Vacuum pouch microfluidic system and its application for thin-film micromixers

Lab on a Chip ◽  
2019 ◽  
Vol 19 (17) ◽  
pp. 2834-2843 ◽  
Author(s):  
Cheng-Je Lee ◽  
Yu-Hsiang Hsu
Keyword(s):  
Thin Film ◽  
Lab On A Chip ◽  
Microfluidic System ◽  
System A ◽  
New Type ◽  
On Chip

Vacuum pouch microfluidic system: a new type of lab-on-a-chip device that uses an on-chip vacuum pouch to drive a thin-film micromixer with a wide operation range.

An Integrated Reservoir for On-Chip Aqueous Storage in Microfluidic Systems

1999 ◽  
Author(s):  
Manoj Patel ◽  
H. Thurman Henderson ◽  
Shekhar Bhansali ◽  
Chong H. Ahn
Keyword(s):  
Contact Surface ◽  
Lab On A Chip ◽  
Pressure Head ◽  
Microfluidic System ◽  
Design Issues ◽  
Microfluidic Systems ◽  
Initial Characterization ◽  
On Chip ◽  
Silicon Based

Abstract A reservoir for a silicon-based “lab-on-a-chip” integrated microfluidic system has been designed, fabricated and initially characterized. The reservoirs are necessary for storing reagents, antibodies and buffers required for on-chip capture of target microorganisms in this work. Aside from the matter of storing fluids and providing a pressure head for flow or flow augmentation one has the issue of biochemical compatibility of the contact surface. Where one does not desire a pressure head, a mere bio-chemically compatible “collapsible” bag is desired. All these factors are included in the device. This paper reports design issues, fabrication, packaging and initial characterization of the reservoirs. Scaling possibilities are essentially unlimited, however in this case standard reservoirs have been developed in modules of 1/8 and 1 ml capacity.

SQUID MICROSCOPE

1999 ◽  
Vol 13 (29n31) ◽  
pp. 3747-3749
Author(s):  
W. J. YEH ◽  
BO CHENG
Keyword(s):  
Magnetic Field ◽  
Thin Film ◽  
Flux Line ◽  
The Other ◽  
Superconducting Thin Film ◽  
Large Loop ◽  
System A ◽  
Tightly Coupled ◽  
New Type ◽  
Higher Temperature

We have developed and tested a new type of SQUID microscope, which can operate in magnetic field and at higher temperature. In the system, a single loop coupling transformer made from high-Tc superconducting thin film is used. At one end of the transformer, a small detecting loop about 20 μm can be placed very close to the sample under investigation. At the other end of the transformer, a large loop is tightly coupled with a NbTi coil, which in turn is connected to a low-Tc SQUID. The position of the detecting loop relative to the sample can be remotely controlled. Different sizes of transformer have been tested and calibrated. The results show that the system is capable of detecting a single flux line.

scholarly journals Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Device for a Biosensor †

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1178 ◽  
Author(s):  
Jorge Prada ◽  
Christina Cordes ◽  
Carsten Harms ◽  
Walter Lang
Keyword(s):  
Microfluidic Device ◽  
Heating Temperature ◽  
Low Cost ◽  
Reaction Chamber ◽  
Microfluidic System ◽  
Heating Process ◽  
Design And Manufacturing ◽  
On Chip ◽  
Working Parameters ◽  
Auto Fluorescence

This contribution outlines the design and manufacturing of a microfluidic device implemented as a biosensor for retrieval and detection of bacteria RNA. The device is fully made of Cyclo-Olefin Copolymer (COC), which features low auto-fluorescence, biocompatibility and manufacturability by hot-embossing. The RNA retrieval was carried on after bacteria heat-lysis by an on-chip micro-heater, whose function was characterized at different working parameters. Carbon resistive temperature sensors were tested, characterized and printed on the biochip sealing film to monitor the heating process. Off-chip and on-chip processed RNA were hybridized with capture probes on the reaction chamber surface and identification was achieved by detection of fluorescence tags. The application of the mentioned techniques and materials proved to allow the development of low-cost, disposable albeit multi-functional microfluidic system, performing heating, temperature sensing and chemical reaction processes in the same device. By proving its effectiveness, this device contributes a reference to show the integration potential of fully thermoplastic devices in biosensor systems.

scholarly journals Microfluidic Network Simulations Enable On-Demand Prediction of Control Parameters for Operating Lab-On-A-Chip-Devices

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1320
Author(s):  
Julia Sophie Böke ◽  
Daniel Kraus ◽  
Thomas Henkel
Keyword(s):  
Fluid Management ◽  
Lab On A Chip ◽  
Microfluidic System ◽  
Flow Rates ◽  
Demand Prediction ◽  
Fast Running ◽  
Microfluidic Network ◽  
Fluid Properties ◽  
Network Simulations ◽  
User Friendly

