
The Past ◽  
Anti Cancer

Over the past decade, there has been a great deal of interest in the integration of nanotechnology and carbohydrates.

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

2020 ◽  
Vol 20 (9) ◽  
pp. 1094-1104 ◽  
Author(s):  
Omid Arjmand ◽  
Mehdi Ardjmand ◽  
Ali M. Amani ◽  
Mohmmad H. Eikani
Keyword(s):  
Graphene Oxide ◽  
Allium Sativum ◽  
Cytotoxicity Assay ◽  
Targeted Treatment ◽  
Cancer Drug ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Targeted Release

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable. Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite. Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated. Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent. Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

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