scholarly journals Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. E. A. Botteon ◽  
L. B. Silva ◽  
G. V. Ccana-Ccapatinta ◽  
T. S. Silva ◽  
S. R. Ambrosio ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Antimicrobial Agents ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Anticancer Activities

AbstractGold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area to volume ratio, and surfaces that can be easily modified with ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, and eco-friendly approach. Brazilian Red Propolis (BRP), a product of bees, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. Here, we described the biosynthesis of AuNPs using BRP extract (AuNPextract) and its fractions (AuNPhexane, AuNPdichloromethane, AuNPethyl acetate) and evaluated their structural properties and their potential against microorganisms and cancer cells. AuNPs showed a surface plasmon resonance (SPR) band at 535 nm. The sizes and morphologies were influenced by the BRP sample used in the reaction. FTIR and TGA revealed the involvement of bioactive compounds from BRP extract or its fractions in the synthesis and stabilization of AuNPs. AuNPdichloromethane and AuNPhexane exhibited antimicrobial activities against all strains tested, showing their efficacy as antimicrobial agents to treat infectious diseases. AuNPs showed dose-dependent cytotoxic activity both in T24 and PC-3 cells. AuNPdichloromethane and AuNPextract exhibited the highest in vitro cytotoxic effect. Also, the cytotoxicity of biogenic nanoparticles was induced by mechanisms associated with apoptosis. The results highlight a potential low-cost green method using Brazilian red propolis to synthesize AuNPs, which demonstrated significant biological properties.

scholarly journals Basic Potential of Carbon Nanotubes in Tissue Engineering Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hisao Haniu ◽  
Naoto Saito ◽  
Yoshikazu Matsuda ◽  
Tamotsu Tsukahara ◽  
Yuki Usui ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Medical Application ◽  
Mechanical And Thermal Properties ◽  
Biological Responses

Carbon nanotubes (CNTs) are attracting interest in various fields of science because they possess a high surface area-to-volume ratio and excellent electronic, mechanical, and thermal properties. Various medical applications of CNTs are expected, and the properties of CNTs have been greatly improved for use in biomaterials. However, the safety of CNTs remains unclear, which impedes their medical application. Our group is evaluating the biological responses of multiwall CNTs (MWCNTs)in vivoandin vitrofor the promotion of tissue regeneration as safe scaffold materials. We recently showed that intracellular accumulation is important for the cytotoxicity of CNTs, and we reported the active physiological functions CNTs in cells. In this review, we describe the effects of CNTsin vivoandin vitroobserved by our group from the standpoint of tissue engineering, and we introduce the findings of other research groups.

scholarly journals Research Progress on the Applications of Electrospun Nanofibers in Catalysis

Catalysts ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 9
Author(s):  
M. Olga Guerrero-Pérez
Keyword(s):  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Internal Diffusion ◽  
Research Progress ◽  
Bibliographic Analysis ◽  
Low Resistance ◽  
Electro Catalysis

During the last two decades, electrospinning has become a very popular technique for the fabrication of nanofibers due to its low cost and simple handling. Nanofiber materials have found utilization in many areas such as medicine, sensors, batteries, etc. In catalysis, these materials also present important advantages, since they present a low resistance to internal diffusion and a high surface area to volume ratio. These advantages are mainly due to the diameter–length proportion. A bibliographic analysis on the applications of electrospun nanofibers in catalysis shows that there are two important groups of catalysts that are being investigated, based on TiO2 and in carbon materials. The main applications found are in photo- and in electro-catalysis. The present study contributes by reviewing these catalytic applications of electrospun nanofibers and demonstrating that they are promising materials as catalysts, underlining some works to prove the advantages and possibilities that these materials have as catalysts. On one hand, the possibilities of synthesis are almost infinite, since with coaxial electrospinning quite complex nanofibers with different layers can be prepared. On the other hand, the diameter and other properties can be controlled by monitoring the applied voltage and other parameters during the synthesis, being quite reproducible procedures. The main advantages of these materials can be grouped in two: one related to their morphology, as has been commented, relative to their low resistance and internal diffusion, that is, their fluidynamic behavior in the reactor; the second group involves advantages related to the fact that the active phases can be nanoscaled and dispersed, improving the activity and selectivity in comparison with conventional catalytic materials with the same chemical composition.

