Metabolomic profiling and biological properties of six Limonium species: novel perspectives for nutraceutical purposes

2021 ◽  
Vol 12 (8) ◽  
pp. 3443-3454
Author(s):  
Biancamaria Senizza ◽  
Leilei Zhang ◽  
Gabriele Rocchetti ◽  
Gokhan Zengin ◽  
Gunes Ak ◽  
...  
Keyword(s):  
Biological Properties ◽  
Industrial Applications ◽  
Large Field ◽  
Metabolomic Profiling

The presented results regarding Limonium species could provide valuable information for a large field of industrial applications, including pharmaceutical and cosmeceutical formulations.

Potentials of Diphenyl Ether Scaffold as a Therapeutic Agent: A Review

2019 ◽  
Vol 19 (17) ◽  
pp. 1392-1406
Author(s):  
Suvarna G. Kini ◽  
Ekta Rathi ◽  
Avinash Kumar ◽  
Varadaraj Bhat
Keyword(s):  
Therapeutic Agent ◽  
Diphenyl Ether ◽  
Biological Properties ◽  
Industrial Applications ◽  
Synthetic Route ◽  
Structure Activity ◽  
Diphenyl Ethers ◽  
Antiviral Activities ◽  
Synthetic Routes ◽  
The 19Th Century

Diphenyl ethers (DPE) and its analogs have exhibited excellent potential for therapeutic and industrial applications. Since the 19th century, intensive research is perpetuating on the synthetic routes and biological properties of DPEs. Few well-known DPEs are Nimesulide, Fenclofenac, Triclosan, Sorafenib, MK-4965, and MK-1439 which have shown the potential of this moiety as a lead scaffold for different pharmacological properties. In this review, we recapitulate the diverse synthetic route of DPE moiety inclusive of merits and demerits over the classical synthetic route and how this moiety sparked an interest in researchers to discern the SAR (Structure Activity Relationship) for the development of diversified biological properties of DPEs such as antimicrobial, antifungal, antiinflammatory & antiviral activities.

scholarly journals Detergent Plants of Northern Thailand: Potential Sources of Natural Saponins

2018 ◽  
Author(s):  
Jiratchaya Wisetkomolmat ◽  
Pongsakorn Suppakittpaisarn ◽  
Sarana Rose Sommano
Keyword(s):  
Plant Species ◽  
Physiological Mechanism ◽  
Structural Diversity ◽  
Bioactive Compound ◽  
Biological Properties ◽  
Industrial Applications ◽  
Natural Forests ◽  
Northern Thailand ◽  
Foaming Agents ◽  
Plant Environment

The natural forests of Northern Thailand are the mother source of many utilisable natural products because of their diverse flora and fauna. Among many plant species found within Northern Thai forests, detergent plants are known for its distinctive cleansing properties. Several local species of detergent plants in Thailand are traditionally used by the locals and indigenous people. However, these plants may become extinct because their habitats have been replaced by industrial agriculture, and their uses have been replaced by chemically synthesised detergents. Researchers need to study and communicate the biology, phytochemistry, and the importance of these plants to conserve natural biodiversity of Northern Thailand. Of many utilisable detergent phytochemicals, natural saponins are known as bio-surfactant and foaming agents. Their physiochemical and biological properties feature structural diversity, which leads to many industrial applications.  In this review, we explained the term “detergent” from the physiological mechanism perspective and the detergent effects of saponin.  We also compiled a list of Thai local plants with cleansing properties focusing on the saponin-containing plants. Future studies should investigate information relative to plant environment, ethnobotanical data and bioactive compound content of these plants. The knowledge acquired from this study will promote the maintenance of the local biodiversity and the conservation of the detergent plant species found in Thailand.

scholarly journals INDUSTRIAL APPLICATIONS OF ARTIFICIAL NEURAL NETWORKS

2014 ◽  
pp. 8-20
Author(s):  
Kurosh Madani
Keyword(s):  
Neural Networks ◽  
Artificial Neural Networks ◽  
Real World ◽  
Industrial Applications ◽  
Large Field ◽  
Nonlinear Functions ◽  
The Past ◽  
Real World Applications ◽  
Ann Models ◽  
Artificial Neural

In a large number of real world dilemmas and related applications the modeling of complex behavior is the central point. Over the past decades, new approaches based on Artificial Neural Networks (ANN) have been proposed to solve problems related to optimization, modeling, decision making, classification, data mining or nonlinear functions (behavior) approximation. Inspired from biological nervous systems and brain structure, Artificial Neural Networks could be seen as information processing systems, which allow elaboration of many original techniques covering a large field of applications. Among their most appealing properties, one can quote their learning and generalization capabilities. The main goal of this paper is to present, through some of main ANN models and based techniques, their real application capability in real world industrial dilemmas. Several examples through industrial and real world applications have been presented and discussed.

scholarly journals Secondary metabolites of a marine-derived Penicillium ochrochloron

