scholarly journals Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Brunner ◽  
Márta Medvecz ◽  
Nóra Makra ◽  
Miklós Sárdy ◽  
Kinga Komka ◽  
...  
Keyword(s):  
Lichen Sclerosus ◽  
Gardnerella Vaginalis ◽  
Control Group ◽  
Vaginal Microbiome ◽  
Microbiome Composition ◽  
Streptococcus Anginosus ◽  
Menopausal Women ◽  
Post Menopausal ◽  
The Individual ◽  
Level Production

AbstractHuman beta defensins (hBDs) may play an important role in the progression of lichen sclerosus (LS), due to their ability to induce excessive stimulation of extracellular matrix synthesis and fibroblast activation. The genetic ability of the individual to produce defensins, the presence of microbes influencing defensin production, and the sensitivity of microbes to defensins together regulate the formation of an ever-changing balance between defensin levels and microbiome composition. We investigated the potential differences in postmenopausal vaginal microbiome composition and vaginal hBD levels in LS patients compared to non-LS controls. LS patients exhibited significantly lower levels of hBD1 (p = 0.0003), and significantly higher levels of hBD2 (p = 0.0359) and hBD3 (p = 0.0002), compared to the control group. The microbiome of the LS patients was dominated by possibly harmful bacteria including Lactobacillus iners, Streptococcus anginosus or Gardnerella vaginalis known to initiate direct or indirect damage by increasing defensin level production. Our observations highlight that correcting the composition of the microbiome may be applicable in supplementary LS therapy by targeting the restoration of the beneficial flora that does not increase hBD2-3 production.

scholarly journals Equol effects on AGE skin products, visceral fat and climacteric symptoms in post-menopausal women: A randomized controlled trial

2021 ◽  
Author(s):  
Remi Yoshikata ◽  
Khin Zay Yar Myint ◽  
Hiroaki Ohta ◽  
Yoko Ishigaki
Keyword(s):  
Randomized Controlled Trial ◽  
Visceral Fat ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Climacteric Symptoms ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Introduction: Equol, an isoflavone derivative whose chemical structure is similar to estrogen, is considered as a potentially effective agent for relieving climacteric symptoms, for the prevention of the lifestyle-related diseases, and for aging care in post-menopausal women. We investigated the effect of an equol-containing supplement on metabolism and aging, and climacteric symptoms, with respect to internally-produced equol in post-menopausal women.Methods: A single center, randomized controlled trial (registration number: UMIN000030975) on 57 post-menopausal Japanese women (mean age: 56±5.37 years), was conducted. Twenty-seven women received the equol supplement, while the remaining received Control. Metabolic and aging-related biomarkers were compared before and after the 3-month intervention. Climacteric symptoms were assessed every month using a validated self-administered questionnaire in Japanese post-menopausal women. Results: Three months post intervention, the treatment group showed significant improvement in climacteric symptoms, when compared to the Control group (81% vs. 53% respectively, p=0.045). We did not observe any beneficial effect on metabolic and aging-related biomarkers in the intervention group. However, in certain populations significant improvement in skin auto-fluorescence, which is a measurement of AGE skin products, and visceral fat area was observed, especially among equol producers. Conclusion: Women receiving equol supplement showed improved climacteric symptoms. This study offered a new hypothesis that there may be a synergy between supplemented equol and endogenously-produced equol to improve skin aging and visceral fat in certain populations.

scholarly journals Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women

2015 ◽  
Vol 114 (11) ◽  
pp. 1868-1874 ◽  
Author(s):  
Sarah M. Bristow ◽  
Greg D. Gamble ◽  
Angela Stewart ◽  
Anne M. Horne ◽  
Ian R. Reid
Keyword(s):  
Blood Pressure ◽  
Blood Coagulation ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Control Group ◽  
Calcium Citrate ◽  
Acute Effects ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Randomised Controlled

AbstractRecent evidence suggests that Ca supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various Ca supplements on blood Ca levels, we also investigated the effects of Ca supplements on blood pressure and their acute effects on blood coagulation. We randomised 100 post-menopausal women to 1 g/d of Ca or a placebo containing no Ca. Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. Blood coagulation was measured by thromboelastography (TEG) in a subgroup of participants (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The reduction in systolic blood pressure was smaller in the Ca group compared with the control group by >5 mmHg between 2 and 6 h (P≤0·02), and the reduction in diastolic blood pressure was smaller at 2 h (between-groups difference 4·5 mmHg, P=0·004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the calcium citrate and control groups. At 4 h, the increase in the coagulation index was greater in the calcium citrate group compared with the control group (P=0·03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that Ca supplements may acutely influence blood pressure and blood coagulation. Further investigation of this possibility is required.

scholarly journals Assessment of effectiveness of spinal exercises and body mechanics on low back pain among post menopausal women

2015 ◽  
Vol 1 (4) ◽  
pp. 191 ◽  
Author(s):  
Angel Rajakumari G ◽  
Soli T. K. ◽  
Malathy D
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Control Group ◽  
Low Back ◽  
Menopausal Women ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental ◽  
Equivalent Control ◽  
Post Menopausal