scholarly journals Starch-Based Hybrid Nanomaterials for Environmental Remediation

2021 ◽  
Author(s):  
Ashoka Gamage ◽  
Thiviya Punniamoorthy ◽  
Terrence Madhujith
Keyword(s):  
Metal Oxide ◽  
Environmental Remediation ◽  
Membrane Filtration ◽  
Anthropogenic Activities ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Hybrid Nanomaterials ◽  
Metal Metal

Environmental pollution is becoming a major global issue with increasing anthropogenic activities that release massive toxic pollutants into the land, air, and water. Nanomaterials have gained the most popularity in the last decades over conventional methods because of their high surface area to volume ratio and higher reactivity. Nanomaterials including metal, metal oxide, zero-valent ions, carbonaceous nanomaterials, and polymers function as adsorbents, catalysts, photocatalysts, membrane (filtration), disinfectants, and sensors in the detection and removal of various pollutants such as heavy metals, organic pollutants, dyes, industrial effluents, and pathogenic microbial. Polymer-inorganic hybrid materials or nanocomposites are highly studied for the removal of various contaminants. Starch, a heteropolysaccharide, is a natural biopolymer generally incorporated with other metal, metal oxide, and other polymeric nanoparticles and has been reported in various environmental remediation applications as a low-cost alternative for petroleum-based polymers. Therefore, this chapter mainly highlights the various nanomaterials used in environmental remediation, starch-based hybrid nanomaterials, and their application and limitations.

Functionalized Magnetic Nanoparticles for Environmental Remediation

2017 ◽  
pp. 705-741
Author(s):  
Ravindra Kumar Gautam ◽  
Shivani Soni ◽  
Mahesh Chandra Chattopadhyaya
Keyword(s):  
Heavy Metals ◽  
Magnetic Nanoparticles ◽  
Environmental Remediation ◽  
Anthropogenic Activities ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Removal Of Heavy Metals

Water pollution by anthropogenic activities is proving to be of critical concern as the heavy metals affect aquatic organisms and can quickly disperse to large distances. This poses a risk to both human health and the aquatic biota. Hence, there is a need to treat the wastewater containing toxic metals before they are discharged into the water bodies. During recent years, magnetic nanoparticles came to the foreground of scientific interest as a potential adsorbent of novel wastewater treatment processes. Magnetic nanoparticles have received much attention due to their unique properties, such as extremely small size, high surface-area-to-volume ratio, surface modifiability, multi functionality, excellent magnetic properties, low-cost synthesis, and great biocompatibility. The multi-functional magnetic nanoparticles have been successfully applied for the reduction of toxic metal ions up to ppb level in waste-treated water. This chapter highlights the potential application of magnetic nanoparticles for the removal of heavy metals.

Functionalized Magnetic Nanoparticles for Environmental Remediation

2015 ◽  
pp. 518-551 ◽  
Author(s):  
Ravindra Kumar Gautam ◽  
Shivani Soni ◽  
Mahesh Chandra Chattopadhyaya
Keyword(s):  
Heavy Metals ◽  
Magnetic Nanoparticles ◽  
Environmental Remediation ◽  
Anthropogenic Activities ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Removal Of Heavy Metals

Water pollution by anthropogenic activities is proving to be of critical concern as the heavy metals affect aquatic organisms and can quickly disperse to large distances. This poses a risk to both human health and the aquatic biota. Hence, there is a need to treat the wastewater containing toxic metals before they are discharged into the water bodies. During recent years, magnetic nanoparticles came to the foreground of scientific interest as a potential adsorbent of novel wastewater treatment processes. Magnetic nanoparticles have received much attention due to their unique properties, such as extremely small size, high surface-area-to-volume ratio, surface modifiability, multi functionality, excellent magnetic properties, low-cost synthesis, and great biocompatibility. The multi-functional magnetic nanoparticles have been successfully applied for the reduction of toxic metal ions up to ppb level in waste-treated water. This chapter highlights the potential application of magnetic nanoparticles for the removal of heavy metals.

