scholarly journals Axial length and its associations in the Ural Very Old Study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mukharram M. Bikbov ◽  
Gyulli M. Kazakbaeva ◽  
Ellina M. Rakhimova ◽  
Iuliia A. Rusakova ◽  
Albina A. Fakhretdinova ◽  
...  
Keyword(s):  
Axial Length ◽  
Educational Level ◽  
High Myopia ◽  
Regression Coefficient ◽  
Multivariable Analysis ◽  
Very Old ◽  
Refractive Power ◽  
Higher Educational ◽  
Corneal Refractive Power ◽  
Axial Myopia

AbstractTo assess the distribution of axial length as surrogate for myopia and its determinants in an old population, we performed the Ural Very Old Study as a population-based cohort study. Out of 1882 eligible individuals aged 85 + years, the Ural Very Old Study performed in an urban and rural region in Bashkortostan/Russia included 1526 (81.1%) individuals undergoing ophthalmological and medical examinations with sonographic axial length measurement. Biometric data were available for 717 (47.0%) individuals with a mean age of 88.0 ± 2.6 years (range 85–98 years; 25%). Mean axial length was 23.1 ± 1.1 mm (range 19.37–28.89 mm). Prevalences of moderate myopia (axial length 24.5–< 26.5 mm) and high myopia (axial length ≥ 26.5 mm) were 47/717 (6.6%; 95% CI 4.7, 8.4) and 10/717 (1.4%; 95% CI 0.5, 2.3), respectively. In multivariable analysis, longer axial length was associated (coefficient of determination r2 0.25) with taller body height (standardized regression coefficient beta:0.16;non-standardized regression coefficient B: 0.02; 95% confidence interval (CI) 0.01, 0.03; P < 0.001), higher level of education (beta: 0.12; B: 0.07; 95% CI 0.02, 0.11; P = 0.002), and lower corneal refractive power (beta: − 0.35; B: − 0.23; 95% CI − 0.28, − 0.18; P < 0.001). Higher prevalence of moderate myopia, however not of high myopia, was associated with higher educational level (OR 1.39; 95% CI 1.09, 1.68; P = 0.007) and lower corneal refractive power (OR 0.77; 95% CI 0.63, 0.94; P = 0.01). In this old study population, prevalence of moderate axial myopia (6.6% versus 9.7%) was lower than, and prevalence of high axial myopia (1.4% versus 1.4%) was similar as, in a corresponding study on a younger population from the same Russian region. Both myopia prevalence rates were higher than in rural Central India (1.5% and 0.4%, respectively). As in other, younger, populations, axial length and moderate myopia prevalence increased with higher educational level, while high myopia prevalence was independent of the educational level.

scholarly journals Evaluation of axial length/total corneal refractive power ratio as a potential marker for ocular diagnosis of Marfan’s syndrome in children

2021 ◽  
Vol 14 (8) ◽  
pp. 1218-1224
Author(s):  
Tian-Hui Chen ◽  
◽  
Yu-Liang Wang ◽  
Min Zhang ◽  
Jia-Hui Chen ◽  
...  
Keyword(s):  
Roc Curve ◽  
Axial Length ◽  
Curve Analysis ◽  
Youden Index ◽  
Control Group ◽  
Marfan’S Syndrome ◽  
Roc Curve Analysis ◽  
Marfan's Syndrome ◽  
Refractive Power ◽  
Corneal Refractive Power

