scholarly journals Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5714-5721 ◽  
Author(s):  
Jessica C. Brooks ◽  
Katarena I. Ford ◽  
Dylan H. Holder ◽  
Mark D. Holtan ◽  
Christopher J. Easley
Keyword(s):  
Adipose Tissue ◽  
Microfluidic Devices ◽  
Microfluidic Channels ◽  
Time Resolved ◽  
Endocrine Tissue ◽  
Tissue Explants ◽  
3D Printed ◽  
Bulk Substrate

3D-printed templates enabled sculpting of design-specific fluidic reservoirs into the bulk substrate of microfluidic devices used for culture and time-resolved sampling of islets and adipose tissue explants.

Comparison of Microscale Rapid Prototyping Techniques for Microfluidic Applications

2014 ◽  
Author(s):  
Gordon D. Hoople ◽  
David A. Rolfe ◽  
Katherine C. McKinstry ◽  
Joanna R. Noble ◽  
David A. Dornfeld ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Laser Ablation ◽  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Optical Microscope ◽  
Microfluidic Channels ◽  
Recent Developments ◽  
3D Printed ◽  
Small Feature ◽  
Scanning Electron

Recent developments in microfluidics have opened up new interest in rapid prototyping with features on the microscale. Microfluidic devices are traditionally fabricated using photolithography, however this process can be time consuming and challenging. Laser ablation has emerged as the preferred solution for rapid prototyping of these devices. This paper explores the state of rapid prototyping for microfluidic devices by comparing laser ablation to micromilling and 3D printing. A microfluidic sample part was fabricated using these three methods. Accuracy of the features and surface roughness were measured using a surface profilometer, scanning electron microscope, and optical microscope. Micromilling was found to produce the most accurate features and best surface finish down to ∼100 μm, however it did not achieve the small feature sizes produced by laser ablation. 3D printed parts, though easily manufactured, were inadequate for most microfluidics applications. While laser ablation created somewhat rough and erratic channels, the process was within typical dimensions for microfluidic channels and should remain the default for microfluidic rapid prototyping.

A simple procedure to produce FDM-based 3D-printed microfluidic devices with an integrated PMMA optical window

2019 ◽  
Vol 11 (8) ◽  
pp. 1014-1020 ◽  
Author(s):  
Lucas P. Bressan ◽  
Cristina B. Adamo ◽  
Reverson F. Quero ◽  
Dosil P. de Jesus ◽  
José A. F. da Silva
Keyword(s):  
Simple Procedure ◽  
Microfluidic Devices ◽  
Microfluidic Channels ◽  
Optical Window ◽  
3D Printed ◽  
The Creation ◽  
Transparent Windows

The protocol developed enables the creation of transparent windows for the easy visualization inside the 3D-printed microfluidic channels.

Automated calibration of 3D-printed microfluidic devices based on computer vision

2021 ◽  
Vol 15 (2) ◽  
pp. 024102
Author(s):  
Junchao Wang ◽  
Kaicong Liang ◽  
Naiyin Zhang ◽  
Hailong Yao ◽  
Tsung-Yi Ho ◽  
...  
Keyword(s):  
Computer Vision ◽  
Microfluidic Devices ◽  
Automated Calibration ◽  
3D Printed

scholarly journals Rapid Production of PDMS Microdevices for Electrodriven Separations and Microfluidics by 3D-Printed Scaffold Removal

Separations ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 67
Author(s):  
Alena Šustková ◽  
Klára Konderlová ◽  
Ester Drastíková ◽  
Stefan Sützl ◽  
Lenka Hárendarčíková ◽  
...  
Keyword(s):  
Organic Dyes ◽  
Microfluidic Devices ◽  
Proof Of Concept ◽  
Magnetic Microparticles ◽  
Mechanical Removal ◽  
Glass Slides ◽  
Rapid Production ◽  
3D Printed