2021 ◽  
Vol 13 (3) ◽  
pp. 11020
Author(s):  
Peter M. EZE ◽  
Ying GAO ◽  
Yang LIU ◽  
Lasse Van GEELEN ◽  
Chika P. EJIKEUGWU ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Biological Properties ◽  
Industrial Applications ◽  
Biologically Active ◽  
Fungal Isolation ◽  
The North ◽  
Wide Range ◽  
Extremophilic Fungi ◽  
Fungal Secondary Metabolites

Extremophilic fungi have received considerable attention recently as new promising sources of biologically active compounds with potential pharmaceutical applications. This study investigated the secondary metabolites of a marine-derived Penicillium ochrochloron isolated from underwater sea sand collected from the North Sea in St. Peter-Ording, Germany. Standard techniques were used for fungal isolation, taxonomic identification, fermentation, extraction, and isolation of fungal secondary metabolites. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded eight compounds: talumarin A (1), aspergillumarin A (2), andrastin A (3), clavatol (4), 3-acetylphenol (5), methyl 2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furanpropanoate (6), emodin (7) and 2-chloroemodin (8). After co-cultivation with Bacillus subtilis, the fungus was induced to express (-)-striatisporolide A (9). Compound 1 was evaluated for antibacterial activity against Staphylococcus aureus, Acinetobacter baumannii, Mycobacterium smegmatis, and M. tuberculosis, as well as cytotoxicity against THP-1 cells. The compound, however, was not cytotoxic to THP-1 cells and had no antibacterial activity against the microorganisms tested. The compounds isolated from P. ochrochloron in this study are well-known compounds with a wide range of beneficial biological properties that can be explored for pharmaceutical, agricultural, or industrial applications. This study highlights the bioprospecting potential of marine fungi and confirms co-cultivation as a useful strategy for the discovery of new natural products.

scholarly journals Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

2018 ◽  
Vol 9 ◽  
pp. 1050-1074 ◽  
Author(s):  
Jaison Jeevanandam ◽  
Ahmed Barhoum ◽  
Yen S Chan ◽  
Alain Dufresne ◽  
Michael K Danquah
Keyword(s):  
Risk Assessment ◽  
Nanostructured Materials ◽  
Mammalian Cells ◽  
Size Composition ◽  
Biological Properties ◽  
Industrial Applications ◽  
Specific Knowledge ◽  
Naturally Occurring ◽  
Physical Chemical ◽  
Toxic Reactions

Nanomaterials (NMs) have gained prominence in technological advancements due to their tunable physical, chemical and biological properties with enhanced performance over their bulk counterparts. NMs are categorized depending on their size, composition, shape, and origin. The ability to predict the unique properties of NMs increases the value of each classification. Due to increased growth of production of NMs and their industrial applications, issues relating to toxicity are inevitable. The aim of this review is to compare synthetic (engineered) and naturally occurring nanoparticles (NPs) and nanostructured materials (NSMs) to identify their nanoscale properties and to define the specific knowledge gaps related to the risk assessment of NPs and NSMs in the environment. The review presents an overview of the history and classifications of NMs and gives an overview of the various sources of NPs and NSMs, from natural to synthetic, and their toxic effects towards mammalian cells and tissue. Additionally, the types of toxic reactions associated with NPs and NSMs and the regulations implemented by different countries to reduce the associated risks are also discussed.

scholarly journals Special Issue: The Antioxidant Capacities of Natural Products

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 492 ◽  
Author(s):  
Susana Cardoso
Keyword(s):  
Oxidative Stress ◽  
Natural Products ◽  
Biological Properties ◽  
Industrial Applications ◽  
Special Issue ◽  
Antioxidant Capacities

Antioxidants are under the research spotlight because of their potential to prevent oxidative stress as well as for their versatile biological properties that grant them multiple industrial applications [...]

Numerical implementation of the microplane constitutive model for shape memory alloys

2017 ◽  
Vol 233 (6) ◽  
pp. 1117-1133 ◽  
Author(s):  
MR Karamooz-Ravari ◽  
B Shahriari
Keyword(s):  
Shape Memory Alloy ◽  
Constitutive Model ◽  
Shape Memory Alloys ◽  
Shape Memory ◽  
Numerical Integration ◽  
Biological Properties ◽  
Industrial Applications ◽  
Stress Increment ◽  
Integration Formulas

With the advent of shape memory alloys, several industrial applications were proposed due to their superior mechanical and biological properties. Since the fabrication and characterization of shape memory alloy devices is challenging and expensive, it is necessary to simulate their thermomechanical responses before fabrication. To do so, a powerful constitutive model capable of simulation of the important features of these materials is necessary. To be able to simulate a shape memory alloy device, it is vital to implement a suitable constitutive model in such a way to be used in finite element models. In this paper, an existing constitutive model based on microplane theory is numerically implemented and the effects of stress increment, different numerical integration formulas, and loading direction on the thermomechanical response of shape memory alloy is investigated through superelastic and shape memory proportional and nonproportional loadings. The obtained results show that the stress increment may have significant effect on the results if the forward Euler scheme is utilized. In addition, for the case of numerical integration over the surface of a unit hemisphere, 61 points integration formula without orthogonal symmetry provides the best results while 21 orthogonally symmetric one is the most inaccurate one. Also, the orthogonally symmetric numerical integration formulas predict the isotropic material response while those without orthogonal symmetry predict a little anisotropy.