AIM: To investigate whether the axial length (AL)/total corneal refractive power (TCRP) ratio is a sensitive and simple factor that can be used for the early diagnosis of Marfan’s syndrome (MFS) in children. METHODS: The relationship between the AL/TCRP ratio and the diagnosis of MFS for 192 eyes in 97 children were evaluate. The biological characteristics, including age, sex, AL, and TCRP, were collected from medical records. Receiver operating characteristic (ROC) curve analysis was performed to investigate whether the AL/TCRP ratio effectively distinguishes MFS from other subjects. The Youden index was used to re-divide the whole population into two groups according to an AL/TCRP ratio of 0.59. RESULTS: Of 96 subjects (mean age 7.46±3.28y) evaluated, 56 (110 eyes) had a definite diagnosis of MFS in childhood based on the revised Ghent criteria, 41 (82 eyes) with diagnosis of congenital ectopia lentis (EL) were included as a control group. AL was negatively correlated with TCRP, with a linear regression coefficient of -0.36 (R2=0.08). A significant correlation was found between age and the AL/TCRP ratio (P=0.023). ROC curve analysis showed that the AL/TCRP ratio distinguished MFS from the other patients at a threshold of 0.59. MFS patients were present in 24/58 (41.38%) patients with an AL/TCRP ratio of ≤0.59 and in 34/39 (87.18%) patients with an AL/TCRP ratio of >0.59. CONCLUSION: An AL/TCRP ratio of >0.59 is significantly associated with the risk of MFS. The AL/TCRP ratio should be measured as a promising marker for the prognosis of children MFS. Changes in the AL/TCRP ratio should be monitored over time.

Corneal refractive power after myopic LASIK

Ophthalmology ◽  
2003 ◽  
Vol 110 (9) ◽  
pp. 1857 ◽  
Author(s):  
Louis E Probst ◽  
Jack T Holladay
Keyword(s):  
Refractive Power ◽  
Corneal Refractive Power

scholarly journals What’s important to you? Socioeconomic inequalities in the perceived importance of health compared to other life domains

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Sanne E. Verra ◽  
Maartje P. Poelman ◽  
Andrea L. Mudd ◽  
Emely de Vet ◽  
Sofie van Rongen ◽  
...  
Keyword(s):  
Low Income ◽  
Educational Level ◽  
Latent Class ◽  
Financial Strain ◽  
Future Research ◽  
Life Domains ◽  
Perceived Importance ◽  
Long Life ◽  
Higher Educational ◽  
Future Focus

Abstract Background Pressing issues, like financial concerns, may outweigh the importance people attach to health. This study tested whether health, compared to other life domains, was considered more important by people in high versus low socioeconomic positions, with future focus and financial strain as potential explanatory factors. Methods A cross-sectional survey was conducted in 2019 among N=1,330 Dutch adults. Participants rated the importance of two health-related domains (not being ill, living a long life) and seven other life domains (e.g., work, family) on a five-point scale. A latent class analysis grouped participants in classes with similar patterns of importance ratings. Differences in class membership according to socioeconomic position (indicated by income and education) were examined using structural equation modelling, with future focus and financial strain as mediators. Results Three classes were identified, which were defined as: neutralists, who found all domains neutral or unimportant (3.5% of the sample); hedonists, who found most domains important except living a long life, work, and religion (36.2%); and maximalists, who found nearly all domains important, including both health domains (60.3%). Of the neutralists, 38% considered not being ill important, and 30% considered living a long life important. For hedonists, this was 92% and 39%, respectively, and for maximalists this was 99% and 87%, respectively. Compared to belonging to the maximalists class, a low income predicted belonging to the neutralists, and a higher educational level and unemployment predicted belonging to the hedonists. No mediation pathways via future focus or financial strain were found. Conclusions Lower income groups were less likely to consider not being ill important. Those without paid employment and those with a higher educational level were less likely to consider living a long life important. Neither future focus nor financial strain explained these inequalities. Future research should investigate socioeconomic differences in conceptualisations of health, and if inequalities in the perceived importance of health are associated with inequalities in health. To support individuals dealing with challenging circumstances in daily life, health-promoting interventions could align to the life domains perceived important to reach their target group and to prevent widening socioeconomic health inequalities.

scholarly journals Prevalence of Medication-Dietary Supplement Combined Use and Associated Factors

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2466
Author(s):  
Ignacio Aznar-Lou ◽  
Cristina Carbonell-Duacastella ◽  
Ana Rodriguez ◽  
Inés Mera ◽  
Maria Rubio-Valera
Keyword(s):  
Angiotensin Ii ◽  
Dietary Supplement ◽  
Educational Level ◽  
Associated Factors ◽  
Potential Interaction ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Civil Status ◽  
Interaction Factors ◽  
Higher Educational