Reliable operation of lab-on-a-chip systems depends on user-friendly, precise, and predictable fluid management tailored to particular sub-tasks of the microfluidic process protocol and their required sample fluids. Pressure-driven flow control, where the sample fluids are delivered to the chip from pressurized feed vessels, simplifies the fluid management even for multiple fluids. The achieved flow rates depend on the pressure settings, fluid properties, and pressure-throughput characteristics of the complete microfluidic system composed of the chip and the interconnecting tubing. The prediction of the required pressure settings for achieving given flow rates simplifies the control tasks and enables opportunities for automation. In our work, we utilize a fast-running, Kirchhoff-based microfluidic network simulation that solves the complete microfluidic system for in-line prediction of the required pressure settings within less than 200 ms. The appropriateness of and benefits from this approach are demonstrated as exemplary for creating multi-component laminar co-flow and the creation of droplets with variable composition. Image-based methods were combined with chemometric approaches for the readout and correlation of the created multi-component flow patterns with the predictions obtained from the solver.

scholarly journals 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
John-Alexander Preuss ◽  
Janina Bahnemann ◽  
Alexander Heisterkamp ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Cells ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Manipulation ◽  
Hydrodynamic Focusing ◽  
Trapping Region ◽  
Dual Beam ◽  
3D Printed ◽  
On Chip

Abstract3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

scholarly journals Analysis of the Practical Implementation of Flicker Measurement Coprocessor for AMI Meters

Energies ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1589
Author(s):  
Krzysztof Kołek ◽  
Andrzej Firlit ◽  
Krzysztof Piątek ◽  
Krzysztof Chmielowiec
Keyword(s):  
Code Generation ◽  
State Of The Art ◽  
Power Grids ◽  
Practical Implementation ◽  
System A ◽  
Measuring Devices ◽  
Point Representation ◽  
Measurement Algorithm ◽  
On Chip ◽  
Vhdl Code

Monitoring power quality (PQ) indicators is an important part of modern power grids’ maintenance. Among different PQ indicators, flicker severity coefficients Pst and Plt are measures of voltage fluctuations. In state-of-the-art PQ measuring devices, the flicker measurement channel is usually implemented as a dedicated processor subsystem. Implementation of the IEC 61000-4-15 compliant flicker measurement algorithm requires a significant amount of computational power. In typical PQ analysers, the flicker measurement is usually implemented as a part of the meter’s algorithm performed by the main processor. This paper considers the implementation of the flicker measurement as an FPGA module to offload the processor subsystem or operate as an IP core in FPGA-based system-on-chip units. The measurement algorithm is developed and validated as a Simulink diagram, which is then converted to a fixed-point representation. Parts of the diagram are applied for automatic VHDL code generation, and the classifier block is implemented as a local soft-processor system. A simple eight-bit processor operates within the flicker measurement coprocessor and performs statistical operations. Finally, an IP module is created that can be considered as a flicker coprocessor module. When using the coprocessor, the main processor’s only role is to trigger the coprocessor and read the results, while the coprocessor independently calculates the flicker coefficients.

Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Ningquan Wang ◽  
Ruxiu Liu ◽  
Norh Asmare ◽  
Chia-Heng Chu ◽  
Ozgun Civelekoglu ◽  
...  
Keyword(s):  
Deep Learning ◽  
Sensor Networks ◽  
Feedback Control ◽  
Closed Loop ◽  
Microfluidic System ◽  
Cell Manipulation ◽  
Integrated Sensor ◽  
Loop Feedback ◽  
Closed Loop Feedback ◽  
On Chip

An adaptive microfluidic system changing its operational state in real-time based on cell measurements through an on-chip electrical sensor network.

scholarly journals Silicon-Quartz Microcapillary Opto-Fluidic Platform Obtained by CMOS-Compatible Die to Wafer 200 mm Dual Bonding Process

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1018
Author(s):  
Giuseppe Fiorentino ◽  
Ben Jones ◽  
Sophie Roth ◽  
Edith Grac ◽  
Murali Jayapala ◽  
...  
Keyword(s):  
Adhesive Bonding ◽  
System Analysis ◽  
Quartz Substrate ◽  
Microfluidic System ◽  
Bonding Process ◽  
Microfluidic Channels ◽  
Fully Integrated ◽  
Lab On Chip ◽  
Human Blood Cells ◽  
On Chip

A composite, capillary-driven microfluidic system suitable for transmitted light microscopy of cells (e.g., red and white human blood cells) is fabricated and demonstrated. The microfluidic system consists of a microchannels network fabricated in a photo-patternable adhesive polymer on a quartz substrate, which, by means of adhesive bonding, is then connected to a silicon microfluidic die (for processing of the biological sample) and quartz die (to form the imaging chamber). The entire bonding process makes use of a very low temperature budget (200 °C). In this demonstrator, the silicon die consists of microfluidic channels with transition structures to allow conveyance of fluid utilizing capillary forces from the polymer channels to the silicon channels and back to the polymer channels. Compared to existing devices, this fully integrated platform combines on the same substrate silicon microfluidic capabilities with optical system analysis, representing a portable and versatile lab-on-chip device.

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