A novel ratiometric fluorescent immunoassay for human α-fetoprotein based on carbon nanodot-doped silica nanoparticles and FITC

2016 ◽  
Vol 8 (27) ◽  
pp. 5398-5406 ◽  
Author(s):  
Yuanyuan Wu ◽  
Peng Wei ◽  
Sumate Pengpumkiat ◽  
Emily A. Schumacher ◽  
Vincent T. Remcho
Keyword(s):  
Detection Limit ◽  
Liver Cancer ◽  
Silica Nanoparticles ◽  
Cancer Biomarker ◽  
Linear Range ◽  
Low Detection Limit ◽  
Fluorescent Carbon

Non-toxic, fluorescent carbon nanodot labels are employed as novel ratiometric immunosensors for α-fetoprotein (AFP), a liver cancer biomarker. The assay generates a broad linear range, a low detection limit, and can be adapted to a variety of immunoassay targets.

Enzyme-free amplified DNA assay: five orders of linearity provided by metal stable isotope detection

2018 ◽  
Vol 54 (98) ◽  
pp. 13782-13785 ◽  
Author(s):  
Yu Liu ◽  
Yonggang Ding ◽  
Ying Gao ◽  
Rui Liu ◽  
Xiaorong Hu ◽  
...  
Keyword(s):  
Detection Limit ◽  
Stable Isotope ◽  
Clinical Diagnosis ◽  
Linear Range ◽  
Dna Assay ◽  
Wide Linear Range ◽  
Low Detection Limit ◽  
Detection Strategy

The metal stable isotope detection strategy demonstrates a wide linear range and a low detection limit, showing promising potential in clinical diagnosis.

3D sandwich-type prostate specific antigen (PSA) immunosensor based on rGO–MWCNT–Pd nanocomposite

2015 ◽  
Vol 39 (7) ◽  
pp. 5522-5528 ◽  
Author(s):  
Lihui Tian ◽  
Lei Liu ◽  
Yueyuan Li ◽  
Qin Wei ◽  
Wei Cao
Keyword(s):  
Detection Limit ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Linear Range ◽  
Wide Linear Range ◽  
Low Detection Limit ◽  
Sandwich Type ◽  
Diagnostic Applications

A signal amplifying sandwich-type immunosensor with a wide linear range and a low detection limit is developed with potential clinical and diagnostic applications.

Highly effective chemosensor of a luminescent silica@lanthanide complex@MOF heterostructured composite for metal ion sensing

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101982-101988 ◽  
Author(s):  
Chang Liu ◽  
Bing Yan
Keyword(s):  
Aqueous Solution ◽  
Detection Limit ◽  
Metal Ion ◽  
Lanthanide Complex ◽  
Linear Range ◽  
Low Detection Limit ◽  
Ion Sensing ◽  
Environmental Systems ◽  
Highly Effective ◽  
Metal Ion Sensing

A highly selective and sensitive heterogeneous sensor to detect Cu2+ in aqueous solution has good fluorescence stability, low detection limit and broad linear range making it a potential chemosensor for Cu2+ in environmental systems.

scholarly journals A Novel Electrochemical Sensor Based on MnO2/Sepiolite Nanocomposite for the Detection of Hydrogen Peroxide in Human Serum Samples

2021 ◽  
Vol 19 (3) ◽  
Author(s):  
AbduRahman Hosseinifar ◽  
Masoud Ghanei-Motlagh ◽  
Maryam Fayazi
Keyword(s):  
Hydrogen Peroxide ◽  
Detection Limit ◽  
Human Serum ◽  
Electrochemical Method ◽  
Linear Range ◽  
Carbon Paste ◽  
Serum Samples ◽  
X Ray ◽  
Human Serum Samples ◽  
Low Detection Limit

