A novel synthetic strategy for covalently bonding dendrimers to ordered mesoporous silica: potential drug delivery applications

2009 ◽  
Vol 19 (47) ◽  
pp. 9012 ◽  
Author(s):  
Blanca González ◽  
Montserrat Colilla ◽  
Carlos López de Laorden ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Ordered Mesoporous Silica ◽  
Potential Drug ◽  
Synthetic Strategy ◽  
Ordered Mesoporous ◽  
Drug Delivery Applications

Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica

2008 ◽  
Vol 391 ◽  
pp. 169-184 ◽  
Author(s):  
T. López ◽  
Fernando Edgar Krötzsch ◽  
E. Ortiz Islas ◽  
M. Alvarez Lemus ◽  
E. Balsadella ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Surface Area ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ordered Mesoporous Silica ◽  
Ordered Mesoporous ◽  
Vis Spectroscopy ◽  
Silica Materials ◽  
Inflammatory Infiltrates

Mesoporous silica type SBA-15 has high specific surface area, well ordered pores and renders larges volumes, reasons for its potential use in controlled drug delivery system; in addition its non toxic nature and good biocompatibility. The aim of this work is to determine the feasibility of loading collagen-polyvinylpyrrolidone (collagen-PVP) molecules into Biocompatible Nanostructured Ordered Mesoporous Silica (BINOM-Silica). Collagen-PVP has several medical uses, such as fibrolytic activity and tissue regeneration. Therefore, this BINOM-Silica/collagen- PVP material could be used as drug delivery system for hypertrophic scarring. Different BINOMSilica materials were prepared using a triblock copolymer in an acid medium and stabilized at 557°C and later, collagen-PVP was loaded into the material. The small angle powder X-ray diffraction patterns of BINOM-Silica materials, in some cases, indicate the existence of a high degree of hexagonal mesoscopic organization. The nitrogen sorption isotherms are type IV typical of mesoporous materials with large surface area. In vitro release of collagen-PVP was carried out by mean of UV/VIS spectroscopy. The cumulative release profiles of Silica-collagen PVP in distilled water indicate a two step release, an initial fast release and a relatively slow subsequent release, indicating an appropriate delivery of collagen-PVP for therapeutic administration. BINOMSilica/ collagen-PVP intradermical administration stimulated inflammatory infiltrates only in an acute phase (day 3), demonstrating that silica materials and their combination with chemical and biological drugs could be safe for therapeutics. The absence of inflammatory infiltrates at day 7 suggested an appropriate integration of BINOM-Silica/collagen-PVP into the tissue. These results indicate that we obtained biocompatible nanostructured ordered mesoporous silica materials useful for delivery systems.

SBA-15 ordered mesoporous silica inside a bioactive glass–ceramic scaffold for local drug delivery

2008 ◽  
Vol 19 (10) ◽  
pp. 3303-3310 ◽  
Author(s):  
V. Cauda ◽  
S. Fiorilli ◽  
B. Onida ◽  
E. Vernè ◽  
C. Vitale Brovarone ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Bioactive Glass ◽  
Glass Ceramic ◽  
Local Drug Delivery ◽  
Ordered Mesoporous Silica ◽  
Ceramic Scaffold ◽  
Ordered Mesoporous

Direct manipulation of particle size and morphology of ordered mesoporous silica by flow synthesis

RSC Advances ◽  
2015 ◽  
Vol 5 (18) ◽  
pp. 13331-13340 ◽  
Author(s):  
T. N. Ng ◽  
X. Q. Chen ◽  
K. L. Yeung
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Hollow Spheres ◽  
Ordered Mesoporous Silica ◽  
Direct Manipulation ◽  
Flow Synthesis ◽  
Precise Control ◽  
Ordered Mesoporous ◽  
Particle Size And Morphology ◽  
Size And Morphology

Flow-synthesis of mesoporous silica allows deliberate and precise control over the size and shapes and enables the preparation of complex microstructures (i.e., hollow spheres).

scholarly journals SPION-decorated organofunctionalized MCM48 silica-based nanocomposites for magnetic solid-phase extraction

2021 ◽  
Vol 2 (3) ◽  
pp. 963-973
Author(s):  
Daniel Garcia-Osorio ◽  
Helton P. Nogueira ◽  
Josué M. Gonçalves ◽  
Sergio H. Toma ◽  
Sergio Garcia-Segura ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Critical Micellar Concentration ◽  
Phase Extraction ◽  
Ordered Mesoporous Silica ◽  
Ordered Mesoporous ◽  
Magnetic Solid ◽  
Magnetic Recovery

(a) Cubic structures formed by CTAB above critical micellar concentration used as a template to generate highly ordered mesoporous silica. (b) Photo showing the magnetic recovery of MCM48/SPION/C8 nanocomposite in 60 s.

Synthesis and characterization of dicationic 4,4′-bipyridinium dichloride ordered mesoporous silica nanocomposite and its application in the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (33) ◽  
pp. 25816-25823 ◽  
Author(s):  
Aigin Bashti ◽  
Ali Reza Kiasat ◽  
Babak Mokhtari
Keyword(s):  
Mesoporous Silica ◽  
Synthesis And Characterization ◽  
Ordered Mesoporous Silica ◽  
One Pot ◽  
Ordered Mesoporous ◽  
Environmentally Safe ◽  
P Application ◽  
The One ◽  
Solvent Free Synthesis

Application of SBA@BiPy2+ 2Cl− nanocomposite as a novel environmentally safe heterogeneous nanoreactor for the one-pot solvent-free synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives.

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