scholarly journals Silica gel Supported Boric tri-Sulfuric Anhydride (SiO2-BTSA): an Efficient Catalytic System for the Synthesis of Phloroglucide analogs as Antimicrobial Agents

2019 ◽  
Author(s):  
Rahele Bargebid ◽  
Ali Khalafi-Nezhad ◽  
Kamiar Zomorodianc ◽  
Mahkameh Moradi ◽  
Soghra Khabnadideh
Keyword(s):  
Silica Gel ◽  
Antimicrobial Agents ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Dilution Method ◽  
Sulfuric Anhydride ◽  
Chemical Structures

An efficient procedure for the synthesis of polyhydroxyl aromatic compounds (phloroglucide analogs) is described. In this procedure a reaction was done between different 4-substituted phenols and 2,6-bis(hydroxymethy) phenols. The reactions proceed in the presence of catalytic amount of silica gel supported boric tri-sulfuric anhydride (SiO2-BTSA) in excellent yields. 16 compounds were synthesized (I1-I16). Chemical structures of all compounds were confirmed by spectroscopic methods. We optimized the chemical reactions in the presence of different acidic catalysts, different solvents and also different temperatures. Catalytic amounts of SiO2-BTSA in dichloroethane (DCE) was the best conditions. Some of the synthesized compounds were screened for their antimicrobial activities. Antifungal and antibacterial activities of the synthesized compounds were evaluated by broth micro dilution method as recommended by CLSI. Some of the tested compounds show good in vitro biological properties.

scholarly journals The toxicology properties of modified hydrothermal nanotitania extraction

2021 ◽  
Author(s):  
Ahmad Harun ◽  
Nor Farid Mohd Noor ◽  
Ramizu Shaari ◽  
Lio Ying ◽  
Mohamad Yusoff ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Health And Safety ◽  
L929 Cell ◽  
Cytotoxicity Activity ◽  
Nano Titanium Dioxide ◽  
L929 Mouse

IntroductionThe nanoparticle has become a part of world industry. This substance has been proven as potentially beneficial for its usage as a catalyst and semi-conductor due to its high surface area and the effects of the quantum size effect. It exhibits potential characteristics and would be applied in a wider scope of usage compared to bulk particles because the smaller the size of the particles, the more room for the extent of their usage. Nano titanium dioxide application as semi-conductors together with a catalyst is highly attributed to its high photochemical stability and ability to be produced at a low-cost. The consequence of this – exposure of nano titanium dioxide particles to humans – raises concerns regarding health and safety. Therefore, this research action works designed to offer a thorough analysis of toxicology impacts produced by our own synthesis modified hydrothermal in vitro experiments.Material and methodsOur nanotitania extraction with 0.05% silver was tested for its toxicity against L929 mouse cells. The cytotoxicity effect of nanotitania extract was evaluated by MTT assay. Cell viability (% CV) was calculated using a formula.ResultsThere are non-cytotoxicity activity of 0.05% nanotitania at concentrations 1.5, 3.1, 6.3, 12.5, and 25 mg/ml on L929 cell lines except at concentration 50 and 100 mg/ml. The result was related to the optical density reading.ConclusionsThere is no cytotoxic effect of nanotitania extraction with 0.05% silver in the growth inhibition test with L929 mouse with the exception of the 100 mg/ml extract.

scholarly journals The Facile Synthesis of Novel ZnO Nanostructure for Galactose Biosensor Application

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Phuong Ha La Phan ◽  
Quang Trung Tran ◽  
Duc Anh Dinh ◽  
Ko Kang Bok ◽  
Chang-Hee Hong ◽  
...  
Keyword(s):  
Low Cost ◽  
High Surface ◽  
Zno Nanorods ◽  
High Surface Area ◽  
Volume Ratio ◽  
Galactose Oxidase ◽  
Electrode Structure ◽  
Detection Range ◽  
Zno Nanostructure ◽  
Biosensor Application

