scholarly journals Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Johannes Glaab ◽  
Neysha Lobo-Ploch ◽  
Hyun Kyong Cho ◽  
Thomas Filler ◽  
Heiko Gundlach ◽  
...  

AbstractMultiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (< 240 nm) irradiation system for their inactivation is presented here. It uses UVC LEDs in combination with a spectral filter and provides a peak wavelength of 233 nm, with a full width at half maximum of 12 nm, and an irradiance of 44 µW/cm2. MRSA bacteria in different concentrations on blood agar plates were inactivated with irradiation doses in the range of 15–40 mJ/cm2. Porcine skin irradiated with a dose of 40 mJ/cm2 at 233 nm showed only 3.7% CPD and 2.3% 6-4PP DNA damage. Corresponding irradiation at 254 nm caused 15–30 times higher damage. Thus, the skin damage caused by the disinfectant doses is so small that it can be expected to be compensated by the skin's natural repair mechanisms. LED-based far-UVC lamps could therefore soon be used in everyday clinical practice to eradicate multiresistant pathogens directly on humans.

1994 ◽  
Vol 339 ◽  
Author(s):  
Shuji Nakamura

ABSTRACTHigh-brightness InGaN/AlGaN double-heterostructure (DH) blue-light-emitting diodes (LEDs) with a luminous intensity of 1.2 cd were fabricated successfully for the first time. As an active layer, a Zn-doped InGaN layer was used. The peak wavelength and the full width at half-maximum of the electroluminescence were 450 nm and 70 nm, respectively. The forward voltage was as low as 3.6V at 20 mA.


1996 ◽  
Vol 440 ◽  
Author(s):  
Ahn Goo Choo ◽  
Seong Heon Kim ◽  
Nam Heon Kim ◽  
Oleg Laboutine ◽  
Joon Sang Yu ◽  
...  

AbstractWe have studied the effects of growth parameters and substrate orientations on InGaP quality using Normarski microscopy, photoluminescence (PL) spectrum and atomic force microscopy (AFM). The full width at half maximum (FWHNM) and peak position of PL spectrum were closely related with the surface morphology. The InGaP layers of narrower FWHM and shorter peak wavelength had smoother surface morphology. The InGaP layers grown on (100) substrates at the moderately low reactor pressure showed rougher surface than those on the tilted substrates. But the surface morphology was noticeably improved to be mirror-like at the lower reactor pressure. The surface morphology was inverted between the exact and tilted substrates in this reactor pressure. Furthermore, the samples grown on the tilted substrate exhibited rougher surface than the samples grown on the exact substrate. (111)B-misoriented growth surfaces had smoother than (111)A-misoriented surfaces.


2021 ◽  
Vol 11 (15) ◽  
pp. 6919
Author(s):  
Majid Masnavi ◽  
Martin Richardson

A series of experiments is described which were conducted to measure the absolute spectral irradiances of laser plasmas created from metal targets over the wavelength region of 123–164 nm by two separate 1.0 μm lasers, i.e., using 100 Hz, 10 ns, 2–20 kHz, 60–100 ns full-width-at-half-maximum pulses. A maximum radiation conversion efficiency of ≈ 3%/2πsr is measured over a wavelength region from ≈ 125 to 160 nm. A developed collisional-radiative solver and radiation-hydrodynamics simulations in comparison to the spectra detected by the Seya–Namioka-type monochromator reveal the strong broadband experimental radiations which mainly originate from bound–bound transitions of low-ionized charges superimposed on a strong continuum from a dense plasma with an electron temperature of less than 10 eV.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adam Huang ◽  
Chung-Wei Lee ◽  
Hon-Man Liu

AbstractMoyamoya disease (MMD) is a chronic, steno-occlusive cerebrovascular disorder of unknown etiology. Surgical treatment is the only known effective method to restore blood flow to affected areas of the brain. However, there are lack of generally accepted noninvasive tools for therapeutic outcome monitoring. As dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) is the standard MR perfusion imaging technique in the clinical setting, we investigated a dataset of nineteen pediatric MMD patients with one preoperational and multiple periodic DSC MRI examinations for four to thirty-eight months after indirect revascularization. A rigid gamma variate model was used to derive two nondeconvolution-based perfusion parameters: time to peak (TTP) and full width at half maximum (FWHM) for monitoring transitional bolus delay and dispersion changes respectively. TTP and FWHM values were normalized to the cerebellum. Here, we report that 74% (14/19) of patients improve in both TTP and FWHM measurements, and whereof 57% (8/14) improve more noticeably on FWHM. TTP is in good agreement with Tmax in estimating bolus delay. Our study data also suggest bolus dispersion estimated by FWHM is an additional, informative indicator in pediatric MMD monitoring.


2016 ◽  
Vol 09 (02) ◽  
pp. 1650023 ◽  
Author(s):  
Bin Peng ◽  
Jianying Jiang ◽  
Guo Chen ◽  
Lin Shu ◽  
Jie Feng ◽  
...  