scholarly journals Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 171 ◽  
Author(s):  
Juliane Deise Fleck ◽  
Andresa Heemann Betti ◽  
Francini Pereira Da Silva ◽  
Eduardo Artur Troian ◽  
Cristina Olivaro ◽  
...  
Keyword(s):  
Vaccine Development ◽  
Cytotoxic T Lymphocyte ◽  
Biological Activities ◽  
Biological Properties ◽  
Industrial Applications ◽  
Chemical Characteristics ◽  
Antigen Uptake ◽  
Quillaja Saponaria ◽  
Discovery Research ◽  
Drug Discovery Research

Quillaja saponaria Molina represents the main source of saponins for industrial applications. Q. saponaria triterpenoids have been studied for more than four decades and their relevance is due to their biological activities, especially as a vaccine adjuvant and immunostimulant, which have led to important research in the field of vaccine development. These saponins, alone or incorporated into immunostimulating complexes (ISCOMs), are able to modulate immunity by increasing antigen uptake, stimulating cytotoxic T lymphocyte production (Th1) and cytokines (Th2) in response to different antigens. Furthermore, antiviral, antifungal, antibacterial, antiparasitic, and antitumor activities are also reported as important biological properties of Quillaja triterpenoids. Recently, other saponins from Q. brasiliensis (A. St.-Hill. & Tul.) Mart. were successfully tested and showed similar chemical and biological properties to those of Q. saponaria barks. The aim of this manuscript is to summarize the current advances in phytochemical and pharmacological knowledge of saponins from Quillaja plants, including the particular chemical characteristics of these triterpenoids. The potential applications of Quillaja saponins to stimulate further drug discovery research will be provided.

scholarly journals Detergent Plants of Northern Thailand: Potential Sources of Natural Saponins

Resources ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
Jiratchaya Wisetkomolmat ◽  
Pongsakorn Suppakittpaisarn ◽  
Sarana Rose Sommano
Keyword(s):  
Physiological Mechanism ◽  
Structural Diversity ◽  
Bioactive Compound ◽  
Biological Properties ◽  
Industrial Applications ◽  
Natural Forests ◽  
Northern Thailand ◽  
Foaming Agents ◽  
Plant Environment ◽  
Local Plants

The natural forests of Northern Thailand are the mother source of many utilisable natural products because of their diverse flora and fauna. Northern Thai people have learned to utilise plants, in particular those of plants with cleansing properties, since the beginning of time. Several local species of detergent plants in Thailand are traditionally used by the locals and indigenous people. However, these plants may become extinct because their habitats have been replaced by industrial agriculture, and their uses have been replaced by chemically synthesised detergents. Researchers need to study and communicate the biology, phytochemistry, and the importance of these plants to conserve natural biodiversity of Northern Thailand. Of many utilisable detergent phytochemicals, natural saponins are known as bio-based surfactant and foaming agents. Their physiochemical and biological properties feature structural diversity, which leads to many industrial applications. In this review, we explained the term “detergent” from the physiological mechanism perspective and the detergent effects of saponins. We also compiled a list of Thai local plants with cleansing properties focusing on the saponin-containing plants. Future studies should investigate information relative to plant environment, ethnobotanical data, and the bioactive compound content of these plants. The knowledge acquired from this study will promote the maintenance of the local biodiversity and the conservation of the detergent plant species found in Thailand.

scholarly journals A Review on Carbon Nanotubes (CNT): Structure, Synthesis, Purification and Properties for Modern day Applications

2021 ◽  
Author(s):  
Nur-Azzah Afifah Binti Taib ◽  
Md. Rezaur Rahman ◽  
Mohammed Mahbubul Matin ◽  
Jamal Uddin ◽  
Muhammad Khusairy Bin Bakri ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Arc Discharge ◽  
Chemical Vapor ◽  
Biological Properties ◽  
Industrial Applications ◽  
Structural Reinforcement ◽  
Structure Synthesis ◽  
Purification And Properties ◽  
Wide Range ◽  
Walled Cnts

Abstract Carbon nanotubes (CNTs), composed of graphene/graphite sheets, have been used since the 1990s and become one of the most important materials owing to its massive applications in energy, environmental and life sciences. In general, there are two types of known CNTs such as single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). They have broader and novel fields of application in the fabric and textile industries, wastewater treatment, energy storage, and also as structural reinforcement materials. CNTs are reported to synthesize by arc discharge, laser ablation and chemical vapor deposition (CVD) methods where CVD technique is found to be the most versatile and largely used method. In all the methods synthesized CNTs contain various degrees of impurities which are purified by oxidation treatment, ultra-sonication, magnetic purification, etc. CNTs have wide range of industrial applications due to their remarkable mechanical, thermal, electrical, chemical and biological properties. In this review, medical and biomedical applications of CNTs and CNTs-based composites are specially focused due to their significant applications in these fields along with their structure, classification, preparation and related properties. Besides, CNTs’ toxicity and biosafety, especially on the human body, are also discussed in this review article.

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