Background: The reliable and easy-to-operate detection of hydrogen peroxide (H2O2) has attracted extensive attention in the fields of biomedicine, food security, and environmental analysis. Objectives: In this work, a novel electrochemical method was proposed for H2O2 monitoring using a carbon paste electrode (CPE) modified with MnO2/sepiolite nanocomposite. Methods: MnO2/sepiolite material was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) technique. The modified CPE was employed for the amperometric monitoring of H2O2 in human serum samples. Results: Electrochemical data showed that the MnO2/sepiolite-CPE displays a high peak current towards H2O2 oxidation. A linear range from 5 to 700 μM and a low detection limit of 0.8 μM for H2O2 were obtained with the proposed sensor. Besides, the electrode depicted excellent reproducibility and anti-interferant ability, promising the applicability of this electrochemical method in practical analyses. Conclusions: This work introduced a new and effective enzyme-less H2O2 sensor based on the MnO2/sepiolite nanocomposite modified CPE. The suggested sensor showed good sensitivity for the rapid detection of H2O2 in a wide linear range with a low detection limit and satisfactory reproducibility, which made it practical for the analysis of hydrogen H2O2 in real samples.

Synthesis of Ag@SiO2 yolk–shell nanoparticles for hydrogen peroxide detection

RSC Advances ◽  
2015 ◽  
Vol 5 (23) ◽  
pp. 17372-17378 ◽  
Author(s):  
Chao Liu ◽  
Jiansheng Li ◽  
Jing Wang ◽  
Junwen Qi ◽  
Wenhong Fan ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Detection Limit ◽  
Linear Range ◽  
Shell Nanoparticles ◽  
Amperometric Response ◽  
Wide Linear Range ◽  
Low Detection Limit ◽  
Hydrogen Peroxide Detection ◽  
Reduction Approach

A novel nonenzymatic H2O2 sensor is fabricated based on Ag@SiO2 yolk–shell nanoparticles (YSNs) via a sequential impregnation–reduction approach. These exhibit outstanding H2O2 reduction, with a fast amperometric response, a low detection limit and a wide linear range.

Graphene quantum dots and Nafion composite as an ultrasensitive electrochemical sensor for the detection of dopamine

2016 ◽  
Vol 8 (24) ◽  
pp. 4912-4918 ◽  
Author(s):  
Pengfei Pang ◽  
Fuqing Yan ◽  
Haizhen Li ◽  
Haiyan Li ◽  
Yanli Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Detection Limit ◽  
Electrochemical Sensor ◽  
Electrode Material ◽  
Graphene Quantum Dots ◽  
Linear Range ◽  
Ultrasensitive Detection ◽  
Wide Linear Range ◽  
Low Detection Limit

A graphene quantum dots-Nafion composite as a novel electrode material was developed for ultrasensitive detection of dopamine with a low detection limit of 0.45 nM and a wide linear range of 5 nM to 100 μM.

Application of Mercaptostyrene Divinyl Benzene Immobilized on Ion-Exchange Polymeric Membrane as Hg(II) Sensor

2020 ◽  
Vol 18 (1) ◽  
pp. 1-4
Author(s):  
Abdellah Hamel ◽  
Karima Morakchi ◽  
Amel Bendjama ◽  
Hiba Mahfoud ◽  
Rochedi Kherrat
Keyword(s):  
Detection Limit ◽  
Impedance Spectroscopy ◽  
Ion Exchange ◽  
Electrochemical Sensor ◽  
Linear Range ◽  
Polymeric Membrane ◽  
Experimental Conditions ◽  
Low Detection Limit ◽  
Divinyl Benzene

Herein, we report the fabrication of electrochemical sensor for the detection of mercury Hg(II) ions using macroporous divinyl benzene immobilized on ion-exchange polymeric ionophore. Impedance spectroscopy was adopted to examine the performance of the fabricated sensor. Various experiments were done to get the optimized experimental conditions of the fabricated sensor. The fabricated sensor demonstrates a linear range of 10–8 to 10–5 M and low detection limit was about 10–4.8 M.

scholarly journals Rapid One-Pot Synthesis of Polydopamine Encapsulated Carbon Anchored with Au Nanoparticles: Versatile Electrocatalysts for Chloramphenicol and Folic Acid Sensors