In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were fully inserted in the PDMS and then carefully removed. The bonded devices were produced by forming imprints of the 3D-printed scaffolds in PDMS, followed by bonding the PDMS parts to glass slides. All these microfluidic devices were then successfully employed in three proof-of-concept applications: capture of magnetic microparticles, formation of droplets, and isotachophoresis separation of model organic dyes.

scholarly journals 3D printed microfluidic devices with immunoaffinity monoliths for extraction of preterm birth biomarkers

2018 ◽  
Vol 411 (21) ◽  
pp. 5405-5413 ◽  
Author(s):  
Ellen K. Parker ◽  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Haifa M. Almughamsi ◽  
Jacob B. Nielsen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Microfluidic Devices ◽  
3D Printed

scholarly journals Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range

2018 ◽  
Vol 23 (06) ◽  
pp. 1 ◽  
Author(s):  
Sayuri Fuse ◽  
Shinsuke Nirengi ◽  
Shiho Amagasa ◽  
Toshiyuki Homma ◽  
Ryotaro Kime ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Near Infrared ◽  
Time Resolved ◽  
Time Resolved Spectroscopy ◽  
Tissue Density ◽  
Brown Adipose ◽  
Age Range

scholarly journals Self-Aligned Interdigitated Transducers for Acoustofluidics

2016 ◽  
Author(s):  
Zhichao Ma ◽  
Adrian J. T. Teo ◽  
Say Hwa Tan ◽  
Ye Ai ◽  
Nam-Trung Nguyen
Keyword(s):  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Particle Separation ◽  
Microfluidic Devices ◽  
Current Approach ◽  
Droplet Generation ◽  
Microfluidic Channels ◽  
Clean Room ◽  
Precise Location ◽  
Innovative Method

Surface acoustic wave (SAW) is effective for the manipulation of fluids and particles in microscale. The current approach of integrating interdigitated transducers (IDTs) for SAW generation into microfluidic channels involves complex and laborious microfabrication steps. These steps often require the full access to clean room facilities and hours to align the transducers to the precise location. This work presents an affordable and innovative method for fabricating SAW-based microfluidic devices without the need of clean room facilities and alignment. The IDTs and microfluidic channels are fabricated in the same process and thus precisely self-aligned in accordance with the device design. With the use of the developed fabrication approach, a few types of different SAW-based microfluidic devices have been fabricated and demonstrated for particle separation and active droplet generation.

scholarly journals Adipokines: mechanisms of metabolic and behavioral disorders

2018 ◽  
Vol 15 (3) ◽  
pp. 14-20
Author(s):  
Yassine Chahirou ◽  
Abdelhalim Mesfioui ◽  
Ali Ouichou ◽  
Aboubaker Hessni
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Behavioral Disorders ◽  
Health Problems ◽  
Endocrine Tissue ◽  
Physiological Functions ◽  
Relationship Of ◽  
The Relationship

Current studies show that metabolic and behavioral disorders represent severe health problems. Several questions arise about the molecular relationship of metabolic and behavioral disorders. This review will discuss the relationship of lipid metabolism and fructose consumption accompanied by an increase in weight as well as associated disorders: hypertension, insulin-resistance, oxidative stress and depression. Adipose tissue is considered as an endocrine tissue with intense secretory activities (metabolic and inflammatory). These adipokines are responsible for an alteration of several physiological functions. In this review we will try to understand how lipogenesis that causes dyslipidemia can influence insulin resistance, hypertension, oxidative stress, depression and the relationship between these various disorders.

scholarly journals Microfluidic Devices for Time-Resolved Cryo-Electron Microscopy

2009 ◽  
Vol 96 (3) ◽  
pp. 411a-412a
Author(s):  
Zonghuan Lu ◽  
David Barnard ◽  
Tanvir R. Shaikh ◽  
Hisham Mohamed ◽  
Xing Meng ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Microfluidic Devices ◽  
Time Resolved ◽  
Cryo Electron Microscopy
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