Aim: To assessment of effectiveness of spinal exercises and body mechanics on low back pain among post menopausal women.Participants and setting: A quasi experimental non equivalent control group pretest post test design was adapted. The study was conducted in the urban area of suryapet. 40 post menopausal women who fulfilled the inclusion criteria were selected by nonprobability purposive sampling technique.Intervention: The intervention such as spinal exercises and body mechanics were performed to overcome the level of low back pain among post menopausal women. The pre and post assessment was done by using a combined numerical and categorical pain scale.Measurement and findings: The women completed the demographic and obstetrical information and pain was measured by 0- 10 Modified combined numerical categorical pain intensity scale. This study revealed that there was high significant difference found in low back pain at p<0.001level between study group.Conclusion: The overall findings in the present study revealed that the spinal exercises and body mechanics was effectives and had brought about significant change in the reduction of low back pain among post menopausal women compared to pre test level of low back pain.

Effects of Hormone Replacement Therapy on Muscle Performance and Balance in Post-Menopausal Women

1996 ◽  
Vol 91 (6) ◽  
pp. 685-690 ◽  
Author(s):  
Alison L. Armstrong ◽  
Janet Oborne ◽  
Carol A. C. Coupland ◽  
Marion B. MacPherson ◽  
E. Joan Bassey ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Test Group ◽  
Muscle Performance ◽  
Control Group ◽  
Menopausal Women ◽  
Significant Difference ◽  
Post Menopausal ◽  
Leg Extensor Power

1. A randomized controlled trial of the effect of oral hormone replacement therapy plus calcium compared with calcium alone on balance, muscle performance and falls was conducted over 48 weeks in 116 post-menopausal women (aged 45–70 years), all of whom had suffered a distal radial fracture during the previous 3 months. Treatment was with Prempak C or Premarin 0.625 mg in the test group with 1 g calcium daily (Sandocal) in both groups. Measurements were made of balance, assessed as sway, leg extensor power and self-paced walking speed, at 12-week intervals over 24 weeks. Hand grip strength was measured every 12 weeks for 48 weeks, and falls in the preceding 12 weeks were recorded at each visit. 2. There was no relation between initial levels of oestradiol and any other variable assessed, except body mass. Levels of follicle-stimulating hormone in the test group were in the premenopausal range. There was no significant change attributable to hormone replacement therapy at any time point in any of the outcome variables. The only significant difference was an increase of 4.2% (95% confidence interval 0.7–7.6%) in leg extensor power in the control group (calcium alone) compared with the group treated with hormone replacement therapy. 3. Of the total group, 37% fell again during the year, with three patients suffering a further fracture. Frequent fallers swayed significantly more often than the others, but there was no evidence that their muscle strength was poorer or that the group treated with hormone replacement therapy fell less frequently. 4. Hormone replacement therapy did not increase muscle performance, improve balance or reduce falls over a year in middle-aged women.

scholarly journals The Vaginal Microbiome: A Long Urogenital Colonization Throughout Woman Life

2021 ◽  
Vol 11 ◽  
Author(s):  
Renata S. Auriemma ◽  
Roberta Scairati ◽  
Guendalina del Vecchio ◽  
Alessia Liccardi ◽  
Nunzia Verde ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hormone Replacement Therapy ◽  
Bacterial Species ◽  
Hormone Replacement ◽  
Vaginal Microbiome ◽  
Microbiome Composition ◽  
Post Menopausal ◽  
Lines Of Evidence

Vaginal microbial niche is a dynamic ecosystem, composed by more than 200 bacterial species which are influenced by genes, ethnic background and environmental-behavioral factors. Several lines of evidence have well documented that vaginal microbiome constantly changes over the course of woman’s life, so to exert an important impact on woman quality of life, from newborn to post-menopausal ages. This review aims at analyzing the role of vaginal microbiome in the maintenance of woman’s homeostasis and at tracking critical changes that commonly occur across woman’s lifetime. The role of hormone replacement therapy in the modulation of vaginal microbiome composition and in the improvement of vaginal wellness in postmenopausal women with decreasing levels of circulating estrogen is discussed.

scholarly journals The Effect of a Proprioceptive Exercises Programme on Disease Activity and Gait Biomechanical Parameters of Post-Menopausal Women with Rheumatoid Arthritis

2021 ◽  
Author(s):  
Pedro Aleixo ◽  
Tiago Atalaia ◽  
José Vaz Patto ◽  
João Abrantes
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Group Intervention ◽  
Stance Phase ◽  
Disease Activity Score ◽  
Exercise Group ◽  
Control Group ◽  
Menopausal Women ◽  
Biomechanical Parameters ◽  
Post Menopausal