Highly c-axis oriented aluminum nitrade (AlN) films were successfully deposited on flexible Hastelloy tapes by middle-frequency magnetron sputtering. The microstructure and piezoelectric properties of the AlN films were investigated. The results show that the AlN films deposited directly on the bare Hastelloy substrate have rough surface with root mean square (RMS) roughness of 32.43[Formula: see text]nm and its full width at half maximum (FWHM) of the AlN (0002) peak is [Formula: see text]. However, the AlN films deposited on the Hastelloy substrate with Y2O3 buffer layer show smooth surface with RMS roughness of 5.46[Formula: see text]nm and its FWHM of the AlN (0002) peak is only [Formula: see text]. The piezoelectric coefficient d[Formula: see text] of the AlN films deposited on the Y2O3/Hastelloy substrate is larger than three times that of the AlN films deposited on the bare Hastelloy substrate. The prepared highly c-axis oriented AlN films can be used to develop high-temperature flexible SAW sensors.


2016 ◽  
Vol 34 (4) ◽  
pp. 675-686 ◽  
Author(s):  
Z.-L. Pan ◽  
J.-H. Yang ◽  
X.-B. Cheng

AbstractAn anti-resonance pulse forming network (PFN) has been designed, analyzed, and tested for its application in generating quasi-square pulses. According to the circuit simulations, a compact generator based on two/three-section network was constructed. Two-section network is applied in the generator due to its compact structure, while three-section network is employed for generating pulses with higher quality. When two-section network is applied in the generator, the full-width at half-maximum of the load pulse is 400 ns, at the same time, its rise time, flat top and fall time are 90, 180 and 217 ns, respectively. When the three-section network is applied with the same pulse width of the load pulse, the rise time of the output decreases to 60 ns, while the flat top increases to 240 ns and the fall time reduces to 109 ns. Meanwhile, this kind of network could be used to shape the output pulses of generators whose equivalent circuit is LC series discharge network, such as MARX generator, into quasi-square pulses. And the preliminary experiment demonstrates that anti-resonance network could work well on four-stage Marx generators. A sine pulse generated by the four-stage Marx generator is shaped into a quasi-square pulse with voltage of 11.8 kV and pulse width about 110 ns based on two-section anti-resonance network.


1996 ◽  
Vol 422 ◽  
Author(s):  
H. Horiguchi ◽  
T. Kinone ◽  
R. Saito ◽  
T. Kimura ◽  
T. Ikoma

AbstractErbium films are evaporated on crystalline silicon substrates and are thermally diffused into silicon in an Ar+02 or H2 flow. Very sharp Er3+-related luminescence peaks are observed around 1.54 μ m.The main peak as well as the fine structures of the luminescence spectra depend on the annealing atmosphere, suggesting different luminescence centers. The full width at half maximum (FWHM) of the main peaks is ≤ 0.5nm at 20K. Thermal diffusion with Al films on top of the Er films is found to increase the intensity of the Er3+-related peaks greatly. The temperature dependence between 20 K and room temperature is relatively small, and a strong luminescence is obtained at room temperature.


2016 ◽  
Vol 24 (4) ◽  
Author(s):  
M. Písařík ◽  
P. Peterka ◽  
J. Aubrecht ◽  
J. Cajzl ◽  
A. Benda ◽  
...  

AbstractWe demonstrated two methods of increasing the bandwidth of a broadband light source based on amplified spontaneous emission in thulium-doped fibres. Firstly, we have shown by means of a comprehensive numerical model that the full-width at half maximum of the thulium-doped fibre based broadband source can be more than doubled by using specially tailored spectral filter placed in front of the mirror in a double-pass configuration of the amplified spontaneous emission source. The broadening can be achieved with only a small expense of the output power. Secondly, we report results of the experimental thulium-doped fibre broadband source, including fibre characteristics and performance of the thulium-doped fibre in a ring laser setup. The spectrum broadening was achieved by balancing the backward amplified spontaneous emission with back-reflected forward emission.


2008 ◽  
Vol 26 (4) ◽  
pp. 605-617 ◽  
Author(s):  
V.F. Tarasenko ◽  
E.H. Baksht ◽  
A.G. Burachenko ◽  
I.D. Kostyrya ◽  
M.I. Lomaev ◽  
...  

AbstractThis paper reports on the properties of a supershort avalanche electron beam generated in the air or other gases under atmospheric pressure and gives the analysis of a generation mechanism of supershort avalanche electron beam, as well as methods of such electron beams registration. It is reported that in the air under the pressure of 1 atm, a supershort (<100 ps) avalanche electron beam is formed in the solid angle more than 2π steradian. The electron beam has been obtained behind a 45 µm thick Al-Be foil in SF6 and Xe under the pressure of 2 atm, and in He, under the pressure of about 15 atm. It is shown that in SF6 under the high pressure (>1 atm) duration (full width at half maximum) of supershort avalanche electron beam pulse is about 150 ps.


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