scholarly journals Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

2017 ◽  
Vol 5 (3) ◽  
pp. 353-377 ◽  
Author(s):  
Rafael R. Castillo ◽  
Alejandro Baeza ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

The control of many biological roles exerted by nucleic acids turned them into a powerful tool for the development of advanced biotechnological materials when in combination with mesoporous silica nanoparticles.

scholarly journals Mesoporous Silica Nanoparticles Based Antigens and Nucleic Acids Delivery: A Review

1970 ◽  
Vol 8 (2) ◽  
pp. 50-57
Author(s):  
Jemal Dilebo
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Mesoporous Structure ◽  
Nucleic Acid Delivery ◽  
Hollow Core ◽  
Small Molecule Drugs ◽  
Cell Accumulation ◽  
Nucleic Acids Delivery

Mesoporous silica nanoparticles (MSN) have been explored for the delivery of small molecule drugs, antigens, and nucleic acids because of their large surface area, pore volume, amenability of their surface for functionalization, stable mesoporous structure, and biocompatibility.  Biomoecules loading capacitites,  release and target cell accumulation efficiencies have been improved for both antigen and nucleic acid delivery by the synthesis of large-pore MSN, dendritic MSN, hollow-core MSN, and multifunctional MSN. This article overview the major advances in the use of MSN for delivery of antigens and therapeutic nucleic acids such as DNA, siRNA, and miRNA aimed for treatment of various diseases.       

scholarly journals Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 432 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Action ◽  
The Creation

The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

scholarly journals Preparation and Applications of Organo-Silica Hybrid Mesoporous Silica Nanoparticles for the Co-Delivery of Drugs and Nucleic Acids

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2466
Author(s):  
Iris Pontón ◽  
Andrea Martí del Rio ◽  
Marta Gómez Gómez ◽  
David Sánchez-García
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Building Blocks ◽  
Combination Therapies ◽  
Design Synthesis ◽  
Cellular Target ◽  
Multiple Drugs ◽  
Complex Drug

Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target. In this context, the use of nanoparticles (NP) as platforms for the co-delivery of multiple drugs is considered a highly promising strategy. In particular, mesoporous silica nanoparticles (MSN) have emerged as versatile building blocks to devise complex drug delivery systems (DDS). This review describes the design, synthesis, and application of MSNs to the delivery of multiple drugs including nucleic acids for combination therapies.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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