This study aimed to assess the effects of a proprioceptive exercises programme on disease activity and on ankle kinematic and kinetic parameters of post-menopausal women with rheumatoid arthritis. Twenty-seven post-menopausal women with rheumatoid arthritis were allocated to exercise group (n = 15) or control group (n = 12). Exercise group intervention: proprioceptive exercises (12 weeks; 3 one-on-one workouts/week; 30 min/workout). Control group intervention: stretching exercises (12 weeks; 1 one-on-one workout every two weeks; 30 min/workout). Disease Activity Score (28 joints) was used to assess disease activity. A 3D motion analysis system (9 cameras, 200 Hz) and a force plate (1000 Hz) were used to collect kinematic and kinetic data during a barefoot walking at self-selected speed. For each subjects’ foot, 7 trials of the stance phase were collected. One subject withdrawal was registered in exercise group. Post-intervention, exercise group’ subjects yielded higher gait speed, shorter stance phase, shorter controlled dorsiflexion sub-phase, and higher ankle power peak (p < 0.05), however, they showed no differences in Disease Activity Score, ankle moment of force peak, and variability of biomechanical parameters; control group’ subjects showed no differences in all parameters. Proprioceptive exercises seemed to be a safe option to gain gait biomechanical improvements in post-menopausal women with rheumatoid arthritis.

scholarly journals Asymptomatic Bacteriuria amongst Menopausal women in Calabar, Nigeria

2018 ◽  
Vol 9 (4) ◽  
pp. 51-56
Author(s):  
Paul Columba Inyang-Etoh ◽  
Abasiodiong Udom Akpan ◽  
Victor Udo Usanga ◽  
Gabriel Chuks Ejezie
Keyword(s):  
Postmenopausal Women ◽  
Prevalence Rate ◽  
Asymptomatic Bacteriuria ◽  
Test Group ◽  
Early Morning ◽  
Control Group ◽  
Menopausal Women ◽  
High Prevalence ◽  
Post Menopausal ◽  
High Level

Background: Bacteriuria is considered a common bacterial infection in women particularly in postmenopausal women which consequently may warrant the need to treat the disease for prevention of bacteriuria developing complications.Aims and Objectives: This work was to investigate the prevalence of asymptomatic bacteriuria among menopausal women in Calabar, the incriminating bacterial pathogens and their antibiotic susceptibility pattern. Materials and Methods: Early morning mid stream urine samples from randomly selected 200 women (comprising of 50 premenopausal, 50 menopausal, 50 postmenopausal women and 50 apparently healthy young ladies of menstruating age (control subjects)) between the ages of 50 to 90 years were cultured by Leigh and Williams’s method. Questionnaires were also administered.Results: 24 (16%) of the test group while 3 (6%) of the control group had infection (p=0.008). Subjects aged 35-40 years had the highest prevalence of infection 6 (18.5%), while age group 66-70yrs had the lowest infection rate 0(0%)( P = 0.841). Post-menopausal women had the highest prevalence of asymptomatic bacteriuria 10(20%) while pre-menopausal and menopausal women had a lower prevalence rate of 7 (14%) each (p=0.0687). The most frequently isolated organism was Staphylococcus aureus (33%) and Ciprofloxacin was the most sensitive antibiotic observed.Conclusion: This work has revealed a high prevalence rate of asymptomatic bacteriuria high level of asymptomatic bacteriuria among menopausal women and the need for routine screening of this category of women for a standard healthy living.Asian Journal of Medical Sciences Vol.9(4) 2018 51-56

scholarly journals Effectiveness of deep breathing and walking exercise in reducing menopausal symptoms among post-menopausal women of Tripura, India

2021 ◽  
Vol 8 (6) ◽  
pp. 2881
Author(s):  
Koyel Deb ◽  
Dolly Gurumayum
Keyword(s):  
Menopausal Symptoms ◽  
Control Group ◽  
Menopausal Woman ◽  
Deep Breathing ◽  
Menopausal Women ◽  
Study Results ◽  
Severe Group ◽  
Walking Exercise ◽  
Post Menopausal ◽  
Experimental Group

Background: Menopause is the part of women’s life. Menopausal symptoms refer any feeling of illness or physical or mental change caused by menopause. Purpose of the study; to evaluate the effectiveness of deep breathing and walking exercise in reducing menopausal symptoms among post-menopausal women in selected community, Tripura and to find out the association between the pre-test menopausal symptoms among post-menopausal women with their selected demographic variables.Methods: A quantitative Quasi experimental research approach with short interrupted time series study design was used. The researcher selected 40 post-menopausal women as a sample by non-probability sampling technique. Data were collected with structured interview schedule on symptoms checklist and deep breathing and walking exercise practice checklist.Results: The study results show that the pre-observation of post-menopausal symptoms in the experimental group were; 12 (60%) post-menopausal women belong to Moderate group, 8 (40%) belong to severe group and nobody belong to mild group. Post-observation of post-menopausal symptoms of the experimental group were; 1(5%) post-menopausal woman belong to mild, 19 (95%) belong to moderate group and nobody belong to severe group. The pre-observation of post-menopausal symptoms in the control group were; post-menopausal women belong to Mild, Moderate and Severe group were 2 (10%), 13 (65%) and 5 (25%) respectively. Post-observation of post-menopausal symptoms of the control group were; 2 (10%) post-menopausal women belong to mild, 15 (75%) belong to moderate and 3 (15%) belong to severe group.Conclusions: The finding of present study revealed that breathing and walking exercise improved the post-menopausal symptoms in experimental group.   

Sign in / Sign up

Export Citation Format

Share Document