Introduction: The use of medication has increased in recent years in the US while the use of dietary supplements has remained stable but high. Interactions between these two kinds of products may have important consequences, especially in the case of widely used medications such as antihypertensives and antibiotics. The aim of this paper is to estimate the prevalence of potentially serious drug–dietary supplement interactions among tetracyclines, thiazides, and angiotensin II receptor blocker users by means of the NHANES 2013–2014 dataset. Methods: Data from 2013–2014 NHANES were obtained. Potential interactions analysed were tetracyclines with calcium, magnesium, and zinc, thiazides with vitamin D, and angiotensin II receptors blockers with potassium. Prevalence was calculated for each potential interaction. Logistic regression was used to assess associated factors. Results: 864 prescriptions issued to 820 patients were analysed. Overall prevalence of potential interaction was 49%. Older age and higher educational level were strongly associated with being at risk of a potential interaction. Factors such as age, race, civil status, citizenship, country of birth, BMI, and physical activity did not show notable associations. Conclusions: Healthcare professionals should be aware of other medical products when they prescribe or dispense a medication or a dietary supplement, especially to the older population and people with a higher educational level.

scholarly journals Endothelin-1 Serum Concentration is Lower in Children and Adolescents with High Myopia, a Preliminary Study

2020 ◽  
Vol 9 (5) ◽  
pp. 1327
Author(s):  
Katarzyna Powierza ◽  
Beata Żelazowska-Rutkowska ◽  
Jolanta Sawicka-Powierza ◽  
Bożena Mikołuć ◽  
Beata Urban ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Axial Length ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Concentrations ◽  
Myopia Progression ◽  
Cross Sectional ◽  
Weak Negative Correlation ◽  
Preliminary Study

The aim of this study is to evaluate the levels of enothelin-1 (ET-1) in children and adolescents with high myopia and its association with the axial length of the eye and the presence of myopic retinal degeneration. The cross-sectional study was carried out in 57 patients with high myopia and 29 control subjects. Serum concentrations of ET-1 were measured using enzyme-linked immunosorbent assay (ELISA) kit. A significantly lower concentration of ET-1 in highly myopic patients compared to controls was found (1.47 (0.91; 1.87) vs. 1.94 (1.1; 2.69) pg/mL, p = 0.005). In patients with high myopia, a weak negative correlation between ET-1 concentration and the longest axial length out of the two eyes was found (r = −0.255, p = 0.0558). Further analysis revealed statistically significant differences in ET-1 concentration between patients with the axial length of the eye > 26 and ≤ 26 mm (p < 0.041) and patients with the axial length of the eye > 26 mm and controls (p < 0.001). ET-1 expression is disturbed in highly myopic children and adolescents. Lower ET-1 concentration in patients with the axial length of the eye > 26 mm may co-occur with high myopia and should be considered a risk factor in the pathophysiology of high myopia progression.

Dome-shaped macula: a potential protective factor for visual acuity after cataract surgery in patients with high myopia

2019 ◽  
Vol 103 (11) ◽  
pp. 1566-1570 ◽  
Author(s):  
Xiangjia Zhu ◽  
Wenwen He ◽  
Shaohua Zhang ◽  
Xianfang Rong ◽  
Qi Fan ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Axial Length ◽  
High Myopia ◽  
Protective Factor ◽  
Choroidal Neovascularisation ◽  
Postoperative Visual Acuity ◽  
Younger Age ◽  
Male Sex ◽  
Central Fovea