We introduce a novel structure of ZnO nanorods (NRs) grown on ZnO NRs (ZnO NRs/NRs) via a facile, low-cost, and environmentally friendly synthesis for galactose biosensor application. The galactose oxidase enzyme (GalOx) is immobilized on the ZnO NR/NR surface to form the novel electrode structure (GalOx|ZnO NRs/NRs). The GalOx|ZnO NR/NR electrode has a linear detection range of current density from 11.30 μA/mm2 to 18.16 μA/mm2 over a galactose concentration range from 40 mM to 230 mM, indicating the increment of electrode sensitivity up to 60.7%. The ZnO NR/NR morphology with a high surface area to volume ratio has a great contribution to the electrochemical performance of galactose biosensor. Our results propose a straightforward approach to fabricate architecturally ZnO-based nanostructure for biosensor application.

scholarly journals Solidago graminifolia L. Salisb. (Asteraceae) as a Valuable Source of Bioactive Polyphenols: HPLC Profile, In Vitro Antioxidant and Antimicrobial Potential

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2666 ◽  
Author(s):  
Anca Toiu ◽  
Laurian Vlase ◽  
Dan Cristian Vodnar ◽  
Ana-Maria Gheldiu ◽  
Ilioara Oniga
Keyword(s):  
Antimicrobial Agents ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Total Phenolic ◽  
Antimicrobial Potential ◽  
Aerial Parts ◽  
Hplc Profile ◽  
Antibacterial And Antifungal

Solidago species are often used in traditional medicine as anti-inflammatory, diuretic, wound-healing and antimicrobial agents. Still, the bioactive compounds and biological activities of some species have not been studied. The present work aimed to investigate the polyphenolic profile and the biological properties of Solidago graminifolia L. Salisb., a poorly explored medicinal plant. The hydroalcoholic extracts from aerial parts were evaluated for total phenolic content (TPC), total flavonoid content (TFC) and the polyphenolic compounds were investigated by HPLC-MS. The antioxidant potential in vitro was determined using DPPH and FRAP assays. Antibacterial and antifungal effects were evaluated by dilution assays and MIC, MBC and MFC were calculated. The results showed that Solidago graminifolia aerial parts contain an important amount of total phenolics (192.69 mg GAE/g) and flavonoids (151.41 mg RE/g), with chlorogenic acid and quercitrin as major constituents. The hydroalcoholic extracts showed promising antioxidant and antimicrobial potential, with potent antibacterial activity against Staphylococcus aureus and important antifungal effect against Candida albicans and C. parapsilosis. The obtained results indicated that the aerial parts of Solidago graminifolia could be used as novel resource of phytochemicals in herbal preparations with antioxidant and antimicrobial activities.

The Unprecedented Role of Gold Nanomaterial in Diabetes Management

2020 ◽  
Vol 13 (3) ◽  
pp. 219-227
Author(s):  
Simpal Kumari ◽  
Vipan Kumar Kamboj ◽  
Diksha Rajpoot ◽  
Anil Kumar Teotia ◽  
Prabhakar Kumar Verma ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetes Management ◽  
High Surface ◽  
High Surface Area ◽  
Biological Properties ◽  
Low Toxicity ◽  
Gold Nanomaterial ◽  
Unique Potential ◽  
Delivery Approach

:Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research on life sciences. The research studies produced new nanodevices and nanotechnology-based biosensing, diagnostics therapeutics, and targeted drug delivery systems. In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles developed for diabetes management. The first part of this review will focus on recent strategies for the treatment of hyperglycemia and its management with the help of gold nanoparticles and the second part of the review focused on recent patents on gold nanoparticles useful in the diabetes management. Gold nanoparticles have proved themselves useful in diabetes therapeutics and diagnostics. Due to the high surface area, and low toxicity, gold nanoparticles have become a unique aspect of the delivery approach. The main issues that need to be covered are the biopharmaceutics, biocompatibility, and potential clinical applications.

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