scholarly journals Synergetic anticancer activity of gold porphyrin appended to phenyl tin malonate organometallic complexes

2021 ◽  
Vol 50 (13) ◽  
pp. 4583-4592
Author(s):  
Christophe Nguyen ◽  
Isabelle Toubia ◽  
Stéphane Diring ◽  
Kamel Hadj-Kaddour ◽  
Magali Gary-Bobo ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Organometallic Complexes ◽  
Equimolar Mixture ◽  
Covalent Attachment

The covalent attachment of these two anticancer chemotherapeutics makes it more efficient and selective than the equimolar mixture.

scholarly journals Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

2013 ◽  
Vol 1 ◽  
Author(s):  
Muhammad Hanif ◽  
Samuel M. Meier ◽  
Alexey A. Nazarov ◽  
Julie Risse ◽  
Anton Legin ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Organometallic Complexes

scholarly journals Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 833
Author(s):  
Jahanzaib Arshad ◽  
Kelvin K. H. Tong ◽  
Sanam Movassaghi ◽  
Tilo Söhnel ◽  
Stephen M. F. Jamieson ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Metal Center ◽  
Organometallic Complexes ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
Exchange Reactions ◽  
Leaving Group ◽  
The Impact ◽  
Orally Active

RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate the impact of the metal center on the anticancer activity and their physicochemical properties, the Os(cym), Rh- and Ir(Cp*) (Cp* = pentamethylcyclopentadienyl) analogues of the most promising and orally active compound plecstatin 2 were prepared and characterized by spectroscopic techniques and X-ray diffraction analysis. Dissolution in aqueous medium results in quick ligand exchange reactions; however, over time no further changes in the 1H NMR spectra were observed. The Rh- and Ir(Cp*) complexes were investigated for their reactions with amino acids, and while they reacted with Cys, no reaction with His was observed. Studies on the in vitro anticancer activity identified the Ru derivatives as the most potent, independent of their halido leaving group, while the Rh derivative was more active than the Ir analogue. This demonstrates that the metal center has a significant impact on the anticancer activity of the compound class.

Expanding on the Structural Diversity of Flavone- Derived RutheniumII(ƞ6-arene) Anticancer Agents

Metallodrugs ◽  
2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Mario Kubanik ◽  
Jason K. Y. Tu ◽  
Tilo Söhnel ◽  
Michaela Hejl ◽  
Michael A. Jakupec ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Phenyl Group ◽  
Organometallic Complexes ◽  
2D Nmr Spectroscopy ◽  
Substitution Pattern ◽  
The Impact

Abstract3-Hydroxyflavones belong to the naturally occurring class of flavonoids and have been extensively studied with regard to medicinal application. Moreover, it has been demonstrated that these compounds act as bioactive chelates to the ruthenium(II)–arene moiety. Such organometallic complexes have shown promising anticancer activity against tumor cells via a multitargeting mode of action, interacting with DNA and inhibiting topoisomerase IIα. In this paper, we present the synthesis and characterization of an extended series of 3-hydroxyflavone ligands and their corresponding ruthenium-p-cymene complexes to study the impact of substitution pattern as well as of electron-withdrawing and –donating substituents at the flavonol-phenyl group. The ligands and complexes were characterized by elemental analysis, ESI-MS, 1D as well as 2D NMR spectroscopy. The structures of four Ru(η6-p-cymene) complexes were determined in solid state by single-crystal X-ray diffraction, and the impact of the substitution pattern with regard to in vitro anticancer activity in human cancer cell lines is discussed. Structural differences, calculated octanol-water partition coefficients (clogP) of the flavonols and aqueous solubility were used to rationalize the finding that chlorido[3-(oxo-κO)-2-(3,5- dimethoxyphenyl)-chromen-4-onato-κO](η6-p-cymene)ruthenium(II) 2b exhibits the highest cytotoxicity with IC50 values in the low μM range in all tested cell lines.

883: The Anticancer Activity of Mycobacterial Cell Wall-DNA Complex (MCC) Against Human Bladder Cancer Cell Lines is Different to BCG

2007 ◽  
Vol 177 (4S) ◽  
pp. 294-294
Author(s):  
Nigel C. Phillips ◽  
Sonia Ménard ◽  
David S. Surprenant ◽  
Danbing Ke ◽  
Mario C. Filion
Keyword(s):  
Bladder Cancer ◽  
Cell Wall ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Human Bladder Cancer Cell ◽  
Mycobacterial Cell Wall ◽  
Dna Complex

Novel LC-MS/MS approaches for metabolite identification of natural compounds, such as curcumin and analogues, with anticancer activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
C Tamvakopoulos ◽  
ZD Sofianos ◽  
AL Skaltsounis ◽  
M Kritsanida
Keyword(s):  
Anticancer Activity ◽  
Metabolite Identification ◽  
Natural Compounds

Anticancer activity of resveratrol analogs from Eugenia rigida DC

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
MA Zaki ◽  
V Samoylenko ◽  
S Khan ◽  
RM Abd slam ◽  
MH Hetta ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Resveratrol Analogs

Specific inhbitor of ERK 1/2 AEZS-131: anticancer activity in models of human cancers with and without overactivation of ERK 1/2

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
JB Engel ◽  
S Meyer ◽  
J Dietl ◽  
B Kwok ◽  
O Ortmann ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Cancers

Anticancer activity of peptide extracted from edible mushroom; Lentinus squarrosulus in human lung cancer cells

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
S Sumkhemthong ◽  
M Suksomtip ◽  
P Chanvorachote ◽  
C Chaotham
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Lung ◽  
Edible Mushroom ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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