PurposeTo evaluate whether the presence of dome-shaped macula (DSM) is a protective factor for visual acuity after cataract surgery in patients with high myopia.MethodsIncluded were 891 highly myopic cataract eyes (600 patients) that were examined by optical coherence tomography (OCT) through the central fovea and underwent cataract surgery in our hospital. DSM was defined as an inward bulge >50 µm in horizontal or vertical OCT sections. The incidences of various maculopathies were compared between eyes with and those without DSM. The influences of age, sex, eye laterality, axial length and DSM on postoperative visual acuity were evaluated by multivariate linear regression.ResultsOf the 891 eyes, 123 (13.8%) had DSM. There was a greater association of DSM with extrafoveal retinoschisis (RS) than with other vision-threatening complications such as foveal RS and choroidal neovascularisation. In addition to axial length and age, sex was associated with the presence of DSM (p=0.016). In bilateral high myopia, the incidence of DSM increased with the degree of anisometropia and was more common in the longer eye of patients with anisometropia. Younger age, male sex, shorter axial length and the presence of DSM were associated with better postoperative visual acuity in highly myopic cataract eyes (β=0.124, p=0.002; β=0.142, p<0.001; β=0.275, p<0.001 and β=−0.088, p=0.038, respectively).ConclusionAssociated with fewer visual threatening macular complications, presence of DSM may be a protective factor for visual function after cataract surgery in highly myopic eyes.

scholarly journals The Association between Macular Thickness and Axial Length in Myopic Eyes

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Yeon Woong Chung ◽  
Moon Young Choi ◽  
Jung-sub Kim ◽  
Jin-woo Kwon
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
High Myopia ◽  
Polynomial Regression ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Regression Analyses ◽  
Foveal Thickness ◽  
P Values ◽  
The Relationship

Purpose. To investigate the relationship between macular thickness and axial length (AL) in myopic eyes. Methods. We included 441 myopic eyes in this study and measured macular thickness at the fovea and in other macular regions, using optical coherence tomography. We got thickness difference indices (TDIs) which by definition are the values of thickness difference obtained by subtracting the foveal thickness from that of each macula sector to evaluate macular contour. We then analyzed the relationships between AL and foveal thickness and AL and the TDIs of each macular sector. Results. In polynomial regression analyses, foveal thickness slope was relatively flat up to an AL of 25.5 mm and began to rise from 25.5–26.0 mm. The TDIs were also relatively flat up to AL of 25.5mm and started to show steepened negative slopes from around AL of 25.5 mm. When grouping myopia participants as high myopia or non-high myopia based on AL of 25.5mm, all macular indices of the high myopia group showed significant correlation with AL (all p values <0.01). But all indices of non-high myopia group had no significant correlation with AL. Conclusions. Average macular thickness profiles showed that appreciable changes started at an AL of 25.5mm.

scholarly journals Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2

2019 ◽  
Vol 104 (7) ◽  
pp. 967-973 ◽  
Author(s):  
Ameenat Lola Solebo ◽  
Jugnoo S Rahi
Keyword(s):  
Adverse Events ◽  
Cataract Surgery ◽  
Axial Length ◽  
Multivariable Analysis ◽  
Population Based ◽  
Secondary Glaucoma ◽  
Bilateral Cataract ◽  
Younger Age ◽  
Age At Surgery ◽  
Unilateral Disease

BackgroundWe investigated glaucoma related adverse events, predictors and impact at 5 years following surgery in the IoLunder2 cohortMethodsPopulation based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 and December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure (IOP). Glaucoma related adverse events were any involving elevated IOP. Multivariable analysis was undertaken to investigate potential predictors of secondary glaucoma with adjustment for within-child correlation in bilateral cataract. Unilateral and bilateral cataract were analysed separately.ResultsComplete follow-up data were available for 235 of 254, 93% of the inception cohort. By 5 years after primary cataract surgery, 20% of children with bilateral cataract and 12% with unilateral had developed secondary glaucoma. Glaucoma related complications had been diagnosed in 24% and 36% of children, respectively. Independent predictors of glaucoma were younger age at surgery (adjusted OR for reduction of week in age: 1.1, 95%C I 1.1 to 1.2, p<0.001); the presence of significant ocular comorbidity (adj OR 3.2, 95% CI 1.1 to 9.6, p=0.01); and shorter axial length (adj OR for each mm 1.7, 95% CI 10.0 to 1, p=0.05) for bilateral cataract. Shorter axial length was the single independent factor in unilateral disease (adj OR 9.6, 95% CI 1.7 to 52, p=0.009)ConclusionsBoth younger age at surgery (the strongest marker of ocular ‘immaturity’) and smaller ocular size (a marker of both immaturity and developmental vulnerability) can be used to identify those at greatest risk of glaucoma due to early life cataract surgery.

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