2020 ◽  
Vol 21 (8) ◽  
pp. 2853 ◽  
Author(s):  
Veerappan Mani ◽  
T.S.T. Balamurugan ◽  
Sheng-Tung Huang
Keyword(s):  
Folic Acid ◽  
Detection Limit ◽  
Au Nanoparticles ◽  
Linear Range ◽  
One Pot ◽  
Wide Linear Range ◽  
Low Detection Limit ◽  
Current State ◽  
Synthetic Procedure ◽  
Reduced Graphene

Designing and engineering nanocomposites with tailored physiochemical properties through teaming distinct components is a straightforward strategy to yield multifunctional materials. Here, we describe a rapid, economical, and green one-pot microwave synthetic procedure for the preparation of ternary nanocomposites carbon/polydopamine/Au nanoparticles (C/PDA/AuNPs; C = carbon nanotubes (CNTs), reduced graphene oxide (rGO)). No harsh reaction conditions were used in the method, as are used in conventional hydrothermal or high-temperature methods. The PDA unit acts as a non-covalent functionalizing agent for carbon, through π stacking interactions, and also as a stabilizing agent for the formation of AuNPs. The CNTs/PDA/AuNPs modified electrode exhibited excellent electrocatalytic activity to oxidize chloramphenicol and the resulting sensor exhibited a low detection limit (36 nM), wide linear range (0.1–534 μM), good selectivity (against 5-fold excess levels of interferences), appreciable reproducibility (3.47%), good stability (94.7%), and practicality (recoveries 95.0%–98.4%). Likewise, rGO/PDA/AuNPs was used to fabricate a sensitive folic acid sensor, which exhibits excellent analytical parameters, including wide linear range (0.1–905 μM) and low detection limit (25 nM). The described synthetic route includes fast reaction time (5 min) and a readily available household microwave heating device, which has the potential to significantly contribute to the current state of the field.

Synthesis of Polyaniline/Zn Bismuthate Nanocomposites and Sensitive Formaldehyde Sensing Performance

2019 ◽  
Vol >15 (5) ◽  
pp. 492-500
Author(s):  
Lizhai Pei ◽  
Fanglv Qiu ◽  
Yue Ma ◽  
Feifei Lin ◽  
Chuangang Fan ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Detection Limit ◽  
Electrode Materials ◽  
Electrochemical Sensors ◽  
Biological Fluid ◽  
Linear Range ◽  
Formaldehyde Concentration ◽  
Liquid Environment ◽  
Wide Linear Range ◽  
Low Detection Limit

Background: Formaldehyde belongs to important pollutant and is usually found in liquid environment, such as juices, beer, cleaning products and biological fluid of the human. The electrochemical sensors using glassy carbon electrode (GCE) modified with polyaniline/Zn bismuthate nanocomposites can effectively detect formaldehyde with broad linear range and good reproducibility. Methods: Polyaniline/Zn bismuthate nanocomposites were prepared by in-situ aniline polymerizing route in aqueous solution. The structure and morphologies of the nanocomposites were analyzed by X-ray diffraction (XRD) and transmission electron microscopy. The electrochemical performance for formaldehyde detection has been investigated by cyclic voltammetry (CV) method using polyaniline/ Zn bismuthate nanocomposites modified GCE. Results: XRD shows that ZnBi38O58 phase exists in the nanocomposites. Amorphous polyaniline attaches to the surface of the Zn bismuthate nanorods. The 20wt.% polyaniline/Zn bismuthate nanocomposites modified GCE shows an irreversible cyclic voltammetry (CV) peak at –0.06 V. The peak current increases sharply with increased scan rate, formaldehyde concentration and acidity. The electrochemical response dependences including the linear range, detection limit were analyzed. 20wt.% polyaniline/Zn bismuthate nanocomposites modified GCE shows low detection limit of 0.0095 µM and wide linear range of 0.00001-2 mM. The detection limit for formaldehyde decreases from 0.028 µM to 0.0075 µM with the increase in the polyaniline content from 10wt.% to 40wt.%. Conclusion: The low detection limit and wide linear range make the nanocomposites modified GCE valuable for sensor application. Polyaniline/Zn bismuthate nanocomposites are identified as the prominent electrode materials for sensitive formaldehyde detection.

Sign in / Sign up

Export Citation Format

Share Document