Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery

2018 ◽  
Vol 47 (11) ◽  
pp. 4198-4232 ◽  
Author(s):  
Hui Wang ◽  
Qianwang Chen ◽  
Shuiqin Zhou
Keyword(s):  
Drug Delivery ◽  
Future Perspectives ◽  
Biomedical Field ◽  
Carbon Based

This review summarizes the latest developments and addresses current applications and future perspectives of carbon-based hybrid nanogels in the biomedical field.

Magnetic and fluorescent carbon-based nanohybrids for multi-modal imaging and magnetic field/NIR light responsive drug carriers

2016 ◽  
Vol 4 (7) ◽  
pp. 1062-1073 ◽  
Author(s):  
Hui Wang ◽  
Shuiqin Zhou
Keyword(s):  
Magnetic Field ◽  
Drug Carriers ◽  
Future Perspectives ◽  
Nir Light ◽  
The Future ◽  
Biomedical Field ◽  
Carbon Based ◽  
Fluorescent Carbon

This mini-review summarizes the latest developments and addresses the future perspectives of carbon-based magnetic and fluorescent nanohybrids in the biomedical field.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

scholarly journals Biomedical application of photo-crosslinked gelatin hydrogels

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Lei Xiang ◽  
Wenguo Cui
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Application ◽  
Biomedical Field ◽  
Or Gene ◽  
Tunable Mechanical Properties ◽  
Bio Compatibility ◽  
Regeneration Of Bone ◽  
Development Prospects

Abstract During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field. Graphical abstract

scholarly journals Nanochitosan: Commemorating the Metamorphosis of an ExoSkeletal Waste to a Versatile Nutraceutical

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 821
Author(s):  
Iyyakkannu Sivanesan ◽  
Manikandan Muthu ◽  
Judy Gopal ◽  
Nazim Hasan ◽  
Syed Kashif Ali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Antitumor Drug ◽  
Organic Polymer ◽  
Clinical Settings ◽  
Future Perspectives ◽  
Research Focus ◽  
Nano Structures

Chitin (poly-N-acetyl-D-glucosamine) is the second (after cellulose) most abundant organic polymer. In its deacetylated form—chitosan—becomes a very interesting material for medical use. The chitosan nano-structures whose preparation is described in this article shows unique biomedical value. The preparation of nanochitosan, as well as the most vital biomedical applications (antitumor, drug delivery and other medical uses), have been discussed in this review. The challenges confronting the progress of nanochitosan from benchtop to bedside clinical settings have been evaluated. The need for inclusion of nano aspects into chitosan research, with improvisation from nanotechnological inputs has been prescribed for breaking down the limitations. Future perspectives of nanochitosan and the challenges facing nanochitosan applications and the areas needing research focus have been highlighted.

scholarly journals Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Lígia N. M. Ribeiro ◽  
Ana C. S. Alcântara ◽  
Gustavo H. Rodrigues da Silva ◽  
Michelle Franz-Montan ◽  
Silvia V. G. Nista ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Toxicity ◽  
Drug Delivery Systems ◽  
Hybrid Polymer ◽  
Future Perspectives ◽  
Sustained Drug Release ◽  
Physicochemical Stability ◽  
Traditional Drug

The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

Electrospun Biomaterials’ Applications and Processing

2021 ◽  
Vol 49 ◽  
pp. 91-100
Author(s):  
Lucie Depeigne ◽  
Emilija Zdraveva
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Review Paper ◽  
Electrospinning Process ◽  
Post Processing ◽  
Natural Polymers ◽  
Main Aspect ◽  
Promising Technique ◽  
Biomedical Field ◽  
Set Up

One of the largest fields of application of electrospun materials is the biomedical field, including development of scaffolds for tissue engineering, drug delivery and wound healing. Electrospinning appears as a promising technique in terms of scaffolds composition and architecture, which is the main aspect of this review paper, with a special attention to natural polymers including collagen, fibrinogen, silk fibroin, chitosan, chitin etc. Thanks to the adaptability of the electrospinning process, versatile hybrid, custom tailored structure scaffolds have been reported. The same is achieved due to the vast biomaterials’ processability as well as modifications of the basic electrospinning set-up and its combination with other techniques, simultaneously or by post-processing.

Nose-to-brain drug delivery: Regulatory aspects, clinical trials, patents, and future perspectives

2021 ◽  
pp. 495-522
Author(s):  
Abhijeet Pandey ◽  
Ajinkya Nikam ◽  
Shreya Basavraj ◽  
Sadhana Mutalik ◽  
Divya Gopalan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Future Perspectives ◽  
Regulatory Aspects ◽  
Brain Drug Delivery

Aerogels for Biomedical Applications

2021 ◽  
pp. 23-42
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Biomedical Applications ◽  
Implantable Devices ◽  
Strategic Development ◽  
The World ◽  
Biomedical Field ◽  
Materials Used

The researchers across the world are actively engaged in strategic development of new porous aerogel materials for possible application of these extraordinary materials in the biomedical field. Due to their excellent porosity and established biocompatibility, aerogels are now emerging as viable solutions for drug delivery and other biomedical applications. This chapter aims to cover the diverse aerogel materials used across the globe for different biomedical applications including drug delivery, implantable devices, regenerative medicine encompassing tissue engineering and bone regeneration, and biosensing.

Quantum Dots Based Material for Drug Delivery Applications

2021 ◽  
pp. 191-215
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Particle Size ◽  
Physical Properties ◽  
Semiconductor Nanoparticles ◽  
Cellular Imaging ◽  
Biological Applications ◽  
Distinct Class ◽  
Imaging Probes ◽  
Biomedical Field

Quantum dots (QDs) have shown promising potential to many biomedical and biological applications, mainly in drug delivery or activation and cellular imaging. These semiconductor nanoparticles, QDs, whose particle size is in the range of 2-10 nanometer with unique photo-chemical and -physical properties that are not possessed by any other isolated molecules, have become one of the distinct class of imaging probes and worldwide platforms for manufacturing of multifunctional nanodevices. In this chapter, properties, applications of QDs, and importance in the biomedical field especially in drug delivery is presented.

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